scholarly journals Impact of Pretreatment Total Cholesterol Level Is Associated With Metastasis of Prostate Cancer

2020 ◽  
Vol 14 (2) ◽  
pp. 155798832091878
Author(s):  
Hisashi Hirano ◽  
Hisamitsu Ide ◽  
Yan Lu ◽  
Yasuyuki Inoue ◽  
Hiroshi Okada ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Cancer Metastasis ◽  
Total Cholesterol Level ◽  
Specific Antigen ◽  
Free Testosterone ◽  
Disease Stage ◽  
Histopathological Diagnosis ◽  
Significant Difference

Metabolic syndrome is reported to play a role in the genesis and development not only of angina, arteriosclerosis, diabetes, and osteoporosis but also of prostate cancer. Hypercholesterolemia is a strong risk factor in prostate cancer development. The current study was conducted to analyze whether pretreatment serum levels of cholesterol correlate with prostate cancer metastasis. Three hundred fifty-one subjects who received a histopathological diagnosis of prostate cancer were evaluated by clinical factors such as age, body mass index (BMI), disease stage, Gleason score, prostate-specific antigen (PSA), total cholesterol, Luteinizing hormone (LH), testosterone, and free testosterone. A multivariate analysis was performed on these factors, and a statistically significant difference was identified in total cholesterol level ( p =.01) and PSA ( p < .001). The total cholesterol level was higher in cases of metastatic prostate cancer compared to nonmetastatic prostate cancer in this study and therefore may be a predictive factor for poor prognosis.

scholarly journals Senam aerobik dan konsumsi zat gizi serta pengaruhnya terhadap kadar kolesterol total darah wanita

2011 ◽  
Vol 8 (1) ◽  
pp. 23
Author(s):  
Siti Fatimah ◽  
Apoina Kartini
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Level ◽  
Total Cholesterol Level ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Adult Women ◽  
Chi Square ◽  
Cross Sectional ◽  
Nutrient Adequacy ◽  
Significant Difference

Background: Hypercholesterolemia is a condition in which levels of cholesterol in the blood above normal levels (≥ 240 mg/dl). Physical exercises done regularly useful in the regulation of cholesterol, is total cholesterol, LDL cholesterol and triglycerides in the blood decreased, while HDL cholesterol increased. Food has an important role in association with the incident hypercholesterolemia.Objective: The purpose of this study was to determine the effect of aerobic exercise on blood total cholesterol level of adult women in the city of Semarang.Method: This research was explanatory research with cross sectional study. Subject was women aged 20-49 years gymnastic participants, as a comparison group was a housewife who was not doing gymnastics. Twenty three samples for group2 by matching on nutritional status and age and with the sampling purposive sampling. Adequacy levels of carbohydrates, proteins, fats, and also vitamins A and C were obtained through 2x24-hour recall was not a sequence, and processed using NutriSurvey. Results of independent t-test used to determine the effect of cholesterol levels between groups, and chi square test was used to determine association with nutrient adequacy levels of total cholesterol.Results: The results showed no significant difference in mean total cholesterol level between groups of gymnastic participants (201.2 g/dl) with housewife group (208.3 g/dl). Housewife group was belonging to hypercholesterolemia by 52.2%, while in group of exercise participants at 43.5%. Sufficiency level of protein showed a role in the total cholesterol level of adult women.Conclusion: The aerobic gymnastics did not affect total cholesterol. Moderate level of protein adequacy contributes to the total cholesterol level of adult women.

scholarly journals Effect of Rice Bran Oil on the Lipid Profile of Mild-Moderate Hypercholesterolemic Male Aged 19-55 year

2017 ◽  
Vol 1 (1) ◽  
pp. 51 ◽  
Author(s):  
Noor Diah Erlinawati ◽  
Samuel Oetoro ◽  
Dwirini Retno Gunarti
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Rice Bran ◽  
Rice Bran Oil ◽  
Total Cholesterol Level ◽  
Cholesterol Absorption ◽  
Nutritional Therapy ◽  
Significant Difference ◽  
Gamma Oryzanol

