Prevalence of gastric cancer precursors in gastroscopy-screened adults by family history of gastric cancer and of cancers other than gastric

Abstract Background People are at a high risk of gastric cancer if their first-degree relatives suffered from atrophic gastritis (AG), intestinal metaplasia (IM), intraepithelial neoplasia (IEN), dysplasia (DYS), or gastric cancer (GC). This study was performed to analyse the association between FDR-GC and GC precursors. Methods A cross-sectional study was performed to screen the prevalence of GC precursors from November 2016 to September 2019. A total of 1329 participants with FDR-GC, 193 participants with a family history of non-gastric cancer in FDRs (FDR-nGC), and 860 participants without a family history of cancer in FDRs (FDR-nC) were recruited in this study. The logistic regression model was used in this study. Results The prevalence of normal, Non-AG, AG/IM, IEN/DYS, and GC was 31.91, 44.21, 13.81, 8.73, and 1.34%, respectively. The prevalence of IEN/DYS was higher in people with FDR-GC and FDR-nGC (FDR-GC: odds ratio (OR) = 1.655; 95%CI, 1.153–2.376; FDR-nGC: OR = 1.984; 95%CI, 1.122–3.506) than those with FDR-nC. The younger the age at which FDRs were diagnosed with GC, the more likely the participants were to develop AG/IM (Ptrend = 0.019). The risk of precursors to GC was higher in participants whose FDR-GC was the mother than in those whose FDR-GC was the father or sibling (OR, non-AG: 1.312 vs. 1.007, 1.274; AG/IM: 1.430 vs. 1.296, 1.378; IEN/DYS: 1.988 vs. 1.573, 1.542). There was no statistically significant difference in non-AG (OR = 1.700; 95%CI, 0.940–3.074), AG/IM (OR = 1.291; 95%CI, 0.579–2.877), and IEN/DYS (OR = 1.265; 95%CI, 0.517–3.096) between participants with one or more FDR-GC. Conclusion People with FDR-GC and FDR-nGC are at a high risk of IEN/DYS. When an FDR was diagnosed at a younger age, the risk of AG/IM was higher. The risk of GC precursors was higher in people whose FDR-GC was the mother.

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The Demographic and Clinical Characteristics of Ulcerative Colitis in a Northeast Brazilian Population

BioMed Research International ◽

10.1155/2015/359130 ◽

2015 ◽

Vol 2015 ◽

pp. 1-8 ◽

Cited By ~ 8

Author(s):

Bruno César da Silva ◽

Andre Castro Lyra ◽

Carlos Maurício Cardeal Mendes ◽

Camila Paula Oliveira Ribeiro ◽

Sonyara Rauedys Oliveira Lisboa ◽

...

Keyword(s):

Weight Loss ◽

Family History ◽

Steroid Therapy ◽

Cross Sectional Study ◽

Immunosuppressive Drugs ◽

Age At Diagnosis ◽

Cross Sectional ◽

Younger Age ◽

History Of ◽

Rural Patients

Introduction. The purpose of this study was to describe the clinical and demographic characteristics of UC in Bahia, a Brazilian state, and to identify the variables associated with extensive colitis, steroid therapy, immunosuppression, and colectomy.Methods. In this cross-sectional study UC patients were interviewed, and additional information was collected from the medical records. Descriptive statistics and multivariate Poisson regression analysis were used.Results. This study included 267 individuals, the mean age of whom was 39.4 years at diagnosis. There was a predominance of females and left-side colitis. Extensive colitis was positively associated with male gender, diarrhea, weight loss, and a younger age at diagnosis. In contrast, active smoking and a family history of IBD were negatively associated with extensive colitis. Positive associations were observed between steroid therapy and diarrhea, weight loss, urban patients, extraintestinal manifestations (EIMs), and hospitalization. Younger age and weight loss at diagnosis, a family history of IBD, extensive colitis, EIMs, hospitalization, and steroid therapy were all positively associated with immunosuppression. In contrast, Caucasian individuals, smokers, patients with rectal bleeding, and rural patients areas were all observed to have a decreased likelihood of immunosuppression.Conclusions. Our results corroborate the association between higher prevalence of extensive colitis and younger age at diagnosis. An association between steroid therapy and clinical presentation at diagnosis was observed. The observation that white individuals and rural patients use less immunosuppressive drugs highlights the need to study the influence of environmental and genetic factors on the behavior of UC in this population.

