scholarly journals MATERNAL NUTRITION AND THE PROBLEM OF INTRAUTERINE DISEASE PROGRAMMING IN CHILDREN

2018 ◽  
Vol 73 (3) ◽  
pp. 190-194
Author(s):  
O. P. Kovtun ◽  
P. B. Tsyvian
Keyword(s):  
Maternal Nutrition ◽  
Metabolic Diseases ◽  
Maternal Diet ◽  
Experimental Studies ◽  
Fetal Exposure ◽  
Macronutrient Composition ◽  
Maternal Environment ◽  
Angiotensin System ◽  
Maternal Undernutrition

Environmental conditions during perinatal development such as maternal undernutrition or overnutrition can program changes in the integration among physiological systems leading to cardio-metabolic diseases. This phenomenon can be understood in the context of the phenotypic plasticity and refers to the adjustment of a phenotype in response to environmental input without genetic change. Experimental studies indicate that fetal exposure to an adverse maternal environment may alter the morphology and physiology that contribute to the development of cardio-metabolic diseases. The significance and role of genetic polymorphism, markers of chronic inflammation, oxidative stress, endothelial dysfunction, leptin synthesis disruption, rennin-angiotensin system in intrauterine cardio-metabolic disease programming are discussed. The study demonstrated that both maternal protein restriction and overnutrition alter the central and peripheral control of arterial pressure and metabolism. Breastfeeding may have beneficial effect on obesity risk later in life in genetically predisposed groups. Understanding the mechanisms which affect health outcomes in the offspring influenced by the macronutrient composition of the maternal diet during pregnancy or lactation may lead to new maternal nutrition recommendations, disease prevention strategies, and therapies that reduce the increasing incidence of cardio-metabolic diseases in children and adults.

scholarly journals The influence of maternal protein nutrition on offspring development and metabolism: the role of glucocorticoids

2011 ◽  
Vol 71 (1) ◽  
pp. 198-203 ◽  
Author(s):  
K. Almond ◽  
P. Bikker ◽  
M. Lomax ◽  
M. E. Symonds ◽  
A. Mostyn
Keyword(s):  
Maternal Diet ◽  
Protein Supplementation ◽  
Maternal Environment ◽  
Maternal Undernutrition ◽  
Low Protein ◽  
Increased Risk ◽  
Neonatal Body Composition ◽  
Tissue Sensitivity ◽  
Protein Diets

The consequences of sub-optimal nutrition through alterations in the macronutrient content of the maternal diet will not simply be reflected in altered neonatal body composition and increased mortality, but are likely to continue into adulthood and confer greater risk of metabolic disease. One mechanism linking manipulations of the maternal environment to an increased risk of later disease is enhanced fetal exposure to glucocorticoids (GC). Tissue sensitivity to cortisol is regulated, in part, by the GC receptor and 11β-hydroxysteroid dehydrogenase (11β-HSD) types 1 and 2. Several studies have shown the effects of maternal undernutrition, particularly low-protein diets, on the programming of GC action in the offspring; however, dietary excess is far more characteristic of the diets consumed by contemporary pregnant women. This study investigated the programming effects of moderate protein supplementation in pigs throughout pregnancy. We have demonstrated an up-regulation of genes involved in GC sensitivity, such as GC receptor and 11β-HSD, in the liver, but have yet to detect any other significant changes in these piglets, with no differences observed in body weight or composition. This increase in GC sensitivity was similar to the programming effects observed following maternal protein restriction or global undernutrition during pregnancy.

Effects of selection for production and maternal diet on maiden dairy heifer fertility

2002 ◽  
Vol 74 (3) ◽  
pp. 415-421 ◽  
Author(s):  
J. E. Pryce ◽  
G. Simm ◽  
J. J. Robinson
Keyword(s):  
Reproductive Performance ◽  
Maternal Nutrition ◽  
Maternal Diet ◽  
Limited Range ◽  
Research Centre ◽  
Selection Line ◽  
Control Line ◽  
Maternal Environment ◽  
Significant Relationships ◽  
The Uk

