Acute simultaneous development of brain tumour–like lesion and demyelinating polyneuropathy in a patient with chronic relapsing myelitis

2017 ◽  
Vol 24 (4) ◽  
pp. 546-550 ◽  
Author(s):  
Marco Puthenparampil ◽  
Alberto Terrin ◽  
Lisa Federle ◽  
Matteo Gizzi ◽  
Paola Perini ◽  
...  
Keyword(s):  
Nervous System ◽  
Brain Tumour ◽  
Demyelinating Polyneuropathy ◽  
Diagnostic Workup ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Simultaneous Development ◽  
History Of

Combined central and peripheral demyelination (CCPD) is a rare chronic inflammatory disorder of the nervous system. We describe the case of a patient with a history of recurrent myelitis that acutely and simultaneously developed a brain tumour–like lesion and a sensitive-motor demyelinating polyneuropathy. The diagnosis of CCPD was supported by a detailed diagnostic workup. Up to date, no similar cases have been reported in the literature.

scholarly journals Korelasi Lama Senam Asma dengan Faal Paru pada Pasien Asma yang Mengikuti Senam Asma

2017 ◽  
Vol 10 (1) ◽  
pp. 17
Author(s):  
Eka Bebasari ◽  
Miftah Azrin
Keyword(s):  
Vital Capacity ◽  
Cross Sectional Study ◽  
University Teaching ◽  
Inflammatory Disorder ◽  
Cross Sectional ◽  
Chronic Inflammatory Disorder ◽  
The Family ◽  
Asthma Patients ◽  
History Of ◽  
Moderate Positive Correlation

Asthma is a chronic inflammatory disorder of the airways. Asthma gymnastics is one of rehabilitation efforts that mayimprove asthma patients lung function. This research was a cross sectional study to determine correlation of durationof asthma gymnastics with pulmonary function. Respondents were all asthma patients who follow asthma gymnasticsin Riau University Teaching Hospital and Health Center Rumbai. Data were collected with spirometry test with totalsampling. Most of respondents were in the age group 41-50 years (38.7%), female respondents 77.4%, most ofrespondents had a history of asthma in the family (61.3%), duration of asthma gymnastics more than 3 months(61.3%), asthma degree was intermittent (38,7%), level of asthma control was controlled 61.3% and spirometry testshowed that 54.8% respondent were classified obstructive. There is a moderate positive correlation between durationof asthma gymnastics with lung vital capacity with r = 0,451 and p = 0,011.

scholarly journals GAMBARAN PERTUMBUHAN PADA ANAK DENGAN RIWAYAT ASMA DI RSUP PROF. DR. R. D. KANDOU

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Prima Kinanti ◽  
Vivekenanda Pateda ◽  
Audrey M. I. Wahani
Keyword(s):  
Data Analysis ◽  
Pediatric Patients ◽  
Normal Growth ◽  
Early Morning ◽  
Primary Diagnosis ◽  
Research Data ◽  
Inflammatory Disorder ◽  
Chest Tightness ◽  
Chronic Inflammatory Disorder ◽  
History Of

