scholarly journals COMPARISON OF THE STATE OF THE MAXILLARY SINUSES IN A NEW CORONAVIRUS INFECTION COVID-19 AND ACUTE RESPIRATORY VIRAL INFECTION

2021 ◽  
Vol 14 (5) ◽  
pp. 28-33
Author(s):  
ALEXANDER V. KOLSANOV ◽  
◽  
TATYANA JU. VLADIMIROVA ◽  
PAVEL V. ZELTER ◽  
OLESYA V. ZELYOVA ◽  
...  
Keyword(s):  
Mucous Membrane ◽  
Paranasal Sinuses ◽  
Chronic Sinusitis ◽  
Respiratory Infections ◽  
Control Group ◽  
Acute Respiratory Infections ◽  
Lower Wall ◽  
Study Results ◽  
Coronavirus Infection ◽  
Maxillary Sinuses

The aim of the study was to identify possible changes in the maxillary sinuses during new coronavirus infection in comparison with the changes in the sinuses occurring during acute respiratory infections and to correlate the gender structure of the study groups. Material and methods. The study included 40 patients (18 women and 22 men) with a confirmed new coronavirus infection, hospitalized at the Covid Hospital Clinics of Samara State Medical University in 2020. All patients underwent multispiral computed tomography of the paranasal sinuses on a Ge revolution Evo 128 tomograph on the 10th day after the appearance of the first clinical symptoms. We also examined a control group of patients with acute respiratory infections with similar complaints of impaired sense of smell, rhinorrhea, and upper maxillary sinus discomfort. This group also included 40 people (24 women and 16 men). Statistical processing of the study results was performed using Microsoft Excel software package, the Mann – Whitney method of statistical significance calculation was used. Results and discussions. In 18 (45%) patients with a confirmed new coronavirus infection, a slight mucosal thickening along the lower wall of the maxillary sinuses was found symmetrically on both sides. Six (15%) of them were women and 12 (30%) were men. The age of the examined patients ranged from 31 to 83 years. Chronic sinusitis was noted in the history of 8 (20%) of the examined patients. In 6 (15%) patients with chronic sinusitis no abnormalities were detected in the maxillary sinuses at the time of examination. Two of them had parietal thickening of the mucous membrane along the lower wall of the maxillary sinuses. In the control group, there was significant symmetric parietal thickening of the mucous membrane of the paranasal sinuses in 24 (60%) examined patients (14 women and 10 men). There were no statistically significant differences in the prevalence of changes in the studied and control groups. Conclusion. According to the results of this study, there were no data on the pattern of occurrence of changes in the mucosa of the maxillary sinuses in new coronavirus infection with gender background or the presence of chronic inflammation of the maxillary sinuses in the history compared with the control group of examined patients after acute respiratory infections.

scholarly journals The role of multistraine probiotics in non-specific seasonal prevention of acute respiratory infections in children with recurrent URTI in organized teams

2021 ◽  
pp. 220-226
Author(s):  
Lyudmila D. Panova Lyudmila D. Panova Lyudmila D. Panova
Keyword(s):  
Treatment Group ◽  
High Risk ◽  
Randomized Clinical Trials ◽  
Comparison Group ◽  
Respiratory Infections ◽  
Evidence Base ◽  
Acute Respiratory Infections ◽  
Infection Period ◽  
Study Results

