ANGPTL4 as Biomarker in Early Detection of Cardiovascular Complications in Diabetic Patients

Diabetes is a prevalent condition affecting millions of patients globally. Some diabetic patients suffer from a deadly condition called Hypoglycemia (sudden drop in blood glucose levels). Continuous Glucose Monitors (CGMs) have been the most pervasive tool used to track blood glucose levels but these tools are invasive and costly. While early detection of hypoglycemia has been studied, current approaches do not leverage tremors; which are a primary symptom of hypoglycemia. A scoping review was conducted to understand the relationship between tremors and hypoglycemia, and to document any efforts that utilized tremor signatures non-invasively to detect hypoglycemic events. Findings suggest that hypoglycemic tremors are a medium frequency tremor, more resistant to hypoglycemic impairment than other symptoms, and have not been fully explored yet. This paper also documents the work in progress to utilize a novel wearable device that predicts the onsets of hypoglycemia using hand tremor sensing.

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The result of treadmill test in asymptomatic type 2 diabetes mellitus

International Journal of Scientific Reports ◽

10.18203/issn.2454-2156.intjscirep20172508 ◽

2017 ◽

Vol 3 (6) ◽

pp. 166 ◽

Cited By ~ 2

Author(s):

Anil Shrinivasrao Joshi ◽

Chandrakant Gunaji Lahane ◽

Akshay Arvind Kashid

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Early Detection ◽

Diabetic Patients ◽

Cross Sectional ◽

Duration Of Diabetes ◽

Asymptomatic Patients ◽

Cardiovascular Morbidity And Mortality

Background: To study the prevalence of silent myocardial ischaemia in asymptomatic patients with type 2 DM.Methods: The present study was conducted in the Govt. Medical College and Hospital Aurangabad. During December 2012 to November 2014 with 50 patients. It was two year cross sectional study with the patients of asymptomatic type 2 diabetes mellitus without clinical and electrocardiographic evidence of coronary artery disease. Results: 12 (24%) out of 50 subjects had positive TMT. It correlated with years of duration of diabetes (9 positive TMT cases with duration of diabetes more than 10 years). 5 (25%) out of 20 had serum cholesterol levels >240, Number of positive TMT were higher in patients with LDL >160 [5 (25%) out of 20].Conclusions: Diabetic patients are at very high risk for cardiovascular morbidity and mortality. Early detection of IHD is very important so that pharmacological therapy, which may improve outcome, can be established. Tread mill exercise TMT being a non-invasive test with high safety, has an important role in early detection of IHD. It is recommended that TMT should be a part of routine management in asymptomatic patients with type II DM.

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Oxidative stress and diabetic cardiovascular disorders: roles of mitochondria and NADPH oxidaseThis review is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease.

Canadian Journal of Physiology and Pharmacology ◽

10.1139/y10-018 ◽

2010 ◽

Vol 88 (3) ◽

pp. 241-248 ◽

Cited By ~ 83

Author(s):

Garry X. Shen

Keyword(s):

