scholarly journals Dynamics of paediatric urogenital schistosome infection, morbidity and treatment: a longitudinal study among preschool children in Zimbabwe

2018 ◽  
Vol 3 (2) ◽  
pp. e000661 ◽  
Author(s):  
Derick Nii Mensah Osakunor ◽  
Takafira Mduluza ◽  
Nicholas Midzi ◽  
Margo Chase-Topping ◽  
Masceline Jenipher Mutsaka-Makuvaza ◽  
...  
Keyword(s):  
Scientific Evidence ◽  
Age Group ◽  
Risk Of Infection ◽  
Schistosome Infection ◽  
Anthropometric Indices ◽  
Number Of Children ◽  
Praziquantel Treatment ◽  
Control Programmes ◽  
Urinary Morbidity ◽  
First Time

BackgroundRecent research has shown that in schistosome-endemic areas preschool-aged children (PSAC), that is, ≤5 years, are at risk of infection. However, there exists a knowledge gap on the dynamics of infection and morbidity in this age group. In this study, we determined the incidence and dynamics of the first urogenital schistosome infections, morbidity and treatment in PSAC.MethodsChildren (6 months to 5 years) were recruited and followed up for 12 months. Baseline demographics, anthropometric and parasitology data were collected from 1502 children. Urinary morbidity was assessed by haematuria and growth-related morbidity was assessed using standard WHO anthropometric indices. Children negative for Schistosoma haematobium infection were followed up quarterly to determine infection and morbidity incidence.ResultsAt baseline, the prevalence of S haematobium infection and microhaematuria was 8.5% and 8.6%, respectively. Based on different anthropometric indices, 2.2%–8.2% of children were malnourished, 10.1% underweight and 18.0% stunted. The fraction of morbidity attributable to schistosome infection was 92% for microhaematuria, 38% for stunting and malnutrition at 9%–34%, depending on indices used. S haematobium-positive children were at greater odds of presenting with microhaematuria (adjusted OR (AOR)=25.6; 95% CI 14.5 to 45.1) and stunting (AOR=1.7; 95% CI 1.1 to 2.7). Annual incidence of S haematobium infection and microhaematuria was 17.4% and 20.4%, respectively. Microhaematuria occurred within 3 months of first infection and resolved in a significant number of children, 12 weeks post-praziquantel treatment, from 42.3% to 10.3%; P<0.001.ConclusionWe demonstrated for the first time the incidence of schistosome infection in PSAC, along with microhaematuria, which appears within 3 months of first infection and resolves after praziquantel treatment. A proportion of stunting and malnutrition is attributable to S haematobium infection. The study adds scientific evidence to the calls for inclusion of PSAC in schistosome control programmes.

Antiticiombin III Deficiency In A Large Family with 41 Affected Members

1981 ◽  
Author(s):  
J Stibbe ◽  
S Adhin ◽  
G L Ong ◽  
R S Panday ◽  
S H Peters ◽  
...  
Keyword(s):  
Autosomal Dominant ◽  
Large Family ◽  
Clinical Information ◽  
Impedance Plethysmography ◽  
Age Group ◽  
Oral Contraceptive Pills ◽  
Contraceptive Pills ◽  
At Iii ◽  
L 51 ◽  
First Time

