scholarly journals Hepatoprotective effect of red ginger rhizome extract in deep frying oil-fed male wistar rats

2017 ◽  
Vol 36 (3) ◽  
pp. 228 ◽  
Author(s):  
Sunarti Sunarti ◽  
Edy Fachrial ◽  
Urip Harahap ◽  
Delyuzar Delyuzar ◽  
Tri Widyawati ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Wistar Rats ◽  
Fatty Degeneration ◽  
Frying Oil ◽  
Deep Frying ◽  
Treatment Groups ◽  
Whitney Test ◽  
Ginger Rhizome ◽  
Male Wistar Rats ◽  
Red Ginger

BACKGROUND<br />Non-alcoholic steatohepatitis (NASH) is a chronic liver disease associated with increased free fatty acids, trans fatty acids and free radical compounds due to the consumption of deep frying oil (DFO). Ginger has hypolipidemic and antioxidant properties, and acts as an insulin sensitizer. The present study was conducted to evaluate the hepatoprotective effect of an ethanol extract of Zingiber officinale Roxb var rubrum (EEZO) in DFO-fed male Wistar rats.<br /><br />METHODS<br />A study of experimental design was conducted involving 24 non-alcoholic steatohepatitis (NASH) male Wistar rats that were randomly divided into 4 groups. Group K1 (control) was given DFO-3 (3 times heated DFO) at a dose of 10 ìl/g BW/day. The treatment groups (P1, P2, P3) were given DFO-3 and red ginger rhizome extract at doses of 100, 200, and 400 mg/kg BW orally for 30 days. The histopathology examination assessed fatty degeneration, and degree of fibrosis. The data were analyzed with the Kruskal-Wallis and Mann-whitney test.<br /><br />RESULTS    <br />The Kruskal-Wallis test showed that fatty degeneration (steatosis, lobular inflammation, hepatocyte ballooning and NASH) were significantly different among the four groups (p&lt;0.05). Mann-Whitney test proved that fatty degeneration was not significantly different between control and treatment groups (p&gt;0.05).<br /><br />CONCLUSION<br />Deep frying oil increased fatty degeneration and NASH, and none of red ginger rhizome extract doses was able to inhibit fatty degeneration significantly. For the future research it is intended to prolong the induction time and the administration of red ginger rhizome extract.

The Consumption of Galactomannan Effervescent Drinks made from Coconut Pulp Waste and Colonic Microbiota in Wistar Rats

2020 ◽  
Vol 15 (1) ◽  
pp. 52-56
Author(s):  
Sri Winarti ◽  
Agung Pasetyo
Keyword(s):  
Fatty Acids ◽  
Gut Microbiota ◽  
Wistar Rats ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
E Coli ◽  
Colonic Microbiota ◽  
Male Wistar Rats ◽  
Lactobacillus Spp ◽  
Chain Fatty Acids

The consumption of prebiotics is known to affect the balance of gut microbiota. The purpose of this study was to explore how a galactomannan-rich effervescent drink can affect the population of Lactobacillus, Bifidobacterium, E. coli, and the concentration of short-chain fatty acids in the cecum of rats. Twenty-eight male Wistar rats (aged 2 months) were divided equally into 7 groups and treated orally each day for 15 days with 2 mL effervescent drinks with increasing levels of prebiotic galactomannan. The dosage of 500 mg galactomannan increased the growth of Lactobacillus spp. and Bifidobacterium spp. with inhibition of the growth of E.coli with increased formation of short-chain fatty acids such as acetate, propionate, and butyrate in the cecum of rats.

scholarly journals A Mixture of Algae and Extra Virgin Olive Oils Attenuates the Cardiometabolic Alterations Associated with Aging in Male Wistar Rats

Antioxidants ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 483 ◽  
Author(s):  
Daniel González-Hedström ◽  
Sara Amor ◽  
María de la Fuente-Fernández ◽  
Antonio Tejera-Muñoz ◽  
Teresa Priego ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Insulin Sensitivity ◽  
Vascular Function ◽  
Wistar Rats ◽  
Unsaturated Fatty Acids ◽  
Saturated Fatty Acids ◽  
Virgin Olive Oil ◽  
Mrna Levels ◽  
Serum Concentrations ◽  
Male Wistar Rats

