Dexamethasone Inhibition of the Development of Dysplastic Bony Lesions in Lp/J Mice

1993 ◽  
Vol 102 (10) ◽  
pp. 814-817 ◽  
Author(s):  
Hilary A. Brodie ◽  
Po-Shen Chang ◽  
Richard A. Chole
Keyword(s):  
Middle Ear ◽  
Otic Capsule ◽  
Significant Difference ◽  
Bony Lesions ◽  
And Control ◽  
Relationship Of ◽  
The Relationship

Inbred LP/J mice have been observed to spontaneously develop abnormal bony lesions of the ossicles and otic capsule that progress throughout the life of the animals. This genetically inherited murine disorder produces bony lesions that share some gross and histologic features with bony lesions seen in human tympanosclerosis. Previous studies on LP/J mice have demonstrated evidence of immunologically mediated injury in the progression of the newly forming bony lesions. This study was designed to examine the effects of dexamethasone on the development of the bony lesions in LP/J mice. The purpose was to attempt to elucidate the relationship of the immunologic injury observed in earlier studies and the progression of the dysplastic bony lesions. The results show that LP/J mice treated with dexamethasone developed significantly fewer dysplastic bony lesions compared to the age-matched, saline-treated controls. There was also a statistically significant difference in the quantity and cellularity of the middle ear effusions between the experimental and control animals.

Plasma kisspeptin and ghrelin levels in puberty variant cases

2017 ◽  
Vol 30 (5) ◽  
Author(s):  
Erdal Kurnaz ◽  
Yaşar Şen ◽  
Süleyman Aydın
Keyword(s):  
Serum Levels ◽  
Control Group ◽  
Control Groups ◽  
Premature Thelarche ◽  
Premature Adrenarche ◽  
Significant Difference ◽  
And Gender ◽  
And Control ◽  
Relationship Of ◽  
The Relationship

AbstractBackground:The aim of this study was to determine the serum levels of kisspeptin and ghrelin (GAH), as well as the relationship of these two peptides with each other in premature thelarche (PT) and premature adrenarche (PA) cases and to investigate the possibility of using these peptides as markers in the differentiation of puberty disorders.Methods:A PT group aged 1–8 years (n = 40), a PA group aged 1–9 years (n = 23, female/male = 20/3) and control groups consistent with each of the previous groups in terms of age and gender were created for the study. Kisspeptin and ghrelin levels were measured with ELISA methods from blood samples drawn while fasting in the morning.Results:When the PT group was compared with the controls, the plasma kisspeptin levels of the cases were significantly higher than the control group (165.47 ± 15.45 pmol/L, 96.82 ± 12.33 pmol/L, p = 0.005, respectively). Kisspeptin levels in the PA group did not show a difference with the control group (121.36 ± 17.99 pmol/L, 95.52 ± 11.54 pmol/L, p = 0.249, respectively). No significant difference could be found when GAH levels in the PT and PA groups were compared with controls. No significant correlation was found between kisspeptin and GAH levels in the PT and PA groups.Conclusions:Our results indicate that kisspeptin plays an important role in the PT, but GAH is not associated with puberty disorders.

STUDIES ON FACTORS INFLUENCING THE HEALTH OF PIGS: I. THE RELATIONSHIP OF BLOOD HAEMOGLOBIN CONCENTRATIONS TO RATE OF GAIN IN SUCKLING PIGS

1942 ◽  
Vol 20d (12) ◽  
pp. 380-386 ◽  
Author(s):  
W. E. Swales ◽  
E. W. Crampton ◽  
G. C. Ashton ◽  
L. Choquette
Keyword(s):  
Body Weight ◽  
Disease Resistance ◽  
Statistical Analysis ◽  
Normal Development ◽  
Factors Influencing ◽  
Significant Difference ◽  
Blood Haemoglobin ◽  
And Control ◽  
Relationship Of ◽  
The Relationship

