State of the Russian Oncology Service: esophageal cancer, median survival, observed and relative survival of patients considering disease stage and histological structure of tumors (population-based study at the federal district level). Part 2

2021 ◽  
Author(s):  
Vakhtang M. Merabishvili
Keyword(s):  
Esophageal Cancer ◽  
Survival Rate ◽  
Russian Federation ◽  
Federal District ◽  
Population Based ◽  
First Year ◽  
The Past ◽  
The Russian Federation ◽  
One Year ◽  
First Time

Esophageal cancer (EC) is the most severe pathology of malignant tumors, with the mortality rate of patients exceeding 70% in the first year of observation. Over the past 19 years, there was a slight improvement in the effectiveness of anticancer measures for this localization of tumors. In February 2019 the Population-based Cancer Registry database (PCRD) of the Northwestern Federal District of the Russian Federation (NWFD RF) was developed with more than 1 million 350 thousand observations which provides insight into ​​the real state of the effectiveness of anti-cancer measures and directs the following development of the database. After a thorough data quality assurance, about 1 million observations were selected for analysis. From 2000 to 2018, 15760 primary EC cases were accumulated in the NWFD RF PCRD. Considering that the levels of standardized morbidity and mortality rates of the population of Russia and the Northwestern Federal District of the Russian Federation are close in terms of the level of indicators, we believe that the data obtained for the first time in Russia on the survival of EC patients in the Northwestern Federal District of the Russian Federation fully reflect the state of the effectiveness of combating EC in Russia. The purpose of the study is to carry out a set of analytical calculations of the survival rates of EC patients in the dynamics over the past 19 years according to the NWFD RF PCRD. All calculations were performed in accordance with the international requirements for such development and, first of all, according to Eurocare standards. The results of our study indicate that the EC median survival rate for both sexes has increased from 5 to 6 months. The mortality rate of patients in the first year of follow-up has decreased from 72.4 to 71.4% (both sexes), from 73.9 to 71.6% among men, from 69.3 to 65.1% among women. The five-year survival rate of EC patients in the NWFD RF had slight fluctuations, especially among the female population. Data grouped by five years for three five-year observation cycles has shown an increase in the five-year survival rate of EC patients from 7.3 to 8.1%, and the one-year survival rate has increased over four five-year cycles from 25.3 to 30.8%. For the first time in Russia, at the population level, the effect of treating EC patients has been shown according to the fourth sign of ICD-10. The greatest treatment success has been achieved for EC patients under the following rubrics: Cervical esophagus (C15.0) from 23.3 to 35.0% (one-year survival), Thoracic esophagus (C15.1) from 29.6 to 35.8% and especially significant improvements have been made for patients with the Upper third of esophagus (C15.3) from 18.2 to 34.0%. It is important to note that over the four observation periods, the proportion of EC patients under C15.9 rubric Esophagus, unspecified has decreased from 29.3 to 19.8%, which indicates a significant improvement in the quality of diagnosis.

scholarly journals Lung cancer (C33, 34). Morbidity, mortality, accuracy of registration, localization and histological structure (population study)

2021 ◽  
Vol 67 (3) ◽  
pp. 361-367
Author(s):  
Vakhtang Merabishvili ◽  
Iuliia Iurkova ◽  
Aleksandr Shcherbakov ◽  
Evgenii Levchenko ◽  
Anton Barchuk ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Russian Federation ◽  
Federal District ◽  
Developed Countries ◽  
First Year ◽  
Histological Structure ◽  
The Real ◽  
Real Value ◽  
The Russian Federation ◽  
First Time

Lung cancer (LC) is the main cause of morbidity and mortality in the population of Russia and many economically developed countries of the world. At the same time, referring to localizations with a high mortality rate, the official data on the number of recorded primary cases (which form the incidence rate) are significantly underestimated, which is confirmed by the registration reliability index, which in many territories is higher than critical values. The aim of our study is to present the real state of the prevalence of PC in Russia, based on the newly created database (DB) of the population cancer register (PRR) of the Northwestern Federal District of the Russian Federation (NWFD RF) — the only one in Russia. We analyzed the loss of the number of primary patients who were not included in the state reporting, showed the real value of the achieved death rate of patients in the first year of dispensary observation, calculated the patterns of annual mortality of patients, the median of survival and 1 and 5-year survival of patients with lung cancer based on the database of the population cancer registry. Northwestern Federal District of the Russian Federation, on the materials of which for the first time in Russia the dynamics of changes in the detailed localization and histological structure of lung cancer was traced.