AbstractThe objectives of this study were to investigate reproductive performance and the influence of maternal environment on reproductive performance in two genetic lines of maiden heifers. These were given food and managed in the same way at the Langhill Dairy Cattle Research Centre. The two genetic lines were established in 1973; one has been selected for high combined yield of fat plus protein (selection line; S) and the other has been maintained at around the UK average for genetic merit of yield of fat plus protein (control line; C). Analysis of the reproductive performance of 988 heifers born between 1981 and 1998 showed that S heifers were poorer (all P < 0·05) than C heifers for all reproductive measures: conception at first service (S: 0·64, s.e. 0·02; C: 0·71, s.e. 0·03), interval between first and last service (S: 18·2 days, s.e. 2·2; C: 13·4 days, s.e. 2·2) and number of services per conception (S: 1·49 services, s.e. 0·06; C: 1·39 services, s.e. 0·06). S heifers were also younger at first service than C heifers (474·9 days v. 480·1 days, s.e. 1·9, for S and C respectively; P • 01). Fertility of service sires may have had some influence on these results, but this could not be investigated here, as S heifers were mated only to high merit bulls and C heifers to average merit bulls. However, within genetic line, the yearly downward trend in the average number of services per conception of heifers was significantly different from zero for the S line, but not the C line. There were no statistically significant relationships between conception rates in maiden heifers and their subsequent reproductive performance in first lactation. The effect of maternal environment on the reproductive performance of daughters as maiden heifers was investigated. There were no statistically significant relationships between daughter reproductive performance and dam parity or the feeding system of the dam (either a high or low level of concentrates). Within the limited range of nutritional status of dams during the periods post calving and in early pregnancy, there was no statistically significant effect of maternal nutrition on daughter reproductive performance.

scholarly journals Maternal calorie restriction modulates placental mitochondrial biogenesis and bioenergetic efficiency: putative involvement in fetoplacental growth defects in rats

2013 ◽  
Vol 304 (1) ◽  
pp. E14-E22 ◽  
Author(s):  
Sylvain Mayeur ◽  
Steve Lancel ◽  
Nicolas Theys ◽  
Marie-Amélie Lukaszewski ◽  
Sophie Duban-Deweer ◽  
...  
Keyword(s):  
Metabolic Diseases ◽  
Maternal Diet ◽  
Atp Production ◽  
Proteomic Screen ◽  
Growth Defects ◽  
Maternal Undernutrition ◽  
Expression Of Genes ◽  
Increased Risk ◽  
Mitochondrial Functions ◽  
Mitochondrial Defects

Low birth weight is associated with an increased risk for developing type 2 diabetes and metabolic diseases. The placental capacity to supply nutrients and oxygen to the fetus represents the main determiner of fetal growth. However, few studies have investigated the effects of maternal diet on the placenta. We explored placental adaptive proteomic processes implicated in response to maternal undernutrition. Rat term placentas from 70% food-restricted (FR30) mothers were used for a proteomic screen. Placental mitochondrial functions were evaluated using molecular and functional approaches, and ATP production was measured. FR30 drastically reduced placental and fetal weights. FR30 placentas displayed 14 proteins that were differentially expressed, including several mitochondrial proteins. FR30 induced a marked increase in placental mtDNA content and changes in mitochondrial functions, including modulation of the expression of genes implicated in biogenesis and bioenergetic pathways. FR30 mitochondria showed higher oxygen consumption but failed to maintain their ATP production. Maternal undernutrition induces placental mitochondrial abnormalities. Although an increase in biogenesis and bioenergetic efficiency was noted, placental ATP level was reduced. Our data suggest that placental mitochondrial defects may be implicated in fetoplacental pathologies.

scholarly journals Maternal diet quality before pregnancy and risk of childhood leukaemia

2016 ◽  
Vol 116 (8) ◽  
pp. 1469-1478 ◽  
Author(s):  
Amanda W. Singer ◽  
Suzan L. Carmichael ◽  
Steve Selvin ◽  
Cecilia Fu ◽  
Gladys Block ◽  
...  
Keyword(s):  
Diet Quality ◽  
Maternal Nutrition ◽  
Case Control Study ◽  
Maternal Diet ◽  
Conditional Logistic Regression ◽  
Childhood Leukaemia ◽  
Dietary Components ◽  
The Relationship ◽  
Control Study

