scholarly journals Prognostic significance of mmp-1, mmp-3, and mthfr genetic polymorphism for evaluation of uterine leiomyoma and adenomyosis progression

2005 ◽  
Vol 54 (3) ◽  
pp. 55-59
Author(s):  
Е. В. Morozova ◽  
А. B. Chukhlovin ◽  
N. V. Kulagina ◽  
А. А. Totolian
Keyword(s):  
Uterine Leiomyoma ◽  
Clinical Course ◽  
Prognostic Significance ◽  
High Growth ◽  
Protective Role ◽  
Promoting Effect ◽  
Matrix Metalloproteinase 1 ◽  
Growth Promoting ◽  
Low Incidence

Carriage of hyperactive alleles of matrix metalloproteinase-1 (MMP-1) gene is associated with enhanced growth of various neoplasias in humans. When studying the frequency of promoter variants of MMP -1 and -3 genes in 170 patients with uterine leiomyoma, significant associations were revealed between low incidence of MMP-1 1G/1G genotype, high growth rates of leiomyoma, multifocal growth and more common adenomyosis development, thus presuming a protective role of MMP-1/1G homozygosity in the development of symptomatic myoma and adenomyosis and growth-promoting effect of the 2G allele. Hence, the promoter genotype of MMP-1 may be considered as possible genetic marker to predict clinical course of the uterine leiomyoma.

An Appraisal of the Role of Islamic Banking Development and Economic Growth

2020 ◽  
Vol 4 (4) ◽  
pp. 215-236
Author(s):  
Talat Hussain ◽  
Noman Arshed ◽  
Rukhsana Kalim
Keyword(s):  
Economic Growth ◽  
Resource Mobilization ◽  
Financial Inclusion ◽  
Islamic Banking ◽  
Islamic Banks ◽  
Promoting Effect ◽  
Efficient Resource ◽  
Growth Promoting ◽  
Banking Development

Literature is well-versed with the contribution of financial inclusion from the deposit and financing size and its role in economic growth. These contributions include a boost in economic transactions and efficient resource mobilization. Islamic financial system is different from conventional banking as it distributes the risk equitably and promotes fairness in dealings. It helps in the integration of business gains as a borrower of Islamic capital with the earnings of savers as depositors. This study has proposed two channels via which Islamic financial development may incur growth. First is bank financing penetration, and second is depositor financial inclusion. Based on the data of 41 full-fledged Islamic banks between 2012 and 2017, the results show that both increases in bank and depositor returns have a growth-promoting effect. This prompts the policymakers with new insights. Policymakers should increase Islamic banking penetration to different sectors and regulate for increased extraction of the depositor contribution from the banking financing activity.

Leukotriene D4-induced proliferation of glomerular epithelial cells: PKC- and Na+-H+ exchanger-mediated response

1989 ◽  
Vol 257 (2) ◽  
pp. C232-C239 ◽  
Author(s):  
L. Baud ◽  
J. Perez ◽  
G. Cherqui ◽  
E. J. Cragoe ◽  
R. Ardaillou
Keyword(s):  
Epithelial Cells ◽  
Growth Effect ◽  
Thymidine Uptake ◽  
Promoting Effect ◽  
Leukotriene D4 ◽  
Glomerular Epithelial Cells ◽  
Ic50 Values ◽  
Growth Promoting ◽  
Pkc Activation

The growth-promoting effect of leukotriene D4 (LTD4) has been observed in a variety of cells, including human glomerular epithelial cells. The purpose of this study was to determine the mechanisms underlying this process. LTD4 induction of [3H]thymidine uptake in human glomerular epithelial cells was blocked by the LTD4 receptor antagonist L648,051 when added in a 50-fold excess and by pertussis toxin. Neither drug affected basal DNA synthesis. These results suggest that the LTD4-mediated signal transduction implies activation of a GTP-binding protein that is coupled to a specific receptor. The possible role of protein kinase C (PKC) activation was also studied. In the presence of the PKC inhibitor H-7 or after downregulation of PKC levels by chronic treatment with phorbol ester, stimulation of [3H]thymidine uptake by LTD4 was greatly inhibited. Moreover, treatment of the cells by LTD4 resulted in a time-dependent increase of cytosolic PKC activity, whereas addition of phorbol 12-myristate 13-acetate reduced this activity. Therefore PKC-dependent mechanisms are likely to mediate the growth-promoting effect of LTD4. Finally, three approaches were used to determine the potential role of the Na+-H+ exchanger. First, progressive removal of extracellular Na+ using N-methyl-D-glucamine+ as a substitute inhibited LTD4-induced [3H]thymidine uptake with a 50% inhibitory concentration (IC50) of 85 mM. Second, addition of amiloride reduced the LTD4 growth effect with an IC50 of 6.5 microM, whereas three amiloride analogues exhibited lower IC50 values in accordance with their greater affinity for the Na+-H+ exchanger.(ABSTRACT TRUNCATED AT 250 WORDS)

