The Effect of Biometric Parameters on Spot Vision Screener Results

Mapping Intimacies ◽

10.21203/rs.3.rs-277866/v1 ◽

2021 ◽

Author(s):

meryem guler alıs ◽

abdulkadir alıs

Keyword(s):

Risk Factors ◽

Negative Correlation ◽

High Specificity ◽

Spherical Equivalent ◽

Biometric Parameters ◽

Clinical Advantage ◽

Moderate Sensitivity ◽

The Relationship ◽

Vision Screener

Abstract objective: Our aim in this study is to investigate the relationship between biometric parameters and spot vision screener [SVS]Materyal-Metods: 250 eyes of 125 children between the age of 6,77±1,59 included the study. The results of cyloplegic [CSVS] and noncycloplegic [NSVS] spot vision screener [Plusoptix p12,Germany] measurements and autorefractometer with cycloplegia [CA] were compared. The spherical equivalent [SE] differences of between CA and NSVS measurements with CA and CSVS measurements were compared with AL, ACD, CR, Mean K and AL / CR values. The relationship between them was examined.Results: According to the amblyopia risk factors [ARFs] based on the criteria from AAPOS 2013 guidelines , 33 eyes [13%] in the NSVS results and 34 eyes [13.6%] in the CSVS results were detected as amblyopic. According to CA results, NSVS had 67.3% sensitivity, 94.5% specificity, CSVS 69.4% sensitivity and 89.1% specificity in detecting amblyopia. When the SE differences of between CA and NSVS values were comparaed with biometric parameters a negative correlation was observed with ACD , AL and especially AL/CR ratio .Conclussion: Both NSVS and CSVS showed moderate sensitivity and high specificity in detecting AFRs based on the criteria from AAPOS 2013 guidelines. CSVS has no additional clinical advantage. Biometric parameters effect the NSVS results.

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Preoperative Lymphocyte-to-monocyte Ratio and CA125 Level as Risk Factors for Advanced Ovarian Cancer

10.21203/rs.3.rs-77009/v1 ◽

2020 ◽

Author(s):

Ying Tang ◽

Huiquan Hu ◽

Yalan Tang ◽

Fangxiang Tang ◽

Dan Lin ◽

...

Keyword(s):

Risk Factors ◽

Ovarian Cancer ◽

Logistic Regression ◽

Early Stage ◽

Advanced Ovarian Cancer ◽

High Specificity ◽

Advanced Stage ◽

Binary Logistic Regression Model ◽

Lymphocyte To Monocyte Ratio ◽

The Relationship

Abstract Background: Detailed descriptions of the relationship between lymphocyte-to-monocyte ratio alone and combined with CA125 (COLC) and advanced stage of ovarian cancer (OC) have been lacking to date. This study is to analyze the relationship between LMR, CA125 and COLC and advanced stage of OC.Methods: A retrospective clinicopathologic review was performed. The receiver-operating characteristic (ROC) curves of LMR, CA125, and COLC staging OC were constructed. Furthermore, a binary logistic regression model was used to assay the independent risk factors.Results: A total of 225 patients with OC were identified in this cohort. Eighty-five patients with OC were diagnosed at an early stage, and 140 OC patients were diagnosed at an advanced stage. The median of LMR at the early stage was higher than the advanced stage (4.39 vs. 2.78), and the median of CA125 was lower than the advanced stage (80 U/mL vs. 251.25 U/mL). Multivariate logistic regression indicated that LMR (OR=0.314, 95% confidence interval [CI]: 0.143–0.687, P=0.004) and CA125 (OR=4.045, 95%CI: 1.883–8.692, P<0.001) were associated with OC staging. Furthermore, the area under the curve of COLC was higher than that of LMR (0.779 vs. 0.732) or CA125 (0.779 vs. 0.708) in staging OC. The specificity of COLC was higher than that of LMR (87.11% vs. 70.61%) or CA125 (87.11% vs. 61.21%) in staging OC.Conclusions: LMR alone or in combination with CA125 might be associated with OC staging. Besides, as a predictive factor, COLC may have high specificity in staging OC.

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Time trend of axial length and associated factors in 4- and 5-year-old children in Shanghai from 2013 to 2019

International Ophthalmology ◽

10.1007/s10792-020-01637-5 ◽

2020 ◽

Author(s):

Tao Li ◽

Ting Wan ◽

Xiaoqian Yao ◽

Huihong Qi ◽

Xuefeng Chen ◽

...