The trends of blood haemoglobin concentrations in suckling pigs in a herd in which clinical anaemia does not occur have been studied and compared to rates of gain in body weight.Ferrous sulphate and reduced iron were then used to keep the haemoglobin concentrations at higher levels, and statistical analysis of the observations snowed a significant difference in body weight at weaning time between the treated and control groups.The results indicate that pigs should be provided with a source of iron within a day or two after birth in order to ensure normal development and, possibly, resistance to disease.Work on this and other possible factors in disease resistance is being continued.

scholarly journals MUC1 and MUC5AC Acting on Helicobacter pylori-Related Deficiency and Solid Syndrome of Spleen and Stomach

2018 ◽  
Vol 2018 ◽  
pp. 1-8
Author(s):  
Ling Hu ◽  
Wanqun Chen ◽  
Ming Cheng ◽  
Ting Zhang ◽  
Shaoyang Lan ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Dynamic Equilibrium ◽  
Deficiency Syndrome ◽  
Blue Staining ◽  
Significant Difference ◽  
Tai Ji ◽  
Hematoxylin And Eosin ◽  
Relationship Of ◽  
Heat Syndrome ◽  
The Relationship

To investigate the relationship of MUC1, MUC5AC, and the syndrome of spleen and stomach, 109 subjects (34 peptic ulcer (PU), 62 chronic gastritis (CG), and 13 healthy volunteers (CON)) were included. All the subjects included were surveyed with questionnaire to classify them into damp-heat syndrome of spleen and stomach (DHSS), spleen-qi deficiency syndrome (SQD), and CON, examined by gastric endoscope, and biopsied. Rapid urease and methylene blue staining (MBS) were performed on every subject to diagnose for Helicobacter pylori (Hp) infection, and both were defined as Hp-positive. Hematoxylin and eosin (HE) staining was performed on every specimen to explore the histomorphology, inflammatory degree, and inflammatory activity of different groups; then Elivision™ plus kit was used to test the expression of MUC1 and MUC5AC. All the results of digital images were reviewed by two experts blindly. The inflammatory degree with Hp infection was higher than those uninfected or CON, but no significant difference was found between DHSS and SQD. And the expressions of MUC5AC with positive Hp was higher than those with negative Hp or CON regardless of the deficiency and solid syndrome of spleen-stomach but not for MUC1. We speculate that the deficiency and solid syndrome of spleen-stomach is a condition like Tai Ji symbol of dynamic equilibrium, showing the higher expression of MUC5AC but no change of MUC1 in the circumstance of Hp infection.

Humankind and Water

2019 ◽  
pp. 36-64
Author(s):  
Edward B. Barbier
Keyword(s):  
Sustainable Development ◽  
Economic Development ◽  
Water Resources ◽  
Complex Relationship ◽  
Market Policy ◽  
Significant Difference ◽  
Water Institutions ◽  
Governance Institutions ◽  
And Control ◽  
The Relationship

This chapter examines how humankind's complex relationship with water evolved historically to create today's water paradox. There is a significant difference between how water is managed and used for economic development today compared to past eras. Starting with the Agricultural Transition around 10,000 years ago, economic development was spurred by harnessing more water resources. Rather than threatening sustainable development, exploiting and controlling water resources was the key to building successful and long-lasting economies. Although the relationship between exploiting water resources and economic development has changed, many of the water institutions and innovations have not. Water may appear to be cheap, but it is only artificially so. Instead, the current market, policy, and governance institutions underprice it, and so people continue to use water excessively as if it were not scarce. Most of the innovations are also geared toward expanding command and control of water resources, not toward reducing use as economies develop.

scholarly journals PENGARUH SUMBER DAYA MANUSIA TERHADAP PROFESIONALISME PRAJURIT PANGKALAN TNI AL DI PANTAI BARAT

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Bambang Supriyono ◽  
Prio Budi Leksono ◽  
Devi Erlita
Keyword(s):  
Human Resource ◽  
West Coast ◽  
Task Force ◽  
Command And Control ◽  
Weapon System ◽  
And Control ◽  
Relationship Of ◽  
The Relationship ◽  
Naval Base ◽  
Operating Units