The state of cancer care in Russia: esophageal cancer (morbidity, mortality, reliability of accounting, typical mortality). Population-based research at the federal district level. Part I.

2021 ◽  
Author(s):  
Vakhtang M. Merabishvili
Keyword(s):  
Esophageal Cancer ◽  
Mortality Rate ◽  
Russian Federation ◽  
Federal District ◽  
Mortality Rates ◽  
Morbidity And Mortality ◽  
First Year ◽  
Male Population ◽  
Accuracy Index ◽  
The Russian Federation

Malignant neoplasms (MNO) of esophagus is the localization with a high mortality rate. Years of searching for effective treatment in Russia have resulted in modest success. The median survival rate of patients is expressed in months, 70% of patients die in the first year of dispensary registration, the levels of one-year mortality rates for men and women practically do not differ. The esophageal cancer (EC) morbidity and mortality rates have slightly decreased in 20002018 in Russia and has declined only among the male population of the Northwestern Federal District. Aim of the study. To study the trends in the morbidity and mortality rates in the population of Russia and the Northwestern Federal District of the Russian Federation. Qualitative analytical indicators, such as the accuracy index and the year-to-year mortality patterns in esophageal cancer patients, will be further considered. Results of the study. The highest standardized EC morbidity rates of the population were found in Zimbabwe (Harare, Africans) 15.5 0/0000, Japan (Miyage) 14.3 0/0000 and the Arkhangelsk region of Russia 12.8 0/0000. In 2000-2019 the level of standardized morbidity rates of the Russian population with EC has decreased from 3.44 to 3.19 0/0000 or 7.3% (both sexes), mortality rates from 3.32 to 2.66 0/0000, or 19.9%. A decrease in the morbidity and mortality rates from EC occurred in the Northwestern Federal District of the Russian Federation, only among the male population. Annual EC mortality rate mainly occurs according to the classical model. The highest level is determined in the first year of follow-up (72-74%); by the end of the decade, only 4.1% of patients remain from those initially recorded. The accuracy index has decreased in Russia and in the Northwestern Federal District of the Russian Federation, respectively, to 0.84 and 0.86 (both sexes) but has remained above the critical mark of 0.7 for localizations with a high mortality rate.

OPTIMIZING THE DIAGNOSIS, A MONITORING AND TREATMENT SYSTEM FOR PSORIATIC ARTHRITIS IN REAL PRACTICE: GENERAL PRINCIPLES FOR ORGANIZING AN ALL-RUSSIAN REGISTER OF PATIENTS WITH PSORIATIC ARTHRITIS

2019 ◽  
Vol 57 (4) ◽  
pp. 407-414
Author(s):  
T. V. Korotaeva ◽  
Yu. L. Korsakova ◽  
E. Yu. Loginova ◽  
E. E. Gubar ◽  
A. D. Koltakova ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
Russian Federation ◽  
Treatment Options ◽  
Population Based ◽  
Information Support ◽  
Psychological Status ◽  
The Russian Federation ◽  
Real Practice ◽  
First Time ◽  
Research Institute

The paper presents the design, general characteristics of and possibilities of data usage from the All-Russian register of patients with psoriatic arthritis (PsA).The purpose of creating and introducing the register into Russian healthcare practice is to evaluate the effectiveness of the diagnosis and treatment of PsA. The All-Russian register of PsA patients was created for the period 2016–2018 within the framework of the All-Russian register of patients with arthritis «OREL» on the basis of the V.A. Nasonova Research Institute of Rheumatology and with the support of the All-Russian public organization «Association of Rheumatologists of Russia». This system is an all-Russian population-based register that allows for the recording and monitoring of patients with PsA throughout the follow-up period. This enables healthcare specialists and organizers to obtain reliable information on the state of care for this category of patients in the region.The main purpose of the register is to provide necessary information support and automated technology for solving the problems of accounting, controlling, and monitoring of the status of PsA patients and to organize information interaction between specialists. The register is based on existing state regulatory legal acts. While developing and testing of the register, there were a number of tasks to be solved: to evaluate the efficiency of existing standard and promising targeted PsA therapies in real practice; to assess and improve the routing of patients with PsA. The use of the register allows an operational analysis of the following characteristics: demographic and socioeconomic parameters of patients with PsA; anamnestic data of patients with this condition; results of clinical examinations, instrumental and laboratory data.The geography of the register covers 27 regions of the Russian Federation; the register includes information on 460 patients with PsA.Creating a register permits one to track the dynamics of various parameters (social, demographic, and medical ones), to compare treatment options and the clinical and functional characteristics of patients with PsA, and to evaluate their performance, disability and changes in the social and labor status during the treatment performed. Thus, for the first time in the Russian Federation, the demographic, functional, and socioeconomic parameters of patients with PsA were comprehensively analyzed and the level of performance and impaired daily activities in PsA patients were studied using the WPAI questionnaire; moreover, the patients’ functional and psychological status was evaluated for the first time, by applying the PsAID-12, FACIT questionnaires (in the patients of the V.A. Nasonova Research Institute of Rheumatology).An analysis of the information available in the register makes it possible to compare the efficiency of different PsA treatment regimens, by estimating the rates of remission and/or minimal disease activity in real practice.

