MEDICAL COLLEGE STUDENTS HEALTH CHANGES DURING THE STUDY PERIOD

The goal of this research is to analyze the change of students’ physical health during the one year of studies in context of lifestyle. The research participants were 103 Medical College’s students aged 19 to 56 years. All tests, measurements and questionnaires were done at falls of 2015 and 2016. Students’ physical health was evaluated in accordance with Apanasenko’s methods based on investigative anthropometric and functional testing measurements. These measurements included body mass index, lungs vital capacity, strength index, Robinson index and Recovery Heart Rate. Students’ lifestyle habits were determined with the help of questionnaire that included question groups regarding the self-evaluation of health status, health problems and illnesses, eating habits, and physical activities. During the research, lipid parameters in blood were also measured determining the total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL).

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The Connection between Young Students' Physical Health and Their Lifestyle

SOCIETY INTEGRATION EDUCATION Proceedings of the International Scientific Conference ◽

10.17770/sie2015vol3.468 ◽

2015 ◽

Vol 3 ◽

pp. 521

Author(s):

Rita Geske ◽

Alevtīna Leice ◽

Madara Miķelsone ◽

Laila Kudrjavceva

Keyword(s):

Physical Health ◽

Vital Capacity ◽

Eating Habits ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Self Evaluation ◽

The Status ◽

Young Students ◽

Formed Part ◽

Lipid Parameters

The goal of this research is to analyze the status of young students’ physical health and its connection with lifestyle. The research participants were 107 Medical College’s 1st year students that formed part of the youth category as it is defined in Latvia, i.e., up until the age of 25. Students’ physical health was evaluated in accordance with Apanasenko’s methods based on investigative anthropometric and functional testing measurements. These measurements included body mass index, vital capacity, strength index, Robinson index and Recovery Heart Rate. Students’ lifestyle habits were determined with the help of questionnaire that included question groups regarding the self-evaluation of health status, health problems and illnesses, eating habits, bad habits, rest and physical activities. During the research, lipid parameters in blood were also measured determining the total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL).

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Estimation of the presence of small dense lipoprotein cholesterol in acute ischemic stroke

Neurology International ◽

10.4081/ni.2015.5973 ◽

2015 ◽

Vol 7 (1) ◽

Cited By ~ 5

Author(s):

Yasuhiro Manabe ◽

Ryuta Morihara ◽

Kosuke Matsuzono ◽

Yumiko Nakano ◽

Yoshiaki Takahashi ◽

...

Keyword(s):

Ischemic Stroke ◽

Acute Ischemic Stroke ◽

Poor Prognosis ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Standard Laboratory ◽

Laboratory Methods ◽

Established Risk Factor ◽

The One ◽

Lipid Parameters

Small dense low-density lipoprotein (sdLDL) is an established risk factor in ischemic heart disease. However, its clinical significance in acute ischemic stroke (AIS) is uncertain. This study evaluates the prognostic value of the presence of sdLDL in patients with AIS by determining whether it contributes to clinical outcome or not. We studied 530 consecutive patients admitted within the first 48 hours after onset of ischemic stroke and 50 corresponding controls. Serum lipid parameters were measured on admission by standard laboratory methods. The percentage of AIS patients with sdLDL was significantly higher than the one of matched controls with sdLDL. Concerning comparisons between AIS patients with or without sdLDL, the percentages of males and patients with histories of smoking, hypertension, and cardiovascular disease were significantly higher in AIS patients with sdLDL. Concerning the grade of severity, modified Rankin Scale (mRS) on discharge was significantly higher in AIS patients with sdLDL. On logistic regression analysis, age (OR=2.29, P3). Our study showed that the presence of sdLDL might be independently associated with a poor prognosis after AIS.

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Psycho-Social Factors in Patients with Cardiovascular Disease Attending a Family-Centred Prevention and Rehabilitation Programme: EUROACTION Model in Spain

Life ◽

10.3390/life11020089 ◽

2021 ◽

Vol 11 (2) ◽

pp. 89

Author(s):

Cristina Buigues ◽

Ana Queralt ◽

Jose Antonio De Velasco ◽

Antonio Salvador-Sanz ◽

Catriona Jennings ◽

...

