scholarly journals Hubungan antara Kadar 25-OH D3 dengan Derajat Fungsi Ginjal pada Pasien Lupus Sistemik Eritematosus

Sari Pediatri ◽  
2020 ◽  
Vol 21 (4) ◽  
pp. 213
Author(s):  
Aninditya Dwi Messaurina ◽  
Agung Triono ◽  
Retno Palupi Baroto ◽  
Cahya Dewi Satria ◽  
Sumadiono Sumadiono

Latar belakang. Defisiensi vitamin D banyak ditemukan pada anak lupus eritematosus sistemik (LSE) dibandingkan dengan anak normal. Berbagai penelitian membuktikan defisiensi vitamin D berkontribusi terhadap perkembangan chronic kidney disease. Belum ada penelitian hubungan vitamin D dengan derajat fungsi ginjal pada anak Lupus. Tujuan. Mengetahui hubungan antara 25-hidroksivitamin D dengan derajat fungsi ginjal pada anak Lupus.Metode. Menggunakan desain cross sectional dengan melibatkan 62 anak Lupus di bagian Ilmu Kesehatan Anak RSUP Dr. Sardjito yang telah mendapatkan protokol dari Januari 2014 sampai April 2018. Hubungan antara kadar serum 25-hidroksivitamin D dan derajat fungsi ginjal dianalisis menggunakan Independent T-test, sedangkan jenis kelamin, kalsium, steroid, dan aktivitas penyakit dengan uji chi-square. Defisiensi vitamin D didefinisikan konsentrasi 25-hidroksivitamin D<20 ng/ml, sedangkan gangguan ginjal didefinisikan GFR<90/ml/mnt/1.73m2.Hasil. Sebagian besar subyek berjenis kelamin perempuan, 93,5% vs 6,5% dengan rerata usia 14,6±3,1 tahun, dan rerata skor Mex-SLEDAI 7,6±5,6. Secara keseluruhan 66% subyek penelitian mengalami defisiensi vitamin D. Analisis dengan Independent T-tes menunjukkan rerata vitamin D yang mengalami gangguan ginjal 14,14±4,9 lebih rendah dibandingkan normal dengan rerata 19,43±10,3 dengan perbedaan yang bermakna p=0,004. Jenis kelamin, kalsium, steroid, dan aktivitas penyakit tidak berpengaruh signifikan terhadap derajat fungsi ginjal, p>0,05.Kesimpulan. Terdapat hubungan signifikan 25-hidroksivitamin D dengan derajat fungsi ginjal pada anak lupus.

2018 ◽  
Vol 2 (1) ◽  
pp. 9
Author(s):  
Kadek G Pebriantari ◽  
IGA Puja Astuti Dewi