AbstractPrevious studies on maternal nutrition and childhood leukaemia risk have focused on the role of specific nutrients such as folate and have not considered broader measures of diet quality, which may better capture intake of diverse nutrients known to impact fetal development. We examined the relationship between maternal diet quality before pregnancy, as summarised by a diet quality index, and risk of childhood acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML) in a case–control study in California. Dietary intake in the year before pregnancy was assessed using FFQ in 681 ALL cases, 103 AML cases and 1076 matched controls. Conditional logistic regression was used to estimate OR and 95 % CI for diet quality continuous score and quartiles (Q1–Q4). Higher maternal diet quality score was associated with reduced risk of ALL (OR 0·66; 95 % CI 0·47, 0·93 for Q4v.Q1) and possibly AML (OR 0·42; 95 % CI 0·15, 1·15 for Q4v.Q1). No single index component appeared to account for the association. The association of maternal diet quality with risk of ALL was stronger in children diagnosed under the age of 5 years and in children of women who did not report using vitamin supplements before pregnancy. These findings suggest that the joint effects of many dietary components may be important in influencing childhood leukaemia risk.

scholarly journals Dietary Patterns of Breastfeeding Mothers and Human Milk Composition: Data from the Italian MEDIDIET Study

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1722
Author(s):  
Francesca Bravi ◽  
Matteo Di Maso ◽  
Simone R. B. M. Eussen ◽  
Carlo Agostoni ◽  
Guglielmo Salvatori ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Human Milk ◽  
Dietary Patterns ◽  
Maternal Nutrition ◽  
Dietary Habits ◽  
Maternal Diet ◽  
Principal Component ◽  
Milk Composition ◽  
Principal Component Factor Analysis

(1) Background: Several studies have reported associations between maternal diet in terms of single foods or nutrients and human milk compounds, while the overall role of maternal diet and related dietary patterns has rarely been investigated. (2) Methods: Between 2012 and 2014, we enrolled 300 healthy Italian mothers, who exclusively breastfed their infant. During a hospital visit at 6 weeks postpartum, a sample of freshly expressed foremilk was collected and information on maternal dietary habits in the postpartum period was obtained through an interviewer-administered food frequency questionnaire. We applied principal component factor analysis to selected nutrients in order to identify maternal dietary patterns, and assessed correlations in human milk macronutrients and fatty acids across levels of dietary patterns. (3) Results: Five dietary patterns were identified, named “Vitamins, minerals and fibre”, “Proteins and fatty acids with legs”, “Fatty acids with fins”, “Fatty acids with leaves”, “Starch and vegetable proteins”. These dietary patterns were correlated with some milk components, namely fatty acids, and in particular ω-3 and its subcomponents. (4) Conclusions: This study showed that overall maternal dietary habits during breastfeeding may influence human milk composition, suggesting the importance of adequate maternal nutrition during lactation not only for the mother herself but also to provide the infant with milk containing adequate amount and quality of nutrients for a balanced nutrition.

scholarly journals Role of Tinospora cordifolia in metabolic health disorders: An updated review

2021 ◽  
pp. 15-23
Author(s):  
Pritika Devi
Keyword(s):  
Metabolic Disorders ◽  
Metabolic Diseases ◽  
Skin Diseases ◽  
Experimental Studies ◽  
Tinospora Cordifolia ◽  
Chronic Diarrhoea ◽  
Traditional System ◽  
Tremendous Amount ◽  
Urinary Problems

The use of various herbal drugs in India has been widely developed in recent years. Guduchi (Tinospora cordifolia) belonging to family Menispermaceae has a tremendous amount of bioactive principles in exploring nutraceuticals from natural source. T. cordifolia is considered as an important herbal drug of traditional system of Indian Medicines. The herb is also well known for its therapeutic efficacy in treatment of various diseases viz. dyspepsia, diabetes, fever, urinary problems, jaundice, chronic diarrhoea, cardiac disease, dysentry, helmenthiasis, skin diseases, leprosy, thyroidand various metabolic diseases. Present review highlights the antidiabetic, hypolipidemic activity of Guduchi and their validation through existing literature, experimental studies. The plant is reported to have various alkaloids, glycosides, steroids and terpenoids. The current study is undertaken to explore and review its role on metabolic disorders.