Keyword(s):

Social Factors ◽

Illness Perceptions ◽

Vegetable Consumption ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Cardiovascular Prevention ◽

Anxiety And Depression ◽

Coronary Patients ◽

Low Levels ◽

One Year

Background: Coronary heart disease (CHD) persists as the leading cause of death worldwide. Cardiovascular prevention and rehabilitation (CVPR) has an interdisciplinary focus, and includes not only in physiological components, but it also addresses psycho-social factors. Methods: The study analysed the Spanish psycho-social data collected during the EUROACTION study. In Spain, two hospitals were randomised in the Valencia community. Coronary patients were prospectively and consecutively identified in both hospitals. The intervention hospital carried out a 16-week CVPR programme, which aimed to assess illness perceptions and establish healthy behaviours in patients and their partners. Results: Illness perceptions were significantly and inversely associated with anxiety and depression. Low levels of anxiety were associated with better self-management of total cholesterol (p = 0.004) and low-density lipoprotein-cholesterol (p = 0.004). There was concordance at one year among patients and partners who participated in the programme related to anxiety (p < 0.001), fruit consumption (p < 0.001), and vegetable consumption (p < 0.001). Conclusions: The EUROACTION study emphasised the importance of assessing psycho-social factors in a CVPR programme and the inclusion of family as support in patients’ changes in behaviour.

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Antioxidant and Chemopreventive Effect of Aliophen® Formulation Based on Malts and Hops

Antioxidants ◽

10.3390/antiox10010029 ◽

2020 ◽

Vol 10 (1) ◽

pp. 29

Author(s):

Idolo Tedesco ◽

Carmela Spagnuolo ◽

Stefania Bilotto ◽

Angelo A. Izzo ◽

Francesca Borrelli ◽

...

Keyword(s):

Health Effects ◽

Low Density Lipoprotein ◽

Antioxidant Properties ◽

Density Lipoprotein ◽

Ldl Oxidation ◽

Preneoplastic Lesions ◽

Chemically Induced ◽

Chemopreventive Effect ◽

The One ◽

Higher Doses

Experimental and clinical studies evidenced the health effects of moderate consumption of beer, mainly due to the presence of bioactive compounds, such as polyphenols, vitamins, or fibers. To exploit the potential beneficial effect on health and in disease prevention of these compounds, a new beverage based on barley malts and hops named Aliophen® has been designed, through a patented production process, with a high total polyphenolic amount compared to alcohol-free beer and similar to the one present in light and dark beers. In the present study, the antioxidant activity of Aliophen® against low-density lipoprotein (LDL) oxidation and its ability to protect erythrocytes from hemolysis have been characterized. Moreover, the chemopreventive effect of Aliophen® against colon cancer has been assessed, employing a mouse model of chemically induced carcinogenesis using azoxymethane (AOM). Data obtained showed that Aliophen at a low dose (3 mg/kg) inhibited the formation of preneoplastic lesions, polyps, and tumors. At higher doses (300 mg/kg) the protective effect was measured in the first phase of the onset of cancer. The antioxidant properties of Aliophen® were also observed in AOM-treated mice where it increased the serum antioxidant capacity. Based on the data presented, Aliophen® can exert promising health effects, including an anticancer capacity presumably associated with its antioxidant properties.

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Correlation of Serum Low Density Lipoprotein Cholesterol and High Density Lipoprotein Cholesterol with Type 2 Diabetes Mellitus

Journal of Dhaka Medical College ◽

10.3329/jdmc.v26i2.38832 ◽

2018 ◽

Vol 26 (2) ◽

pp. 140-147

Author(s):