ABSTRAKLatar Belakang. Hemodialisis aman dan bermanfaat untuk pasien, namun bukan berarti tanpa efek samping. Berbagai komplikasi dapat terjadi pada saat pasien menjalani hemodialisis. Komplikasi ini dapat mengakibatkan timbulnya masalah baru yang lebih kompleks, yaitu dapat mempengaruhi kualitas hidup bahkan menimbulkan kematianTujuan. Untuk mengetahui hubungan komplikasi intra hemodialisis dengan kualitas hidup  pada pasien Chronic Kidney Disease (CKD) Stage V yang menjalani hemodialisis.Metode. Jenis penelitian adalah analitik korelasional dengan pendekatan cross-sectional. Sampel pada penelitian ini berjumlah 166 responden diambil dengan teknik non probability sampling yaitu total sampling. Pengumpulan data menggunakan kuesioner dan lembar observasi,dianalisa dengan uji non parametric (Chi Square).Hasil. Rata – rata jumlah komplikasi intra hemodialisis adalah kurang dari dua komplikasi (sedikit komplikasi). Hipertensi intra hemodialisis adalah komplikasi terbanyak yang ditemukan (52,3%). Kejang dan penurunan kesadaran merupakan komplikasi yang tidak pernah dialami oleh responden selama penelitian (0%).Kualitas hidup pasien CKD stage V yang menjalani HD di BRSU Tabanan masuk dalam kategori kualitas baik. Hasil uji statistik diperoleh nilai p < 0.001 bahwa ada hubungan yang signifikan antara komplikasi intra hemodialisis dengan  kualitas hidup pada pasien yang menjalani HD. Dari hasil analisis diperoleh pula nilai OR = 0,005, artinya responden yang memiliki banyak komplikasi mempunyai peluang 0,005 kali memiliki kualitas hidup buruk dibanding responden yang memiliki sedikit komplikasi.Kesimpulan. Ada hubungan yang signifikan antara komplikasi intra hemodialisis dengan  kualitas hidup pada pasien yang menjalani hemodialisis.KataKunci: Komplikasi Intra Hemodialisis, Kualitas Hidup, Hemodialisis ABSTRACTBackground: Hemodialysis is safe and beneficial to the patient. However, there are various complications may occur when the patients undergo hemodialysis. These complications can lead to the emergence of new problems which are more complex and affect to the quality of life and even cause death.Aim: To determine the relationship of intra hemodialysis complications with quality of life in patients with Chronic Stage Kidney Disease (CKD) Stage V who undergo hemodialysis.Method:This study employed correlational analytic design with cross-sectional approach. To conduct this study, there were 166 respondents recruited as the sample by using probability sampling with total sampling technique. The data were collected by using questionnaire and observation sheet. Further, the data were analyzed by non-parametric test (Chi Square).Finding: The findings indicated that the average number of intra hemodialysis complications is less than two complications (few complications). There were found that 52.3% patients who had complication of hypertension intra hemodialysis. On the other hand, there was 0%of the respondents experienced seizures and decreased awareness complications during the study. The quality of life of CKD stage V patients underwenthemodialysis at BRSU Tabanan is categorized as good quality. The statistical test obtained p <0.001, it meant that there was a significant relationship between intra hemodialysis complications with quality of life in patients underwenthemodialysis. It also found that the analysis results of OR = 0.005, it meant that respondents who had many complications have a chance of 0.005 times experienced poor quality of life rather than the patients who had few complications.Conclusion: There is a significant relationship between intra hemodialysis complications and quality of life in patients undergo hemodialysis. Keywords: Complications of Intra Hemodialysis, Quality of Life, Hemodialysis


Sari Pediatri ◽  
2016 ◽  
Vol 17 (3) ◽  
pp. 200
Author(s):  
Lola Lusita ◽  
Finny Fitri Yani ◽  
Netti Suharti
Keyword(s):  
T Test ◽  

Latar belakang. Vitamin D dan cathelicidin berperan penting dalam sistem imun alamiah terhadap kuman tuberkulosis. VitaminD memediasi sintesis cathelicidin, melalui ekspresi vitamin D nuclear reseptor (VDR) sehingga cathelicidin dapat membunuhkuman mycobacterium tuberculosis.Tujuan. Melihat hubungan kadar vitamin D dan cathelicidin dengan kejadian infeksi tuberkulosis pada anak yang kontak denganpenderita tuberkulosis dewasa BTA positif.Metode. Penelitian cross sectional dengan sampel dibedakan antara terinfeksi tuberkulosis dengan yang tidak terinfeksi tuberkulosis.Sampel dilakukan pengukuran kadar vitamin D, yaitu kadar 25(OH)D dan cathelicidin plasma. Analisis statistik denganmenggunakan chi square, T-test, Mann-Whitney U, dan uji korelasi Spearman’s.Hasil. Anak terinfeksi tuberkulosis dengan gizi kurang 58%. Sumber kontak dengan BTA positif tiga anak yang terinfeksituberkulosis 54%. Tidak terdapat defisiensi vitamin D. Rerata kadar vitamin D anak terinfeksi dan tidak terinfeksi tuberkulosisberturut-turut 24,93±7,42 dan 24,66±6,23 ng/mL (p=0,868). Kadar cathelicidin rendah terdapat pada 62,5% anak yang terinfeksituberkulosis. Pada anak yang terinfeksi dan tidak terinfeksi tuberkulosis berturut-turut 149,76±160,76 dan 190,74±184,95 ng/mL (p=0,139). Tidak terdapat hubungan kadar vitamin D dan cathelicidin plasma pada anak dengan kontak BTA positif (p=0,135dan r=-0,183)Kesimpulan. Kadar cathelicidin pada anak yang tidak terinfeksi tuberkulosis cenderung lebih tinggi dibandingkan anak yang tidakterinfeksi, walaupun secara statistik tidak terdapat perbedaan yang bermakna.


