scholarly journals Human, animal and environmental contributors to antibiotic resistance in low-resource settings: integrating behavioural, epidemiological and One Health approaches

2018 ◽  
Vol 285 (1876) ◽  
pp. 20180332 ◽  
Author(s):  
Emily K. Rousham ◽  
Leanne Unicomb ◽  
Mohammad Aminul Islam
Keyword(s):  
Antibiotic Resistance ◽  
One Health ◽  
Production Systems ◽  
Acquired Resistance ◽  
Social Science Research ◽  
Science Research ◽  
Resistant Bacteria ◽  
Low Resource Settings ◽  
Low Resource ◽  
The One

Antibiotic resistance (ABR) is recognized as a One Health challenge because of the rapid emergence and dissemination of resistant bacteria and genes among humans, animals and the environment on a global scale. However, there is a paucity of research assessing ABR contemporaneously in humans, animals and the environment in low-resource settings. This critical review seeks to identify the extent of One Health research on ABR in low- and middle-income countries (LMICs). Existing research has highlighted hotspots for environmental contamination; food-animal production systems that are likely to harbour reservoirs or promote transmission of ABR as well as high and increasing human rates of colonization with ABR commensal bacteria such as Escherichia coli . However, very few studies have integrated all three components of the One Health spectrum to understand the dynamics of transmission and the prevalence of community-acquired resistance in humans and animals. Microbiological, epidemiological and social science research is needed at community and population levels across the One Health spectrum in order to fill the large gaps in knowledge of ABR in low-resource settings.

scholarly journals Drivers of Antibiotic Resistance Transmission in Low- and Middle-Income Countries from a “One Health” Perspective—A Review

Antibiotics ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 372 ◽  
Author(s):  
Katia Iskandar ◽  
Laurent Molinier ◽  
Souheil Hallit ◽  
Massimo Sartelli ◽  
Fausto Catena ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
One Health ◽  
Geographical Area ◽  
Resistant Bacteria ◽  
Surveillance Systems ◽  
Market Failures ◽  
Middle Income ◽  
Safety Issues ◽  
Middle Income Countries ◽  
The One

Antibiotic resistance is an ecosystem problem threatening the interrelated human-animal-environment health under the “One Health” framework. Resistant bacteria arising in one geographical area can spread via cross-reservoir transmission to other areas worldwide either by direct exposure or through the food chain and the environment. Drivers of antibiotic resistance are complex and multi-sectoral particularly in Lower- and Middle-income countries. These include inappropriate socio-ecological behaviors; poverty; overcrowding; lack of surveillance systems; food supply chain safety issues; highly contaminated waste effluents; and loose rules and regulations. In order to examine the drivers of antibiotic resistance from a “one health” perspective, a literature review was conducted on three databases including PubMed, Medline and Google Scholar. A total of 485 studies of potential relevance were selected, out of which 182 were included in this review. Results have shown that the aforementioned market failures are the leading cause for the negative externality of antibiotic resistance that extends in scope from the individual to the global ecosystem. Incremental and sustainable global actions can make the change, however, the problem will continue to prevail if governments do not prioritize the “One health” approach and if individual’s accountability is still denied in a world struggling with profound socio-economic problems.

scholarly journals Finding What Is Inaccessible: Antimicrobial Resistance Language Use among the One Health Domains

Antibiotics ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 385
Author(s):  
Lauren L. Wind ◽  
Jonathan S. Briganti ◽  
Anne M. Brown ◽  
Timothy P. Neher ◽  
Meghan F. Davis ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Open Access ◽  
Antimicrobial Resistance ◽  
Language Processing ◽  
One Health ◽  
Language Use ◽  
Language Usage ◽  
Health Domains ◽  
Accessibility Issues ◽  
The One