Introduction. A broad evidence base of numerous randomized clinical trials and meta-analyses asserts the role of intestinal microbiota dysbiosis in the development of various diseases, including those of infectious origin, in infancy and later stages of life.Purpose. Assessment of the efficacy of a multi-strain immuno-probiotic during rehabilitation of frequently ill children visiting organized groups during the period of epidemiological distress for acute respiratory diseases.Materials and methods.93 children older than 3 years of age were enrolled in an open comparative prospective clinical observation during the high-risk respiratory infection period  – November, December. Children were observed for 1.5 months during administration of the multi-strain probiotic and 1 month after discontinuation of the probiotic. The subjects were randomized into two groups: the treatment group (60 children) received the multi-strain probiotic in the maximum age-specific dosage variances (children aged 3 to 12 years old – 1 capsule, older than 12 years of age – 2 capsules) once a day in the morning for 14 days and the comparison group (33 children) did not receive the multi-probiotic for the same period.Results and discussion. It was found that the incidence of disease in children receiving the multi-probiotic (the treatment group – 60 children) was statistically lower, and the disease severity was milder than in the group of children, who did not receive the probiotic (the comparison group – 33 children). Not a single child who received the multi-probiotic in the course of disease did not require antibiotic therapy during the entire observation period. Moreover, the incidence of respiratory infections in the treatment group within a month after discontinuation of the probiotic was 4.6 times lower than in the comparison group. No side effects were reported.Conclusions. The study results allowed the author to recommend the use of a multi-strain immuno-probiotic as a nonspecific immunomodulatory supplement for the seasonal prevention of acute respiratory infections, especially in frequently ill children at a high risk of infections.

scholarly journals Cognición sobre infecciones respiratorias agudas de madres con niños preescolares: una intervención de enfermería

2016 ◽  
Vol 18 (3) ◽  
Author(s):  
Helibio Alan-Mamani ◽  
Denices S. Abarca-Fernández ◽  
Tita Flores-de-Quispe
Keyword(s):  
School Children ◽  
Respiratory Infections ◽  
Hypothesis Test ◽  
Educational Institution ◽  
Nursing Intervention ◽  
Acute Respiratory Infections ◽  
Significance Level ◽  
Study Results ◽  
Post Test ◽  
The Impact

<p>La investigación se realizó con el objetivo de determinar el impacto de la intervención enfermería en la cognición sobre prevención de infecciones respiratorias agudas en madres con niños pre escolares y el diseño de un programa de intervención, que propicia el aprendizaje significativo en las madres. El estudio fue de tipo pre experimental con diseño pre y post test. La población estuvo conformada por 50 madres de niños pre-escolares, y la muestra por 33 madres de estudiantes de la Institución Educativa Inicial N° 1357 “Señor de los Milagros” – Juliaca-2015. La recolección de datos se realizó con la encuesta, mediante la aplicación de un cuestionario en el pretest y el postest, 15 días después de concluir con las intervenciones. El análisis de datos se realizó en forma porcentual y la contrastación de la hipótesis con la prueba Z calculada. Los resultados del estudio demuestran que antes de la intervención de enfermería, la cognición de las madres sobre las infecciones respiratorias agudas, el 64% fue deficiente, 27% regular y 9% bueno mientras que, después de la intervención la cognición prospera a bueno al 70% y 30% a regular. Por tanto, la intervención de enfermería con el modelo Andragógico es efectiva para optimizar la cognición, confirmada, con un nivel de significancia de p&lt;0.05.</p><p><strong> </strong></p><p align="center"><strong>ABSTRACT</strong></p><pre>The research was conducted in order to determine the impact of nursing interventions on cognition on acute respiratory infections in mothers with pre school children. The study was pre experimental, with pre and post test design; The population for the study was composed of 50 mothers with pre school children, the sample consisting 0f 33 mothers  from students of initial educational institution  1357 “Señor de los Milagros”  Juliaca-2015. Data collection was performed with the survey, by applying a questionnaire in the pretest and posttest, 15 days after concluding interventions. Data analysis was performed on a percentage basis and the testing of the hypothesis test with the Z calculated. The study results show that before the nursing intervention, cognition of mothers on acute respiratory infections, 64% was poor, 27% regularly and 9% good while after intervention cognition thrives well at 70% and 30% regulate. Therefore, the nursing intervention with Andragogic model is effective to optimize cognition, confirmed, with a significance level of p = 0.05.</pre><pre>Keywords: Nursing care, educational intervention, cognition, acute respiratory infections, children</pre><p> </p>

scholarly journals Acute respiratory infections in outpatient care in the era of the COVID-19 pandemic: the role and position of antibacterial therapy

