scholarly journals Venesection Sites on the Horse in the Veterinary Handbook of al-Nāṣirī

2021 ◽  
Vol 11 (22) ◽  
pp. 567-576
Author(s):  
Zsuzsanna Kutasi
Keyword(s):  
Veterinary Medicine ◽  
Blood Vessels ◽  
Expert Opinion ◽  
Military Training ◽  
The Body ◽  
Medical Treatments ◽  
Body Regions ◽  
Wide Range

The author usually referred to a sal-NāṣirīorIbnal-Mundir (AbūBakrb.Badral-Dīnal-Mundir al-Bayṭārca.A.H.709-741/A.D.1309-1340) composed his handbook on the diseases of horses and the treatments thereof at the request of Nāṣir al-Dīn Muḥammad b. Qalāwūn in the middle of the 14thcentury. Under this Mamluk sultan, he served as a chief veterinarian. A 9th-century work by Ibn AhīḤizām titled Kāmilal-sinā‘tayn served as the basis of l-Nāṣirī’shandbook. As evident from the title of the book, the author offered a summary of a wide range of themes concerning horses, beginning with the important role in the jihad, and proceeding to discuss soft he inbreeds and military training. He compares the equid diseases with human ones, as a structure that allows him to describe their medical treatments as well. The description of venesection sites, of obvious use for practising veterinarians, is featured among the chapters on anatomical structures.Theseventhchapteroftheworkmentionsasmanyas21optional site of bloodletting. Here the text indicates only the silent/non-palpitating blood-vessels” (ġayral-ḍawārib),aconceptthatIsoughttoidentifybyrecoursetomodernveterinary anatomical source sand by consulting the expert opinion of distinguishing the professor of veterinary medicine, Dr Ferenc Szalay(whosehelpIgratefullyacknowledgehere).In the medievalArabiccontext, veins and arteries were not yet defined in a way analogous to modern definitions;inaccordancewithGalen’sandhispredecessors’philosophy, the veins were traced to the liver, and the arteries, to the heart. Veins were thought to carry blood and nutrients to the organs to nourish them, while arteries distribute the innate heat to every part of the body. Al-Nāṣirīclassifiedthebloodsystemasakindoffunctionalanatomy,incontrasttoGalen’s work on bloodletting, which described blood vessels according to the anatomy of the discrete body regions.

A comparative study of fleece growth in Tasmanian Fine Merino and Wiltshire Horn ewes

1961 ◽  
Vol 57 (1) ◽  
pp. 11-19 ◽  
Author(s):  
J. Slee ◽  
H. B. Carter
Keyword(s):  
Growth Rate ◽  
Fibre Diameter ◽  
The Body ◽  
Back Side ◽  
Body Regions ◽  
Wide Range ◽  
Diameter Fibre ◽  
Fibre Growth ◽  
Skin Biopsies ◽  
Three Body

1. From repeated fibre samplings and several skin biopsies on six Tasmanian Fine Merinos and eight Wiltshire Horn adult ewes variations in fibre diameter, fibre growth rate, and fibre regeneration or shedding frequency were measured over a period of 15 months. Slight differences were present in the treatment of the two breeds, but from the combined evidence of the live weights and fibre diameters maintained, it was concluded that these were negligible, that both breeds were under closely comparable conditions, and that their performance was at a moderately high and typical level for each breed.2. In the Merinos fibre diameter (ca. 20 µ) fluctuated little during the period of observation, whereas in the Wiltshires it varied over a wide range from less than 40µ in winter to more than 80µ in summer. There were negligible differences between the three body regions, back, side, and belly, in the Merinos, but in the Wiltshires the belly grew markedly coarser fibres than the other two regions.3. The fibre growth rate in the Merinos did not vary greatly from 7 to 8 mm. per 28 days throughout the period of observation or between the body regions. In the Wiltshires, fibre growth rate showed extreme variations from a minimum of about 3 mm. during the winter to a maximum of about 12 mm. per 28 days at the end of summer, with significant differences between the three body regions. However, in spite of these differences in the mode of growth, the total length of fibre grown per annum at the midside was approximately the same (10 cm.). Thus, were it not for fibre shedding, the Wiltshire Horn breed would grow a short-wool fleece.

COMPARISON OF ANTIHYPERTENSIVE EFFECT OF MOXONIDINE VERSUS CLONIDINE IN RENAL FAILURE PATIENTS.