e-CliniC ◽  
2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Ainivi F. Tangian ◽  
L. F. J. Kandou ◽  
Herdy Munayang

Abstract: Anxiety is defined as a prolonged response to unexpected threats, which include physiological responses, affective, and cognitive changes. Anxiety will appear in families where one member of the family is ill and requires hospitalization. Severe disease especially life threatening can cause anxiety, rejection and anger. The purpose of this research is to know the relationship between the duration of having hemodialysis and the anxiety level of partners ofpatients who suffer from chronic kidney disease at the Prof. dr. R.D. Kandou Manado Hospital. This research has descriptive analytic type with cross-sectional approach. Samples in this study were 34 spouses. This study used Non Probability Sampling with Purposive Sampling. The results showed that anxiety did not occur at 19 respondents (55%). The result of Chi-square correlation test was a value of Sig. 0.064 (P > 0.05) which meant there was no siginificant relationship. Therefore, H0 was approved and H1 was rejected. Conclusion: There was no relationship between the duration of having hemodialysis and the anxiety level of partners of the patients who suffered from chronic kidney disease at the Prof. dr. R.D. Kandou Manado Hospital.Keywords: anxiety, partners of hemodialysis patients, chronic kidney disease, hemodialysisAbstrak: Kecemasan didefinisikan sebagai respon yang berkepanjangan terhadap ancaman yang tak terduga, responyang meliputi fisiologis, afektif, dan perubahan kognitif. Kecemasan akan muncul pada keluarga yang salah satu anggota keluarganya sedang sakit dan memerlukan perawatan di rumah sakit. Penyakit yang berat terutama yang mengancam kehidupan, dapat menimbulkan kecemasan, penolakan, dan marah.Penelitian ini bertujuan untuk mengetahui hubungan lamanya menjalani hemodialisis dengan tingkat kecemasan pada pasangan hidup pasien yang menderita penyakit ginjal kronik di RSUP Prof dr. R. D. Kandou Manado. Penelitian ini bersifat deskriptif analitik dengan pendekatan potong lintang.Jumlah sampel dalam penelitian ini sebanyak 34 pasangan hidup.Sampling yang digunakan adalah Non Probability Sampling dengan metode purposive sampling. Hasil penelitian sebagian besar yaitu 19 responden (55,9%) tidak mengalami kecemasan. Hasil uji korelasi Chi-square adalah nilai Sig. sebesar 0,064. Penggunaan signifikansi α = 5% (0,05), maka nilai p = 0,064 > 0,05 yang berarti tidak ada hubungan yang bermakna. Dapat disimpulkan H0 diterima dan H1 ditolak yang berarti tidak ada hubungan lamanya menjalani hemodialisis dengan tingkat kecemasan pada pasangan hidup pasien yang menderita penyakit ginjal kronik di RSUP Prof dr. R. D. Kandou Manado.Kata kunci: kecemasan, pasangan hidup, penyakit ginjal kronik, hemodialisis


2017 ◽  
Vol 1 (01) ◽  
pp. 23
Author(s):  
Umi Faza ◽  
Dyah Umiyarni Purnamasari ◽  
Saryono Yono

