scholarly journals Health Beneficial Properties of Spirulina in Preventing Non-Communicable Diseases - The Green Metabolic Regulator from the Sea

2021 ◽  
Vol 50 (3) ◽  
pp. 803-819
Author(s):  
SOPHIA OGECHI EKEUKU ◽  
IMA-NIRWANA SOELAIMAN ◽  
KOK-YONG CHIN
Keyword(s):  
Neurological Disorders ◽  
Metabolic Disorders ◽  
Communicable Diseases ◽  
Efficacy And Safety ◽  
Duration Of Treatment ◽  
Non Communicable Diseases ◽  
Beneficial Effects ◽  
Nutritional Components ◽  
Anti Inflammatory ◽  
And Oxidative Stress

Sains Malaysiana 50(3)(2021): 803-819http://dx.doi.org/10.17576/jsm-2021-5003-21Health Beneficial Properties of Spirulina in Preventing Non-Communicable Diseases - The Green Metabolic Regulator from the Sea(Manfaat Kesihatan Spirulina dalam Mencegah Penyakit Tidak Berjangkit - Pengatur Metabolik Hijau dari Laut)SOPHIA OGECHI EKEUKU, IMA-NIRWANA SOELAIMAN, KOK-YONG CHIN*ABSTRACTSpirulina is a type of cyanobacteria containing various micro- and macronutrients and has been used as a functional food. Due to its nutritional components, spirulina possesses antioxidant and anti-inflammatory properties, which can potentially prevent non-communicable diseases (NCDs) triggered by inflammation and oxidative stress. This review aims to provide an overview of the effects of spirulina supplementation on NCDs derived from cellular, animals, and human studies. The current literature generally showed that spirulina could protect against NCDs, such as metabolic disorders, osteoporosis, gastric ulcer, hepatic, renal, and neurological disorders. These beneficial effects were mediated through the antioxidant and anti-inflammatory effects of spirulina and seem to be dependent on dose and duration of treatment. Despite the abundance of preclinical studies, human clinical trials validating the effects of spirulina on NCDs are lacking. These preclinical findings warrant a proper clinical trial to evaluate the efficacy and safety of spirulina supplementation in protecting human against NCDs.

scholarly journals Oleuropein, a Bioactive Compound from Olea europaea L., as a Potential Preventive and Therapeutic Agent in Non-Communicable Diseases

Antioxidants ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 578 ◽  
Author(s):  
Chiara Nediani ◽  
Jessica Ruzzolini ◽  
Annalisa Romani ◽  
Lido Calorini
Keyword(s):  
Olea Europaea ◽  
Kidney Diseases ◽  
Critical Role ◽  
Communicable Diseases ◽  
Non Communicable Diseases ◽  
Beneficial Effects ◽  
Olea Europaea L ◽  
Anti Cancer ◽  
Anti Inflammatory ◽  
Olea Europaéa

Growing scientific literature data suggest that the intake of natural bioactive compounds plays a critical role in preventing or reducing the occurrence of human chronic non-communicable diseases (NCDs). Oleuropein, the main phenolic component of Olea europaea L., has attracted scientific attention for its several health beneficial properties such as antioxidant, anti-inflammatory, cardio- and neuro-protective, and anti-cancer. This article is a narrative review focused on the current literature concerning the effect of oleuropein in NCDs, such as neuro- and cardiovascular diseases, diabetes mellitus, chronic kidney diseases, and cancer, by its putative antioxidant and anti-inflammatory activity, but also for its other peculiar actions such as an autophagy inducer and amyloid fibril growth inhibitor and, finally, for its anti-cancer effect. Despite the increasing number of published studies, looking at the beneficial effects of oleuropein, there is limited clinical evidence focused on the benefits of this polyphenol as a nutraceutical product in humans, and many problems are still to be resolved about its bioavailability, bioaccessibility, and dosage. Thus, future clinical randomized trials are needed to establish the relation between the beneficial effects and the mechanisms of action occurring in the human body in response to the intake of oleuropein.

scholarly journals General Practitioners’ Autonomy in the Management of Non-Communicable Diseases (NCDs) in the JKN Era: Is It Feasible?

