scholarly journals MAMMOGRAM: DETECTION OF MALIGN TUMORS IN WOMEN FROM SANTA CATARINA AND BRAZIL

2016 ◽  
Vol 25 (3) ◽  
Author(s):  
Luciana Martins da Rosa ◽  
Luciana da Silva ◽  
Vera Radunz ◽  
María Angélica Arzuaga
Keyword(s):  
Breast Cancer ◽  
Information Technology ◽  
Observational Study ◽  
Breast Lesion ◽  
Incidence Rates ◽  
Santa Catarina ◽  
Unified Health System ◽  
Neoplastic Lesion ◽  
Neoplastic Lesions ◽  
Proportional Distribution

ABSTRACT The purpose is to analyze the incidence rate of malignant neoplastic lesion by detection type and the proportional distribution of mammograms in women between 40 and 69 years of age from the State of Santa Catarina and from Brazil. This is a descriptive observational study of data from the Information Technology Department of the Unified Health System between 2009 and 2012 and the Brazilian Institute of Geography and Statistics. The greatest mammography coverage was in the group from 45 to 49 years, 22.2% in Brazilians and 23.1% in women from Santa Catarina. The greatest proportional distribution was 89.2% in Brazilian women between 40 and 44 years and women from Santa Catarina between 50 and 54 years. The incidence rates of malignant neoplastic breast lesion diagnosed by imaging increased in Brazil and Santa Catarina. In Brazil, in 2012, the highest detection was by palpation and, in Santa Catarina, by imaging. In conclusion, the screening is below the recommended, the higher proportional distributions of mammograms permitted a larger number of diagnoses of malignant neoplastic lesions and the application of mammograms as from the age of 40 years contributed to the diagnosis of breast cancer between the ages of 40 and 49 years.

scholarly journals STUDY OF CORRELATION BETWEEN THE CYTOLOGICAL AND HISTOPATHOLOGICAL FINDINGS OF NON-NEOPLASTIC AND NEOPLASTIC BREAST LESION

2019 ◽  
pp. 1-2
Author(s):  
Rina Kumari
Keyword(s):  
Observational Study ◽  
Invasive Ductal Carcinoma ◽  
Gold Standard ◽  
Breast Lesion ◽  
Prospective Observational Study ◽  
Ductal Carcinoma ◽  
Benign Lesion ◽  
Malignant Lesion ◽  
Neoplastic Lesion ◽  
Lesion Method

Background: Study of correlation between the cytology and histopathological ndings of nonneoplastic and neoplastic breast lesion. Method : The present prospective observational study was conducated in jlnmc for a period of 6 months from 15th April to 14th Sept. we had studied 100 cases and specimens were received in histopathological section of our department.Gross examination of speciemens did followed by xation ,proper sampling and tissue processing. Result: Total 100 cases were studied of which 38 cases were nonneoplastic, 36 cases were benign neoplastic lesion,5 cases borderline and 21 cases were malignant.Over all broadenoma was most common benign lesion with 18 cases. Invasive ductal carcinoma nos were most common malignant lesion followed by lobular carcinoma.malignant phylloid was the most common nonepithelial malignancy. Conclusion: Histology remains gold standard for diagnosis of breast lesion

ER, PR & HER2 Receptor status in recurrent breast cancer: Its relation to age & time of recurrence

2020 ◽  
Vol 22 (1) ◽  
pp. 16-20
Author(s):  
Abu Khaled Muhammad Iqbal ◽  
Nasima Akhter ◽  
Hasan Shahrear Ahmed ◽  
Md Rassell ◽  
AMM Yahia ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Treatment Approach ◽  
Recurrent Breast Cancer ◽  
Breast Cancer Patients ◽  
Her2 Receptor ◽  
Younger Patients ◽  
Receptor Status ◽  
Increased Risk ◽  
Neoplastic Lesions ◽  
Recurrent Breast