Nahid Yeasmin ◽

Qazi Shamima Akhter ◽

Sayeeda Mahmuda ◽

Sultana Yeasmin ◽

Rumana Afroz ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Low Density ◽

Low Density Lipoprotein Cholesterol ◽

Fasting Serum ◽

Medical College

Background: Diabetes mellitus is one of the most widespread endocrine disorders in female and its complications are increasing all over the world, leading to life threatening medical problems like cardiovascular diseases, stroke and end stage renal diseases. A correlation between hyperlipidemia and type 2 diabetes mellitus has been identified. The study was carried out to observe the correlation of serum low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) level with type 2 diabetes mellitus in adult female subjects.Method: This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka, during the period of January 2011 to December 2011. Total sixty female subjects were selected with age ranging from 30 to 50 years. Among them 30 female subjects with diabetes mellitus were included from out-patient department of Endocrinology, Dhaka Medical College Hospital, Dhaka as study group (B) and 30 apparently healthy females were taken as control group (A) for comparison. Estimation of serum fasting serum LDL-C and HDL-C levels was done by enzymatic method in the department of Physiology, Dhaka Medical College Dhaka in both groups. Fasting serum insulin level was measured by ELISA method in the laboratory of National Institute of ENT, Dhaka and fasting blood glucose was estimated by glucose oxidase method in the department of Physiology, Dhaka Medical College in both groups. Data were analyzed by Unpaired Student’s- test and Pearson’s correlation co-efficient (r) test as applicable.Results: The value of fasting serum LDL-C level was significantly higher in study subjects than those of control. Again, fasting serum HDL-C level was significantly lower in study subjects in comparison to controls. In study subjects fasting serum LDL showed positive correlation and fasting serum HDL-C levels showed negative correlation with fasting blood glucose and serum insulin level.Conclusion: Present study reveals that serum insulin and blood glucose level have positive relationship with low density lipoprotein cholesterol (LDL-C) and negative relationship with high density lipoprotein cholesterol (HDL-C) levels.J Dhaka Medical College, Vol. 26, No.2, October, 2017, Page 140-147

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Abstract TMP16: Morphologic Evolution and Remodelling of Intracranial Atherosclerosis Under Intensive Risk Factor Control

Stroke ◽

10.1161/str.47.suppl_1.tmp16 ◽

2016 ◽

Vol 47 (suppl_1) ◽

Author(s):

Thomas Leung ◽

Yannie Soo ◽

Vincent Ip ◽

Ka Sing Wong ◽

Simon Yu

Keyword(s):

Risk Factor ◽

Medical Therapy ◽

Plaque Rupture ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Risk Factor Control ◽

Luminal Narrowing ◽

Atherosclerotic Stenosis ◽

Before And After ◽

One Year

Introduction: In SAMMPRIS, the benefit of aggressive medical therapy over stenting persisted throughout the extended follow-up. It is uncertain how modern medical management could diminish stroke relapses. Method: In a prospective academic-initiated study, we recruited 40 patients (mean age 63.4±9.0 years) with acute strokes attributed to high-grade (≥70%) intracranial atherosclerotic stenosis for 3D-rotational angiograms before and after intensive medical therapy for 12 months. Treatment targets included low-density lipoprotein <70 mg/dl; HbA1c <6.5%; and systolic blood pressure <140 mmHg. We analyzed the morphologic and geometric evolution of the symptomatic plaques. Results: Overall, the risk factor control reached the pre-specified intensity. Plaque thickness, and hence luminal narrowing, significantly diminished at one year (from 1.50±0.48 to 1.24±0.42mm; p<0.001). The site of maximal stenosis shifted significantly towards mid-portion of the plaque (p<0.001), leading to a diminished upstream angulation. The ulcers noted at baseline (n=3) had all healed by one year. There was no significant change in terms of plaque length or lesion eccentricity. Conclusion: Intracranial plaques might regress and positively remodel under intensive risk factor control. These morphologic changes might stabilise the plaques, alleviate unfavourable hemodynamics across the steno-occlusion, and hence reduce the risk of plaque rupture or platelet aggregation.

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The Relationship of Various Factors in the Pathogenesis of Atherosclerosis

Clinical and Applied Thrombosis/Hemostasis ◽

10.1177/107602969800400205 ◽

1998 ◽

Vol 4 (2) ◽

pp. 105-110 ◽

Cited By ~ 8

Author(s):

Hüseyin Sönmez ◽

Selma Süer ◽

Turgut Ulutin ◽

Emine Kökoglu ◽

Nergiz Uçişik

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Plasminogen Activator ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Tissue Type ◽