Abstract: Asthma is a chronic inflammatory disorder of the airways that causes increased airway hyperresponsiveness which triggers symptoms such as wheezing, breathlessness, chest tightness and coughing, especially at night or early morning. Asthma as a chronic disease in general may affect a child's growth through several factors. The purpose of this study was to determine the growth in children with a history of asthma who were treated in the Division of Pediatric, Prof. Dr. R. D. Kandou Hospital Manado. Research conducted a retrospective descriptive univariate data analysis. Samples were pediatric patients aged 5-18 years with a primary diagnosis of asthma treated in the Division of Pediatric, Prof. Dr. R. D. Kandou Hospital Manado in January 2011 - September 2015. Research data analysis using CDC-2000 growth curve. From the research, based on W / A and H / A, obtained the majority of children with normal growth. Based on the weight / height and BMI, obtained the majority of children with good nutritional status.Keywords: asthma, growth, children.Abstrak: Asma adalah gangguan inflamasi kronik saluran napas yang menyebabkan peningkatan hiperesponsif jalan napas yang menimbulkan gejala berupa mengi, sesak napas, dada terasa berat dan batuk-batuk terutama malam atau dini hari.Asma sebagai penyakit kronik secara umum dapat mempengaruhi pertumbuhan anak melalui beberapa faktor. Tujuan penelitian ini adalah untuk mengetahui pertumbuhan pada anak dengan riwayat asma yang dirawat di Bagian Ilmu Kesehatan Anak RSUP Prof. Dr.R.D. Kandou Manado.Penelitian yang dilaksanakan bersifat deskriptif retrospektif dengan analisis data univariat.Sampel penelitian ini adalah pasien anakusia 5 - 18 tahun dengan diagnosis utama asmayang dirawat di bagian Ilmu Kesehatan Anak Anak RSUP Prof.Dr.R.D. Kandou Manado pada bulan Januari 2011 – September 2015.Analisis data penelitian menggunakan kurva pertumbuhan CDC-2000. Dari hasil penelitian, berdasararkan BB/U dan TB/U, didapatkan mayoritas anak dengan pertumbuhan normal. Berdasarkan BB/TB dan IMT, didapatkan mayoritas anak dengan status gizi baik.Kata Kunci: asma, pertumbuhan, anak.

CLIPPERS and the need for long-term immunosuppression

2017 ◽  
Vol 62 (1) ◽  
pp. 28-33 ◽  
Author(s):  
Tarig M Abkur ◽  
Hugh Kearney ◽  
Michael J Hennessy
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Inflammatory Disorder ◽  
Sustained Remission ◽  
Gait Ataxia ◽  
Immunomodulatory Treatment ◽  
Chronic Inflammatory Disorder ◽  
Cerebellar Peduncles ◽  
The Central Nervous System

Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS) is a rare chronic inflammatory disorder of the central nervous system. Herein, we describe the case of a 62-year-old female who presented with right sided facial tingling, gait ataxia and diplopia. Neuroimaging revealed pontine curvilinear enhancing lesions with extension into cerebellar peduncles, characteristic of CLIPPERS. This report discusses the differential diagnosis and the importance of prolonged immunomodulatory treatment for this rare neuro-inflammatory disorder. Long-term immunosuppression appears to be mandatory in order to achieve sustained remission and prevent disability related to atrophy of the structures involved in repeated attacks.

scholarly journals Association between asthma and suicidality in 9-11-year-old children

2021 ◽  
Author(s):  
Kevin H Hoffman ◽  
Elina Visoki ◽  
Stirling T Argabright ◽  
Grace E DiDomenico ◽  
Barbara H Chaiyachati ◽  
...  
Keyword(s):  
Asthma Severity ◽  
Health Concern ◽  
Inflammatory Disorder ◽  
Baseline Assessment ◽  
Dose Response Relationship ◽  
Chronic Inflammatory Disorder ◽  
History Of ◽  
Using Data ◽  
And Behavior