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Subjective cognitive complaints at age 70: associations with amyloid and mental health

Journal of Neurology Neurosurgery & Psychiatry ◽

10.1136/jnnp-2020-325620 ◽

2021 ◽

pp. jnnp-2020-325620

Author(s):

Ivanna M. Pavisic ◽

Kirsty Lu ◽

Sarah E. Keuss ◽

Sarah-Naomi James ◽

Christopher A. Lane ◽

...

Keyword(s):

Family History ◽

Trait Anxiety ◽

Population Based ◽

Cross Sectional Study ◽

Subjective Cognitive Decline ◽

Cross Sectional ◽

Amyloid Pathology ◽

History Of ◽

Β Amyloid ◽

Anxiety Depression

ObjectiveTo investigate subjective cognitive decline (SCD) in relation to β-amyloid pathology and to test for associations with anxiety, depression, objective cognition and family history of dementia in the Insight 46 study.MethodsCognitively unimpaired ~70-year-old participants, all born in the same week in 1946 (n=460, 49% female, 18% amyloid-positive), underwent assessments including the SCD-Questionnaire (MyCog). MyCog scores were evaluated with respect to 18F-Florbetapir-PET amyloid status (positive/negative). Associations with anxiety, depression, objective cognition (measured by the Preclinical Alzheimer Cognitive Composite, PACC) and family history of dementia were also investigated. The informant’s perspective on SCD was evaluated in relation to MyCog score.ResultsAnxiety (mean (SD) trait anxiety score: 4.4 (3.9)) was associated with higher MyCog scores, especially in women. MyCog scores were higher in amyloid-positive compared with amyloid-negative individuals (adjusted means (95% CIs): 5.3 (4.4 to 6.1) vs 4.3 (3.9 to 4.7), p=0.044), after accounting for differences in anxiety. PACC (mean (SD) −0.05 (0.68)) and family history of dementia (prevalence: 23.9%) were not independently associated with MyCog scores. The informant’s perception of SCD was generally in accordance with that of the participant.ConclusionsThis cross-sectional study demonstrates that symptoms of SCD are associated with both β-amyloid pathology, and more consistently, trait anxiety in a population-based cohort of older adults, at an age when those who are destined to develop dementia are still likely to be some years away from symptoms. This highlights the necessity of considering anxiety symptoms when assessing Alzheimer’s disease pathology and SCD.

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Differential expression of micro RNA-29 family in non-diabetic adults of diabetic and non-diabetic parents

BMC Research Notes ◽

10.1186/s13104-021-05703-8 ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Uzair Abbas ◽

Bushra Imdad ◽

Sikander Adil Mughal ◽

Israr Ahmed Baloch ◽

Afshan Mehboob Khan ◽

...

Keyword(s):

Type 2 Diabetes ◽

Family History ◽

Positive Family History ◽

Cross Sectional Study ◽

Vital Role ◽

Micro Rna ◽

Cross Sectional ◽

Family History Of Diabetes ◽

History Of

Abstract Objective MicroRNAs are known to regulate 60% of genes at post translational level. MicroRNAs including Micro RNA-29 family play a vital role in cellular activities and have validate role in numerous metabolic disorders inclusive of diabetes mellitus and its complications. While micro RNA profile changes years before the occurrence of disease. This cross-sectional study was conducted in non-diabetic adults of diabetic and non-diabetic parents to explore the early changes in expression of micro RNA-29 family as it can be served as early biomarker of type 2 diabetes in non-diabetic adults. This study was conducted from January 2019 to January 2021. Micro RNA was extracted from plasma of 50 participants and expression was compared through qPCR. While data was analyzed through SPSS version 21.0. Results 29a and 29b had lower expression in participants with family history of DM compared to those having no family history of DM (P < 0.0001). While micro RNA 29c was found to be significantly higher in participants with positive family history of type 2 diabetes as compared to those without family history of diabetes (P = 0.001).