scholarly journals Role of ADAM17 in kidney disease

2019 ◽  
Vol 317 (2) ◽  
pp. F333-F342 ◽  
Author(s):  
Vanesa Palau ◽  
Julio Pascual ◽  
Maria José Soler ◽  
Marta Riera
Keyword(s):  
Kidney Disease ◽  
Neurological Diseases ◽  
Experimental Studies ◽  
Renin Angiotensin System ◽  
Renal Tubules ◽  
Ang Ii ◽  
Converting Enzyme ◽  
Angiotensin System ◽  
Renin Angiotensin

It is known that the renin-angiotensin system plays a major role in the pathophysiology of cardiovascular disease and renal injury. Within the renin-angiotensin system, angiotensin-converting enzyme 2 (ACE2) cleaves ANG II to generate ANG(1–7) peptide, which counteracts the adverse effects of ANG II accumulation. ACE2 can undergo cleavage or shedding to release the catalytically active ectodomain into the circulation by a disintegrin and metalloprotease (ADAM)17, also known as TNF-α-converting enzyme. ADAM17 is involved in many pathological processes such as cancer, inflammatory diseases, neurological diseases, cardiovascular diseases, atherosclerosis, diabetes, and hypertension. Clinical and experimental studies have shown that ADAM17 is involved in chronic kidney disease (CKD) with a proinflammatory and profibrotic role, suggesting that it could be an important mediator of CKD progression. ADAM17 inhibition attenuates fibrosis and inflammation, suggesting that its inhibition may be a possible new valuable therapeutic tool in fibrotic kidney disease treatment. In addition, in renal disease, some experimental studies have demonstrated that ADAM17 is differently expressed in the kidney. Thus, ADAM17 is highly expressed in distal renal tubules and increased in the whole kidney in diabetic models. In this article, we will review the role of ADAM17 under physiological and pathological conditions. We will mainly focus on the importance of ADAM17 in the context of CKD.

154 UNDERNUTRITION DURING THE PERICONCEPTIONAL PERIOD IN EWES AFFECTS THE BLOOD PRESSURE AND WEIGHT OF THEIR NEONATAL LAMBS

2007 ◽  
Vol 19 (1) ◽  
pp. 194
Author(s):  
N. A. Smith ◽  
P. Lonergan ◽  
P. Duffy ◽  
T. F. Crosby ◽  
P. Quinn ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Birth Weight ◽  
Maternal Nutrition ◽  
Experimental Studies ◽  
Control Treatment ◽  
Maternal Undernutrition ◽  
Increased Risk ◽  
Periconceptional Period ◽  
Offspring Health ◽  
The Impact

Evidence from epidemiological and experimental studies has shown that maternal undernutrition during pregnancy can alter fetal growth and development and is associated with increased risk of hypertension and cardiovascular disease in the offspring. However, there is a paucity of data examining the effect of undernutrition during the periconceptual period on offspring health. Therefore, we investigated the impact of ewe undernutrition during the periconceptional period on lamb birth weight and blood pressure. Crossbred ewes (n = 166) were individually penned and randomly allocated to 1 of 2 treatments and fed either 0.7 (restricted) or 1.1 (control) maintenance energy requirements from 28 days prior until 7 days post-mating. After Day 7, ewes in both treatments were managed similarly until parturition. Following parturition, lamb gender, birth weight, and blood pressure were recorded. Lamb weight and blood pressure were subsequently measured at 4 and 10 weeks of age. Restricted ewes lost 2.6 � 0.2 kg over the treatment period compared with control ewes which gained 1.7 � 0.58 kg (P &lt; 0.01). There was no treatment effect on lamb birth weight in either singleton or twin gestations. However, at 4 and 10 weeks of age singleton lambs born to nutritionally restricted ewes were heavier than those born to control ewes (males, n = 17: 19.4 � 0.1 vs. 16.4 � 0.1 kg; females, n = 16: 34.9 � 1.0 vs. 30.9 � 1.6 kg, P &lt; 0.05). Blood pressure, measured within the first 24 h of life, was higher (P &lt; 0.05) in singleton lambs born to nutritionally restricted mothers compared to controls (males: systolic 126 � 11 vs. 94 � 5; diastolic 99 � 12 vs. 58 � 5; mean 112 � 11 vs. 77 � 5 mmHg; P &lt; 0.05; females: systolic 126 � 11 vs. 94 � 5; diastolic 99 � 12 vs. 58 � 5; mean 112 � 11 vs. 77 � 5 mmHg; P &lt; 0.05). This difference was no longer apparent at 4 or 10 weeks of age. Mean blood pressures of twin lambs at birth and 4 weeks of age were numerically greater in the restricted than in the control treatment but were significantly different only among male twin groups at 4 weeks of age (diastolic 77 � 4 vs. 94 � 4; mean 96 � 4 vs. 110 � 3 mmHg; P &lt; 0.01). Maternal undernutrition during the periconceptional period was associated with increased offspring weight at 4 and 10 weeks of age in singletons, as well as alterations in offspring cardiovascular function in both singletons and twins. These findings suggest that maternal nutrition at the time of conception influences offspring health. Exact mechanisms remain to be elucidated but may involve genetic modification. This research was funded by IRCSET and University College Dublin.