Background: Suicidal thoughts and behavior (STB) in children are a growing health concern, and more data is needed regarding their biological underpinnings. Immune processes such as inflammation have been associated with STB, primarily in adults. Asthma is a common chronic inflammatory disorder in children and has been associated with STB in adolescent and adult populations, but data in children is lacking. We wished to study associations of asthma with childhood STB given asthmas potential as a clinically relevant model for childhood chronic immune dysregulation. Methods: Using data from the Adolescent Brain Cognitive Development (ABCD) Study (N=11,878, 52% males, mean age 9.9 years at baseline assessment and 10.9 years at 1-year follow up), we assessed associations between asthma and STB at both baseline and 1-year follow up. Results: We found that asthma at baseline assessment (n=2,214, 18.6%) is associated with STB, controlling for multiple confounders including demographics, socioeconomic factors and environmental confounders such as air pollution (odds ratio (OR)=1.2, 95%CI 1.01-1.42, P=0.039). Indicators of recently active asthma were not significantly associated with suicidality at baseline assessment (currently taking asthma medication: OR=1.22, 95%CI 0.93-1.60, P=0.146), or at 1-year follow up (past year asthma-related clinical visit: OR=1.13, 95%CI 0.87-1.47, P=0.357). Proxy-measures of asthma severity (number of asthma medications or clinical visits) did not reveal a significant dose response relationship with STB. Conclusions: Findings suggest an association between history of asthma and STB in children, which may not be related to asthma disease state. Further research is needed to investigate mechanisms underlying this relationship.

scholarly journals Roles of IL-17A and IL-23 in the Pathogenesis of Ulcerative Colitis and Crohn’s Disease

2021 ◽  
pp. 2526-2535
Author(s):  
Sarah S. Abdul-Hussein ◽  
Ekhlass N. Ali ◽  
Nawal M. F. Alkhalidi ◽  
Neihaya H. Zaki ◽  
Ali H. Ad'hiah
Keyword(s):  
Ulcerative Colitis ◽  
Crohn’S Disease ◽  
Family History ◽  
Crohn's Disease ◽  
Smoking Status ◽  
Serum Levels ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
History Of ◽  
Disease Extension

     Inflammatory bowel disease (IBD) is a chronic inflammatory disorder,  the etiology and pathogenesis of which have been suggested to be influenced by cytokines. Two main clinical types of IBD are recognized, namely ulcerative colitis (UC) and Crohn's disease (CD). The present study examined serum levels of two cytokines (IL-17A and IL-23) in 60 IBD patients (30 UC and 30 CD) and 30 healthy controls. The levels were correlated with age, gender, cigarette-smoking status, disease duration, family history, disease extension, symptoms, extra-intestinal manifestations, and medication. The results depicted that IL-17A level was significantly higher in UC and CD patients compared to control (45.2 ± 23.3 and 47.5 ± 34.4 vs. 15.6 ± 7.5 pg/ml, respectively; p < 0.001). Serum level of IL-23 was similarly increased in UC and CD patients compared to control (64.1± 23.7 and 62.5 ± 27.3 vs. 25.2 ± 11.1 pg/ml, respectively). However, the level of both cytokines showed no significant variation between UC and CD patients (p = 0.713 and 0.777, respectively). Distributing UC and CD patients into subgroups according to some characteristics revealed that IL-17A level was significantly increased in UC male compared to female patients (57.3 ± 18.2 vs. 34.5 ± 22.5 pg/ml; p = 0.005). It was also significantly increased in smoker UC patients compared with non-smoker patients (51.9 ± 19.4 vs. 31.6 ± 25.5 pg/ml; p = 0.022). Smoker CD patients also showed a significantly increased level of IL-23 compared to non-smoker patients (72.7 ± 28.5 vs. 52.2 ± 22.6 pg/ml; p = 0.038). In the case of family history, IL-23 level was significantly decreased in UC patients with a family history of IBD compared to CD patients with a family history (84.5 ± 24.3 vs. 50.4 ± 17.0 pg/ml.; p = 0.042). In conclusion, the present data suggest a role for IL-17A and IL-23 in the etiology and pathogenesis of UC and CD.

scholarly journals Redox Imbalance in T Cell-Mediated Skin Diseases

2010 ◽  
Vol 2010 ◽  
pp. 1-9 ◽  
Author(s):  
Saveria Pastore ◽  
Liudmila Korkina
Keyword(s):  
Oxidative Stress ◽  
Atopic Dermatitis ◽  
Contact Dermatitis ◽  
Skin Diseases ◽  
Redox Balance ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Physical Chemical ◽  
Chemical Oxidants ◽  
Beneficial Outcome