<strong><em>Naval base as one of the integral components of the SSAT is the spearhead of power in carrying out support for the tasks of the operating units both in peacetime and during war. In carrying out its duties the Navy has an Integrated Fleet Weapon System (SSAT) which is the integration of strength of the capabilities of the KRI, Aircraft, Marines and Naval base components. To find out the professional level of the soldier, it is necessary to hold a Test of Combat Naval Base Task Force in order to realize, maintain and improve the skills of both individuals and groups, which in turn will increase the establishment of Operational Command and Control, Operational Procedures and the establishment of mastery of appropriate techniques and tactics. With the implementation of the test, it is expected to know about Naval Base Combat Readiness, a condition where the base can carry out its main tasks. Combat Duty Rehearsal is an exercise carried out by KRI or base to maintain the ability and professionalism of soldiers both programmed and programmed. This study aims to determine whether the relationship of human resource readiness influences the professional abilities of the Naval Base on west coast.</em></strong>

scholarly journals Objective psychology. Academician V. Bekhterev. Issue I. St. Petersburg. 1907 year

1907 ◽  
Vol XIV (3-4) ◽  
pp. 194-196
Author(s):  
V. Osipova
Keyword(s):  
Mental Life ◽  
Subjective Experiences ◽  
The Subject ◽  
And Control ◽  
Relationship Of ◽  
The Relationship ◽  
Living Creature

The author begins his work with the words that the psychology that he will expound bears little resemblance to the psychology that has been the subject of study until now. In objective psychology, there should be no place for questions about subjective processes or processes of consciousness, therefore there should be no place for introspection. Self-observation is not enough even to study one's own mental life. Objective psychology has in mind to study and explain only the relationship of a living creature to the surrounding conditions that affect it in one way or another, without aiming to find out those internal or subjective experiences, which are known as conscious phenomena and which are accessible only to self-observation. All mental items should only be subject to objective registration and control.

scholarly journals The Relationship of Surgeon Handedness and Experience on Operative Duration and Hearing Improvement in Ipsilateral and Contralateral Otologic Surgeries

2020 ◽  
Vol 35 (2) ◽  
pp. 17
Author(s):  
Gillian Barzaga
Keyword(s):  
Hearing Improvement ◽  
Ear Surgery ◽  
Hearing Gain ◽  
Operative Duration ◽  
Left Handed ◽  
Significant Difference ◽  
Surgeon Experience ◽  
The Right ◽  
Relationship Of ◽  
The Relationship

ABSTRACT Objective: To determine the relationship of the surgeon handedness and operative site laterality on operative duration and hearing improvement in otologic surgery, and to further explore whether this relationship may be related to surgeon experience. Methods:Design: Retrospective CohortSetting: Tertiary Private Teaching HospitalParticipants: Seventy-three (73) patients aged 18 to 65 years old who underwent primary ear surgery under general anesthesia between January 2016 and December 2019 were retrospectively divided into two groups: 39 contralateral and 34 ipsilateral. The operative durations and hearing improvements were compared using independent t-tests, with consideration of surgeon experience in years further stratifying patients. Results: There was no significant difference in operative duration, t(71) = 1.14, p = .26, between the contralateral (M = 281.95 minutes, SD = 71.82) and ipsilateral (M = 261.15, SD = 79.26) groups. This same pattern was more pronounced among surgeons with 10+ years of experience although there was also no significant difference in operative time, t(33) = 1.31, p = .19 for both ipsilateral and contralateral surgeries There was no statistically significant difference, t(36) = -0.72, p = .47, in overall mean hearing gain among patients in the contralateral (M = +2.22 dB, SD = 10.54) and ipsilateral (M = +5.12 dB, SD = 14.26) groups. Although the difference was also not statistically significant, t(16) = -1.94, p = .07 for contralateral (M = 0.00, SD = 5.43) and ipsilateral (M = +7.95 dB, SD = 11.52) procedures performed by surgeons with experience of 10 years or more, a mean hearing gain of +7 dB in the ipsilateral group compared to 0 dB in the contralateral group was notable. Conclusion: This study did not prove that regardless of surgeon experience, right-handed surgeons operating on the right ear and left-handed surgeons operating on the left ear have better ear surgery outcomes of operative duration and hearing improvement compared to right- handed surgeons operating on the left ear and left-handed surgeons operating on the right ear. Future studies on larger samples with more complete data may yet demonstrate this effect.

