Development and Testing of a Miniature Silicon Microgyroscope Prototype

Author(s):  
Dunzhu Xia ◽  
Bailing Zhou ◽  
Shourong Wang

A silicon microgyroscope with the structure of area-changing capacitor detection is adopted in this paper, and the quality factor of Silicon Microgyroscope sealed with CAN mental package working under the air pressure of 10 Pa is above 3000, so its sense mode detection essentially attains better linear performance and high sensitivity. Single side driving and single side detection methods are applied to make both vibrating amplitude and frequency highly stable in drive mode circuit, and open loop difference detection method is utilized to achieve high precision detection in sense mode circuit. A miniature prototype scheme based on PCB technology has been realized with volume size of 40mm¡ 40mm¡ 30mm and power cost of less than 300 mW. The testing results demonstrate that the useful and quadrate signal will not interact because of their phase decoupling. Under the condition of the scale factor of 9.6 mV/°/s, the zero bias stability attains below 28 ° /h with linearity coefficient less than 500 ppm and simulated bandwidth more than 100 Hz, which has been improved two orders of magnitude better than that at atmospheric pressure. The engineering work is evolving at present.

2021 ◽  
Vol 368 (6) ◽  
Author(s):  
Liwen Zhang ◽  
Qingyu Lv ◽  
Yuling Zheng ◽  
Xuan Chen ◽  
Decong Kong ◽  
...  

ABSTRACT T-2 is a common mycotoxin contaminating cereal crops. Chronic consumption of food contaminated with T-2 toxin can lead to death, so simple and accurate detection methods in food and feed are necessary. In this paper, we establish a highly sensitive and accurate method for detecting T-2 toxin using AlphaLISA. The system consists of acceptor beads labeled with T-2-bovine serum albumin (BSA), streptavidin-labeled donor beads and biotinylated T-2 antibodies. T-2 in the sample matrix competes with T-2-BSA for antibodies. Adding biotinylated antibodies to the test well followed by T-2 and T-2-BSA acceptor beads yielded a detection range of 0.03–500 ng/mL. The half-maximal inhibitory concentration was 2.28 ng/mL and the coefficient of variation was <10%. In addition, this method had no cross-reaction with other related mycotoxins. This optimized method for extracting T-2 from food and feed samples achieved a recovery rate of approximately 90% in T-2 concentrations as low as 1 ng/mL, better than the performance of a commercial ELISA kit. This competitive AlphaLISA method offers high sensitivity, good specificity, good repeatability and simple operation for detecting T-2 toxin in food and feed.


2013 ◽  
Vol 690-693 ◽  
pp. 1449-1454
Author(s):  
Yuan Wang ◽  
Hui Juan Yu ◽  
Bei Lei Qian ◽  
You Qiong Cai ◽  
Dong Mei Huang ◽  
...  

Gold immunochromatography assay (GICA) technique has the following characteristics: rapid and simple, high sensitivity, good specificity, no auxiliary equipment, ease of interpreting results, and satisfactory stability. The technique has become one of the most rapid and sensitive immunological detection methods, which is widely used in medical, biological and other fields. The article focuses on the basic principles and technical characteristics of GICA, and briefly describes the applications and future perspectives in the rapid detection of aquatic products.


2012 ◽  
Vol 229-231 ◽  
pp. 1423-1426
Author(s):  
Yong Zheng Wang ◽  
Lei Jiang ◽  
Mao Zhen Yue ◽  
Su Fang Bian

In this paper, three detection methods were analyzed to determine the chlorine precipitation from the flue gas: Silver nitrate volumetric analysis (SNVA), Volhard method (VM) and Mercuric thiocyanate spectrophotometric method (MTSM). Results indicated that SNVA and VM were simple and convenient, but unsuitable for the detection of blend fuel due to the high lower limit. MTSM was suitable for biomass and coal co-combustion for its low lower limit and high sensitivity. In addition, MTSM needed less sample solution, which made it more suitable for multiple measurements to reduce errors, and the maximum proportional error was only 3.5%.


