scholarly journals A New Perspective on a Morphological Confirmation of the Tissue Repair Process in the Experimental Simulation of a Surgical Dental Extraction in Rats

2021 ◽  
Vol 11 (2) ◽  
pp. 164-168
Author(s):  
Arpine Antonyan ◽  
Dmitriy Kharitonov ◽  
Anna Podoprigora ◽  
Iliya Stepanov ◽  
Оleg Shalaev ◽  
...  
Keyword(s):  
Healing Process ◽  
Model Organism ◽  
Experimental Simulation ◽  
Dental Extraction ◽  
Wound Healing Process ◽  
High Concentration ◽  
Lower Incisor ◽  
Ionic Silver ◽  
Silver Solution ◽  
Surgical Extraction

All stages of a surgical dental extraction are accompanied by risks of various complications. Many ways and methods have been created in order to prevent the development of complications of different genesis. However, this issue still remains relevant since dental surgeons face the challenge of inflammation problems during the post-extraction period. The use of male Wistar rats as a model organism for a surgical extraction of a lower incisor allows us to conduct visual, histological and immunohistochemical evaluations of the wound healing process. The main objective of this study was to compare the effect of ionic silver solution and hydrogen water in high concentration when irrigating the operational field of a surgical dental extraction on the lower jaw. The results obtained showed that the use of water with an increased content of molecular hydrogen during the treatment is able to stimulate the recovery of the EM of the connective periodontal tissue to a greater extent than the ionic silver solution, connected to the participation of MCs and their secretome.

scholarly journals BMP-2 Expression of Post Tooth Extraction that Catfish Oil Application

2017 ◽  
Vol 3 (6) ◽  
pp. 69
Author(s):  
Theresia Indah B. ◽  
Bambang Sumaryono ◽  
Ketut Suardita ◽  
Amelia Putri R.
Keyword(s):  
Fish Oil ◽  
Healing Process ◽  
Clarias Batrachus ◽  
Bone Morphogenetic Protein 2 ◽  
Dental Extraction ◽  
Control Group ◽  
Wound Healing Process ◽  
Omega 3 ◽  
Significant Difference ◽  
Catfish Oil

Catfish (Clarias batrachus) oil contain the highest amount of omega-3-PUFA among other freshwater fish. The omega-3-PUFA in fish oil produced eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). It is known that EPA and DHA in essentials fatty acid (EFA) could improve BMP-2 expression. Bone morphogenetic protein-2 (BMP-2) is bone stimulator which capable of inducing differentiation of mesenchymal cells into osteoblast, stimulating bone formation in wound healing process of dental extraction. Purpose: To prove the increasing expression of BMP-2 after catfish (Clarias batrachus) oil application. Methods: We have used the post test only design in this research. There have been 21 Rattus novergicus as research samples, and those were divided into 3 groups, group KK as control, group KP1 was given catfish (Clarias batrachus) oil in 5% concentration, and group KP2 was given catfish (Clarias batrachus) oil in 10% concentration. Catfish (Clarias batrachus) oil were applied into the socket of dental extraction. Rat was decapulated 7 days after fish oil application and the jaw in the treated regions and control group were cut for immunohistochemistry examination to observe BMP-2 expression. Data was analyzed using one-way ANOVA test.  Result: There is significant difference increased of BMP-2 expression between control and treatment group. In samples given with 10% concentration of catfish oil had the most significant increase of BMP-2 expression. Conclusion: Catfish (Clarias batrachus) oil in 10% concentration could increase the expression of BMP-2 post dental extraction.Key words: Catfish oil, BMP-2, dental extraction.

scholarly journals Penggunaan Scaffold Kitosan-Aloe Vera Terhadap Proliferasi Sel Fibroblas pada Penyembuhan Luka Pasca Pencabutan Gigi Cavia Cobaya

2018 ◽  
Vol 7 (2) ◽  
pp. 24
Author(s):  
Sularsih Sularsih ◽  
Fitria Rahmitasari
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Aloe Vera ◽  
Growth Factor Receptor ◽  
Dental Extraction ◽  
Control Group ◽  
Wound Healing Process ◽  
Fibroblast Cells ◽  
Treatment Groups ◽  
And Control