Background: Malignant neoplastic lesions of the breast are one of the main causes of cancer death among women. In tumor cells the expression status of Estrogen receptor (ER), progesterone receptor (PR), and c-ERBB2 (HER2/neu) are therapeutically and prognostically important markers affecting the treatment approach, management and prognosis of breast carcinoma. Objective: To explore the relation of receptor status in recurrent breast cancer to age and time of recurrence. Methods: This study was conducted in National Institute of Cancer Research and Hospital (NICRH) and included 81 female patients between 20 to 75 years with recurrent breast cancer. Detection of receptor status of ER +ve/-ve, PR +ve/-ve, Her-2+ve/-ve was based on the immunohistochemistry staining of tissue samples of malignant neoplastic lesions prepared from tissue biopsies of patients with recurrent breast cancer. All the information were recorded through the pre-structured data collection sheet and analyzed. Results: This study showed that most of the recurrent breast cancer patients were Triple negative breast cancer (TNBC) (39.5%) and among them most of them were younger patients. Younger patients with TNBC had increased risk of recurrence. Most of the recurrence occurred within 1-2 years. Conclusion: It can be concluded that the assessment of the expression of these biornarkers in recurrent tumors provides reliable information for the treatment approach of locoregional tumors. Journal of Surgical Sciences (2018) Vol. 22 (1): 16-20

A Multicentric non-interventional observational study to determine treatment patterns and response of drugs in various stages of breast cancer along with epidemiology

2020 ◽  
Vol 8 (2) ◽  
pp. 71-81
Author(s):  
Mukkamala Durga Niharika ◽  
Shaik Kulsumbi ◽  
Devagiri Anupama ◽  
Tadigiri Vineela Supriya ◽  
Kotari Navya ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Observational Study ◽  
Receptor Expression ◽  
Breast Cancer Patients ◽  
Female Patients ◽  
Life Threatening ◽  
Guntur District ◽  
Study Population ◽  
Hormone Receptor Expression

Cancer is a life-threatening disease which causes to lose cohesiveness and orderliness of normal tissue. These malignant cells can spread to any other organ through blood flow or lymphatic flow and develop malignancy over there; this phenomenon is called metastasis. The aim is to focus on treatment pattern and response of drugs in various stages of breast cancer along with epidemiology. It is a non- interventional multicentric observational study. Female patients confirmed with Breast cancer are included in the study. All the relevant data were collected on a patient demographic form after obtaining informed consent from individual patients. In our study, the mean age of presentation in breast cancer patients was 41.35 years. Further it was found that 40.5% (n = 81) majority-female patients with Breast cancer are from Guntur District and 21.5% (n= 43). The majority of women with Breast cancer have hormone receptor expression of ER+/PR+HER2- was found to be 33% (n= 50). In the study on analyzing comorbidities of the study population, it was noted that 28.5% of women were affected with Diabetes mellitus. In our study, it was found that most of the patients with Breast cancer have been most often prescribed with Adriamycin 27.86%. From these observations, we conclude that late menarche may be one of the etiological causes of breast cancer in women, Invasive carcinoma in situ is the most commonly reported breast cancer in the study. Patients have been diagnosed with breast cancer at their stage 3 of progression, which may be the reason for making it mandatory for more than 50% of patients to undergo 6 to 8 cycles of chemotherapy. Coming to the patterns of drug use, ADRIAMYCIN, CYCLOPHOSPHAMIDE and DOCETAXEL are the three most commonly used single drug and combinational drug therapies among the study population.

BREAST CANCER STATISTICS IN THE CRIMEA REPUBLIC

2017 ◽  
Vol 63 (4) ◽  
pp. 580-586
Author(s):  
Viktor Oleksenko ◽  
Kazim Aliev ◽  
Tatyana Yefetova ◽  
I. Akinshevich ◽  
O. Dolgopolova
Keyword(s):  
Breast Cancer ◽  
Clinical Examination ◽  
Cancer Mortality ◽  
Comparative Evaluation ◽  
Incidence Rates ◽  
Upward Trend ◽  
Female Population ◽  
Cancer Statistics ◽  
The Crimea ◽  
Accumulation Index

Breast cancer (BC) is the most common diagnosed cancer and the leading cause of cancer mortality in women worldwide. The epidemiological picture of BC among the population of the Crimea Republic is analyzed with a comparative evaluation with nation-wide rates. According to the presented data the incidence of BC in the Crimea Republic has a clear upward trend. Incidence growth is mainly due to the female population among the «employable» contingent that requires regular clinical examination and screening these patients. In prognostic estimates by 2020 the incidence rates of BC in female population will increase by 10 % compared to 2015. The increase of the prevalence, contingent accumulation index, the proportion of patients experiencing more than 5 years, and reduction in mortality of the observed patient cohort shows better results of BC treatment in the Crimea Republic as compared to the All-Russian data.