The skin is permanently exposed to physical, chemical, and biological aggression by the environment. In addition, acute and chronic inflammatory events taking place in the skin are accompanied by abnormal release of pro-oxidative mediators. In this paper, we will briefly overview the homeostatic systems active in the skin to maintain the redox balance and also to counteract abnormal oxidative stress. We will concentrate on the evidence that a local and/or systemic redox dysregulation accompanies the chronic inflammatory disorder events associated to psoriasis, contact dermatitis, and atopic dermatitis. We will also discuss the fact that several well-established treatments for the therapy of chronic inflammatory skin disorders are based on the application of strong physical or chemical oxidants onto the skin, indicating that, in selected conditions, a further increase of the oxidative imbalance may lead to a beneficial outcome.

scholarly journals Acute exudative polymorphous paraneoplastic vitelliform maculopathy (AEPPVM) associated with choroidal melanoma

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Aluisio Rosa Gameiro Filho ◽  
Guilherme Sturzeneker ◽  
Ever Ernesto Caso Rodriguez ◽  
André Maia ◽  
Melina Correia Morales ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Serous Retinal Detachment ◽  
Central Nervous System Involvement ◽  
Choroidal Melanoma ◽  
Posterior Pole ◽  
Pancreatic Metastasis ◽  
Small Areas ◽  
History Of ◽  
The Right

Abstract Background To report a case of acute exudative polymorphous paraneoplastic vitelliform maculopathy in a patient with a history of choroidal melanoma, with metastases to the pancreas, liver, and central nervous system. Case presentation A 63-year-old patient, with a history of enucleation of the right eye due to choroidal melanoma, complained of progressive visual loss during a follow-up visit. Fundoscopic examination revealed multiple small areas of serous retinal detachment scattered throughout the posterior pole and ancillary tests confirmed the diagnosis of acute exudative polymorphous paraneoplastic vitelliform maculopathy (AEPPVM). Screening for systemic metastases showed pancreatic, hepatic, and central nervous system involvement. Conclusions We describe a rare case of acute exudative polymorphous paraneoplastic vitelliform maculopathy, which should be considered in patients with or without a history of melanoma, who have vitelliform retinal detachments. Nevertheless, no previous reviews of literature have shown a correlation between AEPPVM and pancreatic metastasis.

scholarly journals Rituximab Treatment in a Patient with Kimura Disease and Membranous Nephropathy: Case Report

2021 ◽  
pp. 116-123
Author(s):  
Roald Vissing-Uhre ◽  
Alastair Hansen ◽  
Susanne Frevert ◽  
Ditte Hansen
Keyword(s):  
Case Report ◽  
Membranous Nephropathy ◽  
Neck Region ◽  
Renal Diseases ◽  
Kimura’S Disease ◽  
Inflammatory Disorder ◽  
Kimura Disease ◽  
Chronic Inflammatory Disorder ◽  
Eosinophil Granulocytes ◽  
Anti Cd20

Kimura disease (KD) is a chronic, inflammatory disorder with slowly developing subcutaneous tumor-like swellings, often occurring in the head and neck region. KD is diagnosed based on histology, elevated levels of immunoglobulin type E, and increased peripheral eosinophil granulocytes. KD may coexist with glomerular renal diseases, and this case report is based on a patient with KD-associated membranous nephropathy. Patients with membranous nephropathy without KD have demonstrated responsiveness to treatment with monoclonal anti-CD20 antibodies. This case report is the first to investigate the effect of rituximab treatment in a patient with KD-associated membranous nephropathy. A 30-year-old Italian man living in Denmark was diagnosed with Kimura’s disease based on subcutaneous nodules with eosinophil angiolymphoid hyperplasia. The patient was admitted to the hospital due to nephrotic syndrome. Serology showed eosinophil granulocytosis and negative PLA2-receptor antibody. Renal biopsy showed membranous nephropathy, and the patient was treated with systemic methylprednisolone followed by cyclosporin and then cyclophosphamide with only partial remission. Ultimately, treatment with intravenous rituximab was initiated, which resulted in overall remission and no nephrotic relapses at 30 months of follow-up. Thus, intravenous rituximab effectively decreased proteinuria and prevented nephrotic relapses in a patient with treatment-refractory membranous nephropathy due to KD.

