scholarly journals Dopamine: a modulator of circadian rhythms/biological clock

2021 ◽  
Vol 8 (2) ◽  
pp. 316
Author(s):  
Ravi Kant ◽  
Mahendra K. Meena ◽  
Monika Pathania

Circadian rhythm describes the physical, psychological, and behavioural patterns of living organisms that respond to day and night light levels. The important bodily functions like hunger, sleep, gastrointestinal motility, mood, coordination, body temperature, gene transcription, sensory perceptions, sleep-wake cycles and hormone release etc are influenced by circadian rhythm. Abnormal circadian rhythm may result obesity, depression, diabetes, seasonal affective disorder, bipolar disorders and various sleep disorders. The neuromodulator dopamine, originate from small groups of neurons in the mesencephalon (the ventral tegmental area, the substantia nigra) and in the diencephalon. In the retina, olfactory bulb, striatum, midbrain, and hypothalamus, it has been shown to have that dopamine shows circadian like activities, where it regulates, clock genes in some of these areas. Thus, it is likely that dopamine is essential to mechanisms that maintain proper rhythmicity of these five brain areas. Dopamine receptors are located centrally and peripherally. Growing evidence that dopamine is involved in regulating circadian rhythms, either directly or indirectly, in the brain areas through various pathways and dopaminergic receptor groups centrally and peripherally, and plays vital role.  

2021 ◽  
Vol 22 (2) ◽  
pp. 676
Author(s):  
Andy W. C. Man ◽  
Huige Li ◽  
Ning Xia

Every organism has an intrinsic biological rhythm that orchestrates biological processes in adjusting to daily environmental changes. Circadian rhythms are maintained by networks of molecular clocks throughout the core and peripheral tissues, including immune cells, blood vessels, and perivascular adipose tissues. Recent findings have suggested strong correlations between the circadian clock and cardiovascular diseases. Desynchronization between the circadian rhythm and body metabolism contributes to the development of cardiovascular diseases including arteriosclerosis and thrombosis. Circadian rhythms are involved in controlling inflammatory processes and metabolisms, which can influence the pathology of arteriosclerosis and thrombosis. Circadian clock genes are critical in maintaining the robust relationship between diurnal variation and the cardiovascular system. The circadian machinery in the vascular system may be a novel therapeutic target for the prevention and treatment of cardiovascular diseases. The research on circadian rhythms in cardiovascular diseases is still progressing. In this review, we briefly summarize recent studies on circadian rhythms and cardiovascular homeostasis, focusing on the circadian control of inflammatory processes and metabolisms. Based on the recent findings, we discuss the potential target molecules for future therapeutic strategies against cardiovascular diseases by targeting the circadian clock.


PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e4877 ◽  
Author(s):  
Azka Hassan ◽  
Jamil Ahmad ◽  
Hufsah Ashraf ◽  
Amjad Ali

Circadian rhythms maintain a 24 h oscillation pattern in metabolic, physiological and behavioral processes in all living organisms. Circadian rhythms are organized as biochemical networks located in hypothalamus and peripheral tissues. Rhythmicity in the expression of circadian clock genes plays a vital role in regulating the process of cell division and DNA damage control. The oncogenic protein, MYC and the tumor suppressor, p53 are directly influenced by the circadian clock. Jet lag and altered sleep/wake schedules prominently affect the expression of molecular clock genes. This study is focused on developing a Petri net model to analyze the impacts of long term jet lag on the circadian clock and its probable role in tumor progression. The results depict that jet lag disrupts the normal rhythmic behavior and expression of the circadian clock proteins. This disruption leads to persistent expression of MYC and suppressed expression of p53. Thus, it is inferred that jet lag altered circadian clock negatively affects the expressions of cell cycle regulatory genes and contribute in uncontrolled proliferation of tumor cells.


2021 ◽  
Author(s):  
Yang Yang ◽  
Wanwan Han ◽  
Aijia Zhang ◽  
Mindie Zhao ◽  
Wei Cong ◽  
...  