The success of a One Health approach to combating antimicrobial resistance (AMR) requires effective data sharing across the three One Health domains (human, animal, and environment). To investigate if there are differences in language use across the One Health domains, we examined the peer-reviewed literature using a combination of text data mining and natural language processing techniques on 20,000 open-access articles related to AMR and One Health. Evaluating AMR key term frequency from the European PubMed Collection published between 1990 and 2019 showed distinct AMR language usage within each domain and incongruent language usage across domains, with significant differences in key term usage frequencies when articles were grouped by the One Health sub-specialties (2-way ANOVA; p < 0.001). Over the 29-year period, “antibiotic resistance” and “AR” were used 18 times more than “antimicrobial resistance” and “AMR”. The discord of language use across One Health potentially weakens the effectiveness of interdisciplinary research by creating accessibility issues for researchers using search engines. This research was the first to quantify this disparate language use within One Health, which inhibits collaboration and crosstalk between domains. We suggest the following for authors publishing AMR-related research within the One Health context: (1) increase title/abstract searchability by including both antimicrobial and antibiotic resistance related search terms; (2) include “One Health” in the title/abstract; and (3) prioritize open-access publication.

scholarly journals Genetic but No Phenotypic Associations between Biocide Tolerance and Antibiotic Resistance in Escherichia coli from German Broiler Fattening Farms

2021 ◽  
Vol 9 (3) ◽  
pp. 651
Author(s):  
Alice Roedel ◽  
Szilvia Vincze ◽  
Michaela Projahn ◽  
Uwe Roesler ◽  
Caroline Robé ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Antibiotic Resistance ◽  
Acquired Resistance ◽  
Antibiotic Resistance Genes ◽  
Animal Husbandry ◽  
Metal Resistance ◽  
Resistant Bacteria ◽  
Virulence Determinants ◽  
Phylogenetic Distribution ◽  
Resistance Determinants

Biocides are frequently applied as disinfectants in animal husbandry to prevent the transmission of drug-resistant bacteria and to control zoonotic diseases. Concerns have been raised, that their use may contribute to the selection and persistence of antimicrobial-resistant bacteria. Especially, extended-spectrum β-lactamase- and AmpC β-lactamase-producing Escherichia coli have become a global health threat. In our study, 29 ESBL-/AmpC-producing and 64 NON-ESBL-/AmpC-producing E.coli isolates from three German broiler fattening farms collected in 2016 following regular cleaning and disinfection were phylogenetically characterized by whole genome sequencing, analyzed for phylogenetic distribution of virulence-associated genes, and screened for determinants of and associations between biocide tolerance and antibiotic resistance. Of the 30 known and two unknown sequence types detected, ST117 and ST297 were the most common genotypes. These STs are recognized worldwide as pandemic lineages causing disease in humans and poultry. Virulence determinants associated with extraintestinal pathogenic E.coli showed variable phylogenetic distribution patterns. Isolates with reduced biocide susceptibility were rarely found on the tested farms. Nine isolates displayed elevated MICs and/or MBCs of formaldehyde, chlorocresol, peroxyacetic acid, or benzalkonium chloride. Antibiotic resistance to ampicillin, trimethoprim, and sulfamethoxazole was most prevalent. The majority of ESBL-/AmpC-producing isolates carried blaCTX-M (55%) or blaCMY-2 (24%) genes. Phenotypic biocide tolerance and antibiotic resistance were not interlinked. However, biocide and metal resistance determinants were found on mobile genetic elements together with antibiotic resistance genes raising concerns that biocides used in the food industry may lead to selection pressure for strains carrying acquired resistance determinants to different antimicrobials.

scholarly journals Aquatic environments in the One Health context: modulating the antimicrobial resistance phenomenon

2020 ◽  
Vol 32 ◽  
Author(s):  
Juliana Alves Resende ◽  
Vânia Lúcia da Silva ◽  
Claudio Galuppo Diniz
Keyword(s):  
Antimicrobial Resistance ◽  
One Health ◽  
Anthropogenic Activities ◽  
Treatment Strategies ◽  
Chemical Pollution ◽  
Resistant Bacteria ◽  
Aquatic Environments ◽  
Antimicrobial Substances ◽  
Antimicrobial Resistance Genes ◽  
The One