scholarly journals Review of Hantavirus Infections in the World, Epidemiological Situation on Hemorrhagic Fever with Renal Syndrome in the Russian Federation in 2020 and a Forecast for 2021

2021 ◽  
pp. 62-70
Author(s):  
T. A. Savitskaya ◽  
A. V. Ivanova ◽  
G. Sh. Isaeva ◽  
I. D. Reshetnikova ◽  
E. Kabve ◽  
...  
Keyword(s):  
Russian Federation ◽  
Far East ◽  
Statistical Processing ◽  
Federal District ◽  
European Part ◽  
The Past ◽  
Central Federal District ◽  
The World ◽  
The Russian Federation ◽  
Epidemiological Situation

The review used the data from operational monitoring carried out by the Reference Center for Monitoring over HFRS – “Kazan Research Institute of Epidemiology and Microbiology of the Rospotrebnadzor”, based on official data provided by the Rospotrebnadzor institutions in the constituent entities of the Russian Federation. Statistical processing was conducted using conventional methods of variation statistics applying the Excel program. Over the past decades, hantavirus diseases have become very relevant and spread throughout the world. In the territory of the Russian Federation, natural foci of HFRS are located in the European part of the country, Western Siberia and Far East. The most epidemically active foci are situated in the European part of Russia. Over the past decade, the intensive incidence rate of HFRS in the Russian Federation stayed within the range of 3.0–9.5 per 100 thousand of the population, the long-term average annual indicator – 5.2 per 100 thousand of the population. In 2020, 3845 cases of HFRS were registered (2.62 per 100,000 of the population). There was a decrease in the incidence of HFRS by 3.6 times, compared with the indicators of 2019. A factor that may have influenced the decrease in the incidence of HFRS was the depression of the epizootic process among small mammals, the main carriers of HFRS pathogens, due to natural and climatic factors. The nature of the distribution of HFRS incidence across the territory of the Russian Federation in 2020 was heterogeneous. Statistical processing of the data made it possible to identify 5 groups of territories that differ in the level of HFRS incidence. Almost all constituent entities of the Volga Federal District and the Kostroma Region belonging to the Central Federal District were classified as groups of territories with high and very high incidence rates. In 2021, the deterioration of the epidemiological situation is predicted in the summer-autumn period of the year in the Volga Federal District and four entities of the Central Federal District. 

scholarly journals Epidemiology and survival rates of patients with malignant tumors in the Russian Federation

2021 ◽  
Author(s):  
Vakhtang M. Merabishvili
Keyword(s):  
Russian Federation ◽  
Cancer Incidence ◽  
Malignant Tumors ◽  
Survival Rates ◽  
Public Health Problem ◽  
Federal District ◽  
Cancer Registries ◽  
Population Based ◽  
Important Public Health Problem ◽  
The Russian Federation

Malignant tumors remain the most important public health problem in the world, being the second or even the leading cause of death in some countries. Cancer incidence is greatly influenced by the ever-increasing environmental hazards. Population-based Cancer Registries (PCRs) provide necessary data to monitor and assess cancer incidence. PCRs collect obligatory data on incidence rate with time series analysis, mortality and survival rates in patients diagnosed with malignant tumors. The study presents the results of the operation of PCRs as exemplified in the analysis of the PCR of Saint Petersburg and the Northwestern Federal District of the Russian Federation.

scholarly journals Primary disability as a result diseases of the urinary system of an adult population in Moscow

2019 ◽  
Vol 22 (1) ◽  
pp. 9-14
Author(s):  
Ganna M. Calacheva ◽  
Sergey P. Zapariy ◽  
Sergey N. Puzin
Keyword(s):  
Russian Federation ◽  
Adult Population ◽  
Federal District ◽  
Specific Weight ◽  
Urinary System ◽  
Disabled People ◽  
Central Federal District ◽  
Primary Disability ◽  
The Russian Federation ◽  
First Time