Abstract Corticotropin-releasing hormone (CRH), the major secretagogue of the hypothalamic-pituitary-adrenal (HPA) axis, is intricately intertwined with the clock genes to regulate the circadian rhythm of various body functions. N6-methyladenosine (m6A) RNA methylation is involved in the regulation of circadian rhythm, yet it remains unknown whether CRH expression and m6A modification oscillate with the clock genes in chicken hypothalamus and how the circadian rhythms change under chronic stress. Here, we show that chronic exposure to corticosterone (CORT) eliminated the diurnal patterns of plasma CORT and melatonin levels in the chicken. The circadian rhythms of clock genes in hippocampus, hypothalamus and pituitary are all disturbed to different extent in CORT-treated chickens. The most striking changes occur in hypothalamus in which the diurnal fluctuation of CRH mRNA is flattened, together with mRNA of other feeding-related neuropeptides. Interestingly, hypothalamic m6A level oscillates in an opposite pattern to CRH mRNA, with lowest m6A level after midnight (ZT18) corresponding to the peak of CRH mRNA before dawn (ZT22). CORT diminished the circadian rhythm of m6A methylation with significantly increased level at night. Further site-specific m6A analysis on 3’UTR of CRH mRNA indicates that higher m6A on 3’UTR of CRH mRNA coincides with lower CRH mRNA at night (ZT18 and ZT22). Our results indicate that chronic stress disrupts the circadian rhythms of CRH expression in hypothalamus, leading to dysfunction of HPA axis in the chicken. RNA m6A modification is involved in the regulation of circadian rhythms in chicken hypothalamus under both basal and chronic stress conditions.


Hypertension ◽  
2016 ◽  
Vol 68 (suppl_1) ◽  
Author(s):  
Daian Chen ◽  
S Justin Thomas ◽  
David A Calhoun ◽  
David M Pollock ◽  
Jennifer S Pollock

Circadian rhythms are controlled by an endogenous time-keeping system oscillating approximately on a 24-h cycle under constant conditions. These rhythms depend on a network of interacting genes and proteins, including transcriptional activators such as CLOCK, NPAS2, and ARNTL (BMAL1), which induce transcription of the clock genes Period ( Per1 , Per2 , and Per3 ) and Cryptochrome ( Cry1 and Cry2 ). Human salivary cortisol and melatonin follow a clear circadian rhythm as well. Disruption of the circadian rhythm and sleep-wake cycles are considered risk factors for a variety of health problems, especially hypertension and other cardiovascular and metabolic diseases. Here we put together practical methods for assessing circadian rhythms in adult subjects conducted by each individual. This method is non-invasive, inexpensive and provides a predictive profile of an individual’s circadian rhythm related to clock-controlled gene expression in buccal cells, salivary cortisol, salivary melatonin, and subject’s activity or sleep. Subjects are instructed on how to obtain buccal cells using swabs (Whatman OmniSwab) from the inside of their cheeks and collect saliva using salivettes (Sarstedt) every 4 hours starting at 6am, for 2 consecutive days. Subjects also wear actigraphy watches (Phillips Respironics) during the 2 days, to record their activity, light exposure and estimates of sleep times. To monitor adherence to correct time point collections, each subject is given an electronic vial called eCAP (Information Mediary Corp) that records the exact time the container is opened to place samples once collected. We demonstrate feasibility to extract up to 150ng/μl of RNA (Ambion RNAqueous-Micro Total RNA Isolation Kit) from buccal cells swabs. Salivary melatonin and cortisol are measured by radioimmunoassay (Buhlmann Lab) with melatonin peak levels ranging from 14 to 23 pg/ml and cortisol peak levels ranging from 10 to 24 ng/ml. We suggest that buccal cell expression of clock-controlled genes, salivary melatonin, salivary cortisol, and actigraphy data are valuable in providing reliable assessment of human circadian rhythm profiles under a variety of conditions.