Hereditary Antithrombin III (AT III) deficiency was found in a large Hindustani family, living partly in the Netherlands, partly in Suriname. Of 201 members investigated 35 were found to affected: AT III activity (chromogenic substrate) and AT III antigen (immuno-electrophoresis according to Laurell) were about 45 %. Analysis of this fanily clearly demonstrated the autosomal dominant inheritance of the condition. Six non-investigated members (1 living, 5 non-living) were diagnosed as being affected on the basis of affected offspring.Seventeen affected members had no signs of thrombo-embolic(TE) processes (age group 0-10 years old, n=2; 11-20, n=5; 21-30, n=4; 31-40, n=4; 41-50, n=2). Thirteen showed clinical or proven signs of TE processes (first time in age group 0-10 years old, n=0; 11-20, n=l; 21-30, n=G; 31-40, n=4; 41-50,n=l; 51-60, n=0; 61-70, n=l). No clinical information is yet available on the remaining affected members. Deep venous thrombosis (DVT) occurred in 9 patients (age group 21-30, n=5; 31-40, n=3; 61-70, n=l). Triggering factors were none 4, surgery 1, oral contraceptives and preg- nancy4. Pulmonary embolism occurred in 6 patients (2 clinical, 4 proven) and was fatal in 4; ages were 19, 21, 26, 37, 48 and 68 years old. Pregnancy was uncomplicated in 3 women (total of 4 pregnancies), one of these women was treated prophylactically with anticoagulants during pregnancy (1 pregnancy). Two women (9 pregnancies) had a thrombotic episode (1st and 3rd pregnancy respectively) and 1 woman died suddenly 7 days after her 7th childbirth. DVT occurred in 2 of 4 women who used oral contraceptive pills.In some symptomless patients (age 22, 26, 32, 33, 40 years old) impedance plethysmography (n=5), 125I-fibrinogen leg scanning (n=3), 125I-fibrinogen T½(n=3) and 51C-platelet survival (n=l) were normal

scholarly journals Pioneer Legislation on Second Order of Sexual Harassment: Sociolegal Innovation in Addressing Sexual Harassment

2021 ◽  
Author(s):  
Ana Vidu ◽  
Gema Tomás ◽  
Ramon Flecha
Keyword(s):  
Sexual Harassment ◽  
Women's Studies ◽  
Legal System ◽  
Scientific Evidence ◽  
Second Order ◽  
Bystander Intervention ◽  
Policy Implications ◽  
Women’S Studies ◽  
Key Innovation ◽  
First Time

Abstract Backgroud Countless efforts to combat sexual harassment have been proposed, and for the first time in history, the second order of sexual harassment (SOSH) has been legislated under the term second-order violence (SOV) by a unanimous vote of the Catalan Parliament. Advances in preventing and responding to sexual harassment contribute to highlighting the intervention as being crucial to supporting survivors against retaliation. A lack of support provides a general explanation on why bystanders tend not to intervene and highlights the reality that reprisals are suffered by those who support victims. Methods From the existing knowledge about sexual harassment prevention and response mechanisms, this paper analyzes scientific evidence through a review of the literature published in databases, as well as legislation, reports, and other materials. Results The context that enables SOV legislation is grounded in three realms: (1) bystander intervention and protection, (2) the role of support networks in protecting survivors, and (3) awareness and legislation of SOSH. An active bystander refers to the involvement of someone who is aware of potential sexual harassment situations. Conclusions The lack of legislation against SOSH limits bystander intervention and support; therefore, legislating protection for supporters has become urgent and necessary. Legislating SOSH has great social implications because gender equality cannot be fully achieved if bystander protection is not legally considered. Policy Implications: As no legal system has previously contemplated SOSH, its pioneering parliamentarian approval and establishment by Catalan law constitute a legal key innovation for the field of gender and women’s studies. In fact, evidence reported here are important in developing further regulations and policy. Policy Implications As no legal system has previously contemplated SOSH, its pioneering parliamentarian approval and establishment by Catalan law constitute a legal key innovation for the field of gender and women’s studies. In fact, evidence reported here are important in developing further regulations and policy.

scholarly journals COVID-19 and Parental Burnout: Parents Locked Down but Not More Exhausted

2021 ◽  
pp. 0192513X2110300
Author(s):  
Sarah Le Vigouroux ◽  
Astrid Lebert-Charron ◽  
Jaqueline Wendland ◽  
Emilie Boujut ◽  
Céline Scola ◽  
...  
Keyword(s):  
Risk Factors ◽  
Emotional Experience ◽  
Daily Functioning ◽  
Age Group ◽  
Health Crisis ◽  
Environmental Consequences ◽  
Number Of Children ◽  
Two Samples ◽  
Parenting Role ◽  
At Home

Lockdowns put in place in response to the COVID-19 health crisis have changed daily functioning for families and potentially the emotional experience of individuals in their parenting role. Our study aimed to highlight the importance of the environmental consequences associated with lockdowns on parental burnout. We compared data on parental burnout levels from two French samples: the first collected in 2018 ( N = 1332) and the second collected during the last month of lockdown ( N = 522). Our results show that parents included during the lockdown period reported significantly, but slightly, higher saturation (a dimension of the parental burnout construct) than parents included 2 years earlier. However, the number of children per age group, maintaining employment, and having to provide schooling at home are not variables that explain differences in the level of parental burnout between our two samples. Our results are discussed with regard to the risk factors identified and the French context.

