HOW CAN THE LEAN STARTUP APPROACH IMPROVE THE INNOVATION PROCESS OF ESTABLISHED COMPANIES? AN EXPERIMENTAL APPROACH

2020 ◽  
pp. 2150029
Author(s):  
FELIX SCHEUENSTUHL ◽  
PETER M. BICAN ◽  
ALEXANDER BREM
Keyword(s):  
Success Rate ◽  
Experimental Approach ◽  
Traditional Approach ◽  
Innovation Process ◽  
Target Group ◽  
Superior Performance ◽  
Control Group ◽  
Innovation Processes ◽  
Lean Startup

The Lean Startup approach and its related Minimum Viable Product thinking is one of the key trends not only in entrepreneurship, but also in more and more established companies. Before this background, this paper experimentally investigates whether and how the Lean Startup approach improves innovation processes in established companies. For this, the overall experiment had 23 participants, the outcome was then matched against a control group and evaluated through a survey with 146 representatives of the target group of the product. The results show that the Lean Startup approach outperforms the traditional approach and that this method improves the success rate of innovation ideas and thus supports the learning philosophy within established companies. Moreover, the experiment revealed a superior performance, especially relating to financial output. Based on these results, implications for research and companies are discussed, as well as limitations and further research suggestions.

Agile Innovation

2020 ◽  
Vol 11 (1) ◽  
pp. 157-167 ◽  
Author(s):  
Ulrich Lichtenthaler
Keyword(s):  
Artificial Intelligence ◽  
Design Thinking ◽  
Innovation Process ◽  
Digital Transformation ◽  
Front End ◽  
Innovation Processes ◽  
Lean Startup

In light of digital transformation and a stronger application of artificial intelligence, many firms try to increase the agility of their innovation processes. In this regard, they particularly rely on design thinking or on the lean startup approach to reduce some of the deficits of established innovation processes, such as the stage-gate model. This conceptual article shows that merely focusing on design thinking and lean startup in isolation will not enable companies to fully leverage the benefits of agile innovation. Because of the complementarity of design thinking and lean startup, executives should simultaneously pursue these approaches in order to achieve results that are more than the sum of isolated design thinking or isolated lean startup initiatives. This complementarity derives from the specific benefits of design thinking in the front end of the innovation process combined with the particular benefits of lean startup in the back end.

The effect of realistic mathematics education on student achievement in 8th grades geometric objects teaching

2021 ◽  
Vol 9 (1) ◽  
pp. 20-31
Author(s):  
Hasan Huseyin Aksu ◽  
Keyword(s):  
Academic Success ◽  
Traditional Approach ◽  
T Test ◽  
Learning Activities ◽  
Control Group ◽  
Structured Interviews ◽  
Significance Level ◽  
8Th Grade ◽  
And Control ◽  
Dependent Samples

The purpose of this study is to answer if there is a reasonable difference on academical success of students who get education with traditional and RME approach question on “Teaching geometrical objects to 8th grade students” subject. Study group consists of 47 students which contains 21 experimental and 16 control group from “Ordu Anadolu İmam Hatip High School Project School” in Altinordu, Ordu. Experimental and control group have same academical success level, as the school which this study has runned is a school which accepts students with an exam only. After the experimental and control groups were created, a 25 question pre-test was performed to understand the level of knowledge of the group regarding geometrical objects. The same test was performed on the same groups 8 weeks later as retention test. To determine opinions of the students in experimental group regarding RME and related learning activities, semi-structured interviews are conducted. The data obtained from the pretest, posttest and retention tests were analyzed with t-test for independent samples and t-test for dependent samples and variance analysis for mixed measurements with 0.05 significance level. According to the results, it is seen that learning activities prepared according to RME approach are much more effective than learning activities prepared according to the traditional approach on students’ academic success.