UNICIÊNCIAS ◽  
2019 ◽  
Vol 23 (2) ◽  
pp. 70
Author(s):  
Durinézio José de Almeida ◽  
Tays Caroline Duma ◽  
André Luiz Snak ◽  
Guilherme Barroso Langoni de Freitas

O ciclo sono-vigília é parte do ritmo circadiano do indivíduo, sendo de grande valia para um bom funcionamento do organismo. Sua regularidade e eficiência, bem como uma fuga dessas pode levar a grandes alterações em todos os outros mecanismos sono dependentes. O ciclo que regula o sono é influenciado por fatores endógenos (relógio biológico baseado nos clock genes) e fatores exógenos ou ambientais (Zeitgebers). O período de sono é de suma importância para a saúde física e mental, interferências acarretam uma série de efeitos negativos ao organismo em questão. O objetivo do presente trabalho foi realizar uma revisão de literatura especializada, inicialmente, levantando parâmetros gerais fisiológicos, que envolvem a cronobiologia, em seguida, a caracterização dos cronotipos e a sua variação entre os grupos populacionais, dando ênfase para estudantes universitários de períodos do dia diferentes, destacando-se os cronotipos, que mais aparecem no público mencionado. Entre os existentes (matutino, indiferente e vespertino), o predominante na população estudada é o indiferente, seguido do vespertino e matutino. Há fatores fisiológicos que são fortemente influenciados pelo cronotipo como as acrofases de temperatura corporal e liberação de cortisol, bem como o horário de início da liberação de melatonina (hormônio do sono), em que se percebeu que tais fatores são adiantados no indivíduo matutino em relação ao vespertino em aproximadamente duas horas. É de grande importância a identificação dos cronotipos, em cada indivíduo, para uma correta alocação de atividades relacionadas ao ritmo circadiano, visando um maior aproveitamento do mesmo, bem como não prejudicando processos de aprendizado e de decodificação de informações. Palavras-chave: Cronotipo. Universitários. Fisiologia. Qualidade do Sono. AbstractThe sleep-wake cycle is part of the individual’s circadian rhythm, being of paramount importance for a good functioning of the organism. Its regularity and efficiency as well as an escape from these can lead to major changes in all the other sleep dependent mechanisms. The cycle that regulates sleep is influenced by endogenous factors (biological clock based on clock genes) and exogenous (or environmental, Zeitgebers) factors. The sleep period is of paramount importance to the physical and mental health, interferences entail a series of negative effects to the organism in question. The objective of the present work was to perform a review of specialized literature, initially raising general physiological parameters involving chronobiology, then characterizing chronotypes and their variation among population groups, with emphasis on university students, especially chronotypes that appear more often in the aforementioned public. Among the existing ones (morning, indifferent and evening), the predominant in the studied population is the indifferent, followed by the evening and morning ones. There are physiological factors that are strongly influenced by the chronotype as the acrophases of body temperature and cortisol release, as well as the start time of the  melatonin release (sleep hormone), where it was perceived that such factors are advanced in the morning individual in relation to  the afternoon in about two hours. It is of great importance to identify the chronotypes in each individual for a correct activities allocation related to the circadian rhythm, aiming a greater use of the same as well as not harming learning processes and information decoding. Keywords: Chronotype. University students. Physiology. Sleep Quality. 


2021 ◽  
Vol 12 ◽  
Author(s):  
Jingxuan Zhou ◽  
Jiechen Wang ◽  
Xiaozhao Zhang ◽  
Qingming Tang

Circadian clocks participate in the coordination of various metabolic and biological activities to maintain homeostasis. Disturbances in the circadian rhythm and cancers are closely related. Circadian clock genes are differentially expressed in many tumors, and accelerate the development and progression of tumors. In addition, tumor tissues exert varying biological activities compared to normal tissues due to resetting of altered rhythms. Thus, chronotherapeutics used for cancer treatment should exploit the timing of circadian rhythms to achieve higher efficacy and mild toxicity. Due to interpatient differences in circadian functions, our findings advocate an individualized precision approach to chronotherapy. Herein, we review the specific association between circadian clocks and cancers. In addition, we focus on chronotherapies in cancers and personalized biomarkers for the development of precision chronotherapy. The understanding of circadian clocks in cancer will provide a rationale for more effective clinical treatment of tumors.