Aloe vera has been investigated potential use in tissue engineering. Its bioactive compounds interact with growth factor receptor on the fibroblast and stimulate cells proliferation.   The aim of this study was to investigate the proliferation of fibroblast cells on wound healing process of Cavia cobaya dental extraction using scaffold combination chitosan and Aloe vera.  Cavia cobaya male with 300-350 grams of weight and in the age of 3 to 3.5 months. It divided into ten groups (n=5). For Treatment groups, Aloe vera scaffold(Av); Chitosan Scaffold (Ch); Scaffold combination chitosan-Aloe vera (Ch-Av) and scaffold combination chitosan- Aloe vera- hidroksiapatit(Ch-Av-HA) were applied into the socket of dental extraction.  For control group, which were not given scaffold. Cavia cobaya were decaputated at 7 and 14 days  and the jaw in the treated regions and control group were cut for Histopatology Anatomy examination to investigate the proliferation of fibroblast cells. Data were analyzed using One way Anova test. The proliferation of fibroblast cells were found higher in the group which given Av-Ch and Av-Ch-HA scaffold. The result  showed  significant differences in proliferation of fibroblast cells for 7 and 14 days observation  compared to control group (p<0,05). The application of  scaffold combination Chitosan and Aloe vera accelerate the wound healing process of Cavia cobaya dental extraction.

HUBUNGAN MOBILISASI DINI TERHADAP PENYEMBUHAN LUKA POST OPERASI SECTIO CESARIA

2019 ◽  
Vol 2 (1) ◽  
pp. 14-17
Author(s):  
Nurul Aini Siagian ◽  
Syafira Nusaibah ◽  
Andayani Boang Manalu
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Early Mobilization ◽  
Sectio Caesarea ◽  
Wound Healing Process ◽  
P Value ◽  
Cross Sectional ◽  
Care Services ◽  
Healing Wound ◽  
Rapid Healing

Early mobilization includes factors that can affect the process of wound healing after surgery. Immediate mobilization in stages is very useful for the process of healing wounds and preventing infection and venous thrombosis. The purpose of this study was to determine whether there is a relationship between early mobilization and the process of healing wound post operative sectio caesarea at Sinar Husni General Hospital Medan Helvetia. The research design used was analytic survey with cross sectional approach. The sample in this study used the Consecutive Sampling method of data collection using a checklist sheet conducted on a sample of 19 respondents. The results of the study in this study are the majority of respondents who did early mobilization and who experienced rapid wound healing process as many as 4 people (21%) while the minority of respondents who did early mobilization and who experienced slow wound healing process were 1 person (5.3%). The majority of respondents who did not mobilize early and who experienced a slow wound healing process were 11 people (57.9%) and a minority who did not mobilize early and who experienced rapid healing as many as 4 people (21.1%). Statistical test results obtained p value = 0.046 <0.005. The conclusions of the results of this study indicate there is a relationship between early mobilization and the process of healing post operative sectio of caesarea. Suggestions The results of this study can be applied as a reference to improve nursing care services, especially in providing counseling and assistance to patients.

Hydrogels: A Versatile Drug Delivery Carrier Systems

1970 ◽  
Vol 5 (3) ◽  
pp. 1745-1756
Author(s):  
L H Baldaniya ◽  
Sarkhejiya N A
Keyword(s):  
Drug Delivery ◽  
Protein Delivery ◽  
Structural Integrity ◽  
Healing Process ◽  
Polymer Chains ◽  
Wound Healing Process ◽  
Aqueous Environment ◽  
Preparation Methods ◽  
Control Drug

Hydrogels are the material of choice for many applications in regenerative medicine due to their unique properties including biocompatibility, flexible methods of synthesis, range of constituents, and desirable physical characteristics. Hydrogel (also called Aquagel) is a network of polymer chains that are hydrophilic, sometimes found as a colloidal gel in which water is the dispersion medium. Hydrogels are highly absorbent (contain ~99.9% water), natural or synthetic polymers. Hydrogel also possess a degree of flexibility very similar to natural tissue, due to its significant water content. It can serve as scaffolds that provide structural integrity to tissue constructs, control drug and protein delivery to tissues and cultures. Also serve as adhesives or barriers between tissue and material surfaces. The positive effect of hydrogels on wounds and enhanced wound healing process has been proven. Hydrogels provide a warm, moist environment for wound that makes it heal faster in addition to its useful mucoadhesive properties. Moreover, hydrogels can be used as carriers for liposomes containing variety of drugs, such as antimicrobial drugs. Hydrogels are water swollen polymer matrices, with a tendency to imbibe water when placed in aqueous environment. This ability to swell, under biological conditions, makes it an ideal material for use in drug delivery and immobilization of proteins, peptides, and other biological compounds. Hydrogels have been extensively investigated for use as constructs to engineer tissues in vitro. This review describes the properties, classification, preparation methods, applications, various monomer used in formulation and development of hydrogel products.