Introduction: Adult individuals in Indonesia showed changes in diet and lack of physical activity, therefore increasing the risk of hypercholesterolemia and obesity. One of nutritional therapy for hypercholesterolemia is rice bran oil, which contains active substances that works synergistically in controlling lipid profile. The substances are gamma-orzanol, phytosterols, and vitamin E isomers (tocotrienol and tocopherol).Methods: A clinical trial was conducted for 4 weeks in City Hall of Jakarta on 20 males, age 19–55 years old, with mild-moderate hypercholesterolemia, to assess lipid profile improvement of the supplementation of rice bran oil 45 ml/days compared to 15 ml/days without changing eating patterns.Results: After 4 weeks of intervention, there was significant difference in total cholesterol level between both groups (p = 0.049). In the group that received 45 ml/days of rice bran oil, total cholesterol level decreased 14%, and in the group of 15 ml/days total cholesterol level decreased 7.8%. The reduction of LDL and triglycerides and the increase of HDL were not significantly different between both groups (p >0,05). There was no significant changes of body weight in both groups.Conclusion: This study showed that consumption of  45 ml/days rice bran oil led to better improvements in lipid profiles compare to 15 ml/days. It has been demonstrated that gamma oryzanol and plant sterols in rice bran oil have the capability to remove cholesterol from bile salt micelles, thus decreasing cholesterol absorption in intestine.

scholarly journals PENGARUH PENERAPAN MODIFIKASI PERILAKU SEHAT TERHADAP FAKTOR RESIKO DM TIPE II

2016 ◽  
Vol 2 (1) ◽  
pp. 86
Author(s):  
Ernawaty Siagian
Keyword(s):  
Blood Glucose ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Total Cholesterol Level ◽  
Fasting Blood Glucose ◽  
Healthy Diet ◽  
Control Group ◽  
Significant Difference ◽  
Diet And Exercise ◽  
Experimental Group

ABSTRAK Pendahuluan: Banyak penelitian mengindikasikan pengaruh modifikasi perilaku sehat terhadap faktor resiko DM tipe II. Tujuan: penelitian ini bertujuan untuk menguji pengaruh paket modifikasi perilaku sehat terhadap terhadap faktor resiko DM tipe II pada orang dewasa terlepas dari jenis kelamin (laki-laki dan perempuan sebagai subyek), usia 40-65 tahun dan bertempat tnggal di Bandar lampung. Metode: penelitian ini menggunakan desain penelitian quasi eksperimental yang menggunakan pre dan post test dengan 30 orang dewasa. 15 orang untuk control group dan 15 orang dewasa untuk eksperimen group. Penelitian ini  dibatasi hanya 10 (sepuluh) hari untuk menentukan pengaruh penerapan modifikasi perilaku sehat terhadap faktor resiko DM tipe II dengan tindak lanjut pemeriksaan gula darah puasa dan total kolesterol. Hasil: Eksperimen group dan control group menunjukkan tingkat gula darah puasa yang tinggi sebelum 10 (sepuluh) hari intervensi diet diabetic dan olah raga. Kedua group eksperimen dan kontrol group menunjukkan tingkat yang tinggi dari total kolesterol  sebelum intervensi 10 (sepuluh) hari diet diabetic dan olah raga. Adanya perbedaan yang signifikan dalam  gula darah puasa dan tingkat total kolesterol pada subyek sebelum dan sesudah pelaksanaan diet diabetic dan olah raga antara eksperimen group dimana terdapat penurunan yang nyata. Terdapat penurunan yang signifikan dalam gula darah puasa dan tingkat total kolesterol dari subyek di eksperimen group setelah pelaksanaan diet diabetic dan olah raga. Namun control group menunjukkan tidak ada perubahan sama sekali setelah 10 (sepuluh) hari dibandingkan dengan  eksperimen group. Usia sebagai variabel intervening menunjukkan tidak ada perbedaan yang signifikan dalam  gula darah puasa pada subyek. Pada tingkat total kolesterol untuk  nilai pre test dan post test control group adalah sebanding, sedangkan untuk eksperimen group menunjukkan  dengan bertambahnya usia subyek, tingkat total kolesterol mereka menurun. Jenis kelamin tidak menunjukkan perbedaan perbedaan yang signifikan dalam gula darah puasa pada subyek dan tingkat total kolesterol. Diskusi: ada penurunan nyata yang signifikan dalam gula darah puasa dan  total kolesterol pada subyek setelah  pelaksanaan 10 (sepuluh) hari diet diabetic dan olah raga diantara eksperimen group, sementara tidak ada perubahan sama sekali untuk control group. Usia dan jenis kelamin tidak membuat perbedaan yang signifikan dalam  gula darah puasa mereka, tetapi total kolesterol mereka menurun dengan meningkatnya usia mereka. ABSTRACT Introduction: Enough studies indicate the affect of healthy life behaviors on type 2 diabetes mellitus risk factors. Objective: the primary aim of the study is to determine the effect of health related behavior modification package on type 2 diabetes mellitus risk factors of at-risk adults irrespective of gender (men and women subjects) ages 40-65 years old residing in Bandar Lampung, Indonesian. Method: this study uses a quasi experimental research design that uses pre and post test with 15 adults for control group and 15 adults for experimental group. It is only limited to determine the effect of (10) ten day health related behavior modification package consisting of  healthy diet, and exercise with follow-up fasting blood glucose, and total cholesterol. The experimental and control group have shown a high level of fasting blood glucose level before the 10 (ten) days intervention of healthy diet and exercise. Result: both experimental and control group have shown a borderline high level of total cholesterol before the 10 (ten) day intervention of healthy diet and exercise. However, the control group has shown no changes at all after 10 (ten) days compared to the experimental group which is labeled as normal. There is a significant difference in the fasting blood glucose and total cholesterol level of the subjects before and after the implementation of healthy diet and exercise among the experimental group in which a decrease is markedly noted. Discussion: there is a significant decrease in the fasting blood glucose and total cholesterol level of the subjects in the experimental group after the implementation of healthy diet and exercise. Age as an intervening variable shows no significant difference in the subjects’ fasting blood glucose level. However, in the subjects’ total cholesterol level, for control group it is comparable whereas for experimental group it shows that as the age of the subject increases, their total cholesterol level decreases. Gender shows no significant difference in the subjects’ fasting blood glucose and total cholesterol level. It is concluded that there is a markedly significant decrease in the fasting blood glucose and total cholesterol level of the subjects after the 10 (ten) days implementation of healthy diet and exercise, among the experimental group, while no change at all for the control group. The subject’ age and gender makes no significant difference in their fasting blood glucose level but their total cholesterol decreases as their age increases.