2018 ◽  
Vol 6 (9) ◽  
Author(s):  
DR.MATHEW GEORGE ◽  
DR.LINCY JOSEPH ◽  
MRS.DEEPTHI MATHEW ◽  
ALISHA MARIA SHAJI ◽  
BIJI JOSEPH ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renal Failure ◽  
Blood Flow ◽  
Blood Vessel ◽  
Blood Vessels ◽  
High Blood Pressure ◽  
Antihypertensive Effect ◽  
The Body ◽  
Ability To Work ◽  
Blood Flows

Blood pressure is the force of blood pushing against blood vessel walls as the heart pumps out blood, and high blood pressure, also called hypertension, is an increase in the amount of force that blood places on blood vessels as it moves through the body. Factors that can increase this force include higher blood volume due to extra fluid in the blood and blood vessels that are narrow, stiff, or clogged(1). High blood pressure can damage blood vessels in the kidneys, reducing their ability to work properly. When the force of blood flow is high, blood vessels stretch so blood flows more easily. Eventually, this stretching scars and weakens blood vessels throughout the body, including those in the kidneys.

Creating the Wind

2020 ◽  
Vol 2 (4) ◽  
pp. 14-31
Author(s):  
Élodie Dupey García
Keyword(s):  
Indigenous Communities ◽  
The Body ◽  
Historical Sources ◽  
Natural Behavior ◽  
Sensory Experiences ◽  
Identity And Agency ◽  
Wide Range ◽  
Late Postclassic ◽  
Comparative Examination ◽  
Meteorological Phenomenon

This article explores how the Nahua of late Postclassic Mesoamerica (1200–1521 CE) created living and material embodiments of their wind god constructed on the basis of sensory experiences that shaped their conception of this divinized meteorological phenomenon. In this process, they employed chromatic and design devices, based on a wide range of natural elements, to add several layers of meaning to the human, painted, and sculpted supports dressed in the god’s insignia. Through a comparative examination of pre-Columbian visual production—especially codices and sculptures—historical sources mainly written in Nahuatl during the viceregal period, and ethnographic data on indigenous communities in modern Mexico, my analysis targets the body paint and shell jewelry of the anthropomorphic “images” of the wind god, along with the Feathered Serpent and the monkey-inspired embodiments of the deity. This study identifies the centrality of other human senses beyond sight in the conception of the wind god and the making of its earthly manifestations. Constructing these deity “images” was tantamount to creating the wind because they were intended to be visual replicas of the wind’s natural behavior. At the same time, they referred to the identity and agency of the wind god in myths and rituals.

Harnessing clay nano-particles for stem-cell driven tissue regeneration, EPSRC

Impact ◽  
2018 ◽  
Vol 2018 (3) ◽  
pp. 26-28
Author(s):  
Jonathan Dawson ◽  
Richard Oreffo
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Blood Vessels ◽  
The Body ◽  
Biological Molecules ◽  
Nano Particles ◽  
Clay Particles ◽  
Clay Nanoparticles ◽  
Signalling Molecules ◽  
The Right

Gels made from clay could provide an environment able to stimulate stem-cells due to their ability to bind biological molecules. That molecules stick to clay has been known by scientists since the 1960s. Doctors observed that absorption into the blood stream of certain drugs was severely reduced when patients were also receiving clay-based antacid or anti-diarrhoeal treatments. This curious phenomenon was realized to be due to binding of the drugs by clay particles. This interaction is now routinely harnessed in the design of tablets to carefully control the release and action of a drug. Dr Dawson now proposes to use this property of clay to create micro-environments that could stimulate stem cells to regenerate damaged tissues such as bone, cartilage or skin. The rich electrostatic properties of nano (1 millionth of a millimetre) -scale clay particles which mediate these interactions could allow two hurdles facing the development of stem-cell based regenerative therapies to be overcome simultaneously. The first challenge - to deliver and hold stem cells at the right location in the body - is met by the ability of clays to self-organise into gels via the electrostatic interactions of the particles with each other. Cells mixed with a low concentration (less than 4%) of clay particles can be injected into the body and held in the right place by the gel, eliminating, in many situations, the need for surgery. Clay particles can also interact with large structural molecules (polymers) which are frequently used in the development of materials (or 'scaffolds'), designed to host stem cells. These interactions can greatly improve the strength of such structures and could be applied to preserve their stability at the site of injury until regeneration is complete. While several gels and scaffold materials have been designed to deliver and hold stem cells at the site of regeneration, the ability of clay nanoparticles to overcome a second critical hurdle facing stem-cell therapy is what makes them especially exciting. Essential to directing the activity of stem-cells is the carefully controlled provision of key biological signalling molecules. However, the open structures of conventional scaffolds or gels, while essential for the diffusion of nutrients to the cells, means their ability to hold the signalling molecules in the same location as the cells is limited. The ability of clay nano-particles to bind biological molecules presents a unique opportunity to create local environments at a site of injury or disease that can stimulate and control stem-cell driven repair. Dr Dawson's early studies investigated the ability of clay gels to stimulate the growth of new blood vessels by incorporating a key molecular signal that stimulates this process, vascular endothelial growth factor (VEGF). In a manner reminiscent of the observations made in the 60s, Dr Dawson and colleagues observed that adding a drop of clay gel to a solution containing VEGF caused, after a few hours, the disappearance of VEGF from the solution as it became bound to the gel. When placed in an experimental injury model, the gel-bound VEGF stimulated a cluster of new blood vessels to form. These exciting results indicate the potential of clay nanoparticles to create tailor-made micro-environments to foster stem cell regeneration. Dr Dawson is developing this approach as a means of first exploring the biological signals necessary to successfully control stem cell behaviour for regeneration and then, using the same approach, to provide stem cells with these signals to stimulate regeneration in the body. The project will seek to test this approach to regenerate bone lost to cancer or hip replacement failure. If successful the same technology may be applied to harness stem cells for the treatment of a whole host of different scenarios, from burn victims to those suffering with diabetes or Parkinson's.