Success Rate of Obturation of Root Canals by Different Techniques in Primary Molars: A Comparative Clinical Study

2020 ◽  
Vol 2 (1) ◽  
pp. 36-44
Author(s):  
Satyawan G. Damle ◽  
Ritika Bansal ◽  
Dhanashree D. Sakhare
Keyword(s):  
Success Rate ◽  
Study Groups ◽  
Primary Molars ◽  
Control Group ◽  
Second Primary ◽  
Chi Square ◽  
Exact Test ◽  
Root Canals ◽  
Significant Difference ◽  
Comparative Clinical Study

Objective: To compare the success rate of different obturation procedures in primary mandibular second molars clinically and also by digital radiovisiography. Methods: A total of 40 children aged between 4-8 years with deeply carious mandibular second primary molars indicated for single session pulpectomy were selected. Canals were obturated with Metapex. The 3 study groups (Endodontic plugger, Handheld lentulospiral, Navi Tip syringe) were compared with the control group (reamer) both clinically and radiovisiographically. The data collected were statistically analyzed using Pearson’s Chi-square and Fisher’s exact test. Results: The use of Navi tip syringe led to the least number of voids followed by Endodontic plugger and Reamer and the highest number of voids was reported with Lentulospiral. Navitip presented maximum number of optimally filled cases followed by Endodontic plugger and Lentulospiral and least number of optimally filled cases with reamer. However, there was no statistically significant difference (p>0.05) in any of the groups with clinical (pain and tenderness to percussion) and radiographic parameters (presence or absence of voids and length of obturation). Conclusion: Within the limitations of the present study, though the clinical outcome was statistically insignificant, Navitip syringe exhibited encouraging results and is a promising option for obturation in primary teeth.

scholarly journals Improved response of human gingival fibroblasts to titanium coated with micro-/nano-structured tantalum

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Chu-nan Zhang ◽  
Lin-yi Zhou ◽  
Shu-jiao Qian ◽  
Ying-xin Gu ◽  
Jun-yu Shi ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Underlying Mechanism ◽  
Cell Number ◽  
Human Gingival Fibroblasts ◽  
Superior Performance ◽  
Control Group ◽  
Human Gingival Fibroblast ◽  
Gingival Fibroblast ◽  
Gingival Fibroblasts ◽  
Integrin Β1

Abstract Objectives This study aims to evaluate the ability of tantalum-coated titanium to improve human gingival fibroblasts’ adhesion, viability, proliferation, migration performance, and the potential molecular mechanisms. Materials and methods Titanium plates were divided into two groups: (1) no coating (Ti, control), (2) Tantalum-coated titanium (Ta-coated Ti). All samples were characterized by scanning electronic microscopy, surface roughness, and hydrophilicity. Fibroblasts’ performance were analyzed by attached cell number at 1 h, 4 h, and 24 h, morphology at 1 h and 4 h, viability at 1 day, 3 days, 5 days, and 7 days, recovery after wounding at 6 h, 12 h, and 24 h. RT-PCR, western blot were applied to detect attachment-related genes’ expression and protein synthesis at 4 h and 24 h. Student’s t test was used for statistical analysis. Results Tantalum-coated titanium demonstrates a layer of homogeneously distributed nano-grains with mean diameter of 25.98 (± 14.75) nm. It was found that after tantalum deposition, human gingival fibroblasts (HGFs) adhesion, viability, proliferation, and migration were promoted in comparison to the control group. An upregulated level of Integrin β1 and FAK signaling was also detected, which might be the underlying mechanism. Conclusion In the present study, adhesion, viability, proliferation, migration of human gingival fibroblasts are promoted on tantalum-coated titanium, upregulated integrin β1 and FAK might contribute to its superior performance, indicating tantalum coating can be applied in transmucosal part of dental implant. Clinical significance Tantalum deposition on titanium surfaces can promote human gingival fibroblast adhesion, accordingly forming a well-organized soft tissue sealing and may contribute to a successful osseointegration.

scholarly journals Gynecological, reproductive and sexual outcomes after uterine artery embolization for post-partum haemorrage