Role of iron chelators in growth-promoting effect on mouse hybridoma cells in a chemically defined medium

1987 ◽  
Vol 23 (12) ◽  
pp. 815-820 ◽  
Author(s):  
Noritsugu Yabe ◽  
Miwa Kato ◽  
Yutaka Matsuya ◽  
Isao Yamane ◽  
Muneaki Iizuka ◽  
...  
Keyword(s):  
Defined Medium ◽  
Hybridoma Cells ◽  
Iron Chelators ◽  
Chemically Defined Medium ◽  
Promoting Effect ◽  
Growth Promoting

scholarly journals Holistic solution to an old "mystery": the global role of antibiotic consumption patterns in the spread of certain non-contagious diseases in EU countries

2020 ◽  
pp. 1-3
Author(s):  
Gábor Ternák
Keyword(s):  
Antibiotic Consumption ◽  
Human Beings ◽  
Promoting Effect ◽  
Contagious Diseases ◽  
Causative Factors ◽  
Animal Excreta ◽  
Slow Moving ◽  
Growth Promoting

The discovery and extensive utilization of antibiotics are highly contributed to the considerable lengthening life expectancy of human beings. Antibiotics, mixed with animal fodder, produced considerable growth promoting effect and hence, extended the indications of antibiotics at a much higher level. The indiscriminate use of antibiotics quickly resulted in the emergence of poly-resistant pathogens and the extensive antibiotic pollution of the environment, particularly of the surface water and rivers trough human and animal excreta. Along with extensive and ever increasing antibiotic consumption/pollution, the pandemic-like spreading of certain non-contagious diseases like obesity, diabetes (Type 1-2 T1DM, T2DM), Alzheimer disease (AD), Parkinson disease, multiple sclerosis (MS) etc. started unfolding, which was called as a slow moving disaster, without having any appropriate explanation of the phenomenon. The parallel appearance of those “pandemics”, which appeared simultaneously with the extensive antibiotic consumption, might indicate some kind of association. As far as several publications have reported the crucial role of altered gut flora in the development of metabolic disorders (diabetes, obesity) and neurodegenerative diseases alike (PD, AD, MS), it might be suspected that antibiotics, acting through the modification of microbiome, could influence the morbidity (prevalence) of those, non-infectious diseases. This concept, described below, might serve as a unified explanation, not excluding other, contributing causative factors, for the phenomenon, outlined above.

scholarly journals Papaya (Carica papaya L.) seed as a potent functional feedstuff for poultry – A review

2020 ◽  
Vol 13 (8) ◽  
pp. 1613-1619
Author(s):  
Sugiharto Sugiharto
Keyword(s):  
Steady Increase ◽  
Immunomodulatory Activity ◽  
Poultry Production ◽  
Growth Promoters ◽  
Promoting Effect ◽  
Antibiotic Growth Promoters ◽  
Growth Promoting ◽  
Protein Feed ◽  
Papaya Seed

The steady increase in the price of protein feed ingredients and the retraction of antibiotics from diets has encouraged nutritionists to search the alternatives for protein source and functional feedstuffs that can substitute the role of antibiotic growth promoters in poultry production. With crude protein of 24-30%, in vitro protein digestibility of 80% and proportion of essential amino acids of 47%, seed from ripe papaya may be exploited as the alternative protein feed ingredient for poultry. Moreover, the growth promoting effect, antimicrobial and antiparasitic activities, and immunomodulatory and antioxidative activities may confirm the potential of papaya seed as a functional feedstuff that could replace the role of antibiotic growth promoters for poultry. The in-depth study is needed to further elucidate the functionalities of papaya seed on poultry. This review provides the updates on the nutritional contents of papaya seed, the potential of papaya seed as an alternative to conventional protein-rich ingredient, the growth-promoting effect of feeding papaya seed, the antimicrobial and antiparasitic activities of papaya seed, antioxidative activities of papaya seed, and the immunomodulatory activity of papaya seed on poultry.