scholarly journals Prevention of Increasing Total Cholesterol Level Using Cowpea Yoghurt

2020 ◽  
Vol 3 (1) ◽  
pp. 38
Author(s):  
Maulana Rahmat Hidayatullah
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Level ◽  
Total Cholesterol Level ◽  
Lipoprotein Metabolism ◽  
Male Rats ◽  
Control Group ◽  
Control Group Design ◽  
Metabolism Disorder ◽  
Significant Difference ◽  
Coa Reductase

Atherosclerosis is lipoprotein metabolism disorder which is marked by an increase of total cholesterol level in blood serum. Cowpea contains a lot of isoflavones that can inhibit the activity of the enzyme HMG-CoA reductase in the cholesterologenesis process. The aim of this study is to find out cowpea yogurt which can prevent the increasing total cholesterol level. This study used an experimental study with a post-test only control group design in 30 male rats. It was divided into 5 groups: Results showed that the total cholesterol level among the fifth group was a significant difference (Kruskal-Wallis, p = 0,000). The conclusion of this study is cowpea yogurt can prevent the increasing total cholesterol levels of Wistar rats induced by a high-fat diet.

MANFAAT JERUK NIPIS (CITRUS AURANTIFOLIA) DAN OLAHRAGA UNTUK MENURUNKAN KOLESTEROL TOTAL KLIEN DEWASA

2016 ◽  
Vol 1 (2) ◽  
Author(s):  
Yunus Elon ◽  
Jacqueline Polancos
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Level ◽  
Total Cholesterol Level ◽  
Sampling Technique ◽  
Blood Cholesterol ◽  
Lime Juice ◽  
Citrus Aurantifolia ◽  
Significant Difference ◽  
Blood Total Cholesterol ◽  
Quasi Experimental