Development and Validation of a New Scoring Tool to Evaluate the Clinical Evolution of Adult Patients with Nonsegmental Vitiligo

Dermatology ◽  
2021 ◽  
pp. 1-9
Author(s):  
María Luisa Peralta-Pedrero ◽  
Denisse Herrera-Bringas ◽  
Karla Samantha Torres-González ◽  
Martha Alejandra Morales-Sánchez ◽  
Fermín Jurado Santa-Cruz ◽  
...  
Keyword(s):  
Body Surface ◽  
Task Force ◽  
Intraclass Correlation ◽  
The Body ◽  
Response To Treatment ◽  
Similar Response ◽  
Clinical Evolution ◽  
Wide Range ◽  
Patient Reported ◽  
Extreme Groups

<b><i>Background:</i></b> Vitiligo has an unpredictable course and a variable response to treatment. Furthermore, the improvement of some vitiligo lesions cannot be considered a guarantee of a similar response to the other lesions. Instruments for patient-reported outcome measures (PROM) can be an alternative to measure complex constructions such as clinical evolution. <b><i>Objective:</i></b> The aim of this study was to validate a PROM that allows to measure the clinical evolution of patients with nonsegmental vitiligo in a simple but standardized way that serves to gather information for a better understanding of the disease. <b><i>Methods:</i></b> The instrument was created through expert consensus and patient participation. For the validation study, a prospective cohort design was performed. The body surface area affected was measured with the Vitiligo Extension Score (VES), the extension, the stage, and the spread by the evaluation of the Vitiligo European Task Force assessment (VETFa). Reliability was determined with test-retest, construct validity through hypothesis testing, discriminative capacity with extreme groups, and response capacity by comparing initial and final measurements. <b><i>Results:</i></b> Eighteen semi-structured interviews and 7 cognitive interviews were conducted, and 4 dermatologists were consulted. The instrument Clinical Evolution-Vitiligo (CV-6) was answered by 119 patients with a minimum of primary schooling. A wide range was observed in the affected body surface; incident and prevalent cases were included. The average time to answer the CV-6 was 3.08 ± 0.58 min. In the test-retest (<i>n</i> = 53), an intraclass correlation coefficient was obtained: 0.896 (95% CI 0.82–0.94; <i>p</i> &#x3c; 0.001). In extreme groups, the mean score was 2 (2–3) and 5 (4–6); <i>p</i> &#x3c; 0.001. The initial CV-6 score was different from the final one and the change was verified with VES and VETFa (<i>p</i> &#x3c; 0.05, <i>n</i> = 92). <b><i>Conclusions:</i></b> The CV-6 instrument allows patient collaboration, it is simple and brief, and it makes it easier for the doctor to focus attention on injuries that present changes at the time of medical consultation.

scholarly journals Hydromechanics of low-Reynolds-number flow. Part 2. Singularity method for Stokes flows