Control Group ◽

Low Density ◽

Lipid Parameters ◽

Pai 1

In this study we investigated the levels of lipid parameters, fibronectin, tissue-type plasminogen activator and plasminogen activator inhibitor (t-PA-PAI-1) complex and si alidase in patients with coronary heart disease and a control group. Total cholesterol, triglyceride, low-density lipoprotein (LDL), and very-low-density lipoprotein (VLDL) cholesterol and lipoprotein Lp(a), levels in patients with coronary heart disease were found to be significantly higher than in the control group (p < .001). High-density lipoprotein (HDL) cholesterol levels in patient group were significantly lower than control group (p < .001). Plasma fibronectin and t-PA-PAI-1 complex levels in patients with coronary heart disease were found to be significantly higher than control group (p < .05 and p < .001, respectively). In addition, we found that serum sialidase levels in patients with coronary heart disease were significantly higher than in the control group (p < .001). The electrophoretic mobility of lipoproteins from patients with coronary heart dis ease was found to be greater than those from the control group. As a result Lp(a) may play an important role in the pathogen esis of atherosclerosis by causing foam cell formation because of interacting with LDL or fibronectin and by interfering with the fibrinolytic system because of binding to plasminogen re ceptors. In addition, modifications of Lp(a) (including desi alylation) may effect these events. Key words: Coronary heart disease—tPA-PAI-1 complex-Fibronectin-sialidase-Lipid parameters.

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Uricase-deficient rat is generated with CRISPR/Cas9 technique

PeerJ ◽

10.7717/peerj.8971 ◽

2020 ◽

Vol 8 ◽

pp. e8971 ◽

Cited By ~ 1

Author(s):

Yun Yu ◽

Nan Zhang ◽

Xianxiang Dong ◽

Nan Fan ◽

Lei Wang ◽

...

Keyword(s):

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Urate Oxidase ◽

Male Rats ◽

Wild Type ◽

Sprague Dawley ◽

Normal Ranges ◽

Model Animal ◽

Renal Changes ◽

One Year

Urate oxidase (uricase, Uox) is a big obstacle for scientists to establish stable animal models for studying hyperuricemia and associated disorders. Due to the low survival rate of uricase-deficient mice, we generated a Uox-knockout model animal from Sprague Dawley (SD) rats using the CRISPR/Cas9 technique by deleting exons 2 to 4 of the Uox gene. The uricase-deficient rats were named “Kunming-DY rats”, and were apparently healthy with more than a 95% survival up to one year. The male rats’ serum uric acid (SUA) increased to 48.3 ± 19.1 µg/ml, significantly higher than those of wild-type rats. Some indexes of the blood fat like total triglyceride, low density lipoprotein, and renal function indexes including blood urea nitrogen and serum creatinine were significantly different from those of wild-type rats, however, all the indexes were close to or in normal ranges. Histological renal changes including mild glomerular/tubular lesions were observed in these uricase-deficient rats. Thus, “Kunming-DY rats” with stable uricase-deficiency were successfully established and are an alternative model animal to study hyperuricemia and associated diseases mimicking human conditions.

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Gender- and age-specific reference intervals of common biochemical analytes in chinese population – derivation using real laboratory data

Journal of Medical Biochemistry ◽

10.2478/jomb-2019-0046 ◽

2019 ◽

Vol 0 (0) ◽

Author(s):

Danchen Wang ◽

Chaochao Ma ◽

Yutong Zou ◽

Songlin Yu ◽

Honglei Li ◽

...

Keyword(s):