Abstract: From an anthropocentric perspective, aquatic environments are important to maintain health and survival, however, as they are sometimes managed based on misconception, they are considered a convergent pathway for anthropogenic residues and sanitation. Thus, it is observed that these ecosystems have been threatened by chemical pollution due to xenobiotics, especially from a more contemporary approach, by the selective pressure associated with antimicrobials. There are several studies that report the enrichment of antimicrobial resistant bacteria and mobilizable antimicrobial resistance genes in aquatic and adjacent ecosystems. From the perspective of the emerging and reemerging number of diseases related to the interplay of human, animal, and environmental factors, a new conception arose to address these issues holistically, which is known as the One Health approach. Scientific and political discourse on this conception should lead to effective action plans for preventing and controlling the spread of infectious diseases in open environment, including those impacted by anthropogenic activities. Therefore, nowadays, discussions on antimicrobial resistance are becoming broader and are requiring a multi-disciplinary view to address health and environmental challenges, which includes aquatic environment management. Water may represent one of the most important ecosystems for the in antimicrobial resistance phenomenon that arises when a dynamic and singular microbial community may be influenced by several characteristics. As antimicrobial substances do not all degrade at the same time under the same treatment, strategies concerning their removal from the environment should consider their individualized chemical characteristics.

scholarly journals Hagnýting menntunar meðal háskólamenntaðs starfsfólks einkarekinna fyrirtækja og opinberra stofnana

2017 ◽  
Vol 13 (1) ◽  
pp. 151
Author(s):  
Ingi Rúnar Eðvarðsson ◽  
Guðmundur Kristján Óskarsson ◽  
Jason Már Bergsteinsson
Keyword(s):  
Social Science Research ◽  
Science Research ◽  
Target Population ◽  
University Education ◽  
Private Companies ◽  
Public Companies ◽  
National Population Register ◽  
The Difference ◽  
The One ◽  
The University

The aim of the article is to examine whether there is a difference in the utilization of education among university educated employees in private companies on the one hand and public institutions on the other. The target population of the research was based on a random sample drawn from the National Population Register by the National Survey of the Social Science Research Institute of the University of Iceland from 9 March to 9 April 2016. The survey included 2,001 individuals, aged 18 or above, from all over the country. A total of 1,210 persons responded to the survey. This research only involved those participants in the sample who had completed a university education and were salaried employees in Iceland. After data cleansing, 374 participants remained, 178 males and 196 females. The initial results of the research indicated that 20.3% of participants were over-educated for their jobs. The majority of females work in public companies, while the majority of males work in private companies. Individuals with under-education are most likely to be found within public companies, at the same time as over-educated individuals are most likely to be found in private companies (the difference lies in the under- and over-education of females). Those working in public companies come primarily from educational and health sicences, while engineers and natural sicentists work primarily at private companies. Incomes are higher in private companies.

Characterization of bacteria and antibiotic resistance in commercially-produced cheeses sold in China

2021 ◽  
Author(s):  
Jinghui Yao ◽  
Jing Gao ◽  
Jianming Guo ◽  
Hengan Wang ◽  
En Zhang ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Acquired Resistance ◽  
Antibiotic Resistance Genes ◽  
16S Rrna Gene Sequencing ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Rrna Gene ◽  
Rrna Gene Sequencing