Chemical Reactions of Iodoform in the Study of Post-Extraction Alveolites

2017 ◽  
Vol 68 (10) ◽  
pp. 2378-2381
Author(s):  
Cristian Budacu ◽  
Mihai Constantin ◽  
Iulia Chiscop ◽  
Carmen Gabriela Stelea ◽  
Raluca Dragomir
Keyword(s):  
Healing Process ◽  
Maxillofacial Surgery ◽  
Post Treatment ◽  
Dental Extraction ◽  
Oral And Maxillofacial Surgery ◽  
Key Factors ◽  
Mucosal Regeneration ◽  
Prophylactic Measures ◽  
The Social ◽  
The Face

Post-operative alveolitis is a topical issue in dental practice, which is also reflected by the etiopathogenic aspects. The conservative principle requires the maintenance of dento-periodontal units in the arch for as long as possible, but there are situations where dental extraction is required. The healing process of the post-surgical wound is complex and involves processes of gingival mucosal regeneration and bone reshaping, involving several local factors: wound size, presence of infection, alveolar vascularization, intraalveolar foreign bodies, and general factors, especially general condition, age and body reactivity. The quality, structure, maintenance, and retraction of the clot are key factors in the formation of connective tissue during the healing of the post-extraction would. At the Oral and Maxillofacial Surgery Clinic of Gala�i, during a 2-year period between January 2015 and December 30, 2016, 2780 patients that required surgery - dental extraction were consulted and diagnosed. We found that among those 2780 patients with dental extractions 105 (3.77%) had post-treatment alveolitis. No post-surgical alveolitis from the case study was complicated by osteomyelitis of the jaws or by suppurations of the superficial or deep compartments of the face. The prophylactic measures in each dental extraction, together with the correct and timely curative treatment, combined with the dentist�s competence and responsibility, can shorten the time of suffering, actively combating the risk factor and accelerating the social reintegration of the patient with post-treatment alveolitis.

Hubungan Status Gizi Dengan Proses Penyembuhan Luka Di Rsud H. Andi Sulthan Daeng Radja Kabupaten Bulukumba

2017 ◽  
Vol 2 (1) ◽  
pp. 20-28
Author(s):  
Fitriani ◽  
Tenriwati
Keyword(s):  
Wound Healing ◽  
Nutritional Status ◽  
Healing Process ◽  
Data Retrieval ◽  
Observational Research ◽  
Wound Healing Process ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Chi Square Test

At present, the incidence of injuries in Indonesia is quite high, as seen from data on traffic accidents in the general public. There are several factors that affect wound healing, one of which is nutritional status. Based on the preliminary data retrieval conducted by researchers in the seruni surgery room in the last 1 month namely in March, it was found that the number of wounded patients was 109 patients, where the number of men was 78 (71.56%) while the number of women was 31 ( 28.44%) The purpose of this study was to determine the relationship between nutritional status and the wound healing process in RSUD. H. Andi. Sulthan Daeng Radja Kab. Bulukumba. This research uses the type of design of this research is quantitative research. This type of research uses analytic observational research with cross sectional approach. The sample of this study were 41 respondents taken by purposive sampling method. Data analysis in this study used the chi-square test (chi square test). The results of the analysis used the chi-square statistical test with a confidence level (α = 0.05). Based on the results of this test, the p value is 0.001, thus p <α (0.001 <0.05), then Ho is rejected and Ha is accepted. The conclusion of this study is that there is a relationship between nutritional status and the process of wound healing in RSUD. H. Andi. Sulthan Daeng Radja Kab. Bulukumba. Researchers suggest that this study be used as a material consideration in the fulfillment of nutrition in wound care patients in RSUD.H.A. Sulthan Daeng Radja Kab. Bulukumba and this research can be continued by conducting research related to the wound healing process and linking it with other variables.

Natural, Synthetic and their Combinatorial Nanocarriers Based Drug Delivery System in the Treatment Paradigm for Wound Healing Via Dermal Targeting

2020 ◽  
Vol 26 (36) ◽  
pp. 4551-4568
Author(s):  
Mohammad Kashif Iqubal ◽  
Sadaf Saleem ◽  
Ashif Iqubal ◽  
Aiswarya Chaudhuri ◽  
Faheem Hyder Pottoo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Photodynamic Therapy ◽  
Growth Factors ◽  
Combination Therapy ◽  
Healing Process ◽  
Wound Healing Process ◽  
Wound Site ◽  
Synthetic Drugs ◽  
Treatment Paradigm