2019 ◽  
Vol 2 (3) ◽  
pp. 89
Author(s):  
Nur Afrainin Syah
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Heart Attack ◽  
Metabolic Disorders ◽  
Communicable Diseases ◽  
Increase Life Expectancy ◽  
Non Communicable Diseases ◽  
Indonesian Population ◽  
Type 2 Dm

Demographic, epidemiological, and nutritional transitions increase life expectancy, changes in lifestyles and behaviors of Indonesian people. These changes are resulting in a growing contribution of non-communicable diseases (NCDs) to morbidity and mortality, especially metabolic disorders, such as type 2 diabetes mellitus (DM), hypertension, and dyslipidemia. Approximately 10.9% of the Indonesian population above 15 years old suffers from type 2 DM (21.2 million) and 34.1% have hypertension (66.3 million) in 2018. These figures increase significantly from 2013 figure; 6.9% and 25.8% respectively1. The metabolic disorders, which in turn, are responsible for vascular problems such as renal failure, stroke, and heart attack. Not surprisingly, then, 60% of Indonesian national health insurance (JKN) funds are spent on the NCDs. This condition causes a deficit and threatens the sustainability of the JKN program.

scholarly journals Wine Intake in the Framework of a Mediterranean Diet and Chronic Non-Communicable Diseases: A Short Literature Review of the Last 5 Years

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 5045
Author(s):  
Simona Minzer ◽  
Ramon Estruch ◽  
Rosa Casas
Keyword(s):  
Mediterranean Diet ◽  
Dietary Habits ◽  
Intervention Strategy ◽  
Communicable Diseases ◽  
Non Communicable Diseases ◽  
Wine Consumption ◽  
Beneficial Effects ◽  
The Past ◽  
Positive Item ◽  
Determining Factor

Dietary habits are a determining factor of the higher incidence and prevalence of chronic non-communicable diseases (NCDs). In the aim to find a possible preventive and intervention strategy, the Mediterranean diet (MedDiet) has been proposed as an effective approach. Within the MedDiet, moderate wine consumption with meals is a positive item in the MedDiet score; however, recent studies have reported a dose-response association between alcohol consumption and higher risk of a large number of NCDs. This review aimed to evaluate the association between NCDs and wine consumption in the framework of the MedDiet, with a simple review of 22 studies of the highest-level literature published over the last five years. We found that the information regarding the effects of wine in different health outcomes has not varied widely over the past five years, finding inconclusive results among the studies evaluated. Most of the literature agrees that light to moderate wine intake seems to have beneficial effects to some extent in NCDs, such as hypertension, cancer, dyslipidemia and dementia, but no definitive recommendations can be made on a specific dose intake that can benefit most diseases.

scholarly journals Inflammation and Oxidative Stress in Chronic Kidney Disease—Potential Therapeutic Role of Minerals, Vitamins and Plant-Derived Metabolites

2019 ◽  
Vol 21 (1) ◽  
pp. 263 ◽  
Author(s):  
Shara Francesca Rapa ◽  
Biagio Raffaele Di Iorio ◽  
Pietro Campiglia ◽  
August Heidland ◽  
Stefania Marzocco
Keyword(s):  
Oxidative Stress ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Antioxidant Properties ◽  
Small Sample ◽  
Beneficial Effects ◽  
Antioxidant Agents ◽  
Antioxidative Agents ◽  
Anti Inflammatory ◽  
And Oxidative Stress

Chronic kidney disease (CKD) is a debilitating pathology with various causal factors, culminating in end stage renal disease (ESRD) requiring dialysis or kidney transplantation. The progression of CKD is closely associated with systemic inflammation and oxidative stress, which are responsible for the manifestation of numerous complications such as malnutrition, atherosclerosis, coronary artery calcification, heart failure, anemia and mineral and bone disorders, as well as enhanced cardiovascular mortality. In addition to conventional therapy with anti-inflammatory and antioxidative agents, growing evidence has indicated that certain minerals, vitamins and plant-derived metabolites exhibit beneficial effects in these disturbances. In the current work, we review the anti-inflammatory and antioxidant properties of various agents which could be of potential benefit in CKD/ESRD. However, the related studies were limited due to small sample sizes and short-term follow-up in many trials. Therefore, studies of several anti-inflammatory and antioxidant agents with long-term follow-ups are necessary.