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Béatrice Eggel ◽  
Maude Bernasconi ◽  
Thibaud Quibel ◽  
Antje Horsch ◽  
Yvan Vial ◽  
...  
Keyword(s):  
Success Rate ◽  
Uterine Artery Embolization ◽  
Uterine Artery ◽  
Post Partum ◽  
Mode Of Delivery ◽  
Subsequent Pregnancy ◽  
Control Group ◽  
Artery Embolization ◽  
Interval Time ◽  
Sexual Outcomes

AbstractIn this case control study, long-term gynecological, reproductive and sexual outcomes after uterine artery embolization (UAE) for postpartum hemorrhage (PPH) were evaluated. The study was performed in a single referral hospital for PPH in Lausanne from 2003 to 2013. Each woman whose delivery was complicated by PPH and treated by UAE was included, and compared to a control group of women whose delivery was uncomplicated. Cases were matched by maternal age, parity, ethnicity, year and mode of delivery, birth weight and gestational age in a 1–3 ratio. A total of 77 patients treated by UAE for PPH were identified in our obstetrical database. Among them, 63 were included and compared to 189 matched patients (no PPH). The mean interval time between UAE and this study was 8.1 years. Time to menstrual cycle recovery after delivery (3.9 vs 5.6 months, p = 0.66), spotting (7.9% vs 7.2%, p = 0.49), dysmenorrhea (25.4% vs 22.2%, p = 0.60) and amenorrhea (14.3% vs 12.2%, p = 0.66) were similar between the two groups. There was no difference in the FSFI score between the groups (23.2 ± 0.6 vs 23.8 ± 0.4; p = 0.41). However, the interval time to subsequent pregnancy was longer for patients after UAE than the control group (35 vs 18 months, p = 0.002). In case of pregnancy desire, the success rate was lower after UAE compared to controls (55% vs 93.5%, p < 0.001). The rate of PPH was higher in those with previous PPH (6.6% vs 36.4%, p = 0.010). Patients treated by UAE for PPH did not report higher rates of gynecological symptoms or sexual dysfunction compared to patients with uneventful deliveries. The inter-pregnancy interval was increased and the success rate was reduced. In subsequent pregnancies, a higher rate of PPH was observed in those that underwent UAE.

scholarly journals Comparative performance of MRI-derived PRECISE scores and delta-radiomics models for the prediction of prostate cancer progression in patients on active surveillance

2021 ◽  
Author(s):  
Nikita Sushentsev ◽  
Leonardo Rundo ◽  
Oleg Blyuss ◽  
Tatiana Nazarenko ◽  
Aleksandr Suvorov ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Active Surveillance ◽  
Cancer Progression ◽  
Predictive Value ◽  
Machine Learning Algorithms ◽  
Superior Performance ◽  
Control Group ◽  
P Value ◽  
Lasso Regression

Abstract Objectives To compare the performance of the PRECISE scoring system against several MRI-derived delta-radiomics models for predicting histopathological prostate cancer (PCa) progression in patients on active surveillance (AS). Methods The study included AS patients with biopsy-proven PCa with a minimum follow-up of 2 years and at least one repeat targeted biopsy. Histopathological progression was defined as grade group progression from diagnostic biopsy. The control group included patients with both radiologically and histopathologically stable disease. PRECISE scores were applied prospectively by four uro-radiologists with 5–16 years’ experience. T2WI- and ADC-derived delta-radiomics features were computed using baseline and latest available MRI scans, with the predictive modelling performed using the parenclitic networks (PN), least absolute shrinkage and selection operator (LASSO) logistic regression, and random forests (RF) algorithms. Standard measures of discrimination and areas under the ROC curve (AUCs) were calculated, with AUCs compared using DeLong’s test. Results The study included 64 patients (27 progressors and 37 non-progressors) with a median follow-up of 46 months. PRECISE scores had the highest specificity (94.7%) and positive predictive value (90.9%), whilst RF had the highest sensitivity (92.6%) and negative predictive value (92.6%) for predicting disease progression. The AUC for PRECISE (84.4%) was non-significantly higher than AUCs of 81.5%, 78.0%, and 80.9% for PN, LASSO regression, and RF, respectively (p = 0.64, 0.43, and 0.57, respectively). No significant differences were observed between AUCs of the three delta-radiomics models (p-value range 0.34–0.77). Conclusions PRECISE and delta-radiomics models achieved comparably good performance for predicting PCa progression in AS patients. Key Points • The observed high specificity and PPV of PRECISE are complemented by the high sensitivity and NPV of delta-radiomics, suggesting a possible synergy between the two image assessment approaches. • The comparable performance of delta-radiomics to PRECISE scores applied by expert readers highlights the prospective use of the former as an objective and standardisable quantitative tool for MRI-guided AS follow-up. • The marginally superior performance of parenclitic networks compared to conventional machine learning algorithms warrants its further use in radiomics research.