PUBLIC HEALTH

PEDIATRICS ◽  
1960 ◽  
Vol 25 (2) ◽  
pp. 343-347
Author(s):  
George M. Wheatley ◽  
Stephen A. Richardson
Keyword(s):  
Public Health ◽  
United States ◽  
Cause Of Death ◽  
United States Public Health ◽  
The United States ◽  
Vital Statistics ◽  
West Germany ◽  
Medical Attention ◽  
Age Group ◽  
Number Of Children

IN ALL COUNTRIES for which there are vital statistics, accidents are a major cause of death and disability among children. In countries where the food supply is adequate and infectious diseases have been brought under control, accidents have become the leading cause of death in the age group 1 to 19 years. For example, in such countries as Australia, Canada, Sweden, West Germany, and the United States, more than one-third of all deaths in this age group are caused by accidents. The number of children who are injured by accidents fan exceeds the number who are killed. Although no accurate international figures are available, the Morbidity Survey conducted by the United States Public Health Service indicates that in the United States, for every child under 15 killed by accident, 1,100 children are injured severely enough to require medical attention or to be restricted in their activity for at least a day.

scholarly journals Contraception and Sexsual Activity as Factor Influenced Leucorrhea

2017 ◽  
Vol 5 (3) ◽  
pp. 371
Author(s):  
Sari Priyanti
Keyword(s):  
Hormonal Contraception ◽  
Cross Sectional Study ◽  
Childbearing Age ◽  
Cross Sectional ◽  
The Public ◽  
First Sexual Intercourse ◽  
Number Of Children ◽  
Study Population ◽  
The Impact ◽  
First Time

ABSTRACTCervical cancer was non communicable desease that worries the public and causes an increase mortality in women. One of the first sign causes of cervical cancer is occourrence of Leucorrhoe. The incidence of Leucorrhoe in women Indonesia by 90% of which >75% of women experience once of leucorrhoe and experience ≥ 2 times by 25%. Leucorrhoe should not be considered an ordinary thing because can be caused to itchy on genetalia, pain during sexsual, infection  can be caused odema on genetalia, hot like burned on vagina even the impact if not treated promptly will caused infertility and cancer. Aims of study was to analyze factors of influenced on Leucorrhoe incident. Design of study was cross sectional study. Population was women of childbearing age who use contraceptives in the karang jeruk village, Jatirejo sub district, Mojokerto district in March of 2017. Sample in this study was 33 people. Data analyze with logistic regresion. Result of study showed contraceptive and sexsual activity has significant influenced with leucorrhoe (PR = 10.000; 95% CI= 1,732-57,722 dan PR=8,750; 95% CI=1,466-52,232). Suggestion: should be married and have first sexual intercourse for the first time at the age of  ≥ 20 years, limit the number of children not more than 2 as the greater the number of children the greater the risk of Leucorrhoe, and not using hormonal contraception for a along time that more than 2 years. Keywords: contraceptive,sexsual activity, leucorrhoe

scholarly journals Study of mammography reports made between 2015 and 2019

Mastology ◽  
2020 ◽  
Vol 30 (Suppl 1) ◽  
Author(s):  
Marina Hernandes Carvalho ◽  
Pedro César Garcia Gonçalves ◽  
Gabriel Carvalho Carnelossi ◽  
Maria Júlia Carvalho Carnelossi ◽  
Felipe Colombelli Pacca
Keyword(s):  
Breast Cancer ◽  
Information System ◽  
High Risk ◽  
Scientific Evidence ◽  
Radiological Finding ◽  
Develop Breast Cancer ◽  
Cáncer De Mama ◽  
Cancer Information ◽  
Age Group ◽  
Number Of Patients