Olive oil consumption can prevent non-communicable diseases and COVID-19 : Review

2021 ◽  
Vol 22 ◽  
Author(s):  
Debabrata Majumder ◽  
Mousumi Debnath ◽  
Kamal Nayan Sharma ◽  
Surinder Singh Shekhawat ◽  
G.B.K.S Prasad ◽  
...  
Keyword(s):  
Olive Oil ◽  
Mediterranean Diet ◽  
Communicable Diseases ◽  
Potential Candidate ◽  
Oil Consumption ◽  
Non Communicable Diseases ◽  
Phytochemical Composition ◽  
Upstream Processing ◽  
The Mediterranean ◽  
Anti Inflammatory

: The Mediterranean diet is appraised as the premier dietary regimen and its espousal is correlated with the prevention of degenerative diseases and extended longevity. The consumption of olive oil stands out as the most peculiar feature of the Mediterranean diet. Olive oil rich in various bioactive compounds like oleanolic acid, oleuropein, oleocanthal, and hydroxytyrosol is known for its anti-inflammatory as well as cardioprotective property. Recently in silico studies have indicated that phytochemicals present in olive oil are a potential candidate to act against SARS-CoV-2. Although extensive studies on olive oil and its phytochemical composition; still, some lacunas persist in understanding how the phytochemical composition of olive oil is dependent on upstream processing. The signaling pathways regulated by olive oil in the restriction of various diseases is also not clear. To answer these queries, a detailed search of research and review articles published between 1990 to 2019 were reviewed in this effect. Olive oil consumption was found to be advantageous for various chronic non-communicable diseases. Olive oil’s constituents are having potent anti-inflammatory activities and thus restrict the progression of various inflammation-linked diseases ranging from arthritis to cancer. But it is also notable that the amount and nature of phytochemical composition of household olive oil are regulated by its upstream processing and the physicochemical properties of this oil can give a hint regarding the manufacturing method as well as its therapeutic. Moreover, daily uptake of olive oil should be monitored as excessive intake can cause body weight gain and change in the basal metabolic index. So, it can be concluded that olive oil consumption is beneficial for human health, and particularly for the prevention of cardiovascular diseases, breast cancer, and inflammation. The simple way of processing olive oil maintains the polyphenol constituents and provides more protection against non-communicable diseases and SARS-CoV-2.

scholarly journals Role of Polyphenols and Other Phytochemicals on Molecular Signaling

2015 ◽  
Vol 2015 ◽  
pp. 1-15 ◽  
Author(s):  
Swapna Upadhyay ◽  
Madhulika Dixit
Keyword(s):  
Chronic Diseases ◽  
Molecular Signaling ◽  
Beneficial Effects ◽  
Profound Knowledge ◽  
Anti Inflammatory ◽  
Voltage Gated Ion Channels ◽  
Circulating Levels ◽  
And Oxidative Stress ◽  
Significant Attention

Optimized nutrition through supplementation of diet with plant derived phytochemicals has attracted significant attention to prevent the onset of many chronic diseases including cardiovascular impairments, cancer, and metabolic disorder. These phytonutrients alone or in combination with others are believed to impart beneficial effects and play pivotal role in metabolic abnormalities such as dyslipidemia, insulin resistance, hypertension, glucose intolerance, systemic inflammation, and oxidative stress. Epidemiological and preclinical studies demonstrated that fruits, vegetables, and beverages rich in carotenoids, isoflavones, phytoestrogens, and phytosterols delay the onset of atherosclerosis or act as a chemoprotective agent by interacting with the underlying pathomechanisms. Phytochemicals exert their beneficial effects either by reducing the circulating levels of cholesterol or by inhibiting lipid oxidation, while others exhibit anti-inflammatory and antiplatelet activities. Additionally, they reduce neointimal thickening by inhibiting proliferation of smooth muscle cells and also improve endothelium dependent vasorelaxation by modulating bioavailability of nitric-oxide and voltage-gated ion channels. However, detailed and profound knowledge on specific molecular targets of each phytochemical is very important to ensure safe use of these active compounds as a therapeutic agent. Thus, this paper reviews the active antioxidative, antiproliferative, anti-inflammatory, or antiangiogenesis role of various phytochemicals for prevention of chronic diseases.

scholarly journals Melatonin May Increase Anticancer Potential of Pleiotropic Drugs