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A Cross-Sectional Study to Compare Differences on Clinical and Laboratory Findings in Children with Seropositive and Seronegative Lupus

10.21203/rs.3.rs-1113288/v1 ◽

2021 ◽

Author(s):

Shima Salehi ◽

Rozita Hosseini Shamsabadi ◽

Hassan Otukesh ◽

Reza Shiari ◽

Monir Sharafi

Keyword(s):

Autoimmune Disease ◽

Disease Diagnosis ◽

Cross Sectional Study ◽

Rapid Identification ◽

The Body ◽

Musculoskeletal Symptoms ◽

Laboratory Findings ◽

Cross Sectional ◽

Significant Difference ◽

History Of

Abstract Background: Lupus is an inflammatory and autoimmune disease that involves various tissues and organs of the body. Identification of diagnostic elements to rapid identification of seronegative lupus cases is very important in order to prevent morbidity and progression of disease. This study aimed to compare clinical and laboratory findings of seropositive cases with seronegative lupus patients. Methods: This cross-sectional analytic study was performed on 43 children (17 seronegative and 26 seropositive) with lupus who were admitted to Ali Asghar Hospital during 2007-2017. Seropositive patients had anti-nuclear antibody (ANA) titration >1/80, while seronegative patients had ANA titration <1/80 (at the time of disease diagnosis). Clinical and laboratory findings were compared between two groups.Results: Serositis in patients with ANA- was significantly higher than ANA+ (41.17% vs. 23.07%; p = 0.042). ANA- group had higher autoimmune disease history than ANA+ group (42.85% vs. 15.0%; p = 0.041). The family history of the disease in the ANA- group was greater than ANA+ group (50% vs. 23.52%). The percentage of hypertensive patients in ANA- group was higher than ANA+ group (52.94% vs. 26.92%; p = 0.037). Neurologic symptoms in ANA+ and ANA- groups were 38.46% and 17.64%, respectively (p = 0.043). The frequency of patients with thrombocytopenia in ANA+ group was significantly greater than ANA- group (32% vs. 12.5%; p=0.041). There was no significant difference in other clinical and laboratory findings between two groups. Conclusion: Seronegative lupus patients had higher percentage of musculoskeletal symptoms, autoimmune disease history, familial history of disease, and hypertension, while neurological and thrombocytopenia symptoms were higher in seropositive patients compared to seronegative cases. Therefore, evaluation of these factors can be helpful to diagnosis of seronegative patients.

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Impact of family history of metabolic traits on severity of non-alcoholic steatohepatitis related cirrhosis: A cross-sectional study

Liver International ◽

10.1111/liv.13396 ◽

2017 ◽

Vol 37 (9) ◽

pp. 1397-1404 ◽

Cited By ~ 9

Author(s):

Ajeet S. Bhadoria ◽

Chandan K. Kedarisetty ◽

Chhagan Bihari ◽

Guresh Kumar ◽

Ankur Jindal ◽

...

Keyword(s):

Family History ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Metabolic Traits ◽

Alcoholic Steatohepatitis ◽

History Of

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High Rate of Obesity-Associated Hypertension among Primary Schoolchildren in Sudan

International Journal of Hypertension ◽

10.4061/2011/629492 ◽

2011 ◽

Vol 2011 ◽

pp. 1-5 ◽

Cited By ~ 14

Author(s):

Zeena Salman ◽

Gregory D. Kirk ◽

Mark D. DeBoer

Keyword(s):

Family History ◽

Cross Sectional Study ◽

Normal Weight ◽

Overweight And Obesity ◽

Sub Saharan Africa ◽

High Rate ◽

Cross Sectional ◽

Primary Schoolchildren ◽

History Of ◽

Family History Of Hypertension

Cardiovascular disease (CVD) frequently has roots in childhood, including following childhood-onset hypertension. Incidence of CVD has increased in developing countries in East Africa during recent urbanization. Effects of these shifts on childhood hypertension are unclear. Our objectives were to (1) Determine the prevalence of hypertension among primary schoolchildren in Khartoum, Sudan; (2) Determine whether hypertension in this setting is associated with obesity. We performed a cross sectional study of 6-12y children from two schools randomly selected in Khartoum, Sudan. Height, weight, BMI, BP and family history of hypertension were assessed. Age-, height- and gender-specific BP curves were used to determine pre-hypertension (90–95%) and hypertension (>95%). Of 304 children, 45 (14.8%) were overweight; 32 (10.5%) were obese; 15 (4.9%) were pre-hypertensive and 15 (4.9%) were hypertensive. Obesity but not family history of hypertension was associated with current hypertension. In multiple logistic regression, adjusting for family history, children who were obese had a relative-risk of 14.7 (CI 2.45-88.2) for systolic hypertension compared to normal-weight children. We conclude that overweight and obesity are highly prevalent among primary schoolchildren in urban Sudan and are strongly associated with hypertension. That obesity-associated cardiovascular sequelae exist in the developing world at young ages may be a harbinger of future CVD in sub-Saharan Africa.