Micromachines ◽  
2021 ◽  
Vol 12 (11) ◽  
pp. 1375
Author(s):  
Junji Pu ◽  
Kai Zeng ◽  
Yulie Wu ◽  
Dingbang Xiao

In recent years, the optical accelerometer based on the optical trapping force effect has gradually attracted the attention of researchers for its high sensitivity and high measurement accuracy. However, due to its large size and the complexity of optical path adjustment, the optical force accelerometers reported are only suitable for the laboratory environment up to now. In this paper, a miniature optical force dual-axis accelerometer based on the miniature optical system and a particles cavity which is prepared by Micro-Electro-Mechanical Systems (MEMS) technology is proposed. The overall system of the miniature optical levitation including the miniature optical system and MEMS particles cavity is a cylindrical structure with a diameter of about 10 mm and a height of 33 mm (Φ 10 mm × 33 mm). Moreover, the size of this accelerometer is 200 mm × 100 mm × 100 mm. Due to the selected light source being a laser diode light source with elliptical distribution, it is sensitive to the external acceleration in both the long axis and the short axis. This accelerometer achieves a measurement range of ±0.17 g–±0.26 g and measurement resolution of 0.49 mg and 1.88 mg. The result shows that the short-term zero-bias stability of the two orthogonal axes of the optical force accelerometer is 4.4 mg and 9.2 mg, respectively. The main conclusion that can be drawn is that this optical force accelerometer could provide an effective solution for measuring acceleration with an optical force effect for compact engineering devices.


2021 ◽  
Vol 27 (1) ◽  
Author(s):  
Mei Tao ◽  
Ming Zheng ◽  
Yanhua Xu ◽  
Shuo Ma ◽  
Weiwei Zhang ◽  
...  

AbstractCircular RNAs (circRNAs), a novel type of non-coding RNAs (ncRNAs), have a covalently closed circular structure resulting from pre-mRNA back splicing via spliceosome and ribozymes. They can be classified differently in accordance with different criteria. As circRNAs are abundant, conserved, and stable, they can be used as diagnostic markers in various diseases and targets to develop new therapies. There are various functions of circRNAs, including sponge for miR/proteins, role of scaffolds, templates for translation, and regulators of mRNA translation and stability. Without m7G cap and poly-A tail, circRNAs can still be degraded in several ways, including RNase L, Ago-dependent, and Ago-independent degradation. Increasing evidence indicates that circRNAs can be modified by N-6 methylation (m6A) in many aspects such as biogenesis, nuclear export, translation, and degradation. In addition, they have been proved to play a regulatory role in the progression of various cancers. Recently, methods of detecting circRNAs with high sensitivity and specificity have also been reported. This review presents a detailed overview of circRNAs regarding biogenesis, biomarker, functions, degradation, and dynamic modification as well as their regulatory roles in various cancers. It’s particularly summarized in detail in the biogenesis of circRNAs, regulation of circRNAs by m6A modification and mechanisms by which circRNAs affect tumor progression respectively. Moreover, existing circRNA detection methods and their characteristics are also mentioned.


Sensors ◽  
2018 ◽  
Vol 18 (9) ◽  
pp. 3001 ◽  
Author(s):  
Feng Bu ◽  
Dacheng Xu ◽  
Heming Zhao ◽  
Bo Fan ◽  
Mengmeng Cheng

In order to solve the problem where existing mode-matching methods in microelectromechanical systems (MEMS) vibrating gyroscopes fail to meet real-time and reliability requirements, this paper presents a novel method to accomplish automatic and real-time mode-matching based on phase-shifted 45° additional force demodulation (45° AFD-RM). The phase-shifted 45° additional force signal has the same frequency as the quadrature force signal, but it is phase-shifted by 45° and applied to the sense mode. In addition, two-way phase-shifted 45° demodulations are used at the sense-mode detection output to obtain a phase metric that is independent of the Coriolis force and can reflect the mode-matching state. Then, this phase metric is used as a control variable to adaptively control the tuning voltage, so as to change the sense-mode frequency through the negative stiffness effect and ultimately achieve real-time mode-matching. Simulation and experimental results show that the proposed 45° AFD-RM method can achieve real-time matching. The mode frequency split is controlled within 0.1 Hz, and the gyroscope scale factor, zero-bias instability, and angle random walk are effectively improved.


