scholarly journals Fifty years of Bryology in Mexico

2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Claudio Delgadillo-Moya
Keyword(s):  
Recombinant Proteins ◽  
Physcomitrella Patens ◽  
Current Knowledge ◽  
Scientific Journal ◽  
Wide Distribution ◽  
Mitochondrial Genomes ◽  
The Status ◽  
Floristic Studies ◽  
Potential Use

Background: Mexican botanists were not involved in bryophyte research fifty years ago; only four small floristic contributions were published between 1942-1958. Questions: What has been learned in the last fifty years? How many bryophytes are there in Mexico? What are the contributions by Mexican scientists? Studied species: Bryophyte flora. Study site and dates: Mexico, between 1942-2021. Methods:  Bibliographic compilations were used to revise the status of bryophyte research in Mexico. Data for the last fifty years cited there and in an updated version of Latmoss served to determine the current knowledge of Mexican bryophytes as contributed by Mexican scientists. No thesis research was considered unless published in a scientific journal. Results: There are 16 species of Anthocerotophyta, ca. 600 of Marchantiophyta, and 997 Bryophyta in Mexico. At least seven phytogeographic elements are represented: Northern, Meso-American, Caribbean, Southern, Wide distribution, and Endemic. Highlights of Mexican research include the discovery of Hypnodontopsis sp., a Miocene amber fossil from Chiapas, identification of heavy metals deposits in urban mosses in Mexico City and Toluca, determination of chloroplast and mitochondrial genomes of Pseudocrossidium replicatum, and the potential use of recombinant proteins from Physcomitrella patens. Conclusions: Taxonomic and floristic studies should be continued along with the bryological exploration of the country. Conservation is urgent, but studies of drought tolerance, air pollution, climate change, and potential uses in medicine require support and collaboration from other scientists.

Leptin, a mediator of cardiac damage associated with obesity

2014 ◽  
Vol 18 (1) ◽  
Author(s):  
E. Martínez-Martínez ◽  
R. Jurado-López ◽  
P. Cervantes-Escalera ◽  
V. Cachofeiro ◽  
M. Miana
Keyword(s):  
Oxidative Stress ◽  
Adipose Tissue ◽  
Current Knowledge ◽  
Wide Distribution ◽  
Cardiac Damage ◽  
Systemic Oxidative Stress ◽  
Cardiovascular Damage ◽  
Morphological Adaptations ◽  
The Status ◽  
And Function

AbstractObesity and excess of adipose tissue are associated with the development of cardiovascular risk factors such as diabetes, hypertension, and hyperlipidemia. At the cardiac level, various morphological adaptations in cardiac structure and function occur in obese individuals. Different mechanisms linking obesity to these modifications have been postulated. Adipose tissue and epicardial fat releases a large number of cytokines and bioactive mediators such as leptin. Leptin circulates in proportion to body fat mass, thus serving as a satiety signal and informing central metabolic control centers as to the status of peripheral energy stores. It participates in numerous other functions both peripherally and centrally, as indicated by the wide distribution of leptin and the different isoforms of its receptor in different tissues including the heart. This hormone has distinct effects on the reproductive, cardiovascular, and immune systems; however, its role in the heart could mediate wide physiological effects observed in obese individuals. Oxidative stress is associated with obesity and may be considered to be a unifying mechanism in the development of obesity-related comorbidities. It has been reported that obesity may induce systemic oxidative stress; in turn, oxidative stress is associated with an irregular production of adipokines. We herein review the current knowledge of cardiac effects of leptin and the possible mechanisms that are involved, including oxidative stress that plays a major role in the development of cardiovascular damage.

scholarly journals Семь десятилетий ойратоведения в КНР (1949‒2019 гг.)

2020 ◽  
Vol 13 (6) ◽  
pp. 1524-1536
Author(s):  
Na. Alatengaoqier ◽  
◽  
Baazr A. Bicheev ◽  
Keyword(s):  
Inner Mongolia ◽  
Scientific Journal ◽  
Historical Science ◽  
Main Research ◽  
The Past ◽  
Scientific Analysis ◽  
The Status ◽  
Development Methods ◽  
Further Development