The effectiveness of using reciprocal technique in developing the skillful self and teaching some basic football skills among literary fifth grade students

2021 ◽  
Vol 20 (1) ◽  
pp. 0015
Author(s):  
MUSA ADNAN ALANI
Keyword(s):  
Experimental Approach ◽  
Basic Skills ◽  
Fifth Grade ◽  
Control Group ◽  
Preparatory School ◽  
Fifth Grade Students ◽  
Independent Variable ◽  
Reciprocal Method ◽  
Experimental Group

ABSTRACT   The research aims to know the effectiveness of the use of reciprocal style in developing the skillful self and learning some basic skills in football among fifth grade literary students as well as knowing which is better (reciprocal style or the method used) in the variables of the current study, the researcher used the experimental approach to suit the nature of the research as for the research sample It was represented by the literary fifth grade students in Anah Preparatory School for Boys, and the number (20) students were divided into two groups by (10) students for each group, for whom pre-tests were taken on the scale of self-skill and basic skills in football.                  Then the experimental group applied its independent variable (the reciprocal method), then the control group applied (the method used), and the researcher applied the principle of the gradation from easy to difficult in implementing the exercises during the lesson session, and the results were processed by the statistical bag program (SPSS), and the researcher concluded that Positive effectiveness in developing self-skill and learning some basic football skills among literary fifth-grade students, and the researcher recommended using this method in other activities and paying attention to all soccer skills in football.                                                       

The Effectiveness of Instructional Aids in Assisting Students to Understand Concepts in Principles of Accounting

2021 ◽  
Vol 12 (3) ◽  
pp. 1064-1073
Author(s):  
Norlia Mat Norwani
Keyword(s):  
Teaching And Learning ◽  
Positive Impact ◽  
Traditional Approach ◽  
School Administrator ◽  
Control Group ◽  
Text Book ◽  
Quasi Experimental ◽  
Principles Of Accounting ◽  
Learning School ◽  
Instructional Aids

This study was conducted to determine the effectiveness of instructional aids in the teaching and learning (T&L) of Principles of Accounting among form four students. This is quasi-experimental study involving 60 form four students in a secondary school in Klang, Selangor. The instructional aids utilized are concept charts, brief notes, powerpoint slides and supported by the text book. Pre-test and post-test were conducted to assess students’ performance before and after the treatment. The findings of the study found that the performance of experimental group is significantly better than the control group using the traditional approach. Consequently, the positive impact of using various aids in T&Lcannot be denied. Teachers should take the time to incorporate instructional aids in T&L to assist students learning. School administrator must provide the facilities required to encourage teachers to employ instructional aids in T&L.

Neue Geschäftsmodelle in der Life Science Industrie durch einen ganzheitlichen Innovationsprozess

2021 ◽  
Vol 62 (1) ◽  
pp. 17-29
Author(s):  
Ouelid Ouyeder ◽  
Julia Hitzbleck ◽  
Henning Trill
Keyword(s):  
Business Models ◽  
Design Thinking ◽  
Life Science ◽  
Real Life ◽  
Idea Generation ◽  
Innovation Process ◽  
Innovation Activities ◽  
New Business ◽  
End To End ◽  
Lean Startup