The analysis of primary disability as a result of diseases of the urinary system with the outcome of chronic kidney disease among the adult population of Moscow, the Central Federal District and the Russian Federation for the period 2015-2019 has revealed that the extensive indicators for the number of certified as disabled for the first time in Moscow is comparable in terms of primary disability in the Central Federal District and are lower than in the Russian Federation. Intensive indicators in Moscow are lower than in the Central Federal District and the Russian Federation. Extensive and intensive indicators of primary disability in Moscow, the Central Federal District, and the Russian Federation tended to increase. The age structure of the certified as disabled for the first time contingent as a result of diseases of the urinary system in Moscow, the Central Federal District and the Russian Federation do not differ significantly in values and dynamics among young and middle-aged population. The predominance of persons of retirement age was revealed with a tendency to increase their level. The severity of disability was dominated by I group of disabled people with a tendency to increase their specific weight. The second place was taken by disabled people of III group with a tendency to increase their share and a stable level of disability.

scholarly journals Assessment of social aspects of seismic hazard

2021 ◽  
Vol 929 (1) ◽  
pp. 012030
Author(s):  
T I Danilova ◽  
S A Peretokin ◽  
N S Medvedeva ◽  
K N Akatova
Keyword(s):  
Seismic Hazard ◽  
Russian Federation ◽  
Federal District ◽  
Social Aspects ◽  
Population Estimates ◽  
Seismic Zoning ◽  
The Russian Federation ◽  
Far Eastern ◽  
First Time ◽  
High Seismicity

Abstract This paper is intended to illustrate the applicability of the results obtained from the investigations of social aspects of seismic hazard of the Russian Federation (RF) through the example of the high-seismicity region – the Far Eastern Federal District (FED). Within the FED the comparison of the areas of various seismic zones as per regulatory maps of General Seismic Zoning dated 2016 (GSZ-2016) has been performed and population estimates for each zone have been obtained. For the first time population estimates for zones with increased seismic hazard – grades A, B and C as per GSZ-2016 – are provided. The data obtained may be used for the evaluation of additional risks for FED’s population.

scholarly journals Assessment of Epidemiological Situation on Hemorhhagic Fever with Renal Syndrome around the World and in Russia, Forecast for 2020

2020 ◽  
pp. 62-70
Author(s):  
T. A. Savitskaya ◽  
A. V. Ivanova ◽  
G. Sh. Isaeva ◽  
I. D. Reshetnikova ◽  
V. A. Trifonov ◽  
...  
Keyword(s):  
Russian Federation ◽  
Far East ◽  
Federal District ◽  
Ambient Air ◽  
European Part ◽  
The Past ◽  
The World ◽  
Federal Districts ◽  
The Russian Federation ◽  
Epidemiological Situation

Objective of the review is to characterize the nature of epidemiological situation on HFRS around the world and to conduct a comparative analysis of intensity and dynamics of the epidemiological process in the Russian Federation by Federal Districts, as well as make forecast for 2020. The analysis of the epidemiological situation is based on the materials of the official websites of healthcare organizations in the USA and Europe, WHO, the data from operational monitoring carried out by the reference center for HFRS monitoring “Kazan Research Institute of Epidemiology and Microbiology”, materials provided by the Rospotrebnadzor Institutions in the constituent entities of the Russian Federation. The analysis included all administrative territories of the Russian Federation. Statistical processing was carried out by standard methods of variation statistics applying Excel software. The epidemiological situation on hemorrhagic fever with renal syndrome around the world and in Russia remains tense. In the Russian Federation, epidemically active foci are located in the European part of the country, in Western Siberia and in the Far East. Infections over the period of 2010–2019 were registered in 8 federal districts of the Russian Federation, in 58 constituent entities. However, the incidence distribution across the territory of the country was differential. In 97 % of the cases, the incidence was recorded in the European part of Russia. In the Volga Federal District, HFRS incidence amounted to 82.16 % of the total incidence recorded on the whole in Russia. High incidence rates are also recorded in the Central Federal District (CFD). Over the past 10 years (2010–2019), there has been an increase in the incidence of HFRS in the Central and North-West Federal Districts, and a decrease in the incidence in the Ural and Far Eastern Federal Districts. Varying degree of anthropogenic impact on the natural HFRS foci and climate change manifested in increased ambient air temperatures are of great importance for the spread of HFRS over the past decade. At the end of the review the forecast of the development of the epidemiological situation on HFRS in the Russian Federation for 2020 is presented.