scholarly journals Serum-derived extracellular vesicles inhibit osteoclastogenesis in active-phase patients with SAPHO syndrome

2021 ◽  
Vol 13 ◽  
pp. 1759720X2110069
Author(s):  
Yanpan Gao ◽  
Yanyu Chen ◽  
Lun Wang ◽  
Chen Li ◽  
Wei Ge
Keyword(s):  
Bone Metabolism ◽  
Extracellular Vesicles ◽  
Inflammatory Marker ◽  
Active Phase ◽  
Sapho Syndrome ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Reactive Protein ◽  
Amyloid A

Objective: Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare chronic inflammatory disorder and the underlying pathogenesis is unclear. In this study, 88 SAPHO patients and 118 healthy controls were recruited to investigate the role of serum-derived extracellular vesicles (SEVs) in SAPHO syndrome. Methods: Quantitative proteomics was applied for SEVs proteome identification, and ELISA and Western blotting was performed to verify the results of mass spectrum data. In vitro osteoclastogenesis and osteogenesis assay was used to confirm the effects of SEVs on bone metabolism. Results: Tandem mass tagging-based quantitative proteomic analysis of SAPHO SEVs revealed differential expressed proteins involved in bone metabolism. Of these, serum amyloid A-1 (SAA1) and C-reactive protein (CRP) were upregulated. Higher SAA1 levels in SAPHO patients were confirmed by ELISA. In addition, SAA1 levels were positively correlated with CRP, an inflammatory marker related to the condition of patients. In vitro celluler studies confirmed that SAPHO SEVs inhibited osteoclastogenesis in patients mainly in the active phase of the disease. Further analysis demonstrated that Nucleolin was upregulated in osteoclasts of active-phase patients under SAPHO SEVs stimulation. Conclusion: In this study, we identified SAA1 as an additional inflammation marker that can potentially assist the diagnosis of SAPHO syndrome, and speculated that Nucleolin is a key regulator of osteoclastogenesis in active-phase patients.

scholarly journals Atypical cutaneous and musculoskeletal manifestation of SARS-CoV-2: ‘COVID-19 toes’ and spasticity in a 48-year-old woman

2021 ◽  
Vol 14 (3) ◽  
pp. e241410
Author(s):  
Avery Kopacz ◽  
Cameron Ludwig ◽  
Michelle Tarbox
Keyword(s):  
Nervous System ◽  
Adult Patient ◽  
Early Identification ◽  
Lower Limbs ◽  
Rare Occurrence ◽  
Cutaneous Manifestations ◽  
Crucial Component ◽  
History Of ◽  
Screening Questions ◽  
Insight Into

Establishing accurate symptomatology associated with novel diseases such as COVID-19 is a crucial component of early identification and screening. This case report identifies an adult patient with a history of clotting dysfunction presenting with rare cutaneous manifestations of COVID-19, known as ‘COVID-19 toes’', previously described predominantly in children. Additionally, this patient presented with possible COVID-associated muscle spasticity of the lower limbs, as well as a prolonged and atypical timeline of COVID-19 infection. The rare occurrence of ‘COVID-19 toes’' in this adult patient suggests that her medical history could have predisposed her to this symptom. This supports the coagulopathic hypothesis of this manifestation of COVID-19 and provides possible screening questions for patients with a similar history who might be exposed to the virus. Additionally, nervous system complaints associated with this disease are rare and understudied, so this novel symptom may also provide insight into this aspect of SARS-CoV-2.

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