1975 ◽  
Vol 67 (4) ◽  
pp. 787-815 ◽  
Author(s):  
Allen T. Chwang ◽  
T. Yao-Tsu Wu
Keyword(s):  
Exact Solutions ◽  
Stokes Flow ◽  
Fundamental Solutions ◽  
The Body ◽  
Circular Cylinders ◽  
Geometrical Parameters ◽  
Flow Problems ◽  
Singularity Method ◽  
Wide Range ◽  
Body Shapes

The present study further explores the fundamental singular solutions for Stokes flow that can be useful for constructing solutions over a wide range of free-stream profiles and body shapes. The primary singularity is the Stokeslet, which is associated with a singular point force embedded in a Stokes flow. From its derivatives other fundamental singularities can be obtained, including rotlets, stresslets, potential doublets and higher-order poles derived from them. For treating interior Stokes-flow problems new fundamental solutions are introduced; they include the Stokeson and its derivatives, called the roton and stresson.These fundamental singularities are employed here to construct exact solutions to a number of exterior and interior Stokes-flow problems for several specific body shapes translating and rotating in a viscous fluid which may itself be providing a primary flow. The different primary flows considered here include the uniform stream, shear flows, parabolic profiles and extensional flows (hyper-bolic profiles), while the body shapes cover prolate spheroids, spheres and circular cylinders. The salient features of these exact solutions (all obtained in closed form) regarding the types of singularities required for the construction of a solution in each specific case, their distribution densities and the range of validity of the solution, which may depend on the characteristic Reynolds numbers and governing geometrical parameters, are discussed.

scholarly journals A Computational Study on the Role of Parameters for Identification of Thyroid Nodules by Infrared Images (and Comparison with Real Data)

Sensors ◽  
2021 ◽  
Vol 21 (13) ◽  
pp. 4459
Author(s):  
José R. González ◽  
Charbel Damião ◽  
Maira Moran ◽  
Cristina A. Pantaleão ◽  
Rubens A. Cruz ◽  
...  
Keyword(s):  
Heat Transfer ◽  
Thyroid Nodules ◽  
Numerical Study ◽  
Computational Study ◽  
Internal Heat ◽  
Heat Transfer Process ◽  
The Body ◽  
Physical Parameters ◽  
Infrared Sensors ◽  
Wide Range

According to experts and medical literature, healthy thyroids and thyroids containing benign nodules tend to be less inflamed and less active than those with malignant nodules. It seems to be a consensus that malignant nodules have more blood veins and more blood circulation. This may be related to the maintenance of the nodule’s heat at a higher level compared with neighboring tissues. If the internal heat modifies the skin radiation, then it could be detected by infrared sensors. The goal of this work is the investigation of the factors that allow this detection, and the possible relation with any pattern referent to nodule malignancy. We aim to consider a wide range of factors, so a great number of numerical simulations of the heat transfer in the region under analysis, based on the Finite Element method, are performed to study the influence of each nodule and patient characteristics on the infrared sensor acquisition. To do so, the protocol for infrared thyroid examination used in our university’s hospital is simulated in the numerical study. This protocol presents two phases. In the first one, the body under observation is in steady state. In the second one, it is submitted to thermal stress (transient state). Both are simulated in order to verify if it is possible (by infrared sensors) to identify different behavior referent to malignant nodules. Moreover, when the simulation indicates possible important aspects, patients with and without similar characteristics are examined to confirm such influences. The results show that the tissues between skin and thyroid, as well as the nodule size, have an influence on superficial temperatures. Other thermal parameters of thyroid nodules show little influence on surface infrared emissions, for instance, those related to the vascularization of the nodule. All details of the physical parameters used in the simulations, characteristics of the real nodules and thermal examinations are publicly available, allowing these simulations to be compared with other types of heat transfer solutions and infrared examination protocols. Among the main contributions of this work, we highlight the simulation of the possible range of parameters, and definition of the simulation approach for mapping the used infrared protocol, promoting the investigation of a possible relation between the heat transfer process and the data obtained by infrared acquisitions.

scholarly journals Polymer-Drug Conjugates as Nanotheranostic Agents

2021 ◽  
Vol 2 (1) ◽  
pp. 63-81
Author(s):  
Sajana Manandhar ◽  
Erica Sjöholm ◽  
Johan Bobacka ◽  
Jessica M. Rosenholm ◽  
Kuldeep K. Bansal
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Treatment Options ◽  
The Body ◽  
Drug Conjugates ◽  
Imaging Characteristics ◽  
Wide Range ◽  
Systemic Side Effects ◽  
Theranostic Agents ◽  
The Stability