scholarly journals Relationship Of Age And Parity With Preeclampsia Incidence In Pregnant Women At dr. M. Yunus Hospital In Bengkulu

2020 ◽  
Vol 6 (2) ◽  
pp. 29-34
Author(s):  
Metha Fahriani ◽  
Sefti Fusvita Sari ◽  
Yuni Ramadhaniati
Keyword(s):  
Pregnant Women ◽  
Random Sampling ◽  
Sampling Technique ◽  
Case Control ◽  
Service Improvement ◽  
Maternal Deaths ◽  
Systematic Random Sampling ◽  
And Control ◽  
Relationship Of ◽  
The Relationship

In 2017 the number of maternal deaths was 28, consisting of 6 maternal deaths, 10 maternal deaths and 12 puerperal maternal deaths. The purpose of this study is to know the relationship of age and parity with the incidence of preeclampsia in pregnant women at dr. M. Yunus Hospital in Bengkulu year 2018. The type of research used is case control. The population in this study were all pregnant women in dr. M. Yunus Hospital in Bengkulu year 2018. The sampling technique was a case sample using total sampling, namely all pregnant women with preeclampsia and control samples using systematic random sampling technique that is sampling using multiples recorded in the hospital register of dr. M. Yunus Hospital in Bengkulu year 2018. The results of this study there is no relationship between age and the incidence of preeclampsia in pregnant women at RSUD dr. M. Yunus in 2018. With the value of p = 0.424> α = 0.05 and the value of Odds Ratio or Risk Estimate = 1.496 and there is a significant relationship between parity and the incidence of preeclampsia in pregnant women at RSUD dr. M. Yunus Bengkulu in 2018. With the value of p = 0.011 <α = 0.05 with the medium category.It is expected that the results of this study can be a program development and service improvement in reducing the prevalence of preeclampsia.

Relationship of Psychological well-being with Depression and Anxiety among Heart Patients

2021 ◽  
Vol 15 (11) ◽  
pp. 3101-3102
Author(s):  
Babar Javaid ◽  
Abrar Ahmed ◽  
Gohar Ali Arshad ◽  
M Shoaib Akhtar ◽  
Shazia Taj ◽  
...  
Keyword(s):  
Null Hypothesis ◽  
Well Being ◽  
Military Hospital ◽  
P Value ◽  
Depression And Anxiety ◽  
Psychological Well Being ◽  
Heart Patients ◽  
Significant Difference ◽  
Relationship Of ◽  
The Relationship

The study was designed to investigate the relationship of psychological well-being with depression and anxiety among heart patients.1 For this purpose, a sample of 200 patients was taken, including 100 men and 100 women, educated uneducated, employed and unemployed volunteers. The sample was taken from Nishtar Hospital, Combined military hospital and other private hospitals in Multan. The age range from 25 to 60 (mean age 43.085).2,3 Objective: To observe the effect of demographic variables (age, education, gender and source of finance) on psychological well-being and depression, anxiety in heart patients. Methods: 1. Low psychological well-being would be positively correlated with depression and anxiety. 2. Older age (above 50) heart patients would have low sense of psychological well-being as compared to younger age (above 35) heart patients. Results: Different statistical procedures were used to determine the relationship of psychological well-being with depression and anxiety among heart patients. Correlation was computed to see the relationship among variables. It was found that there is negative correlation between psychological well-being with depression and anxiety. Since the p-value in less than α (p-value < 0.01), so we reject null hypothesis Ho, and conclude that low psychological well-being is positively correlated with depression and anxiety. Conclusion: This study also finds out important findings on the role of stresses, feeling of worthlessness in depression and anxiety disorder. It is concluded that psychological well-being, depression and anxiety are not significant correlated with each other. Source of income or job and sex of the heart patients have significant effect on psychological well being. However there is no significant difference between men and women regarding the rate of depression and anxiety. Keywords: P-Value, Correlation, Null Hypothesis , Depression

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