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TO STUDY THE ONSET AND PROGRESSION OF AIRWAY ABNORMALITY IN TERMS OF ALTERATION IN PFT IN ASYMPTOMATIC SMOKERS.

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v3i11.748 ◽

2019 ◽

Vol 3 (11) ◽

Author(s):

Dr. Hitesh Kumar Solanki ◽

Dr. Omnath P Yadav ◽

Dr. Anita J Gojiya

Keyword(s):

Lung Function ◽

Cross Sectional Study ◽

Cross Sectional ◽

Medical College ◽

Group I ◽

Significant Difference ◽

History Of ◽

Young Smokers ◽

The Mean ◽

Group Ii

The study was conducted in department of physiology, B J Medical College, Ahmedabad from Mar. 2012 to Feb. 2013. This was a cross-sectional study to evaluate the effect of smoking on lung function and serum lipids in asymptomatic smokers and comparable non smokers. The mean of the various spirometric parameters were calculated of the subjects for both the groups. The mean FVC in group I and group II was 2.60 ± 0.62 L and 4.10 ± 0.64L respectively. The mean FEV1 in group I was 1.91 ± 0.57L and 3.19 ± 0.77L in group II Group I had mean FEF25% - 75% and PEFR of 1.98 ± 0.67L/sec and 4.50 ± 1.57L/sec respectively. Group II had mean FEF25 – 75% of 4.22 ± 1.23L/sec and a mean PEFR of 7.22 ± 1.42L/sec. In young smokers and asymptomatic, still the spirometric values were significantly deranged as compared to controls. Even smokers with history of less pack years of smoking also had significant abnormalities of lung function. All he spirometric values in the two groups had statistically highly significant difference and were higher in non-smokers as compared to smokers. The spirometric values were reduced in smokers with history of smoking for as low as two pack years. Keywords: Progression, PFT, Asymptomatic & Smokers

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threatening a teacher

Journal of the Faculty of Medicine Baghdad ◽

10.32007/jfacmedbagdad.6311817 ◽

2021 ◽

Vol 63 (1) ◽

pp. 24-30

Author(s):

Tuka Younis Hassan

Keyword(s):

Well Being ◽

Cross Sectional Study ◽

School Type ◽

Cross Sectional ◽

Intermediate Schools ◽

Frequency Scale ◽

Significant Difference ◽

History Of ◽

Being There ◽

Behavior Frequency

Abstract Background: Threatening teachers increases teacher stress and impairs emotional well-being. There are many reasons for violence against teachers. There are communication errors and conceptual differences in applying the rules that emphasizes corporal punishment rather than persuasive punishment. Also, it is related to a parent complaint that expresses Parents' belief in the education their child received in school is getting weaker. In addition to the incompetence that teachers must implement, like personal, social and professional aspects that make students offend teachers. Threatening someone considered as physical aggression. Aggression is any behavior intended to harm another person that wishes to avoid such harm High rates of aggression were reported recently in Iraq, especially after wars. Some studies have shown that students, whose friends engage in negative activities such as dropping out of school and have lower academic performance, may engage in aggressive activities toward teachers and/or other students. Objectives: To estimate the prevalence of students’ aggressive act towards teachers. Methodology: A cross-sectional study was carried out in Al-Sadr city in Baghdad. A total of 720 adolescent secondary schools students from both genders were included in the study. They were selected by multistage random sampling. Their age was ranged from 13-21 years. Data was collected from 1st of February 2019 to 30 of April 2019 through a self-reported questionnaire (Aggression-Problem Behavior Frequency Scale). Results: The mean age of participants was 16.2±2.04 years. Of all participants, 84.3% were assessed to be aggressive. There was a significant difference between aggressive act (threatening a teacher) and sex, school type, grade, history of absence from school and employed mother,(P=0.038, 0.009, 0.0001,p= 0.02 and p=0.018, respectively). 10% of male threatening a teacher. Conclusion: A high prevalence of aggression among students was found. Threatening a teacher was dominant among male students, intermediate schools, 4th grade, students with history of absence from school, and not employed mother.