scholarly journals TERRITORY OF THE URAL FEDERAL DISTRICT AND LEGAL ASPECTS OF IMPROVING THEIR PROTECTION FROM FIRES

2021 ◽  
pp. 16-25
Author(s):  
С.В. КУПЛЕВАЦКИЙ ◽  
И.С. ЗАХАРОВА ◽  
Н.Н. ШАБАЛИНА
Keyword(s):  
Russian Federation ◽  
Federal District ◽  
Legal Aspects ◽  
Population Based ◽  
Forest Protection ◽  
Regulatory Documents ◽  
Average Area ◽  
Effi Ciency ◽  
The Russian Federation ◽  
The Difference

На основании анализа данных о фактической горимости лесов в пределах субъектов Российской Федерации, входящих в Уральский федеральный округ (УрФО), за период с 2001 по 2021 гг. предпринята попытка установления причин в различии количества лесных пожаров и пройденной ими площади по годам. Установленные различия в сроках начала и окончания пожароопасного сезона позволяют повысить эффективность охраны лесов от пожаров за счет оперативной переброски сил и средств пожаротушения. Установлены причины в различии средней площади лесных пожаров по субъектам Российской Федерации, входящих в УрФО. Данные о причинах возникновения лесных пожаров позволяют повысить эффективность лесопожарной пропаганды и тем самым снизить количество лесных пожаров по вине населения. На основании анализа количества лесных пожаров и пройденной ими площади даны рекомендации по совершенствованию охраны лесов от пожаров. Отмечается, что совершенствование нормативно-правовых документов по охране лесов от пожаров снизит показатели фактической горимости лесов и минимизирует риски для населения. Based on the analysis of data on the actual fi re rate of forests with in the constituent entities of the Russian Federation included in the Ural Federal District for the period from 2011 to 2021. An attempt was made to establish the reasons for the difference in the number of forest fi res and the area covered by them by years. Differences in the timing of the beginning and end of the fi re hazardous season have been established, which mane et possible to increase the effi ciency of forest protection from fi res due to the operational transfer of fi re extinguishing forces and fi refi ghting means. The reasons for the difference in the average area of the forest fi res in the constituent entities of Russian Federation included in the Ural Federal District has been established. Data on the causes of forest fi res can increase the effectiveness of the forest fi re propaganda and thereby reduce the number of forest fi res caused by the population. Based on the analysis of the number of the forest fi res and the areas covered by them, recommendations are given for improving the protection of forests from fi res. In is noted that the improvement of regulatory documents on the protection of forests from fi res will reduce the optical fi re rate of forests indicators a minimize risks to the population.

NEW RACES OF PUCCINIA HELIANTHI SCHWEIN – IS THE CAUSATIVE AGENT OF SUNFLOWER RUST IN THE RUSSIAN FEDERATION

1970 ◽  
pp. 23-26
Author(s):  
T. S. Antonova ◽  
N. M. Araslanova ◽  
М. V. Ivebor ◽  
S. L. Saukova ◽  
Yu. V. Pitinova
Keyword(s):  
Russian Federation ◽  
Causative Agent ◽  
Weather Conditions ◽  
Breeding For Resistance ◽  
The Past ◽  
Puccinia Helianthi ◽  
Rust Pathogen ◽  
The Russian Federation ◽  
New Races ◽  
First Time

Over the past two decades, over different years, depending on weather conditions, a strong distribution of rust on sunflower has been systematically observed in the Tambov, Lipetsk, Saratov, Volgograd regions, Krasnodar Territory and other places of the Russian Federation. This disease caused by the highly specialized fungus Puccinia helianthi Schwein was noticed in Russia in 1866. Since then, systematically recurring epiphytoties have been described by many domestic authors as well as by scientists from other countries where sunflower is cultivated and affected by this pathogen. Sunflower  breeding for resistance to rust was not carried out in the Russian Federation since 1983. The objectives of our research was to determine the race of some isolates of the sunflower rust pathogen collected in the Krasnodar Territory, Saratov and Lipetsk regions using an internationally accepted set of sunflower resistance differentiating lines. Eight standard lines were used: CM 90, CM 29, P-386, HA-R1, HA-R2. HA-R3, HA-R4, HA-R5. As a differentiator, susceptible to all races of the pathogen, we used the sunflower variety VNIIMK 8883. Six physiological races of P. helianthi were revealed. Four of them: 700, 710, 722, 772 were discovered in the Russia for the first time. In addition to these new pathotypes, the old races 100 and 300 have been identified. It is possible that there are other pathogen races that have not yet been found on the territory of the Russian Federation. Therefore, it is necessary to examine a larger number of fields in different regions and increase the number of isolate samples for identification.

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