Introduction. Historically, the Oirats of China mainly live in the territory of Xinjiang, in the provinces of Qinghai, Gansu, and in the Western part of Inner Mongolia. Some of the Olets (descendants of Dzungars) live in the steppe part of the Emin Gol of the Hulun Buir Aimag of Inner Mongolia, in Fuyu County of Heilongjiang Province, and in Chengdu, Hebei Province. In the modern historical science of China, until the mid-20th century the Oirats were not distinguished from the bulk of China’s Mongols, and, consequently, their history, culture and language were not subjects of individual studies. Only after its formation in 1949, Chinese Oirat studies started gaining visible features as an important part of Mongolian studies and the historical science of China as a whole. At the same time, Oirat studies as a historical direction were created by several generations of scientists of different nationalities (Han Chinese, Mongols, and Oirats themselves). Goals. The article aims to provide a general overview and scientific analysis of the formation and development of Oirat studies in China over the past seven decades (1949–2019), and to identify the historical paradigm of conducted researches and prospects of further development. Methods. The main research method is historical and chronological analysis. Despite Oirat studies have been existing as an integral part of Mongolian science for seven decades, no analysis of its historical development was ever carried out. Results. This work fills the gap and highlights the most important achievements in the study of China-based Oirats’ history and culture. A prominent attention in this study is given to the materials of ten scientific conferences that have the status of ‘all-China’ ones and were devoted to the study of the history and culture of the Oirats, as well as the scientific journal ‘Barayun mongyol sudul’ (‘Journal of Western Mongolian Studies’), which plays an important role in the development and determination of promising areas of Oirat studies. Conclusion. The analysis of Oiratological research over the past seven decades has revealed the historical paradigm of Oirat studies and prospects for their further development.

The Validity of Rector�s Circular Letter on the Covid-19 Pandemic

2020 ◽  
Vol 7 (1) ◽  
pp. 126 ◽  
Author(s):  
Fradhana Putra Disantara
Keyword(s):  
Legal Theory ◽  
Legal Issues ◽  
State Universities ◽  
Ministry Of Education ◽  
Conceptual Approach ◽  
State Of Emergency ◽  
Circular Letter ◽  
The Status ◽  
The Government

This study aims to analyze the relevance of the �health emergency� status to the existing legal theory and condition as well as to identify the validity of the Circular Letter of the Rector of State Universities. To this end, this study applied the statute and conceptual approach. The study was conducted by inventorying primary and secondary legal materials to obtain a proper and critical review of the legal issues under study. The results showed that the determination of the �health emergency� status by the government was inappropriate due to the uncertainty of the regulations issued by the government to determine the current condition. Thus, the status of the COVID-19 pandemic is a �legal emergency� status. Further, the Rector�s policy through the Circular Letter is valid judicially, sociologically, and philosophically. The determination of the �legal emergency� status can be done by issuing a Perppu without a �state of emergency� from the President. Finally, it is suggested to firstly get an approval from the Ministry of Education and Culture regarding the issuance of the Rector�s Circular Letter. Besides, further study is needed as this study was conducted during the COVID-19 pandemic.�Keabsahan Surat Edaran Rektor Perguruan Tinggi dalam Pandemi Covid-19Tujuan dari penelitian ini adalah untuk menganalisa relevansi status �darurat kesehatan� dengan teori hukum dan kondisi yang ada dan keabsahan atas Surat Edaran Rektor Perguruan Tinggi Negeri. Metode yang digunakan dalam penelitian ini adalah statute approach dan conseptual approach. Penelitian dilakukan dengan menginventarisasi bahan hukum primer dan sekunder, guna mendapatkan kajian yang seyogianya dan telaah kritis terkait isu hukum. Hasil penelitian menyatakan penetapan status darurat kesehatan oleh pemerintah kurang tepat, dikarenakan tidak menentu-nya peraturan yang dikeluarkan oleh pemerintah untuk menetapkan kondisi saat ini. Sehingga, status pandemi COVID-19 merupakan status darurat hukum. Kebijakan rektor melalui Surat Edaran adalah absah secara aspek yuridis, sosiologis, dan filosofis. Penetapan darurat hukum cukup dilakukan dengan menerbitkan Perppu tanpa pernyataan darurat dari Presiden. Saran peneliti adalah di perlukan persetujuan pada Kementerian Pendidikan dan Kebudayaan terkait terbitnya Surat Edaran Rektor, dan dibutuhkan penelitian lebih lanjut dikarenakan penelitian ini dilakukan pada masa COVID-19 yang bersifat temporal.�

scholarly journals Cancer of Unknown Primary: Challenges and Progress in Clinical Management

Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 451
Author(s):  
Noemi Laprovitera ◽  
Mattia Riefolo ◽  
Elisa Ambrosini ◽  
Christiane Klec ◽  
Martin Pichler ◽  
...  
Keyword(s):  
Current Knowledge ◽  
Distant Metastases ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
Diagnostic Strategies ◽  
Molecular Features ◽  
Tissue Of Origin ◽  
Novel Therapeutic Strategies ◽  
Aggressive Clinical Behavior

Distant metastases are the main cause of cancer-related deaths in patients with advanced tumors. A standard diagnostic workup usually contains the identification of the tissue-of-origin of metastatic tumors, although under certain circumstances, it remains elusive. This disease setting is defined as cancer of unknown primary (CUP). Accounting for approximately 3–5% of all cancer diagnoses, CUPs are characterized by an aggressive clinical behavior and represent a real therapeutic challenge. The lack of determination of a tissue of origin precludes CUP patients from specific evidence-based therapeutic options or access to clinical trial, which significantly impacts their life expectancy. In the era of precision medicine, it is essential to characterize CUP molecular features, including the expression profile of non-coding RNAs, to improve our understanding of CUP biology and identify novel therapeutic strategies. This review article sheds light on this enigmatic disease by summarizing the current knowledge on CUPs focusing on recent discoveries and emerging diagnostic strategies.

scholarly journals Applicability of Cork as Novel Modifiers to Develop Electrochemical Sensor for Caffeine Determination

Materials ◽  
2020 ◽  
Vol 14 (1) ◽  
pp. 37
Author(s):  
Mayra K. S. Monteiro ◽  
Djalma R. Da Silva ◽  
Marco A. Quiroz ◽  
Vítor J. P. Vilar ◽  
Carlos A. Martínez-Huitle ◽  
...  
Keyword(s):  
Electrochemical Sensor ◽  
Linear Response ◽  
High Performance ◽  
Low Cost ◽  
Pharmaceutical Formulations ◽  
Caffeine Concentration ◽  
Real Samples ◽  
Wide Range ◽  
Potential Use

This study aims to investigate the applicability of a hybrid electrochemical sensor composed of cork and graphite (Gr) for detecting caffeine in aqueous solutions. Raw cork (RAC) and regranulated cork (RGC, obtained by thermal treatment of RAC with steam at 380 °C) were tested as modifiers. The results clearly showed that the cork-graphite sensors, GrRAC and GrRGC, exhibited a linear response over a wide range of caffeine concentration (5–1000 µM), with R2 of 0.99 and 0.98, respectively. The limits of detection (LOD), estimated at 2.9 and 6.1 µM for GrRAC and GrRGC, suggest greater sensitivity and reproducibility than the unmodified conventional graphite sensor. The low-cost cork-graphite sensors were successfully applied in the determination of caffeine in soft drinks and pharmaceutical formulations, presenting well-defined current signals when analyzing real samples. When comparing electrochemical determinations and high performance liquid chromatography measurements, no significant differences were observed (mean accuracy 3.0%), highlighting the potential use of these sensors to determine caffeine in different samples.

scholarly journals Influence of a Natural Plant Antioxidant on the Ageing Process of Ethylene-norbornene Copolymer (Topas)

2021 ◽  
Vol 22 (8) ◽  
pp. 4018
Author(s):  
Anna Masek ◽  
Angelika Plota
Keyword(s):  
Mechanical Properties ◽  
Food Packaging ◽  
Colour Change ◽  
Good Alternative ◽  
Plant Origin ◽  
Aging Behavior ◽  
Current State ◽  
Ft Ir ◽  
Potential Use

In the field of polymer technology, a variety of mainly synthetic additives are used to stabilize the materials during processing. However, natural compounds of plant origin can be a green alternative to chemicals such as synthetic polyphenols. An analysis of the effect of hesperidin on the aging behavior of ethylene-norbornene copolymer was performed. The evaluation of changes in the tested samples was possible by applying the following tests: determination of the surface energy and OIT values, mechanical properties analysis, colour change measurements, FT-IR and TGA analyses. The obtained results proved that hesperidin can be effectively used as natural stabilizer for polymers. Furthermore, as a result of this compound addition to Topas-silica composites, their surface and physico-mechanical properties have been improved and the resistance to aging significantly increased. Additionally, hesperidin can act as a dye or colour indicator and only few scientific reports describe a possibility of using flavonoids to detect changes in products during their service life, e.g., in food packaging. In the available literature, there is no information about the potential use of hesperidin as a stabilizer for cycloolefin copolymers. Therefore, this approach may contribute not only to the current state of knowledge, but also presents an eco-friendly solution that can be a good alternative to synthetic stabilizers.