Low Density Lipoprotein ◽

Laboratory Data ◽

Density Lipoprotein ◽

Inorganic Phosphorus ◽

Reference Intervals ◽

Peking Union Medical College ◽

Lipoprotein Cholesterol ◽

Specific Reference ◽

College Hospital ◽

Medical College

Summary Background Indirect sampling methods are not only inexpensive but also efficient for establishing reference intervals (RIs) using clinical data. This study was conducted to select fully normal records to establish age- and gender-specific RIs for common biochemical analytes by laboratory data mining. Methods In total, 280,206 records from 2014 to 2018 were obtained from Peking Union Medical College Hospital. Common biochemical analytes [total protein, albumin, total bilirubin (TBil), direct bilirubin (DBil), alanine aminotransferase (ALT), glutamyltranspeptidase (GGT), alkaline phosphatase (ALP), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), potassium, sodium, chlorine, calcium, urea, glucose, uric acid (UA), inorganic phosphorus, creatinine (Cr), total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol] were measured using an automatic analyzer. Sources of variation were identified by multiple regression analysis. The 2.5th and 97.5th percentiles were calculated as the lower and upper limits of the RIs, respectively. Results Metode indirektnog uzorkovanja nisu samo jeftine, već su i efikasne za uspostavljanje referentnih intervala (RI) korišćenjem velike količine kliničkih podataka. Ova studija je sprovedena sa ciljem da se odaberu potpuno normalni pojedinačni zapisi da bi se utvrdio RI za starost i pol za zajedničke biohemijske analite pomoću laboratorijski dobijenih podataka. Conclusions Ukupno je uzeto 280.206 pojedinačnih rezultata u periodu od 2014. do 2018. godine iz bolnice Peking Union Medical College-a. Uobičajeni biohemijski analiti [ukupni protein, albumin, ukupni bilirubin (TBil), direktni bilirubin (DBil), alanin aminotransferaza (ALT), glutamiltranspeptidaza (GGT), alkalna fosfataza (ALP), aspartat aminotransferaza (AST), laktat dehidrogenaza (LAT) kalijum, natrijum, hlor, kalcijum, ureja, glukoza, mokraćna kiselina (UA), neorganski fosfor, kreatinin (Cr), ukupni hole sterol, trigliceridi, lipoprotein holesterola visoke gustine i lipoprotein holesterola niske gustine] mereni su korišćenjem automatskog analizatora. Izvori varijacije identifikovani su višestrukom regresionom analizom. Postoci (2,5 i 97,5) su izračunati kao donja i gornja granica RI, svaki ponaosob.

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Hepatocurative potentials of methanol extracts/fractions of Tapinanthus bangwensis and Moringa oleifera on carbon tetrachlorideinduced hepatotoxicity in Wistar rats

Ife Journal of Science ◽

10.4314/ijs.v22i2.1 ◽

2020 ◽

Vol 22 (2) ◽

pp. 001-014

Author(s):

G.O. Ihegboro ◽

A.J. Alhassan ◽

E. Afor ◽

C.J. Ononamadu ◽

T.A. Owolarafe ◽

...

Keyword(s):

Antioxidant Activity ◽

Wistar Rats ◽

Moringa Oleifera ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Mineral Elements ◽

Toxic Substances ◽

Methanol Extracts ◽

Lipid Parameters

Bioaccumulation of toxic substances in liver poses a serious threat to its functionality and consequently leads to damage/injury. Medicinal plants have been reported to be effective in the treatment and management of various diseases. The present study is aimed at evaluating the hepatocurative potentials of Tapinanthus bangwensis and Moringa oleifera on carbon tetrachloride-induced hepatotoxicity in Wistar rats. Atomic absorption spectroscopy (AAS) and ultraviolet-visible spectrophotometry were respectively used to assay for mineral elements and antioxidant activity of methanol extracts/fractions of T. bangwensis and M. oleifera. Concentrations of potassium in methanol extract of M. oleifera (MeCE 2) and magnesium in T. bangwensis (MeCE 1) were found to be significantly high (p < 0.05). Concentrations of trace elements were low in the range of 0.07 mg/kg to 0.60 mg/kg. The in vitro lipid peroxidation assay showed that ethylacetate fraction and acetone fraction of T. bangwensis (ETF 1 and ACF 1) respectively exhibited the strongest and lowest antioxidant activity compared to other extracts/fractions. Oral administration of methanol extracts/fractions of T. bangwensis and M. oleifera significantly increased superoxide dismutase (SOD) and catalase (CAT) activities, increased glutathione (GSH) level and decreased malondialdehyde (MDA) level. The liver function indices (or liver biomarkers) such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), albumin, total protein, total and conjugated bilirubin and lipid parameters (low density lipoprotein (LDL-c), cholesterol and triglyceride) were also significantly reduced. However high density lipoprotein (HDL-c) increased in the groups induced and treated with methanol extracts/fractions of T. bangwensis and M. oleifera compared to the group induced but untreated. It can be concluded that the plants possessed hepatocurative potential against CCl - 4 induced hepatotoxicity in Wistar rats Keywords: Bioaccumulation, Hepatotoxicity, Liver biomarkers, Moringa oleifera Tapinanthus bangwensis

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