A wound refers to the epithelial loss, accompanied by loss of muscle fibers collagen, nerves and bone instigated by surgery, trauma, frictions or by heat. Process of wound healing is a compounded activity of recovering the functional integrity of the damaged tissues. This process is mediated by various cytokines and growth factors usually liberated at the wound site. A plethora of herbal and synthetic drugs, as well as photodynamic therapy, is available to facilitate the process of wound healing. Generally, the systems used for the management of wounds tend to act through covering the ruptured site, reduce pain, inflammation, and prevent the invasion and growth of microorganisms. The available systems are, though, enough to meet these requirements, but the involvement of nanotechnology can ameliorate the performance of these protective coverings. In recent years, nano-based formulations have gained immense popularity among researchers for the wound healing process due to the enhanced benefits they offer over the conventional preparations. Hereupon, this review aims to cover the entire roadmap of wound healing, beginning from the molecular factors involved in the process, the various synthetic and herbal agents, and combination therapy available for the treatment and the current nano-based systems available for delivery through the topical route for wound healing.

A Comprehensive Review On Alginate As Wound Dressing Biomaterial

2020 ◽  
Vol 04 ◽  
Author(s):  
Sourav Mohanto ◽  
Prithviraj Chakraborty ◽  
Chidambaram Soundra Pandian ◽  
Shubhradeep Manna ◽  
Joni Dutta
Keyword(s):  
Therapeutic Efficacy ◽  
Wound Dressing ◽  
Chronic Wound ◽  
Healing Process ◽  
Wound Healing Process ◽  
Detailed Knowledge ◽  
Pathophysiological Mechanisms ◽  
Moist Environment ◽  
Bioactive Agents ◽  
Mechanical Nature

Background: The design and characteristics of alginate biomaterial have a significant role in wound dressing and tissue regeneration. The ideal biomaterial for wound dressing must have biodegradable, biocompatible, non-inflammatory, non-toxic. Objective: Wound dressing should promote the re-epithelization and protect the wound for further infection by creating a moist environment. The physical and mechanical nature of the alginate biopolymer has the potential to influence the pathophysiological mechanisms in the chronic wound actively. The application of this biomaterial provides an ampule advantage to synthetic polymers. Method: The wound healing process is a critical step involved in different phases. The presence of cross-linkers, polymers along with alginate lead to a decrease in the mechanical property of dressing. Hence the effective material choosing along with alginate is a very critical decision. The therapeutic efficacy of the alginate dressing system (film, hydrogel, wafer, etc.) influenced by the incorporation of different materials such as bioactive agents, nanoparticles, cross-linker, nature of the excipients, etc. Results: The ion exchange occurring between dressing and exudates resulted in the formation of gel, due to the glucuronic acid presence in alginate. This gel absorbs moisture and maintains an appropriate moist environment and actively influence the pathophysiological mechanisms in the chronic wound. Conclusion: This review gives a detailed knowledge of the researchers to work with alginate and provides knowledge about the incorporation of the appropriate material and their therapeutic efficacy in wound dressing.

Scientific aspect on Diet explained by Susrutha in Wound Healing

2017 ◽  
Vol 2 (05) ◽  
Author(s):  
Manoj Kumar ◽  
Amareshappa . ◽  
Anjali Bharadwaj ◽  
Shailaja S. V.
Keyword(s):  
Wound Healing ◽  
Mineral Metabolism ◽  
Healing Process ◽  
Surgical Techniques ◽  
The Body ◽  
Wound Healing Process ◽  
Human Being ◽  
Different Sources ◽  
Scientific Aspect ◽  
Important Branch

Wound healing has been the burning problem in a surgical practice because of a remarkable increase in the number of traumatic cases. A wound causes a number of changes in the body that can affect the healing process, including changes in energy, protein, carbohydrate, fat, vitamin and mineral metabolism. Various Ayurveda literatures, particularly, Sushruta Samhita, which is said to be an ancient textbook of surgery in Ayurveda, has mentioned about the diet for the person suffering from the wound, and the author said that diet plays a very important role in the wound healing process. Sushruta - The father of surgery has scientifically classified it in a systemic manner, whose wealth of clinical material and the principles of management are valid even today. Shalya Tantra (surgical branch in Ayurveda Science) is one of the important branch of Ayurveda, in which surgical and para-surgical techniques has described for management of various diseases. Vrana is the most important and widely described chapter of Shalya Tantra. Vrana (wound) is one of them, which have been managed by human being from starting of civilization. Under the circumstances, the first thing which the men came across was the injury from different sources which caused him the Vrana. Vrana is seen as debilitating and scaring disorder, usually seen affecting the human being at any age. Well balanced nutrition plays an essential role in the wound healing.

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