2018 ◽  
Vol 19 (12) ◽  
pp. 3910 ◽  
Author(s):  
Bianka Bojková ◽  
Peter Kubatka ◽  
Tawar Qaradakhi ◽  
Anthony Zulli ◽  
Karol Kajo
Keyword(s):  
Cancer Risk ◽  
Adjuvant Therapy ◽  
Cancer Prevention ◽  
Metabolic Disorders ◽  
Preclinical Studies ◽  
Beneficial Effects ◽  
Prevention Therapy ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Cancer And Inflammation

Melatonin (N-acetyl-5-methoxytryptamine) is not only a pineal hormone, but also an ubiquitary molecule present in plants and part of our diet. Numerous preclinical and some clinical reports pointed to its multiple beneficial effects including oncostatic properties, and as such, it has become one of the most aspiring goals in cancer prevention/therapy. A link between cancer and inflammation and/or metabolic disorders has been well established and the therapy of these conditions with so-called pleiotropic drugs, which include non-steroidal anti-inflammatory drugs, statins and peroral antidiabetics, modulates a cancer risk too. Adjuvant therapy with melatonin may improve the oncostatic potential of these drugs. Results from preclinical studies are limited though support this hypothesis, which, however, remains to be verified by further research.

ANALYSIS OF METABOLIC DISORDERS IN POLYMORBID PATHOLOGY

2021 ◽  
pp. 51-56
Author(s):  
Марина Михайловна Романова ◽  
Алексей Викторович Чернов ◽  
Елена Альбертовна Борисова ◽  
Ирина Леонидовна Панина
Keyword(s):  
Risk Factors ◽  
Health Care ◽  
Nutritional Status ◽  
Metabolic Disorders ◽  
Survey Methods ◽  
Communicable Diseases ◽  
Medical Rehabilitation ◽  
Scientific Medicine ◽  
Non Communicable Diseases ◽  
The Individual

Хронические неинфекционные заболевания представляют наиболее большую группу болезней современного человека, вносят наибольший вклад в общую смертность, инвалидизацию населения. Коморбидная и полиморбидная патология занимает особое место в научной медицине и практическом здравоохранении и нуждается в дальнейшем всестороннем изучении. Статья посвящена изучению и анализу распространенности нарушений метаболизма, нутритивного статуса и факторов риска хронических неинфекционных заболеваний у больных с коморбидной и полиморбидной соматической патологией. Применялись методы анкетирования с помощью специальных опросников, комплексная методика оценки пищевого статуса, статистические методы обработки полученных данных с применением компьютерных программ. В выборке пациентов с коморбидными хроническими неинфекционными заболеваниями наблюдалась высокая распространенность нарушений нутритивного статуса, метаболизма, факторов риска хронических неинфекционных заболеваний. При наличии полиморбидности изменения были достоверно более выражены. Выявлены тесные корреляционные связи между отдельными изучаемыми параметрами. Результаты исследования следует учитывать при проведении дальнейших научных исследований, а также в практической медицине рамках трехуровневой и трехэтапной системы организации отечественного здравоохранения, в том числе при оказании медицинской помощи по медицинской реабилитации Chronic non-communicable diseases represent the largest group of diseases of modern man, make the greatest contribution to the overall mortality and disability of the population. Comorbid and polymorbid pathology occupies a special place in scientific medicine and practical health care and needs further comprehensive study. The article is devoted to the study and analysis of the prevalence of metabolic disorders, nutritional status and risk factors for chronic non-communicable diseases in patients with comorbid and polymorbid somatic pathology. We used survey methods using special questionnaires, a comprehensive method for assessing nutritional status, and statistical methods for processing the data obtained using computer programs. In the sample of patients with comorbid chronic non-communicable diseases, there was a high prevalence of violations of nutritional status, metabolism, and risk factors for chronic non-communicable diseases. In the presence of polymorbidity, the changes were significantly more pronounced. Close correlations between the individual parameters studied were revealed. The results of the study should be taken into account when conducting further scientific research, as well as in practical medicine within the framework of a three-level and three-stage system of organizing national health care, including when providing medical care for medical rehabilitation

scholarly journals Substance Abuse and BMI Are Associated with Increased Inflammation and Oxidative Stress in Participants of the Miami Adult Studies on HIV (MASH) Cohort