Introduction: Screening and early diagnosis are crucial strategies for the detection of breast cancer. In Brazil, the Ministry of Health recommends annual clinical screening in women over 40 years of age, with the addition of biennial mammography for those aged between 50 and 69 years. However, high-risk patients should have mammography annually after the age of 35 years. Objectives: To study the reasons for mammography screening in the age group 50 to 69 years. Method: This is an ecological study of the number of patients per mammography report according to age group, from 2015 to 2019. Data from the Cancer Information System (Sistema de Informação do Câncer – SISCAN) were obtained from the Technology Department of the public health system (Departamento de Informática do Sistema Único de Saúde – DATASUS). Results: When comparing data from the Breast Cancer Information System (Sistema de Informação do Câncer de Mama – SISMAMA) from 2015 to 2019, we found 8,569,457 mammographies, of which 5,216,473 were performed in women aged 50 years to 69 years, which corresponds to 60.87% of the procedures. In addition, 4.90% of these women were high-risk individuals, and 1.24% had been treated for breast cancer. Mammography reports showed that 12.01% of the results were inconclusive, 38.28% were normal, 46.12% had a benign radiological finding, 2.58% had a probably benign finding, 0.78% had a suspicious finding, 0.14% had a highly suspicious finding, and 0.04% had malignant confirmation. The proportion of BI-RADS categories 4, 5, and 6 totaled 83,852 screenings, the equivalent to 0.97% of reports. In addition, 59.49% (49,891) of women who presented mammographic findings with malignant characteristics belonged to the age group 50–69 years. Conclusion: This study concluded that the strategy of biennial breast cancer screening shows scientific evidence of mortality reduction, given that 59.49% of the reports with malignant characteristics corresponded to the age group 50 to 69 years. However, the data presented did not allow calculating the number of women outside this age group who do not receive care and develop breast cancer.

scholarly journals Quality assessment of praziquantel tablets sold in medicine stores in Kano Metropolis

2018 ◽  
Vol 11 (1) ◽  
pp. 208-210
Author(s):  
M.A. Gadanya ◽  
K.A. Ahmad
Keyword(s):  
Standard Dose ◽  
Poor Quality ◽  
Regulatory Agencies ◽  
Cure Rate ◽  
Quality Cost ◽  
Expiry Date ◽  
Drug Of Choice ◽  
Praziquantel Treatment ◽  
Control Programmes

The efficacy, availability, tolerable side effects and relative affordability of praziquantel makes it the drug of choice in the treatment and various control programmes of schistosomiasis in the endemic areas with excellent outcomes. However, there are reports of low cure rate with praziquantel observed by clinicians with various speculations on the likely causes. This study explored poor drug quality as a possible cause of praziquantel treatment failure in schistosomiasis. On the spot sampling of twelve different samples of praziquantel tablets from various patent medicine shops in Kano metropolis were assayed for active ingredient using British Pharmacopeia methods. Only 6 out of 12 (50%) of the praziquantel tablets studied were found to be acceptable of quality. Cost and number of months before expiry date were not found to be significantly associated with the quality of the drug. Poor quality praziquantel currently in the market may possibly explain failure of standard dose of the drug in the treatment of schistosomiasis. Therefore, it is recommended that additional vigilance by regulatory agencies is required to ensure quality drugs in the market.Keywords: Efficacy, Kano, praziquantel, quality, schistosomiasis

scholarly journals Tuberculin Survey in Government High School of Dharan Municipality

2005 ◽  
Vol 44 (157) ◽  
Author(s):  
Narayan Kumar ◽  
D D Baral ◽  
S Tamrakar
Keyword(s):  
Control Program ◽  
Tween 80 ◽  
Age Group ◽  
Risk Of Infection ◽  
Japan International Cooperation Agency ◽  
Development Region ◽  
National Tuberculosis ◽  
Tuberculosis Programme ◽  
Financial Research ◽  
Annual Risk