The Role of Angiotensin-(1-7)/Mas Axis and Angiotensin Type 2 Receptors in the Central Nervous System in Cardiovascular Disease and Therapeutics: A Riddle to be Solved

2019 ◽  
Vol 17 (4) ◽  
pp. 319-325 ◽  
Author(s):  
Vasiliki Katsi ◽  
Spyridon Maragkoudakis ◽  
Maria Marketou ◽  
Costas Tsioufis ◽  
Fragkiskos Parthenakis ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Experimental Studies ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Pressure Lowering ◽  
The Central Nervous System ◽  
Novel Therapeutic Strategies ◽  
Angiotensin Type

: In recent years, the Angiotensin-(1-7)/Mas receptor [Ang-(1-7)/Mas] sub-branch of the Renin-Angiotensin System (RAS) in the brain, and Angiotensin Type 2 Receptors (AT2R), have attracted scientific interest, as there is evidence that they constitute an essential pathway in cardiovascular regulation, in health and in disease. By acting centrally, the Ang-(1-7)/Mas axis - that has been termed ‘the axis of good’- can exert blood pressure-lowering effects, while also favourably altering baroreflex sensitivity and noradrenergic neurotransmission. Thus, research has focused on the possible neuro- and cardioprotective effects of this pathway in the setting of cardiovascular disease, ultimately aiming to evaluate the potential for development of novel therapeutic strategies based on its modulation. : We summarize the available evidence from experimental studies in this context, aiming to assess current limits of scientific knowledge relevant to this newly-described ‘player’ in haemodynamic regulation, that may become a potential therapeutic target.

scholarly journals Maternal resveratrol consumption and its programming effects on metabolic health in offspring mechanisms and potential implications

2018 ◽  
Vol 38 (2) ◽  
Author(s):  
Sheng Zheng ◽  
Qianyun Feng ◽  
Jing Cheng ◽  
Jia Zheng
Keyword(s):  
Maternal Nutrition ◽  
Metabolic Diseases ◽  
Metabolic Health ◽  
Health Interventions ◽  
Polyphenolic Compound ◽  
Limited Efficacy ◽  
Wide Range ◽  
Maternal Overweight ◽  
Antidiabetic Effects

A growing body of evidence has clearly demonstrated that maternal nutrition can strongly determine the susceptibility to the development of metabolic diseases in offspring. With the increasing prevalence of maternal overweight, obesity, and gestational diabetes mellitus, it yields enormous burden for individual and public health. Interventions during pregnancy have been proven to be challenging, with limited efficacy and low compliance. Resveratrol, as a natural polyphenolic compound, has a wide-range of beneficial properties, including potent antiobesogenic, antiatherosclerotic, and antidiabetic effects. However, the role of maternal resveratrol intake on metabolic health in offspring has not been extensively investigated. Therefore, the aim of this study was to review the effects of maternal resveratrol supplementation on metabolic health in offspring and its potential mechanisms.

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