scholarly journals The Usefulness of Spectral Mammography in Surgical Planning of Breast Cancer Treatment—Analysis of 999 Patients with Primary Operable Breast Cancer

2021 ◽  
Vol 28 (4) ◽  
pp. 2548-2559
Author(s):  
Andrzej Lorek ◽  
Katarzyna Steinhof-Radwańska ◽  
Anna Barczyk-Gutkowska ◽  
Wojciech Zarębski ◽  
Piotr Paleń ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Predictive Value ◽  
Breast Imaging ◽  
Incidence Rates ◽  
Diagnostic Sensitivity ◽  
Breast Cancer Surgery ◽  
Imaging Method ◽  
Treatment Change ◽  
Contrast Enhanced ◽  
General Number

Contrast-enhanced spectral mammography (CESM) is a promising, digital breast imaging method for planning surgeries. The study aimed at comparing digital mammography (MG) with CESM as predictive factors in visualizing multifocal-multicentric cancers (MFMCC) before determining the surgery extent. We analyzed 999 patients after breast cancer surgery to compare MG and CESM in terms of detecting MFMCC. Moreover, these procedures were assessed for their conformity with postoperative histopathology (HP), calculating their sensitivity and specificity. The question was which histopathological types of breast cancer were more frequently characterized by multifocality–multicentrality in comparable techniques as regards the general number of HP-identified cancers. The analysis involved the frequency of post-CESM changes in the extent of planned surgeries. In the present study, MG revealed 48 (4.80%) while CESM 170 (17.02%) MFMCC lesions, subsequently confirmed in HP. MG had MFMCC detecting sensitivity of 38.51%, specificity 99.01%, PPV (positive predictive value) 85.71%, and NPV (negative predictive value) 84.52%. The respective values for CESM were 87.63%, 94.90%, 80.57% and 96.95%. Moreover, no statistically significant differences were found between lobular and NST cancers (27.78% vs. 21.24%) regarding MFMCC. A treatment change was required by 20.00% of the patients from breast-conserving to mastectomy, upon visualizing MFMCC in CESM. In conclusion, mammography offers insufficient diagnostic sensitivity for detecting additional cancer foci. The high diagnostic sensitivity of CESM effectively assesses breast cancer multifocality/multicentrality and significantly changes the extent of planned surgeries. The multifocality/multicentrality concerned carcinoma, lobular and invasive carcinoma of no special type (NST) cancers with similar incidence rates, which requires further confirmation.

scholarly journals A study of crystalluria: effectiveness of including hygienic-dietary recommendations in laboratory reports

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Paula Sienes Bailo ◽  
María Santamaría González ◽  
Silvia Izquierdo Álvarez ◽  
Raquel Lahoz Alonso ◽  
Patricia Serrano Frago ◽  
...  
Keyword(s):  
General Population ◽  
Observational Study ◽  
Renal Colic ◽  
Incidence Rates ◽  
Retrospective Observational Study ◽  
Dietary Recommendations ◽  
Group A ◽  
Group B

Abstract Objectives To assess the effectiveness of incorporating hygienic-dietary recommendations in laboratory reports in reducing the incidence of renal colic (RC). A study was performed to compare the incidence of RC in two groups of patients who had suffered at least a crystalluria event associated with the risk of urolithiasis. Recommendations were only incorporated in the laboratory reports of one group. Methods A retrospective observational study. The study sample was composed of patients who had at least an episode of crystalluria associated with a higher risk of urolithiasis. The laboratory reports of patients in Group A (n=1,115), treated in 2017, did not include any hygienic-dietary recommendations, whereas patients in Group B (n=1,692), treated in 2018, received hygienic-dietary recommendations through their laboratory reports. χ2 and Mann-Whitney U test were used to assess differences based on sex, age, and type of urinary crystals. Results The incidence of RC was 2.02 times higher in group A (2.24%) than in group B (1.12%). No significant differences were observed in the incidence of RC based on the type of urinary crystal. The incidence of RC was substantially higher in patients who suffered at least an event of crystalluria associated with a higher risk for urolithiasis as compared to the general population during the same period (0.46%, consistently with the incidence rates reported in the literature). Conclusions The incorporation of messages alerting on the risk of urolithiasis and the inclusion of hygienic-dietary recommendations in laboratory reports may be useful for reducing the incidence of RC.

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