2020 ◽  
Vol 4 (4) ◽  
pp. 214-218
Author(s):  
R.F. Khamitov ◽  
Keyword(s):  
Health Care ◽  
Outpatient Care ◽  
Viral Infections ◽  
Respiratory Infections ◽  
Respiratory Viruses ◽  
Acute Respiratory Infections ◽  
The Novel ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
Care Costs

Acute respiratory infections of the upper and lower respiratory tract are currently the leading cause of human morbidity, mainly due to the seasonal rise of the incidence rates of viral infections. This results in the heavy burden of annual health care costs. The COVID-19 pandemic exacerbated the problem. The associations between respiratory viruses and bacteria are not always clear thus accounting for the diversity of the risks of the complicated course and fatal outcomes of various bacterial viral coinfections. Influenza virus is associated with the high rate of bacterial complications (in particular, during seasonal peaks). Meanwhile, this is less typical of the novel coronavirus infection. In addition, several studies demonstrate the competitive edge of SARS-CoV-2 when interacting with other respiratory viruses. The specificities of viral bacterial associations greatly affect the treatment whose inadequacy (in particular, the prescription of antibiotics) is the leading cause of the increasing antimicrobial resistance of contemporary germs. The novel coronavirus infection SARS-CoV-2 is no exception in terms of inappropriate antibiotic prescribing as occurred often in the seasonal rise of acute respiratory viral infections. The understanding of this issue, the optimization of treatment strategies, and a reduction in health care costs will allow for preserving antibiotics as a class of highly effective medications. KEYWORDS: acute respiratory infections, COVID-19, bacterial coinfection, outpatient care, lung damage, antimicrobial therapy. FOR CITATION: Khamitov R.F. Acute respiratory infections in outpatient care in the era of the COVID-19 pandemic: the role and position of antibacterial therapy. Russian Medical Inquiry. 2020;4(4):214–218. DOI: 10.32364/2587-6821-2020-4-4-214-218.

A prognostic model to calculate the probability of severe preeclampsia in healthy young reproductive age woman

GYNECOLOGY ◽  
2020 ◽  
Vol 22 (5) ◽  
pp. 17-21
Author(s):  
Nataly I. Frolova ◽  
Tatiana E. Belokrinitskaya ◽  
Kristina A. Kolmakova
Keyword(s):  
Predictive Models ◽  
Prognostic Model ◽  
Respiratory Infections ◽  
Severe Preeclampsia ◽  
Reproductive Age ◽  
Prognostic Models ◽  
Individual Risk ◽  
Control Group ◽  
Acute Respiratory Infections ◽  
Quality Model

Aim.To develop the prognostic model to calculate the probability of severe preeclampsia in healthy young reproductive age woman. Materials and methods.This study included two groups of healthy women aged 1835 years with spontaneous singleton pregnancy: 100 patients with severe preeclampsia (patient group), and 100 women with non-complicated pregnancy (control group). All women had not a risk factors of preeclampsia such as history of hypertension, autoimmune, metabolic, renal, or cardiac diseases, and family or individual history preeclampsia or thromboembolism before this pregnancy. Their body mass index in the 1-st trimester of gestation was 35 kg/sq. m. Gene polymorphisms were detected using the polymerase chain reaction-real time technique. The data were analyzed with methods of binary and multifactorial mathematical statistics. Our analysis of the predictive models was performed by using logistic regression. To determine the diagnostic value of the predictive models used the ROC-curve is followed by determining the area under it (AUC). Results.Some prognostic models to calculate the probability of severe preeclampsia were build using an anamnestic, clinical and genotypic characteristics and multifactorial analysis. Combination of genotypesAGTR2-1675АA/eNOS3-786СC; tobacco smoking; bacteriuria; acute respiratory infections and/or acute vulvovaginitis during 23 trimester of gestation were determinate as most informative predictors of severe preeclampsia. Logistic model included three predictors: bacteriuria; acute respiratory infections and/or acute vulvovaginitis during 23 trimester of gestation had higher prognostic value. ROC analysis identified a high specificity (89.58%) and sensitivity (76.47%) of the model, and the integral index of the effectiveness of predictive markers (AUC=0.885), according to the expert scale of values which is indicative of a very high quality model. Conclusion.It is recommended to use this elaborated predictive model for the purpose of individual risk assessment of severe preeclampsia in healthy young reproductive age woman.