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1521-1521
Author(s):  
Nicholas Gonzalez ◽  
Jacqueline Hernandez ◽  
Colby Teeman ◽  
Yongjun Huang ◽  
Jose Bastida Rodriguez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Communicable Diseases ◽  
Normal Weight ◽  
People Living With Hiv ◽  
Cigarette Use ◽  
Hiv Status ◽  
Non Communicable Diseases ◽  
Cocaine Use ◽  
Cocaine Users ◽  
And Oxidative Stress

Abstract Objectives Inflammation and oxidative stress are considered important factors in the development of non-communicable diseases with aging. We determined associations between body mass index (BMI), oxidative stress (OS), and inflammation in people living with HIV (PLWH) and un-infected substance users. Methods Overweight/obesity (OW/OB) was defined as BMI ≥ 25 and normal weight (NW) as BMI ≤ 24.9 in participants of the MASH cohort. Cocaine use was assessed with questionnaires and urine toxicology. Smoking was assessed with questionnaires. Blood was collected to assess inflammation (high sensitivity C-reactive protein [hsCRP] >3 m/L) by LabCorp, and OS with ARBOR ASSAYS (Ann Arbor, MI) glutathione colorimetric detection kit with %oxidized glutathione above median (>2.33%) as elevated. HIV viral load (VL) was obtained from medical charts. Regressions compared substance-abusing PLWH and un-infected people and controlled for age, sex, HIV status, and BMI. Results Mean age of the 605 participants was 54.4 ± 7.4 years, 54.7% male, 70.1% Black; 76% were OW/OB; 73% used cocaine and smoked cigarettes. PLWH comprised 45.5% of the population and 75% had suppressed VL. Regardless of HIV status, OW/OB cocaine users had higher odds for inflammation (OR = 3.1, 95% CI: 1.7–5.6, P < 0.001) and higher OS (OR = 2.0, 95% CI: 1.1–3.4, P = 0.018) than NW cocaine users. OW/OB cocaine + cigarette users also had higher odds for inflammation (OR = 2.6, 95% CI: 1.6–4.2, P = 0.001) and higher OS (OR = 1.9, 95% CI: 1.2–2.9, P = 0.006) than NW cocaine + cigarette users. There were no differences in inflammation or OS between OW/OB cocaine alone or with cigarette use and non-users (P = 0.707). HIV status was not independently associated with inflammation or high OS (P > 0.33). Conclusions These results indicated that OW/OB is associated with higher levels of inflammation and oxidative stress than normal weight even when accompanied with cocaine use as well as cocaine + cigarette use. These findings suggest that the use of substances does not increase inflammation or OS beyond overweight/obesity. In addition, in this cohort, with largely suppressed VL, HIV status was not independently associated with greater inflammation or OS. OW/OB is prevalent among PLWH and healthy people and may play an important role in the development of non-communicable diseases. Funding Sources National Institute on Drug Abuse.

scholarly journals Seafood Intake as a Method of Non-Communicable Diseases (NCD) Prevention in Adults

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1422
Author(s):  
Dominika Jamioł-Milc ◽  
Jowita Biernawska ◽  
Magdalena Liput ◽  
Laura Stachowska ◽  
Zdzisław Domiszewski
Keyword(s):  
Healthy Lifestyle ◽  
Meta Analysis ◽  
Premature Mortality ◽  
Well Being ◽  
Communicable Diseases ◽  
Therapeutic Effects ◽  
Food Groups ◽  
Non Communicable Diseases ◽  
Chronic Respiratory Diseases ◽  
Beneficial Effects

Seafood (fish in particular) is one of the main food groups in nutrition models with proven health benefits. Seafood has long been considered a very valuable dietary component, mainly due to presence of n-3 polyunsaturated fatty acids (n-3 PUFA) but it is also an important source of protein (including collagen), anserine, taurine, iodine, selenium, vitamin A, vitamin K, vitamin D, tocopherols, B vitamins and astaxanthin. Considering the beneficial effects of these ingredients on blood pressure, lipid profile and the inflammatory process, seafood should be an essential component of the diet. Non-communicable diseases (NCD) such as cardiovascular diseases, cancer, diabetes and mental disorder, chronic respiratory diseases are common diseases associated with advanced age. Promotion of a healthy lifestyle (including proper nutritional behavior) and prevention of diseases are the most effective and efficient ways to decrease premature mortality from NCD and to maintain mental health and well-being. This review article shows the potential preventive and therapeutic effects of seafood with an emphasis on fish. Our narrative review presents the results of systematic reviews and meta-analysis.

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