2019 ◽  
Vol 8 (1) ◽  
pp. 57-68 ◽  
Author(s):  
Shuhui Ma ◽  
Zixu Wang ◽  
Jing Cao ◽  
Yulan Dong ◽  
Yaoxing Chen

The avian pineal gland, an independent circadian oscillator, receives external photic cues and translates them for the rhythmical synthesis of melatonin. Our previous study found that monochromatic green light could increase the secretion of melatonin and expression of CLOCK and BMAL1 in chick pinealocytes. This study further investigated the role of BMAL1 and CLOCK in monochromatic green light-induced melatonin secretion in chick pinealocytes using siRNAs interference and overexpression techniques. The results showed that si-BMAL1 destroyed the circadian rhythms of AANAT and melatonin, along with the disruption of the expression of all the seven clock genes, except CRY1. Furthermore, overexpression of BMAL1 also disturbed the circadian rhythms of AANAT and melatonin, in addition to causing arrhythmic expression of BMAL1 and CRY1/2, but had no effect on the circadian rhythms of CLOCK, BMAL2 and PER2/3. The knockdown or overexpression of CLOCK had no impact on the circadian rhythms of AANAT, melatonin, BMAL1 and PER2, but it significantly deregulated the circadian rhythms of CLOCK, BMAL2, CRY1/2 and PER3. These results suggested that BMAL1 rather than CLOCK plays a critical role in the regulation of monochromatic green light-induced melatonin rhythm synthesis in chicken pinealocytes. Moreover, both knockdown and overexpression of BMAL1 could change the expression levels of CRY2, it indicated CRY2 may be involved in the BMAL1 pathway by modulating the circadian rhythms of AANAT and melatonin.


2021 ◽  
Vol 12 ◽  
Author(s):  
Xunwen Xue ◽  
Yasser F. Ali ◽  
Wanrong Luo ◽  
Caorui Liu ◽  
Guangming Zhou ◽  
...  

The intrinsic earth magnetic field (geomagnetic field, GMF) provides an essential environmental condition for most living organisms to adapt the solar cycle by rhythmically synchronizing physiological and behavioral processes. However, hypomagnetic field (HMF) of outer space, the Moon, and the Mars differs much from GMF, which poses a critical problem to astronauts during long-term interplanetary missions. Multiple experimental works have been devoted to the HMF effects on circadian rhythm and found that HMF perturbs circadian rhythms and profoundly contributes to health problems such as sleep disorders, altered metabolic as well as neurological diseases. By systemizing the latest progress on interdisciplinary cooperation between magnetobiology and chronobiology, this review sheds light on the health effects of HMF on circadian rhythms by elaborating the underlying circadian clock machinery and molecular processes.


2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Beibei Luo ◽  
Xin Zhou ◽  
Qingming Tang ◽  
Ying Yin ◽  
Guangxia Feng ◽  
...  

AbstractMetabolism is one of the most complex cellular biochemical reactions, providing energy and substances for basic activities such as cell growth and proliferation. Early studies have shown that glucose is an important nutrient in osteoblasts. In addition, amino acid metabolism and fat metabolism also play important roles in bone reconstruction. Mammalian circadian clocks regulate the circadian cycles of various physiological functions. In vertebrates, circadian rhythms are mediated by a set of central clock genes: muscle and brain ARNT like-1 (Bmal1), muscle and brain ARNT like-2 (Bmal2), circadian rhythmic motion output cycle stagnates (Clock), cryptochrome 1 (Cry1), cryptochrome2 (Cry2), period 1 (Per1), period 2 (Per2), period 3 (Per3) and neuronal PAS domain protein 2 (Npas2). Negative feedback loops, controlled at both the transcriptional and posttranslational levels, adjust these clock genes in a diurnal manner. According to the results of studies on circadian transcriptomic studies in several tissues, most rhythmic genes are expressed in a tissue-specific manner and are affected by tissue-specific circadian rhythms. The circadian rhythm regulates several activities, including energy metabolism, feeding time, sleeping, and endocrine and immune functions. It has been reported that the circadian rhythms of mammals are closely related to bone metabolism. In this review, we discuss the regulation of the circadian rhythm/circadian clock gene in osteoblasts/osteoclasts and the energy metabolism of bone, and the relationship between circadian rhythm, bone remodeling, and energy metabolism. We also discuss the therapeutic potential of regulating circadian rhythms or changing energy metabolism on bone development/bone regeneration.


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