Oxidative Stress ◽

Nitric Oxide ◽

Endothelial Cells ◽

Cardiovascular Diseases ◽

Mitochondrial Dysfunction ◽

Cardiovascular Complications ◽

Hypoglycemic Agents ◽

Diabetic Patients ◽

Plasminogen Activator Inhibitor 1 ◽

In Cells

Cardiovascular diseases are the predominant cause of death in patients with diabetes mellitus. Underlying mechanism for the susceptibility of diabetic patients to cardiovascular diseases remains unclear. Elevated oxidative stress was detected in diabetic patients and in animal models of diabetes. Hyperglycemia, oxidatively modified atherogenic lipoproteins, and advanced glycation end products are linked to oxidative stress in diabetes. Mitochondria are one of major sources of reactive oxygen species (ROS) in cells. Mitochondrial dysfunction increases electron leak and the generation of ROS from the mitochondrial respiratory chain (MRC). High levels of glucose and lipids impair the activities of MRC complex enzymes. NADPH oxidase (NOX) generates superoxide from NADPH in cells. Increased NOX activity was detected in diabetic patients. Hyperglycemia and hyperlipidemia increased the expression of NOX in vascular endothelial cells. Accumulated lines of evidence indicate that oxidative stress induced by excessive ROS production is linked to many processes associated with diabetic cardiovascular complications. Overproduction of ROS resulting from mitochondrial dysfunction or NOX activation is associated with uncoupling of endothelial nitric oxide synthase, which leads to reduced production of nitric oxide and endothelial-dependent vasodilation. Gene silence or inhibitor of NOX reduced oxidized or glycated LDL-induced expression of plasminogen activator inhibitor-1 in endothelial cells. Statins, hypoglycemic agents, and exercise may reduce oxidative stress in diabetic patients through the reduction of NOX activity or the improvement of mitochondrial function, which may prevent or postpone the development of cardiovascular complications.

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DYSLIPIDEMIA – TYPE2 DIABETES AND NON DIABETES POPULATION IN AND AROUND ERODE DISTRICT, TAMILNADU

10.36106/ijar/4900437 ◽

2021 ◽

pp. 8-9

Author(s):

Murugesan Thinakaran ◽

Thangadurai Chitra

Keyword(s):

Diabetes Mellitus ◽

Cardiovascular Complications ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Lipid Status ◽

Type2 Diabetes ◽

Patients With Diabetes ◽

Tertiary Hospitals ◽

Low Hdl

Background and objects: Patients with diabetes mellitus are at high risk of cardiovascular events because of abnormal lipid status. Dyslipidemia is common in diabetes mellitus and is associated with cardiovascular complications. Early diagnosis and treatment is the main cornerstone in the prevention of its multiple complications. The aim of the study was to determine the prevalence of abnormal lipid prole levels. Materials and Method: The study population was made up of Eighty-ve (85) already diagnosed type 2 diabetic patients and Ninety-two (92) with an age range of 28 to 70 years, who come from routine health, follow up at various tertiary hospitals in Erode. The samples were analyzed using the chemical analyzer COBAS INTEGRA 400. Results and Conclusion: Dyslipidemia was found in 63.52% in type2 diabetes patients and 43.47% in non-diabetic patients. High TG, high LDL-C, high TC and low HDL-C exhibited an increasing trend in the proportion of patients with dyslipidemia. The following risk factors namely female sex, age above 50- years, BMI (overweight and obese), poor glycemic control, central obesity and physical inactivity were associated with diabetic dyslipidemia. This study presents some interesting and novel ndings which may be very important in the care and management of patients with type-2 diabetes.

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The screening episode: visual acuity, mydriasis, and digital photography

Diabetic Retinopathy: Screening to Treatment (Oxford Diabetes Library) ◽

10.1093/med/9780198834458.003.0010 ◽

2020 ◽

pp. 89-100

Author(s):

David K. Roy ◽

Prashant Amrelia

Keyword(s):

Visual Acuity ◽

Diabetic Retinopathy ◽

Chronic Disease ◽

Image Quality ◽

Early Detection ◽

Subsequent Treatment ◽

Diabetic Patients ◽

Eye Screening ◽

Diabetic Eye Screening ◽

Acceptable Image Quality

Early eye screening detection and treatment is fundamental in managing significant complications of chronic disease, both for improving diabetic retinopathy (DR) clinical outcomes and improving the economic burdens. Early detection and subsequent treatment can substantially reduce the risk of blindness from DR. This chapter will review the screening episode, measuring visual acuity, drop instillation, contraindications, and correct camera operation. It will review problems associated with incorrect camera operation and the NHS Diabetic Eye Screening Programme (NHSDESP) standards of acceptable image quality. This will guide the screener in obtaining clear, well-centred, gradable digital images of the retina in diabetic patients with vision better than no perception of light in both eyes, as well as providing a greater understanding of issues associated with screening.