Abstract  The aim of this study was to determine factors associated with diminished appetite in CKD patients undergoing hemodialysis therapy. This study is an observational analytic research with cross sectional design. Population of this study was CKD outpatients undergoing hemodialysis therapy in July- August 2016 in Prof. Dr. Margono Soekarjo Hospitals. Amount of 58 subjects taken by consecutive sampling. Appetite, sex, age, length of hemodialysis, frequency of nausea/vomiting, and depression were measured using questionnaire. Subjects who diminished appetite were 58,6%. More than half subjects were male (56,9%). Amount of 84,5% subjects were adults (19-59 years), 63,8% undergoing hemodialysis >1year, 39,7% experienced nausea/ vomiting and 53,4% were depression. Based on Chi-Square Test/ Fisher Exact Test, diminished appetite significantly associated with length of hemodialysis (p=0,041), frequency of nausea/vomiting (p=0,014), and depression (p=0,002). Dominant factors affected diminished appetite were depression and length of hemodialysis. Diminished appetite in CKD patients undergoing hemodialysis therapy associated with length of hemodialysis, frequency of nausea/vomit, and depression. Keyword : appetite, chronic kidney disease, hemodialysi  Abstrak Penelitian ini bertujuan untuk mengetahui faktor- faktor yang berhubungan dengan penurunan nafsu makan pada pasien Gagal Ginjal Kronik (GGK) yang menjalani terapi hemodialisis. Penelitian ini merupakan penelitian analitik observasional dengan pendekatan cross sectional. Populasi dari penelitian ini adalah pasien GGK rawat jalan yang menjalani terapi hemodialisis pada bulan Juli- Agustus 2016 di RSUD Prof. Dr. Margono Soekarjo Purwokerto. Sebanyak 58 subjek diambil dengan cara consecutive sampling. Nafsu makan, jenis kelamin, usia, lama hemodialisis, frekuensi mual/muntah, dan depresi diukur menggunakan kuesioner. Responden yang mengalami penurunan nafsu makan sebanyak 58,6%. Lebih dari separuh responden (56,9%) berjenis kelamin laki- laki dan 84,5% responden berusia dewasa (19-59 tahun). Sebanyak 63,8% responden menjalani hemodialisis >1tahun. Responden yang mengalami mual/muntah berat sebanyak 39,7% dan 53,4% mengalami depresi. Berdasarkan analisis bivariat menggunakan Uji Chi- Square/ Fisher Exact diperoleh hasil bahwa nafsu makan berhubungan secara signifikan dengan lama hemodialisis (p=0,041), frekuensi mual/ muntah (p=0,014), dan depresi (p=0,002). Faktor dominan yang mempengaruhi penurunan nafsu makan adalah depresi dan lama hemodialisis. Penurunan nafsu makan pada pasien GGK yang menjalani terapi hemodialisis berhubungan dengan lama hemodialisis, frekuensi mual/muntah, dan depresi. Kata kunci : gagal ginjal, hemodialisa, nafsu makan  


2021 ◽  
Vol 3 (2) ◽  
pp. 272-284
Author(s):  
Fiora Ladesvita ◽  
Lilis Mulyani

Chronic Kidney Disease (CKD) didefinisikan sebagai kerusakan ginjal dengan penurunan Glomerular Filtration Rate (GFR) kurang dari 60 ml/menit/1,73 m2 yang terjadi selama lebih dari tiga bulan. Penurunan fungsi ginjal dapat menyebabkan produksi hormon eritropoietin yang berfungsi untuk memproduksi sel darah berkurang sehingga dapat menyebabkan penurunan kadar hemoglobin. Selain itu, kerusakan ginjal dapat menyebabkan penurunan aktivasi vitamin D yang dapat menyebabkan penyerapan kalsium di usus berkurang. Tujuan dari penelitian ini adalah untuk mengetahui hubungan GFR dengan kadar hemoglobin dan kadar kalsium pada pasien CKD yang menjalani hemodialisis. Penelitian ini menggunakan desain cross sectional dengan pendekatan retrospektif menggunakan rekam medis pasien CKD yang menjalani hemodialisis dari bulan Januari sampai Desember 2020. Penelitian ini dilakukan pada 95 sampel dengan metode consecutive sampling. Uji korelasi pearson menunjukkan nilai p 0,000 dan nilai r 0,974 untuk korelasi antara GFR dan kadar hemoglobin. Juga pengujian menunjukkan nilai p 0,000 dan nilai r 0,950 untuk korelasi antara GFR dan kadar kalsium. Kesimpulannya, ada hubungan yang signifikan antara GFR dengan kadar hemoglobin dan kadar kalsium.   Kata kunci: Penyakit Ginjal Kronis, Laju Filtrasi Glomerulus, Hemoglobin, Kalsium


2019 ◽  
Vol 15 (2) ◽  
pp. 77
Author(s):  
Isnur Hatta ◽  
Khairunnisa Amalia Pratami ◽  
Maharani Laillyza Apriasari