scholarly journals Efficacy of probiotics on digestive disorders and acute respiratory infections: a controlled clinical trial in young Vietnamese children

2020 ◽  
Author(s):  
Truong Tuyet Mai ◽  
Pham Thi Thu ◽  
Hoang Thi Hang ◽  
Tran Thi Thu Trang ◽  
Shintaro Yui ◽  
...  
Keyword(s):  
Nutritional Status ◽  
Respiratory Infections ◽  
Daily Intake ◽  
Fermented Milk ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Acute Respiratory Infections ◽  
Intervention Period ◽  
Probiotic Group

Abstract Objectives To evaluate the efficacy of fermented milk containing Lactobacillus casei strain Shirota (LcS) on the incidence of constipation, diarrhea, acute respiratory infections (ARI), and nutritional status of young Vietnamese children. Methods A controlled field trial was conducted with 1003 children (3–5 years old) in Thanh Hoa province in Vietnam. The probiotic group (n = 510) consumed fermented milk 65 mL/day containing 108 CFU/mL of LcS for the 12-week intervention period, whereas the control group (n = 493) was not given any. The incidence of constipation, diarrhea, ARI, and anthropometry in children was determined at baseline, after 4, 8, and 12-week intervention, and after the 4-week follow-up period. Results Probiotic drink decreased the incidence of constipation after the 12-week intervention period (12.0% vs. 32.0%, OR = 0.28 (95% CI: 0.21–0.40), p < 0.001), tended to decrease the incidence of diarrhea (4.9% vs. 7.9%, OR = 0.60 (95% CI: 0.35–1.01), p = 0.068), and prevented the occurrence of ARI (15.9% vs. 24.5%, OR = 0.58 (95% CI: 0.42–0.79), p < 0.001), when compared with the control group. In contrast, no probiotic effects were observed for the duration of diarrhea or ARI. Weight gain was higher in the probiotic group than in the control group after 4, 8, and 12-week intervention and after the 4-week follow-up period (p < 0.05). Conclusions Daily intake of fermented milk containing LcS strongly prevented the incidence of constipation and ARI in Vietnamese children. This study also revealed the potential effects of the use of a probiotic drink on diarrhea prevention as well as nutritional status improvement.

scholarly journals HUBUNGAN KEBIASAAN MEROKOK DI DALAM RUMAH DENGAN KEJADIAN PENYAKIT INFEKSI SALURAN PERNAPASAN AKUT (ISPA) PADA BALITA DI PUSKESMAS BATURETNO I

2017 ◽  
Vol 5 (2) ◽  
Author(s):  
Budi Kristanto ◽  
Ambrosius Setya Widri Hanggara
Keyword(s):  
Cigarette Smoke ◽  
Acute Respiratory Infection ◽  
Respiratory Infections ◽  
Control Group ◽  
Research Use ◽  
Acute Respiratory Infections ◽  
Age Group ◽  
Cross Sectional ◽  
Under Five ◽  
The Relationship

Background : deaths due to ARI disease in infants reaching 12.4 million in toddlers 0-5year age group every year worldwide, two thirds are babies, that is 0-1 years old and80.3% of deaths occur in developing countries (Kemenkes , 2010). The prevalence ofARI occurrence in Indonesia is 25.0% (Riskesdas, 2013: 23). Smoking habits of parentsin the home make toddlers as passive smokers are always exposed to cigarette smoke.Research purposes : to determine the relationship between exposure to secondhandsmoke with the incidence of acute respiratory infections in infants.Subject : toddlers who checked at Puskesmas Baturetno 1 in February-March 2017 werediagnosed with acute respiratory infection.Methods : this research use correlation research design with cross sectional method. Thepopulation is all parents of children under five who checked their children to Baturetno IPuskesmas in February and March with an acute respiratory infection diagnosis, a total of20 respondents. Control group of children who did not experience acute respiratory tractinfection of 20. Researchers used questionnaire tools. Data obtained then tabulated andanalyzed using SPSS 16 for Windows.Results : 15 children (75%) were exposed to cigarette smoke and 5 children (25%) werenot exposed to cigarette smoke. There was an association between ARI occurrence andexposure of cigarette smoke to under-five children at Puskesmas Baturetno I with p:0.011 <α: 0.05Conclusion : There is a correlation between ARI occurrence and exposure of tobaccosmoke in infants at Puskesmas Baturetno I.Keywords: smoking, acute respiratory infections, less than five years