Aging is one of the major risk factors for suffering cardiovascular and metabolic diseases. Due to the increase in life expectancy, there is a strong interest in the search for anti-aging strategies to treat and prevent these aging-induced disorders. Both omega 3 polyunsaturated fatty acids (ω-3 PUFA) and extra virgin olive oil (EVOO) exert numerous metabolic and cardiovascular benefits in the elderly. In addition, EVOO constitutes an interesting ingredient to stabilize ω-3 PUFA and decrease their oxidation process due to its high content in antioxidant compounds. ω-3 PUFA are commonly obtained from fish. However, more ecological and sustainable sources, such as algae oil (AO) can also be used. In this study, we aimed to study the possible beneficial effect of an oil mixture composed by EVOO (75%) and AO (25%) rich in ω-3 PUFA (35% docosahexaenoic acid (DHA) and 20% eicosapentaenoic acid (EPA)) on the cardiometabolic alterations associated with aging. For this purpose; young (three months old) and old (24 months old) male Wistar rats were treated with vehicle or with the oil mixture (2.5 mL/kg) for 21 days. Treatment with the oil mixture prevented the aging-induced increase in the serum levels of saturated fatty acids (SFA) and the aging-induced decrease in the serum concentrations of mono-unsaturated fatty acids (MUFA). Old treated rats showed increased serum concentrations of EPA and DHA and decreased HOMA-IR index and circulating levels of total cholesterol, insulin and IL-6. Treatment with the oil mixture increased the mRNA levels of antioxidant and insulin sensitivity-related enzymes, as well as reduced the gene expression of pro-inflammatory markers in the liver and in cardiac and aortic tissues. In addition, the treatment also prevented the aging-induced endothelial dysfunction and vascular insulin resistance through activation of the PI3K/Akt pathway. Moreover, aortic rings from old rats treated with the oil mixture showed a decreased response to the vasoconstrictor AngII. In conclusion, treatment with a mixture of EVOO and AO improves the lipid profile, insulin sensitivity and vascular function in aged rats and decreases aging-induced inflammation and oxidative stress in the liver, and in the cardiovascular system. Thus, it could be an interesting strategy to deal with cardiometabolic alterations associated with aging.

Prophylactic and therapeutic effects of Mytilus edulis fatty acids on adjuvant-induced arthritis in male Wistar rats

2010 ◽  
Vol 82 (2-3) ◽  
pp. 97-103 ◽  
Author(s):  
Sarah McPhee ◽  
Lynn D. Hodges ◽  
Paul F.A. Wright ◽  
Paul M. Wynne ◽  
Nicolette Kalafatis ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Mytilus Edulis ◽  
Wistar Rats ◽  
Therapeutic Effects ◽  
Adjuvant Induced Arthritis ◽  
Male Wistar Rats

scholarly journals The Effectiveness Fig Leaves (FICUS CARICA L) Steeping Water Towards SGOT SGPT Serum on Male Wistar Rats in Critical Hepatitis Model

2019 ◽  
Vol 7 (1) ◽  
pp. 826-835
Author(s):  
Yosi Julianti ◽  
Untung Sudharmono
Keyword(s):  
Treatment Group ◽  
Wistar Rats ◽  
Ficus Carica ◽  
Negative Group ◽  
Positive Group ◽  
Treatment Groups ◽  
Significant Difference ◽  
Male Wistar Rats ◽  
Food And Drink ◽  
One Way Anova

Critical Hepatitisis is the inflammation of the liver that is caused by viruses, alchol and drugs which are characterized by the increasing values of SGOT SGPT. The purpose of this study is to determine the effectiveness of fig leaves (Ficuss carica L) steeping water towards the decrease of SGOT SGPT serum on male wistar rats in critical hepatitis model. The object of this study is 30 male wistar rats with the age of 2-3 months and weight 180-200 grams and randomly divide into 3 groups, which are the negative group that is only by giving an usual food and drink, the positive group and the treatment groups are given paracetamol 120mg/ oral for 7 days. The treatment group is given 0.65 gram/ day of fig leaves steeping water for 7 days. One way ANOVA of SPSS version 24 is used to analyze this research. The result of the study shows that there is a significant difference in SGOT serum level between the treatment group, positive group and negative group (p<0,05). And there is a significant difference  in SGPT level between the treatment group and the positive group (p<0,05). The conclusion of this study is tin leaves (Ficus carica L) steeping water has an effect towards the decrease of SGOT SGPT in male Wistar rats in critical hepatitis model.

scholarly journals Anti-malaria and hypoglycaemic activities of Diosgenin on alloxan-induced, diabetic Wistar rats

2021 ◽  
Vol 15 (3) ◽  
pp. 073-079
Author(s):  
Omoirri Moses Aziakpono ◽  
Madubogwu Ngozi Ukamaka ◽  
Oraekei Daniel Ikechukwu ◽  
Ataihire Johnson Uyovwiesevwa ◽  
Chukwuemeka Charles Ofili ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Sugar ◽  
Wistar Rats ◽  
World Health ◽  
Treatment Groups ◽  
Male Wistar Rats ◽  
Normal Rat ◽  
Sugar Levels ◽  
Health Organization ◽  
Alloxan Monohydrate