Why Repentance Affects Divine Punishment but Not Human Punishment?

2015 ◽  
Vol 4 (1) ◽  
pp. 96-115
Author(s):  
Shoval Shafat
Keyword(s):  
Criminal Law ◽  
Human Beings ◽  
The Status ◽  
Divine Punishment ◽  
Divine Mercy ◽  
Rabbinic Courts

The aim of the discussion in this article is to explore two different Rabbinic explanations for the status of repentance in human and divine punishment, and to emphasize the essential distinction between them. According to the first explanation the source of accepting repentance is divine mercy upon human beings. Since mercy is not a legitimate consideration in conviction or even in determination of punishment in Jewish criminal law there is no wonder why repentance does not have any role during the criminal procedures in rabbinic court. According to the second explanation the acceptance of repentance by God is similar to the acceptance of flattery and bribe by a Roman corrupted judge. God decides to accept repentance and to forgive the transgressors since it better serves God’s interests. This analogy between repentance and flattery and bribery then explains why rabbinic courts do not take repentance into account.

The champions' mitochondria: is it genetically determined? A review on mitochondrial DNA and elite athletic performance

2011 ◽  
Vol 43 (13) ◽  
pp. 789-798 ◽  
Author(s):  
Nir Eynon ◽  
María Morán ◽  
Ruth Birk ◽  
Alejandro Lucia
Keyword(s):  
Mitochondrial Dna ◽  
Endurance Exercise ◽  
Current Knowledge ◽  
Geographic Origin ◽  
Aerobic Performance ◽  
East African ◽  
Athletic Status ◽  
The Status ◽  
Genetically Determined ◽  
Mtdna Variants

Aerobic ATP generation by the mitochondrial respiratory oxidative phosphorylation system (OXPHOS) is a vital metabolic process for endurance exercise. Notably, mitochondrial DNA (mtDNA) codifies 13 of the 83 polypeptides implied in the respiratory chain. As such, there is a strong rationale for identifying an association between mtDNA variants and “aerobic” (endurance) exercise phenotypes. The aim of this review is to summarize current knowledge on the association between mtDNA, nuclear genes involved in mitochondriogenesis, and elite endurance athletic status. Several studies in nonathletic people have demonstrated an association between certain mtDNA lineages and aerobic performance, characterized by maximal oxygen uptake (V̇o2max). Whether mtDNA haplogroups are also associated with the status of being an elite endurance athlete is more controversial, with differences between studies arising from the different ethnic backgrounds of the athletic cohorts (Caucasian of mixed geographic origin, Asiatic, or East African).

Potential use of biomarkers for the clinical evaluation of sarcoidosis

2021 ◽  
pp. jim-2020-001659
Author(s):  
Amir Mousapasandi ◽  
Cristan Herbert ◽  
Paul Thomas
Keyword(s):  
Clinical Evaluation ◽  
Clinical Presentation ◽  
Current Knowledge ◽  
Epithelioid Cell ◽  
Pulmonary Sarcoidosis ◽  
Biological Molecules ◽  
Unknown Etiology ◽  
Chronic Antigenic Stimulation ◽  
Host Genetic ◽  
Potential Use

Sarcoidosis is a systemic granulomatous disease of unknown etiology and pathogenesis with a heterogeneous clinical presentation. In the appropriate clinical and radiological context and with the exclusion of other diagnoses, the disease is characterized by the pathological presence of non-caseating epithelioid cell granulomas. Sarcoidosis is postulated to be a multifactorial disease caused by chronic antigenic stimulation. The immunopathogenesis of sarcoidosis encompasses a complex interaction between the host, genetic factors and postulated environmental and infectious triggers, which result in granuloma development.The exact pathogenesis of the disease has yet to be elucidated, but some of the inflammatory pathways that play a key role in disease progression and outcomes are becoming apparent, and these may form the logical basis for selecting potential biomarkers.Biomarkers are biological molecules that are altered pathologically. To date, there exists no single reliable biomarker for the evaluation of sarcoidosis, either diagnostically or prognostically but new candidates are emerging. A diagnosis of sarcoidosis ideally requires a biopsy confirming non-caseating granulomas, but the likelihood of progression that requires intervention remains unpredictable. These challenging aspects could be potentially resolved by incorporating biomarkers into clinical practice for both diagnosis and monitoring disease activity.This review outlines the current knowledge on sarcoidosis with an emphasis on pulmonary sarcoidosis, and delineates the understanding surrounding the implication of biomarkers for the clinical evaluation of sarcoidosis.

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