Since the last decade, the polymer-drug conjugate (PDC) approach has emerged as one of the most promising drug-delivery technologies owing to several benefits like circumventing premature drug release, offering controlled and targeted drug delivery, improving the stability, safety, and kinetics of conjugated drugs, and so forth. In recent years, PDC technology has advanced with the objective to further enhance the treatment outcomes by integrating nanotechnology and multifunctional characteristics into these systems. One such development is the ability of PDCs to act as theranostic agents, permitting simultaneous diagnosis and treatment options. Theranostic nanocarriers offer the opportunity to track the distribution of PDCs within the body and help to localize the diseased site. This characteristic is of particular interest, especially among those therapeutic approaches where external stimuli are supposed to be applied for abrupt drug release at the target site for localized delivery to avoid systemic side effects (e.g., Visudyne®). Thus, with the help of this review article, we are presenting the most recent updates in the domain of PDCs as nanotheranostic agents. Different methodologies utilized to design PDCs along with imaging characteristics and their applicability in a wide range of diseases, have been summarized in this article.

scholarly journals Sustainable Sources from Aquatic Organisms for Cosmeceuticals Ingredients

Cosmetics ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. 48
Author(s):  
Carmen G. Sotelo ◽  
María Blanco ◽  
Patricia Ramos ◽  
José A. Vázquez ◽  
Ricardo I. Perez-Martin
Keyword(s):  
Social Issues ◽  
Good Condition ◽  
Aquatic Organisms ◽  
The Body ◽  
Fishing Activity ◽  
Marine Biomass ◽  
Cosmetic Industry ◽  
Wide Range ◽  
Long Life ◽  
By Products

Long life expectancy of populations in the developing world together with some cultural and social issues has driven the need to pay special attention to health and physical appearance. Cosmeceuticals are gaining interest in the cosmetic industry as their uses fulfills a double purpose: the requirements of a cosmetic (clean, perfume, protect, change the appearance of the external parts of the body or keeping them in good condition) with a particular bioactivity function. The cosmetics industry, producing both cosmetics and cosmeceuticals, is currently facing numerous challenges to satisfy different attitudes of consumers (vegetarianism, veganism, cultural or religious concerns, health or safety reasons, eco-friendly process, etc.). A currently growing trend in the market is the interest in products of low environmental impact. Marine origin ingredients are increasingly being incorporated into cosmeceutical preparations because they are able to address several consumer requirements and also due to the wide range of bioactivities they present (antioxidant, whitening, anti-aging, etc.). Many companies claim “Marine” as a distinctive marketing signal; however, only a few indicate whether they use sustainable ingredient sources. Sustainable marine ingredients might be obtained using wild marine biomass through a sustainable extractive fishing activity; by adopting valorization strategies including the use of fish discards and fish by-products; and by sustainably farming and culturing marine organisms.

Electromechanical fields in a hollow piezoelectric cylinder under non-uniform load: flexoelectric effect

2021 ◽  
pp. 108128652110207
Author(s):  
Olha Hrytsyna
Keyword(s):  
Analytical Solutions ◽  
Point Group ◽  
The Body ◽  
Small Scale ◽  
Gradient Theory ◽  
Local Mass ◽  
Wide Range ◽  
Mass Displacement ◽  
Local Mass Displacement ◽  
Local Gradient

The relations of a local gradient non-ferromagnetic electroelastic continuum are used to solve the problem of an axisymmetrical loaded hollow cylinder. Analytical solutions are obtained for tetragonal piezoelectric materials of point group 4 mm for two cases of external loads applied to the body surfaces. Namely, the hollow pressurized cylinder and a cylinder subjected to an electrical voltage V across its thickness are considered. The derived solutions demonstrate that the non-uniform electric load causes a mechanical deformation of piezoelectric body, and vice versa, the inhomogeneous radial pressure of the cylinder induces its polarization. Such a result is obtained due to coupling between the electromechanical fields and a local mass displacement being considered. In the local gradient theory, the local mass displacement is associated with the changes to a material’s microstructure. The classical theory does not consider the effect of material microstructure on the behavior of solid bodies and is incapable of explaining the mentioned phenomena. It is also shown that the local gradient theory describes the size-dependent properties of piezoelectric nanocylinders. Analytical solutions to the formulated boundary-value problems can be used in conjunction with experimental data to estimate some higher-order material constants of the local gradient piezoelectricity. The obtained results may be useful for a wide range of appliances that utilize small-scale piezoelectric elements as constituting blocks.

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