ABSTRAK Pendahuluan: Tanpa penanganan kesehatan,klien hiperkolesterolemia akan mengalami komplikasi penyakit kardiovaskular dan bahkan kematian. Berolahraga dan pengobatan antihiperlipidemia dapat menurunkan resiko tersebut. Jeruk nipis (Citrus Aurantifolia) mengandung fitokimia yang memiliki efek menurunkan kolesterol darah. Tujuan: Untukmengetahui efek dari terapi jeruk nipis dan terapi jeruk nipis dibarengi olaraga terhadap penurunan kadar kolesterol total darah. Metode: Penelitian ini menggunakan quasi-experimental research design dengan membandingkan dua kelompok intervensi. Teknik sampling purposive digunakan untuk memilih 20 orang partisipan yang secara acak dibagi dalam 2 kelompok intervensi. Partisipan di kelompok pertama meminum jus jeruk nipis 1,5 cc/kgbb setiap pagi selama 7 hari. Sedangkan partisipan di kelompok kedua meminum jus jeruk nipis dengan dosis yang sama ditambah dengan olahraga 30 menit perhari selama 6 hari. Hasil: Rata-rata kadar kolesterol total responden pada kedua kelompok sebelum dan sesudah intervensi menunjukkan perubahan yang signifikan (p=<.05). Sedangkan skor pencapaian oleh kedua kelompok menunjukkan perbedaan yang tidak signifikan. Diskusi: Terapi jus jeruk nipis efektif  menurunkan kadar kolesterol darah karena kandungan fitokimianya yang aktif sebagai agen hipolipidemik.   Kata Kunci: Jeruk nipis, Kadar kolesterol darah ABSTRACT Introduction: Without health management, hypercholesterolemic clients would have cardiovascular diseases as complication, and even death. Exercise and anti-hyperlipidemic medication can decreased these health risks Lime (Citrus aurantifolia) possess phytochemicals that have reducing effects on blood cholesterol. Aim: To determine the effects of lime (Citrus aurantifolia) therapy and lime therapy with exercise on reducing blood total cholesterol level. Method: This study utilized a quasi-experimental design which compared two groups intervention. A purposive sampling technique was used to select 20 participants that randomly divided into 2 intervention groups.  Participants in the first group drinks 1,5 cc/kgbw  of lime juice every morning for 7 days. While participants in the second group drinks the same dosage of lime juice with 30 minutes exercise every day for 6 days. Results: The mean of total cholesterol level of participants in both groups before and after intervention reveal a significant changes (p=<.05). While the gain score of the two groups reveals no significant difference. Discussion: Lime juice therapy effective in reducing blood total cholesterol level for its active phytochemicals that acts as hypolipidemic agent. Key words: Cholesterol level, Lime Full printable version: PDF

scholarly journals ​Modelling the Evolution of Serum Cholesterol Level of Broiler Chickens

2021 ◽  
Author(s):  
M. Alam ◽  
M. Ohid Ullah ◽  
M.S. Islam
Keyword(s):  
Total Cholesterol ◽  
Cholesterol Level ◽  
Linear Mixed Model ◽  
Total Cholesterol Level ◽  
Repeated Measurements ◽  
Linear Mixed Effect Model ◽  
Mixed Effect ◽  
Broiler Industry ◽  
Significant Difference ◽  
Over Time

Background: With the demand of the growing population, the broiler industry has grown up rapidly over the last few decades and it plays as an affordable source of good quality nutritious animal protein. This broiler industry focuses mainly on optimizing the profit through improving body weight and feed efficiency but the health issues of consumers are not taken into consideration seriously. It is important to know the changing pattern of concentration level of the biochemical parameter (total cholesterol) due to different feeds as well as different ages of chicken. Methods: This experimental study through longitudinal data was conducted using repeated measurements from each of seventy randomly selected broilers, partitioned into two groups according to two types of feed, at four-time points. Since measurements from the same subject were taken at four time periods, traditional approach of analysis may not be appropriate as it ignore the correlation between repeated measurements. Therefore, linear mixed model was adopted for the analysis of our obtained dataset. Result: Linear mixed effect model did not reveal any significant difference of standard and hatcher’s supplied feeds over time on the evolution of total cholesterol level. This might be due to little difference in different compositions of both feeds. However, both exploratory data analysis and modelling confirmed that irrespective of the available feed types, total cholesterol level of broiler serum increased significantly over time (age) which leads to a recommendation for the consumers to eat younger age (lower weight) broiler chicken.