Abstract The aim of this paper is to introduce an end-to-end development process for non-biomedical innovation and new business models of a Life Science company that integrates different methods such as Design Thinking, Lean Startup, Agility and others within one framework. Since 2016 this innovation process is an essential part of the internal Employee Innovation program and proves its applicability in a real-life setting. Projects teams develop and implement their new digital business models successfully by taking the introduced innovation process as guideline. This process enables the Life Science organization to run two global entrepreneurship programs (Catalyst Fund and Catalyst Box) that foster customer focus with fast and evidence-based experimentation. The article encompasses a real-life case study out of the Catalyst Fund program about the Farm Advisory Team from India. By using this example each phase of the innovation process is described schematically. Idea generation is easy-to-apply, but the implementation of ideas is one of the biggest challenges in larger corporations. The proposed end-to-end innovation process connects the dots of different innovation methods and provides guidance to company decision makers and project teams in order to structure their business model innovation activities/strategy and discussions. Zusammenfassung Das Ziel dieses Beitrags ist es, einen durchgängigen Innovationsprozess für nicht-biomedizinische Lösungen und Geschäftsmodelle eines Life-Science-Unternehmens vorzustellen, der verschiedene Methoden wie Design Thinking, Lean Startup, Agilität und andere innerhalb eines Gestaltungsrahmens integriert. Seit 2016 ist der Innovationsprozess ist ein wesentlicher Bestandteil des internen Employee Innovation Programms und beweist seine Anwendbarkeit in einem realen Umfeld. Projektteams entwickeln und implementieren ihre neuen digitalen Geschäftsmodelle erfolgreich, indem sie den vorgestellten Innovationsprozess als Leitfaden nutzen. Dieser Prozess ermöglicht es dem Life-Science-Unternehmen, zwei globale Entrepreneurship-Programme (Catalyst Fund und Catalyst Box) durchzuführen, die den Kundenfokus mit schnellen und evidenzbasierten Experimenten fördern. Der Artikel umfasst eine reale Fallstudie aus dem Catalyst Fund Programm über das Farm Advisory Team aus Indien. Anhand dieses Beispiels wird jede Phase des Innovationsprozesses schematisch beschrieben. Die Ideengenerierung ist leicht anwendbar, aber die Umsetzung von Ideen ist eine der größten Herausforderungen in größeren Unternehmen. Der vorgeschlagene End-to-End-Innovationsprozess integriert die verschiedenen Innovationsmethoden und bietet Entscheidungsträgern und Projektteams in Unternehmen eine Anleitung, um ihre Aktivitäten bzw. Strategie und Diskussionen zur Geschäftsmodellinnovation zu strukturieren.

Innovationen multi-perspektiv entwickeln*/Multi-perspective development of innovations - Holistic view of innovation processes for the derivation of manufacturing strategic decision areas

2017 ◽  
Vol 107 (03) ◽  
pp. 189-193
Author(s):  
M. Röhm ◽  
T. Prof. Bauernhansl ◽  
T. Schrodi
Keyword(s):  
Process Development ◽  
Innovation Process ◽  
Strategic Decision ◽  
Maturity Model ◽  
Market Demand ◽  
Critical Fields ◽  
Holistic View ◽  
Development Processes ◽  
Technology Market ◽  
Innovation Processes

Für eine marktgerechte Produktentwicklung gibt es in Anlehnung an das Technologie-Reifegradmodell eine Vielzahl von Ansätzen, die den Entwicklungsstand von Technologie und Markt bewerten. Um im Innovationsprozess produktionsstrategische Lücken rechtzeitig aufzuzeigen, müssen Entwicklungsprozesse von Technologie, Markt und Produktion jedoch ganzheitlich betrachtet werden. Hierfür werden unterschiedliche Reifegradmodelle gegenübergestellt, Korrelationen aufgezeigt und erfolgsentscheidende Entwicklungsstufen abgeleitet. &nbsp; Based on the technology maturity model, there is a variety of approaches describing the maturity of market demand and technology in order to combine technology push and market pull perspectives. However, to be able to show strategic gaps during the innovation process, development processes of technology, market and manufacturing skills have to be viewed holistically. For this purpose, the authors present different degrees of maturity models, show correlations and derive critical fields of action.

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