scholarly journals Structure Characterization of Polysaccharide from Chinese Yam (Dioscorea opposite Thunb.) and Its Growth-Promoting Effects on Streptococcus thermophilus

Foods ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 2698
Author(s):  
Jia Ou-Yang ◽  
Feng Wang ◽  
Wenjia Li ◽  
Qingming Li ◽  
Xiaojun Su
Keyword(s):  
Molecular Weight ◽  
Spatial Configuration ◽  
Deae Cellulose ◽  
High Growth ◽  
Streptococcus Thermophilus ◽  
Basic Structure ◽  
Structure Characterization ◽  
Promoting Effect ◽  
Relationship Analysis ◽  
Growth Promoting

To clarify the mechanisms underlying the growth-promoting effects of yam polysaccharide on Streptococcus thermophilus (S. thermophilus), the yam polysaccharide was extracted using a deep eutectic solvents (DESs) method and separated into four fractions by DEAE-cellulose 52. These fractions were used as the alternative carbon source to substitute lactose to compare their growth-promoting effects on S. thermophilus. Furthermore, their molecular weight, monosaccharide and functional groups’ composition, microscopic forms and other basic structure characterizations were analyzed. The results showed that all the fractions could significantly promote S. thermophilus growth, and fractions exhibited significantly different growth-promoting effects, whose viable count increased by 6.14, 6.03, 11.48 and 11.29%, respectively, relative to those in the M17 broth medium. Structure-activity relationship analysis revealed that the high growth-promoting activity of yam polysaccharide might be more dependent on the higher molecular weight, the higher galacturonic acid content and its complex spatial configuration, and the existence of β-glycosides would make the yam polysaccharide have a better growth-promoting effect on S. thermophilus.

Protective role of peroxiredoxin-4 in heart failure

2020 ◽  
Vol 134 (1) ◽  
pp. 71-72
Author(s):  
Naseer Ahmed ◽  
Masooma Naseem ◽  
Javeria Farooq
Keyword(s):  
Heart Failure ◽  
Cardiac Fibroblasts ◽  
Protective Role ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Total Antioxidant ◽  
Galectin 3 ◽  
Consequent Increase ◽  
And Oxidative Stress

Abstract Recently, we have read with great interest the article published by Ibarrola et al. (Clin. Sci. (Lond.) (2018) 132, 1471–1485), which used proteomics and immunodetection methods to show that Galectin-3 (Gal-3) down-regulated the antioxidant peroxiredoxin-4 (Prx-4) in cardiac fibroblasts. Authors concluded that ‘antioxidant activity of Prx-4 had been identified as a protein down-regulated by Gal-3. Moreover, Gal-3 induced a decrease in total antioxidant capacity which resulted in a consequent increase in peroxide levels and oxidative stress markers in cardiac fibroblasts.’ We would like to point out some results stated in the article that need further investigation and more detailed discussion to clarify certain factors involved in the protective role of Prx-4 in heart failure.

Parenting Behaviors and Anxiety in Young Adults

2015 ◽  
Vol 36 (3) ◽  
pp. 170-176 ◽  
Author(s):  
Erin N. Stevens ◽  
Joseph R. Bardeen ◽  
Kyle W. Murdock
Keyword(s):  
Effortful Control ◽  
Parenting Behaviors ◽  
Protective Role ◽  
Anxiety Symptoms ◽  
Interactive Effects ◽  
Parental Overprotection ◽  
High Control ◽  
Development Of Anxiety ◽  
The Relationship

Parenting behaviors – specifically behaviors characterized by high control, intrusiveness, rejection, and overprotection – and effortful control have each been implicated in the development of anxiety pathology. However, little research has examined the protective role of effortful control in the relation between parenting and anxiety symptoms, specifically among adults. Thus, we sought to explore the unique and interactive effects of parenting and effortful control on anxiety among adults (N = 162). Results suggest that effortful control uniquely contributes to anxiety symptoms above and beyond that of any parenting behavior. Furthermore, effortful control acted as a moderator of the relationship between parental overprotection and anxiety, such that overprotection is associated with anxiety only in individuals with lower levels of effortful control. Implications for potential prevention and intervention efforts which specifically target effortful control are discussed. These findings underscore the importance of considering individual differences in self-regulatory abilities when examining associations between putative early-life risk factors, such as parenting, and anxiety symptoms.

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