Pengaruh Pemberian Terapi Oksigen Hiperbarik Terhadap Kadar Kolesterol Total Pada Tikus Putih (Rattus novergicus) Jantan Galur Wistar Yang Di Induksi Diet Tinggi Lemak

2018 ◽  
Vol 16 (1) ◽  
pp. 1 ◽  
Author(s):  
AZRUL HILDAN SAFRIZAL
Keyword(s):  
Cardiovascular Disease ◽  
Total Cholesterol ◽  
Cholesterol Level ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
High Fat Diet ◽  
Oxygen Therapy ◽  
Total Cholesterol Level ◽  
High Fat ◽  
Cholesterol Levels

<p>The pattern and lifestyle of today's society with the presence of an interner facility makes people spend more time sitting out than on exercise and increased consumption of high-fat foods may increase the risk of cardiovascular disease. An effective therapy is needed in preventing the occurrence of cardiovascular disease. Hyperbaric oxygen now starts to develop for the treatment of several diseases, which in turn can increase the gene forming antioxidant enzymes and ROS. To determine effect of hyperbaric oxygen therapy on total cholesterol levels of wistar white rats (Rattusnovergicus) induced bye high fat. The study was carried out in an expeative post test only group control of three groups. One group is given standard feed. All groups induced high-fat diet and standard feed. Of the two groups induced, one group was given hyperbaric oxygen therapy with a dose of 3 x 30 minutes for six days on day 7 at a blood test to determine total cholesterol levels<strong>. </strong>One way Anova parametric statistic test showed that p = 0.007 &lt; α proved hypothesis that hyperbaric oxygen therapy giving effect to total cholesterol level of white mice of jantangalurist rings induced by high fat diet. Total cholesterol was significantly different between K (-) and K (+) and between K (-) and P. It was found that hyperbaric oxygen therapy had an effect on total cholesterol level dose of 3x30 minutes for six days.</p>

scholarly journals Downregulation and Prognostic Performance of MicroRNA 224 Expression in Prostate Cancer

2013 ◽  
Vol 59 (1) ◽  
pp. 261-269 ◽  
Author(s):  
Konstantinos Mavridis ◽  
Konstantinos Stravodimos ◽  
Andreas Scorilas
Keyword(s):  
Prostate Cancer ◽  
Cox Regression ◽  
Specific Antigen ◽  
Progression Free Survival ◽  
Prognostic Indicator ◽  
Disease Stage ◽  
Clinical Value ◽  
Prostate Tumors ◽  
Tissue Samples ◽  
Total Rna

INTRODUCTION The extensive use of prostate-specific antigen as a general prostate cancer biomarker has introduced the hazards of overdiagnosis and overtreatment. Recent studies have revealed the immense biomarker capacity of microRNAs (miRNAs) in prostate cancer. The aim of this study was to analyze the expression pattern of miR-224, a cancer-related miRNA, in prostate tumors and investigate its clinical utility. METHODS Total RNA was isolated from 139 prostate tissue samples. After the polyadenylation of total RNA by poly(A) polymerase, cDNA was synthesized with a suitable poly(T) adapter. miR-224 expression was assessed by quantitative real-time PCR and analyzed with the comparative quantification cycle method, Cq(2−ΔΔCq). We performed comprehensive biostatistical analyses to explore the clinical value of miR-224 in prostate cancer. RESULTS miR-224 expression was significantly downregulated in malignant samples compared with benign samples (P &lt; 0.001). Higher miR-224 expression levels were found in prostate tumors that were less aggressive (P = 0.017) and in an earlier disease stage (P = 0.018). Patients with prostate cancer who were positive for miR-224 had significantly enhanced progression-free survival intervals compared with miR-224–negative patients (P = 0.021). Univariate bootstrap Cox regression confirmed that miR-224 was associated with favorable prognosis (hazard ratio 0.314, P = 0.013); nonetheless, multivariate analysis, adjusted for conventional markers, did not identify miR-224 as an independent prognostic indicator. CONCLUSIONS miR-224 is aberrantly expressed in prostate cancer. Its assessment by cost-effective quantitative molecular methodologies could provide a useful biomarker for prostate cancer.

Sign in / Sign up

Export Citation Format

Share Document