The rising threat of Plasmodium falciparum resistance to Monotherapies has prompted the world health organization (WHO) 2006 guidelines to recommend the use of different anti-malarias. In this study, the anti-malaria and hypoglycaemic activities of Diosgenin, a potent, yet poorly reported saponin was investigated on P. falciparum inoculated and Alloxan-Induced, Diabetic Wistar Rats. Fort two (42) adult male wistar rats of between 100g and 150g were procured, acclimatized (for two weeks), and grouped into seven of six (6) rats per group. While Group 1 (Normal control) received normal rat chow and water ad libitum, groups 2 – 4 received no treatment (untreated), 10 mg/kg body weight of anti-diabetic Metformin and 25 mg/kg body weight of diosgenin respectively after inducing diabetes mellitus (DM) with alloxan monohydrate; whereas, groups 5-7 (all malaria infected) were untreated (negative malaria control), 25 mg/kg body weight of diosgenin and 56 mg/kg body weight of anti-malaria coartem respectively. Following treatment period, blood samples were obtained and assayed for fasting blood sugar, packed cell volume (PCV) and total white blood cell count (TWBCC). From the result, P. falciparum exposed rats showed lowered PCV values than control with observed improvements in coartem (significant at p < 0.05) and diosgenin (insignificant) treatment groups. Also, diabetic, diosgenin treated rats showed an insignificant reduction in blood sugar levels compared to control, even though this change was apparently improved compared to diabetic, untreated group. Again, TWBCC caused notable decrease in diosgenin treated, though this decrease signified a huge recovery compared to untreated rats. Corroborative studies on diosgenin with other systems is recommended.

scholarly journals PENGAMATAN AKTIVITAS TIKUS WISTAR JANTAN DENGAN ALAT OPTO- VARIMEX® PADA KONDISI DIET TINGGI MINYAK TRANS

Jurnal BIOMA ◽  
2015 ◽  
Vol 11 (1) ◽  
pp. 89
Author(s):  
NURUL MASYITA ◽  
KOEKOEH SANTOSO ◽  
NASTITI KUSUMORINI ◽  
ARYANI SISMIN SATYANINGTIJAS ◽  
ATIN SUPIYANI
Keyword(s):  
Adipose Tissue ◽  
Wistar Rats ◽  
Feeding Activity ◽  
Wistar Rat ◽  
Control Group ◽  
Trans Fat ◽  
Treatment Groups ◽  
Track System ◽  
Male Wistar Rats ◽  
Auto Track

ABSTRACT Excessive energi consumption of high-fat diet increase the body’s adipose tissue which also affect the increased secretion of leptin, this is because leptin secretion is proportional to the mass of adipose tissue. Leptin activates the lateral hypothalamus as the center of hunger and feeding activity. The aim of this study was to obtain the relationship between high trans fat feeding on male Wistar rats and feeding activity. This method uses male Wistar rats (Rattus norvegicus) as an animal model. Sixteen rats were grouped into 4 treatment groups. The first group was given additional feed 20% trans fat, the second group was given additional feed 40% trans fat, a third group was given additional feed 60% trans fat, and the last as a control group. This feed was given once a day for 70 days. Observation of activities perform using Opto-varimex® auto-track system ver. 4.31. The results showed an corellation between activity based doses of trans fat. Keywords: Opto-varimex®, Trans fat, Activity, Wistar rat.

Polyunsaturated fatty acids in the blood of spontaneously or induced muricidal male Wistar rats

2003 ◽  
Vol 60 (1-2) ◽  
pp. 161-165 ◽  
Author(s):  
S Augier ◽  
M.C Penes ◽  
G Debilly ◽  
A.S Miachon
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Wistar Rats ◽  
Male Wistar Rats

scholarly journals Marine n-3 fatty acids promote size reduction of visceral adipose depots, without altering body weight and composition, in male Wistar rats fed a high-fat diet

2009 ◽  
Vol 102 (7) ◽  
pp. 995-1006 ◽  
Author(s):  
Merethe H. Rokling-Andersen ◽  
Arild C. Rustan ◽  
Andreas J. Wensaas ◽  
Olav Kaalhus ◽  
Hege Wergedahl ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Mrna Expression ◽  
High Fat Diet ◽  
Wistar Rats ◽  
Plasma Lipid ◽  
Feed Consumption ◽  
High Fat ◽  
Male Wistar Rats ◽  
Similar Body ◽  
Visceral Adipose

We evaluated the effects of partly substituting lard with marine n-3 fatty acids (FA) on body composition and weight, adipose tissue distribution and gene expression in five adipose depots of male Wistar rats fed a high-fat diet. Rats were fed diets including lard (19·5 % lard) or n-3 FA (9·1 % lard and 10·4 % Triomar™) for 7 weeks. Feed consumption and weight gain were similar, whereas plasma lipid concentrations were lower in the n-3 FA group. Magnetic resonance imaging revealed smaller visceral (mesenteric, perirenal and epididymal) adipose depots in the n-3 FA-fed animals (35, 44 and 32 % reductions, respectively). n-3 FA feeding increased mRNA expression of cytokines as well as chemokines in several adipose depots. Expression of Adipoq and Pparg was enhanced in the mesenteric adipose depots of the n-3 FA-fed rats, and fasting plasma insulin levels were lowered. Expression of the lipogenic enzymes Acaca and Fasn was increased in the visceral adipose depots, whereas Dgat1 was reduced in the perirenal and epididymal depots. Cpt2 mRNA expression was almost doubled in the mesenteric depot and liver. Carcass analyses showed similar body fat (%) in the two feeding groups, indicating that n-3 FA feeding led to redistribution of fat away from the visceral compartment.

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