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Cardiovascular complications of novel multiple myeloma treatments

ESC CardioMed ◽

10.1093/med/9780198784906.003.0293 ◽

2018 ◽

pp. 1176-1178

Author(s):

Daniel J. Lenihan

Keyword(s):

Heart Failure ◽

Multiple Myeloma ◽

Heart Disease ◽

Early Detection ◽

Antithrombotic Therapy ◽

Cardiovascular Events ◽

Cardiovascular Complications ◽

Novel Therapies ◽

Cardiac Events ◽

Increased Risk

The treatment of multiple myeloma has dramatically changed in the last decade. Novel therapies have had an important impact on the overall outcome for patients but are associated with important cardiovascular events. There is certainly concern about the development of heart failure but also treatment-induced hypertension and a known increased risk of thrombotic events, including ischaemic heart disease. The management of these cardiac events includes prevention, early detection, and optimal treatment with antithrombotic therapy as well as medical therapy for heart failure.

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Acid–Base Disturbances

The Brigham Intensive Review of Internal Medicine ◽

10.1093/med/9780199358274.003.0059 ◽

2014 ◽

pp. 594-602

Author(s):

Julian L. Seifter

Keyword(s):

United States ◽

Cardiovascular Disease ◽

Peritoneal Dialysis ◽

Renal Transplantation ◽

End Stage Renal Disease ◽

The United States ◽

Cardiovascular Complications ◽

Diabetic Patients ◽

Stage Renal Disease ◽

End Stage

According to projections from the United States Renal Data Service (USRDS), 〉600,000 individuals in the United States will have end-stage renal disease (ESRD) by 2010. The leading cause of ESRD in the United State is diabetes, followed by hypertension. As the care of diabetic patients has improved, particularly in the area of cardiovascular disease, they are living through their cardiovascular complications long enough to develop ESRD. As a consequence, since the inception of the Medicare ESRD program. the dialysis population has gradually become older with increasing numbers of comorbid conditions. Renal replacement therapy in the form of hemodialysis or peritoneal dialysis may serve as a bridge to the best form of renal replacement, renal transplantation. The demand for suitable kidneys for transplantation far exceeds the supply, leaving many patients on dialysis for extended periods of time.

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Utility of Tissue Inhibitor Metalloproteinase-1 and Osteopontin as Prospective Biomarkers of Early Cardiovascular Complications in Type 2 Diabetes

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2018.081 ◽

2018 ◽

Vol 6 (2) ◽

pp. 314-319 ◽

Cited By ~ 1

Author(s):

Doaa Samir Salah El-Din ◽

Ahmed Ibrahim Amin ◽

Ahmed Osman Egiza

Keyword(s):

Type 2 Diabetes ◽

Cardiovascular Complications ◽

Enzyme Linked Immunosorbent Assay ◽

Control Group ◽

Diabetic Patients ◽

Tissue Inhibitor ◽

Type 2 Diabetic Patients ◽

Healthy Control ◽

Clinical Measurements

AIM: This work investigated associations between tissue inhibitor metalloproteinase-1 and diabetic cardiovascular diseases in type 2 diabetic patients; also it investigated the role of osteopontin in the diagnosis of type 2 cardiovascular diabetes complications.SUBJECTS AND METHODS: These were examined on eighty subjects, divided into three groups as follows: twenty volunteer healthy control subjects, thirty type 2 diabetes mellitus (DM) patients, and thirty cardiovascular, diabetic patients. Full clinical measurements were carried out, and the expression level of tissue inhibitor metalloproteinase-1 in blood samples was analysed by real-time PCR, using gene-specific primer pairs. Also osteopontin concentrations had been measured by the enzyme-linked immunosorbent assay. Data were tested statistically by parametric tests.RESULTS: The concentrations of osteopontin and the expression levels of tissue inhibitor metalloproteinase-1 were significantly increased in diabetic and cardiovascular diabetic groups compared to control group also they were significantly increased in the cardiovascular diabetic group compared to the diabetic group.CONCLUSION: Tissue inhibitor metalloproteinase-1 and osteopontin concentrations were significantly increased in diabetic patients with cardiovascular complications than other groups.

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