The consumption of cheese in China is increasing rapidly. Little is known about the microbiota, the presence of antibiotic-resistant bacteria, or the distribution of antibiotic resistance genes (ARGs) in commercially-produced cheeses sold in China. These are important criteria for evaluating quality and safety. Thus, this study assessed the metagenomics of fifteen types of cheese using 16S rRNA gene sequencing. Fourteen bacterial genera were detected. Lactococcus , Lactobacillus , and Streptococcus were dominant based on numbers of sequence reads. Multidrug-resistant lactic acid bacteria were isolated from most of the types of cheese. The isolates showed 100% and 91.7% resistance to streptomycin and sulfamethoxazole, respectively, and genes involved in acquired resistance to streptomycin ( strB) and sulfonamides ( sul2) were detected with high frequency. To analyze the distribution of ARGs in the cheeses in overall, 309 ARGs from eight categories of ARG and nine transposase genes were profiled. A total of 169 ARGs were detected in the 15 cheeses; their occurrence and abundance varied significantly between cheeses. Our study demonstrates that there is various diversity of the bacteria and ARGs in cheeses sold in China. The risks associated with multidrug resistance of dominant lactic acid bacteria are of great concern.

Digitalisierung und Nachbarschaft

2019 ◽  
Keyword(s):  
Social Media ◽  
Digital Media ◽  
Local Community ◽  
Social Science Research ◽  
Science Research ◽  
The Other ◽  
The Internet ◽  
The Social ◽  
The One ◽  
The Relationship

There has hardly been any other development that has changed our everyday lives as significantly as digitalisation, and there is hardly anything as commonplace as neighbourship. Despite the links between these two concepts growing, they have been neglected in social science research in Germany so far. The prevailing sentiment is that the Internet and social media sites have no connection to the real world, but there are countless neighbourship groups on Facebook, Twitter hashtags named after neighbourhoods or entire websites, such as ‘nebenan.de’, which endeavour to strengthen local community bonds through digital means. In short, the social developments in this respect are already considerably more advanced than the knowledge that exists about it. This anthology makes a fundamental contribution to the sociological debate on digitalisation and neighbourship by aiming to provide an overview of the relationship between digitalisation and neighbourship on the one hand, and open up avenues for further research on the other. It therefore examines and systematises attempts to strengthen local community bonds using digital media from different perspectives.

scholarly journals Extraintestinal Pathogenic Escherichia coli: Virulence Factors and Antibiotic Resistance

Pathogens ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1355
Author(s):  
Valerio M. Sora ◽  
Gabriele Meroni ◽  
Piera A. Martino ◽  
Alessio Soggiu ◽  
Luigi Bonizzi ◽  
...  
Keyword(s):  
Public Health ◽  
One Health ◽  
Production Systems ◽  
E Coli ◽  
Opportunistic Bacteria ◽  
Food Animal ◽  
Pathogenic Escherichia Coli ◽  
Resistant Strains ◽  
The One ◽  
Animal Production Systems

The One Health approach emphasizes the importance of antimicrobial resistance (AMR) as a major concern both in public health and in food animal production systems. As a general classification, E. coli can be distinguished based on the ability to cause infection of the gastrointestinal system (IPEC) or outside of it (ExPEC). Among the different pathogens, E. coli are becoming of great importance, and it has been suggested that ExPEC may harbor resistance genes that may be transferred to pathogenic or opportunistic bacteria. ExPEC strains are versatile bacteria that can cause urinary tract, bloodstream, prostate, and other infections at non-intestinal sites. In this context of rapidly increasing multidrug-resistance worldwide and a diminishingly effective antimicrobial arsenal to tackle resistant strains. ExPEC infections are now a serious public health threat worldwide. However, the clinical and economic impact of these infections and their optimal management are challenging, and consequently, there is an increasing awareness of the importance of ExPECs amongst healthcare professionals and the general public alike. This review aims to describe pathotype characteristics of ExPEC to increase our knowledge of these bacteria and, consequently, to increase our chances to control them and reduce the risk for AMR, following a One Health approach.

scholarly journals Contextualizing Social Science in Nepal

1970 ◽  
Vol 2 ◽  
pp. 1-30
Author(s):  
Dev Raj Dahal
Keyword(s):  
Social Science ◽  
Social Life ◽  
Scientific Reasoning ◽  
Social Science Research ◽  
Linear Structure ◽  
Science Research ◽  
Practical Experience ◽  
Contextual Knowledge ◽  
Social Scientists ◽  
The One