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Study on Associated Risk Factors of Hypertension at Sipaghat of Sindhupalchowk District, Nepal

Nepalese Journal of Statistics ◽

10.3126/njs.v1i0.18818 ◽

2017 ◽

Vol 1 ◽

pp. 73-82

Author(s):

Naresh Manandhar

Keyword(s):

Risk Factors ◽

Family History ◽

Alcohol Consumption ◽

Lifestyle Modification ◽

Percent Level ◽

Cross Sectional Study ◽

Cross Sectional ◽

History Of ◽

Family History Of Hypertension ◽

Associated Risk Factors

Background: Hypertension is a progressive cardiovascular syndrome arising from complex and interrelated etiologies. Males have slightly higher prevalence than female in most of countries of Southeast-Asian region.Objective: The objective of study is to find out prevalence and the risk factors of hypertension at Sipaghat, Sindhulchowk, Nepal.Materials and Methods: A cross-sectional study was conducted at Sipaghat of Sindhupalchowk district in May 2016 and 260 persons were selected randomly. Results: The prevalence of hypertension was higher in male (25.4%) than female (17.4%). Mean age of study population was 42.08 years with standard deviation, 15.95 years. Variables namely age group, smoking, alcohol consumption and family history of hypertension were found to be significant at 5 percent level of significance. Alcohol consumption and smokers have more than two times higher chance of getting hypertension compared to alcohol non-consumer and nonsmoker with 95% confidence intervals were 1.08-4.80 and 1.21-6.10, respectively. Persons with family history of hypertension have 3.8 times more chance of getting hypertension compared to no family history of hypertension with 1.89-7.61 of 95% confidence interval.Conclusion: Lifestyle modification reduces blood pressure which prevents or delays the incidence of hypertension. Hypertension can be controlled and prevented by modifying the lifestyle. People should be advised to avoid modifiable risk factors of hypertension like smoking, consumption of alcohol and physical inactivity through health education programs.Nepalese Journal of Statistics, 2017, Vol. 1, 73-82

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Evaluation of blood pressure in school children aged 12-16 years

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20172607 ◽

2017 ◽

Vol 4 (4) ◽

pp. 1218

Author(s):

Balakrishnan Nadesan ◽

Mani Madhavan Sachithananthamoorthi ◽

Sivaraman Thirumalaikumarasamy ◽

Ezhilarasu Ramalingam

Keyword(s):

Blood Pressure ◽

Family History ◽

Diastolic Blood Pressure ◽

School Children ◽

Diastolic Pressure ◽

Systolic Pressure ◽

Cross Sectional ◽

Significant Difference ◽

History Of ◽

Family History Of Hypertension

Background: Hypertension is considered as a major health issue in developed as well as developing countries and its possible origin during childhood prompts pediatricians to routinely include measurement of blood pressure (BP) as an integral part of pediatric physical examination. The objectives of the study were to evaluate the normal range of blood pressure in adolescent school going students of 12-16 years, prevalence of hypertension and relationship of BP with variables like age, body mass index (BMI), socioeconomic status and family history of hypertension.Methods: A cross sectional study was undertaken for a period of one year in adolescent school children in age groups between 12-16 years. Detailed clinical examination was done in 1060 adolescent school children and BP was recorded in right upper limb and correlation of BP with BMI, family history of hypertension and diabetes were studied.Results: Mean systolic and diastolic pressure showed linear relationship with age. There was a highly statistically significant difference between mean systolic and diastolic blood pressure between lower and middle socio-economic class. Prevalence of obesity in our study was 1.13%, overweight was 7.83%. Prevalence of hypertension in obese children was 33.33% and in overweight children 18.07%. Family history of hypertension and diabetes carry a significant correlation with elevated systolic and diastolic blood pressure in adolescents.Conclusions: This study revealed that socio economic factors play a significant role in determining the blood pressure of the individual. Children of middle class have significantly elevated mean systolic pressure and mean diastolic pressure than low socio-economic groups.

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