Abstract: Chronic kidney disease (CKD) is a world health problem where the incidence continues to increase, has a poor prognosis and high-level financing. Clinical manifestations of the oral cavity can occur in CKD patients with hemodialysis therapy due to a decrease in the immune system. To analyze the descriptively the clinical manifestations of oral cavity in CKD patients with hemodialysis therapy at RSUD Ulin Banjarmasin South Kalimantan, period January-March 2019. This is a descriptive analysis with a cross sectional study design, based on history and clinical examination of the oral cavity. Data was entered and analyzed using chi square test. Sampling by purposive sampling. there is a relationship between uremic odor and duration of hemodialysis (p = 0.017). There was a relationship between xerostomia and gender (p = 0.035) and there was a relationship between xerostomia and the duration of hemodialysis (p = 0.007). There is a relationship between gingival swelling and age (p = 0.010) and there is a relationship between gingival swelling and diabetes mellitus (p = 0,000). Manifestations found in the oral cavity of CKD patients with hemodialysis therapy are uremic odor, mouthache, xerostomia, mucosal lesions, candidiasis, and gingival swelling. There is a relationship between sex with xerostomia, the relationship between age with gingival swelling, the relationship between the duration of hemodialysis with uremic odor and xerostomia, the association between DM with gingival swelling. Keywords: Chronic Kidney Disease, Clinical Manifestations, Hemodialysis, Oral Cavity


Author(s):  
Andressa Keiko Matsumoto ◽  
Michael Maes ◽  
Ana Paula Michelin ◽  
Abel Esteves Soares ◽  
Laura de Oliveira Semeão ◽  
...  

Abstract Introduction: The progressive decline in 25-hydroxyvitamin D [25(OH)D] in chronic kidney disease (CKD) limits the kidney ability of synthesizing the vitamin. Vitamin D deficiency as defined by KDIGO (25(OH)D <20 ng/mL) is prevalent in CKD patients and associated to oxidative stress (OS). We studied a possible association between vitamin D deficiency and OS in pre-dialysis patients. Methods: A cross-sectional study with 206 CKD patients was carried out. Laboratory tests for 25(OH)D, 1,25(OH)2D, inflammatory markers, and OS were added to routine tests including creatinine, albumin, calcium, phosphorus, alkaline phosphatase, iPTH, glucose, hemoglobin, uric acid, total cholesterol, LDL, HDL, and triglycerides. Results: Vitamin D deficiency was present in 55 CKD patients and normal vitamin D levels were seen in 149 patients. There was a significant association between vitamin D and estimated glomerular filtration rate (eGRF). Homocysteine levels were best predicted by eGRF, sex, and age; high sensitivity C-reactive protein (hsCRP) by staging and BMI; nitric oxide metabolites (NOx) were increased in late disease; leptin was influenced by BMI and higher in women than man; and adiponectin levels were higher in women. Conclusions: OS biomarkers were not correlated with vitamin D deficiency but increased NOx were seen in stages 4-5 CKD patients. Even though a relatively large number of CKD patients was included and a broad number of OS and inflammatory biomarkers were used in this studied we failed to find an association between vitamin D levels and eGRF. More studies are needed to evaluate the influence of vitamin D status in OS in pre-dialysis CKD patients.


2020 ◽  
Vol 8 (2) ◽  
pp. 107-116
Author(s):  
Peri Zuliani ◽  
Dita Amita

Chronic Kidney Disease (CKD) is a progressive and irreversible disorder of renal function, in which the body's ability to fail to maintain metabolism and balance of fluids and electrolytes, causing uremia. The purpose of this study in general was to determine the relationship between hemoglobin levels and quality of life in chronic kidney disease patients undergoing hemodialysis at dr. M. Yunus Bengkulu. This type of research is descriptive analytic with cross sectional approach. The study sample was 64 patients with CKD who underwent hemodialysis at the hemodialysis installation with accidental sampling technique. The results showed that most patients with chronic kidney disease who underwent haemodialysis (71.9%) had severe anemia and most (56.3%) had a poor quality of life. Chi square test results obtained ρ value 0,000 (α = 0.05). Conclusion, There is a statistically significant correlation between anemia and quality of life in CKD patients undergoing hemodialysis in the RDUD Dr. Hemodialysis room. M. Yunus. Suggested to Dr. Hospital M. Yunus Bengkulu to control the incidence and symptoms of anemia experienced by CKD patients. Keywords: Anemia, Hemodialysis, quality of life, CKD


2011 ◽  
Vol 27 (3) ◽  
pp. 1107-1113 ◽  
Author(s):  
J. Schaible ◽  
M. Wigger ◽  
H. Staude ◽  
E. Drueckler ◽  
G. Kundt ◽  
...  

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