Social science informs about the ideals and trains experts to deal with the complex social realities. It has a public purpose rooted in what we call dharma (professional and institutional responsibility) as opposed to the arrogance of reason, self-will and self-rationalization intrinsic to contemporary rational choice and modernity. Learning has a synergy - establishing connection between the world of social science theories and the drama of social life. A lack of mutual learning between Nepal's traditional faith intellectuals and modern reason-based social scientists has created a big hiatus and contradiction. The academic life of social scientists in Nepal is completely outside of spiritual, moral and ethical influence experienced by ordinary public. The spiritual blindness of modern social scientists has thus opened multiple gaps between their worldview and those of the citizens on various frontiers--theoretical knowledge and practical experience, technical understanding and composite knowledge and secularity of social science and the vitality of the Hindu-Buddhist scriptures in the popular mind, culture, behavior and practices. This has reinforced a division between the system of knowledge of social scientists and the life-world of people. The proponents of new social movements in Nepal, such as women, Dalits, Janajatis, Madhesis, youths and marginalized population are seeking a structural shift in reason-based knowledge to both reason and feeling in social science knowledge discovery. This movement can open the "captive mind" to social learning of contextual knowledge, conduct research with the citizens, provide inputs to the policy makers and reverse their linear, structure-bound, rationalist and disciplinary thinking into the one that represents what the Nepal mandala, the Nepali space, is really like and how to improve it for the better. The renewal and indigenization of qualitative social science research is important to overcome the spirited challenges posed by social forces in Nepal and contribute to the application of scientific reasoning in public policy and social change.Key Words: social movement, NepalDOI = 10.3126/dsaj.v2i0.1356Dhaulagiri Journal of Sociology and Anthropology Vol.2 pp.1-30

scholarly journals Reservoir water in Singapore contains ESBL-producing and carbapenem-resistant bacteria with conjugatable conserved gene cluster transfer between different species.

2021 ◽  
Author(s):  
Yang Zhong ◽  
Siyao Guo ◽  
Joergen Schlundt
Keyword(s):  
One Health ◽  
Gene Clusters ◽  
Resistant Bacteria ◽  
Klebsiella Pneumonia ◽  
Sequencing Analysis ◽  
Metagenomic Sequencing ◽  
Beta Lactamase ◽  
Reservoir Water ◽  
The One ◽  
Conserved Gene

As the role of the aquatic environment in the One-Health approach has called increasing attention, the studies of Antimicrobial resistance (AMR) spreading in the water bodies have been reported worldwide. However, there are still limited studies on the AMR carrier in the reservoir water in Singapore. Since 2018, our group has collect water samples from six reservoirs in Singapore and isolated the beta-lactam-resistant bacteria from them. We then characterized the isolates with Whole-genome sequencing (WGS) and successfully identified ESBL-producing bacteria from three sampling reservoirs, and confirmed their resistance with both phenotypic and sequencing methods. To better understand the AMR spreading locally, we compared our isolates with isolates from other WGS studies in Singapore covered humans, food, and the enviroment. From there, we noticed the same sequence type (ST) as ST10, ST23, and ST38 has been shared among the environment, food, and humans, as well as the same beta-lactamase genes, are widely distributed among multiple sources. Further genetic environment comparison of beta-lactamase has suggested their spreading as conserved gene clusters among different species and sources. And this hypothesis has been supported by the successful conjugation of blaCTX-M-15 from Klebsiella pneumonia to Escherichia coli (E .coli). We also applied the shotgun metagenomic sequencing to understand the community of bacteria in reservoir water and detect the AMR genes. The composition of bacteria has shown different diversity among different samples. Besides, different beta-lactamase genes have been identified compared to culture depended methods. Here, we suggest that sequencing analysis has great potential in understanding AMR spreading in the One-Health approach. A genetic-based AMR risk assessment is in urgent need in Singapore.

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