scholarly journals About olfactory dysfunction in patients with neurotic disorders

1996 ◽  
Vol XXVIII (1-2) ◽  
pp. 35-35
Author(s):  
A. Y. Popelyansky
Keyword(s):  
Respiratory Infections ◽  
Olfactory Dysfunction ◽  
Olfactory Function ◽  
Healthy People ◽  
Control Group ◽  
Acute Respiratory Infections ◽  
Runny Nose ◽  
Neurotic Disorders ◽  
Specialized Department ◽  
Clinical Experiment

In a specialized department of neuroses, the olfactory function was studied in 74 persons (68 women and 6 men from 21 to 63 years old) without a runny nose and other signs of acute respiratory infections. The control group consisted of 30 relatively healthy people. Attention was paid to anamnestic information about the originality of smell (dysesthesia, hyper- or hyposmia). A clinical experiment was conducted to recognize the smell of cologne, perfumes, deodorants and food products, taking into account the time and accuracy of the determination.

scholarly journals Place of mucolytics in the treatment of acute sinusitis

2019 ◽  
pp. 52-56
Author(s):  
A. I. Kryukov ◽  
A. B. Turovskiy ◽  
I. G. Kolbanova ◽  
K. M. Musayev ◽  
A. B. Karasov ◽  
...  
Keyword(s):  
Mucous Membrane ◽  
Paranasal Sinuses ◽  
Chronic Sinusitis ◽  
Acute Sinusitis ◽  
Current Understanding ◽  
Mucociliary Transport ◽  
Analytical Evaluation ◽  
Treatment Results ◽  
Rational Pharmacotherapy

Aim of the study - the analysis of the current understanding of local changes in the mucous membrane of PNS in AS, as well as methods of pharmacotherapy of the disease. The authors consider the main mechanisms of pathogenesis of both acute and chronic sinusitis. One of the reasons underlying the development of infectious inflammation is described in detail: disturbance of drainage function of paranasal sinuses, aeration, mucociliary transport. Analytical evaluation of modern means of rational pharmacotherapy was made. It is concluded that the use of mucolytic drugs improves treatment results.

scholarly journals The role of human β-defensin 2 (HbD-2) and cathelicidin (LL-37) in the local protection of the upper respiratory tract in children with allergic rhinitis and bronchial asthma

2021 ◽  
Vol 26 (1) ◽  
pp. 150-155
Author(s):  
Yu.K. Bolbot ◽  
T.A. Bordiі ◽  
Ya.V. Vilenskyi
Keyword(s):  
Allergic Rhinitis ◽  
Respiratory Tract ◽  
Antimicrobial Peptides ◽  
Bronchial Asthma ◽  
Respiratory Infections ◽  
Allergic Diseases ◽  
Control Group ◽  
Acute Respiratory Infections ◽  
Upper Respiratory Tract ◽  
Upper Respiratory