Author(s):  
Brian H. Bornstein ◽  
Jeffrey S. Neuschatz

The deception detection method Münsterberg advocates is grounded on principles of association. Although this approach derives partially from a Freudian view of the unconscious, it is not terribly dissimilar to more modern, physiologically based lie detection methods. In recent years, deception detection has become a major focus within psychology and law. Research shows that humans’ ability to detect deception is limited but, summarizing across the body of studies, slightly better than chance. However, most police investigators believe they can detect when suspects are lying. This chapter covers the reliability of modern deception detection techniques with the exception of the polygraph, which is covered in the next chapter.


2018 ◽  
Vol 170 ◽  
pp. 04009
Author(s):  
Benoit Geslot ◽  
Adrien Gruel ◽  
Stéphane Bréaud ◽  
Pierre Leconte ◽  
Patrick Blaise

Pile oscillator techniques are powerful methods to measure small reactivity worth of isotopes of interest for nuclear data improvement. This kind of experiments has long been implemented in the Mineve experimental reactor, operated by CEA Cadarache. A hybrid technique, mixing reactivity worth estimation and measurement of small changes around test samples is presented here. It was made possible after the development of high sensitivity miniature fission chambers introduced next to the irradiation channel. A test campaign, called MAESTRO-SL, took place in 2015. Its objective was to assess the feasibility of the hybrid method and investigate the possibility to separate mixed neutron effects, such as fission/capture or scattering/capture. Experimental results are presented and discussed in this paper, which focus on comparing two measurements setups, one using a power control system (closed loop) and another one where the power is free to drift (open loop). First, it is demonstrated that open loop is equivalent to closed loop. Uncertainty management and methods reproducibility are discussed. Second, results show that measuring the flux depression around oscillated samples provides valuable information regarding partial neutron cross sections. The technique is found to be very sensitive to the capture cross section at the expense of scattering, making it very useful to measure small capture effects of highly scattering samples.


Author(s):  
S T Smith ◽  
D G Chetwynd

Sprung translation mechanisms driven by electromagnetic force actuators are often used to produce controllable motions. This paper is concerned with one family of such devices incorporating linear spring mechanisms suitable for short-range, high-precision applications. In these, a permanent magnet is attached to the movable translating stage which is, in turn, surrounded by a solenoid coil attached to a fixed datum. Design considerations are discussed, principally an optimum dimensional design for a uniformly wound circular cylindrical coil. Design models are verified by the construction of a simple device in steel and aluminium which demonstrates an open-loop positional accuracy of better than 0.5 per cent over a displacement range of 100 nm to 50 μm.


2020 ◽  
Vol 11 ◽  
Author(s):  
Peiqiong Luo ◽  
Lin Zhang ◽  
Lidan Yang ◽  
Zhenmei An ◽  
Huiwen Tan

TSH-secreting pituitary neuroendocrine tumor (PitNET) is one of the causes of central hyperthyroidism. The incidence of TSH PitNET is far lower than that of other PitNETs. The clinical manifestations of TSH PitNETs mainly include thyrotoxicosis or thyroid goiter, secretion disorders of other anterior pituitary hormones, and mass effect on the pituitary gland and its surrounding tissues. The application of high-sensitivity TSH detection methods contributes to the early diagnosis and timely treatment of TSH PitNETs. Improvements in magnetic resonance imaging (MRI) have advanced the noninvasive visualization of smaller PitNETs. Treatments for TSH PitNETs include surgery, drugs, and radiotherapy. This review focuses on the progress in pathogenesis, diagnosis, and treatment of TSH PitNETs to provide more information for the clinician.


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