This survey was done in 682 out of 1672 children tested with Batch of Tuberculin used for Testing (PPD RT23 with Tween 80) in Jan. 1997 with financial research grant of B.P. Koirala Institute of Health Sciences,Dharan.Dharan City is situated in Eastern Development Region (EDR) of Nepal where a high percentage of migrated population is residing with very high number of sputum positive cases. The majority of populationare from high hills & mountain region where the Annual Risk of Infection (ARI) is less. This survey was doneto know the epidemiological situation of Tuberculosis (TB) in Dharan.Tuberculin survey was done in Eastern Development Region (EDR) (1994) by National Tuberculosis Centre(NTC) / Japan International Cooperation Agency (JICA) in Saptari & Morang. The reported result ofaverage Annual Risk of Infection (ARI) is 2.49% & 2.38% respectively.The mean age of surveyed population was 14.8 yrs. The Bacilli Calmette Guerin (BCG) coverage (scar rate)was 38.3% & BCG 4 - 8 age group 83.3% was highest & it gradually decreased to 37.5% in 12 + age group.The average 23 Tween – 8 – Batch of Tuberculin used for Testing (PPD) positive is 33.6% with 10 mminduration as cutoff line. Annual Risk of Infection (ARI) based on above was 2.7% in 9 - 11 age group &1.31% in 12 + age group. This survey is suggestive of tuberculosis being highly prevalent in Dharan. Thesurvey also showed average ARI to be 2.44% in Dharan in 10 - 15 yrs age group. The finding is suggestive ofhigh ARI although the populations has migrated from hill & mountain. Previous report of average ARI inthis area was 2.5% (Morang & Saptari). The survey result suggests that high priority, effective tuberculosisprogram is necessary and intensive control program can only give impact to control of tuberculosis in Dharan.Key Words: Tuberculin survey, school children, BCG coverage, ARI, Effective tuberculosis programme.

scholarly journals Regression of Schistosoma mansoni associated morbidity among Ugandan preschool children following praziquantel treatment: A randomised trial

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0259338
Author(s):  
Allen Nalugwa ◽  
Edridah Muheki Tukahebwa ◽  
Annette Olsen ◽  
Fred Nuwaha
Keyword(s):  
Single Dose ◽  
Preschool Children ◽  
Liver Fibrosis ◽  
Schistosoma Mansoni ◽  
Randomised Trial ◽  
Double Dose ◽  
Number Of Children ◽  
Praziquantel Treatment ◽  
Significant Difference ◽  
Liver Enlargement

Preschool children suffer from morbidity attributable to Schistosoma mansoni. We compared a single and double dose of praziquantel treatment on the regression of S. mansoni associated morbidity in children less than six years in Uganda. We measured the sizes of spleen and liver as well as liver fibrosis before treatment and 8 months after treatment among children who either received one dose (n = 201) or two doses (n = 184) of praziquantel (standard oral dose of 40 mg/kg body weight). Heamoglobin measurements were also taken. Overall, liver enlargement reduced from 52.2% (95% CI (Confidence interval) 45.1, 59.3) to 17.9% (95% CI 12.9, 23.9) with a single dose and from 48.4 (95% CI 40.9, 55.8) to 17.9% (95% CI 12.7, 24.3) with a double dose and there was no significant difference between the changes in proportion of children with enlarged liver between the two treatment groups. The proportion of children with enlarged spleen was not significantly reduced in the group treated with either one or two doses, 47.8% (95% CI 41.7, 54.9) to 45.3% (95% CI 38.3, 52.4) and 48.4% (95% CI 40.9,55.8) to 40.8% 95% CI 33.6, 48.2), respectively. Liver fibrosis detected among children getting single dose (n = 9) or double doses (n = 13) resolved after treatment with praziquantel. The number of children with low heamoglobin significantly reduced from 51.2% (95% CI 44.1, 58.3) to 0.5% (0.2, 0.8) and 61.4% (95% CI 53.9,68.5) to 1.1% (95% CI 0.1, 3.9) after single and double dose treatment, respectively. These results suggest that there is no evidence of a difference in effect between one dose of praziquantel and two doses in reversing morbidity attributable to S. mansoni among children less than six years of age.

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