Allergic diseases of the respiratory system seriously affect the psychological, physical and social aspects of the live of sick children, morally and financially exhausting members of their families as well. It is known that exacerbations of allergic diseases of the respiratory tract occur due to interaction with numerous triggers, one of which is a respiratory viral infection. At the same time, it is widely known that patients with allergic respiratory diseases are more prone to to acute respiratory infections. One of the reasons for this tendency often is an insufficient activity of non-specific factors of local immunity of the respiratory system – endogenous amphiphilic antimicrobial peptides, in particular the most studied their representatives - the family of defensins and human cathelicidin. Current research proves that these antimicrobial peptides are characterized by broad antiviral, antimicrobial and immunomodulatory activity. The aim of this study was to study the concentrations of local immune factors - human HbD-2 and LL-37 - in the secretion of the mucous membranes of the upper respiratory tract in children with asthma and allergic rhinitis and to clarify their role in protection against respiratory viral infections in this contingent of patients. We performed laboratory and clinical examinations of 76 children aged 7 to 18 years, of whom 24 were diagnosed with allergic rhinitis, 28 children - bronchial asthma, and 24 - bronchial asthma and allergic rhinitis. The control group consisted of 20 healthy children of the appropriate sex and age. In addition to general clinical methods, patterns of respiratory morbidity were analyzed and concentrations of antimicrobial peptides were determined: by ELISA human cathelicidin (LL-37), β-defensin 2 (HbD-2) in the secretion of the upper respiratory tract, statistical analysis was performed. It was found that children with allergic diseases of the respiratory tract are characterized by a higher frequency of acute respiratory infections with more frequent involvement of the lower respiratory tract, which led to an increase in the duration of the disease compared to their healthy peers. In children with allergic rhinitis and bronchial asthma, there was revealed a significant decrease in the concentrations of antimicrobial peptides in the secretion of the upper respiratory tract compared with the control group.

Preventive anti-inflammatory therapy during the acute respiratory infections in children with mild and moderate bronchial asthma

2020 ◽  
Vol 15 (6) ◽  
pp. 35-41
Author(s):  
V.A. Revyakina ◽  
◽  
I.A. Larkova ◽  
E.D. Kuvshinova ◽  
◽  
...  
Keyword(s):  
Bronchial Asthma ◽  
Respiratory Infections ◽  
Average Duration ◽  
Clinical Manifestations ◽  
Main Group ◽  
Control Group ◽  
External Respiration ◽  
Acute Respiratory Infections ◽  
Acute Period ◽  
Anti Inflammatory

Objective. To evaluate the efficacy and safety of using anti-inflammatory drugs based on ammonium glycyrrhizinate (AG) (Reglisam, CJSC “VIFITECH”, Russia) in children with BA in the acute period of ARI. Patients and methods. Under observation there were 42 children (from 6 to 10 years old) with a diagnosis of BA in the acute period of ARI (1–2 days from the beginning of clinical manifestations). Patients were randomized into the main group – 20 patients who were prescribed the drug ammonium glycyrrhizinate (Reglisam) in addition to symptomatic ARI therapy, and the control group – 22 children who were prescribed only symptomatic ARI therapy. The observation period was 14 days with 2 checkpoints (1st and 14th days), when the following parameters were evaluated: general clinical examination; asthma symptoms; PCR diagnostics of acute respiratory viral infection and influenza pathogens; external respiration and BA control test (C-ACT), administration of additional medications and development of adverse events. Results. There was a decrease in the average scores of daily and night symptoms of BA in the study group, both in dynamics and in comparison with the control group at visit 2 (p < 0.05). The average duration of ARI in the main group was 6.34 ± ± 1.15 days and was less than that in the control group of patients (10.95 ± 1.45 days) (p < 0.05). The average duration of the use of short-acting β2-agonists in the main group was 3.37 ± 1.05 days and was less in comparison with the control group (6.75 ± 1.6) (p < 0.05). On the 14th day of observation in the main group, the median of C-ACT parameters increased and corresponded to good control of BA, and the level of blood eosinophils decreased to normal values; in the control group, no such dynamics was found. In 78% of patients in the main group, on the 14th day of observation, the persistence of previously detected respiratory viruses and influenza was not determined, the proportion of such patients in the control group was more than 2 times less. Conclusion. The data obtained indicate the feasibility and effectiveness of the inclusion of the drug AG as a preventive therapy for children with asthma in the acute period of ARI to improve control over the course of the disease. Key words: bronchial asthma, children, therapy, ammonium glycyrrhizinate, acute respiratory infections

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