Keyword(s):

Risk Factors ◽

Axial Length ◽

Associated Factors ◽

Time Trend ◽

Multivariate Analyses ◽

Body Height ◽

Spherical Equivalent ◽

Corneal Curvature ◽

Significant Difference ◽

The Relationship

Abstract Purpose To evaluate the time trend of axial length (AL) and associated factors in 4- and 5-year-old children in Shanghai from 2013 to 2019. Methods This was a 7-year observational study of 985 four-year-old and 1059 five-year-old children in Shanghai. AL, horizontal and vertical corneal curvature, spherical equivalent (SE), and body height and weight were measured. Furthermore, a questionnaire was collected, including time outdoors and bad eyesight habits. Results In 4-year-old children, no significant difference was found in AL (P = 0.526), but significant differences were observed in SE (P = 0.001), horizontal corneal curvature (P = 0.006), vertical corneal curvature (P = 0.004), height (P < 0.001), and weight (P = 0.022) from 2013 to 2019. In 5-year-old children, no significant differences were found in AL (P = 0.304), SE (P = 0.200), or weight (P = 0.292), but significant differences were observed in horizontal corneal curvature (P = 0.040), vertical corneal curvature (P = 0.015), and height (P < 0.001) from 2013 to 2019. Multivariate analyses revealed that AL was mainly significantly associated with boys and time outdoors in the 4- and 5-year-old children. Conclusions The AL of 4- and 5-year-old children remained relatively stable in Shanghai from 2013 to 2019. Longitudinal studies are needed to confirm the relationship between AL elongation and environmental risk factors.

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Relationships between Pre-Stroke SARC-F Scores, Disability, and Risk of Malnutrition and Functional Outcomes after Stroke—A Prospective Cohort Study

Nutrients ◽

10.3390/nu13103586 ◽

2021 ◽

Vol 13 (10) ◽

pp. 3586

Author(s):

Masafumi Nozoe ◽

Hiroki Kubo ◽

Masashi Kanai ◽

Miho Yamamoto

Keyword(s):

Multivariate Analysis ◽

Functional Outcomes ◽

Primary Outcome ◽

Screening Tool ◽

High Specificity ◽

Receiver Operating Curve ◽

Modified Rankin Scale ◽

Stroke Patients ◽

Moderate Sensitivity ◽

The Relationship

SARC-F is a screening tool for sarcopenia; however, it has not yet been established whether SARC-F scores predict functional outcomes. Therefore, we herein investigated the relationship between SARC-F scores and functional outcomes in stroke patients. The primary outcome in the present study was the modified Rankin Scale (mRS) 3 months after stroke. The relationship between SARC-F scores and poor functional outcomes was examined using a logistic regression analysis. Furthermore, the applicability of SARC-F scores to the assessment of poor functional outcomes was analyzed based on the area under the receiver operating curve (ROC). Eighty-one out of the 324 patients enrolled in the present study (25%) had poor functional outcomes (mRS ≥ 4). The results of the multivariate analysis revealed a correlation between SARC-F scores (OR = 1.29, 95% CI = 1.05–1.59, p = 0.02) and poor functional outcomes. A cut-off SARC-F score ≥ 4 had low-to-moderate sensitivity (47.4%) and high specificity (87.3%). The present results suggest that the measurement of pre-stroke SARC-F scores is useful for predicting the outcomes of stroke patients.

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Evaluation of serological test in the diagnosis of Helicobacter pylori and risk factors associated with the infection

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20201936 ◽

2020 ◽

Vol 8 (5) ◽

pp. 1828

Author(s):

Ayman Mohamed Alfadil Mohamed ◽

Ream Elzain Abdelgadir ◽

Abdel Rahim Mahmoud Muddathir

Keyword(s):

Risk Factors ◽

Serological Test ◽

High Specificity ◽

Antigen Test ◽

Stool Antigen Test ◽

Factors Associated ◽

Moderate Sensitivity ◽

Stool Antigen ◽

H Pylori ◽

Blood Grouping

Background: Serological testing has been widely used for the diagnosis of H. pylori. This study aimed to evaluate the serological test and to determine the sensitivity and specificity of the test in the diagnosis of H. pylori. The study also aimed to address if there are risk factors like blood grouping, Smoking, Age, gender, and residence of the patients associated with H. pylori infection.Methods: A prospective cross‑sectional study was performed among 100 symptomatic patients attending Dr. Suliman dispensary, Elnehoud city in west Kordofan state-Sudan, from March to September 2016. H. pylori were detected on plasma by using Healgen immunochromatography test cards from Xiamen Boson Biotech Co., Ltd (China), and identified from a stool by using monoclonal antigen detection from the same trademarked company. Data for the risk factors associated with the infection were assessed in a participant interview.Results: The serological test showed significant differences when compared to the stool antigen test p-value = 0.000. The statistical analysis showed moderate sensitivity and high specificity of the serological test compared to the stool antigen detection test. The study also showed that smoking [odds ratio (OR): 1.20, 95% confidence interval (CI): (1.24-4.02) and blood grouping (OR: 1.10, 95% CI: (1.08-1.60) were risk factors for H. pylori infection.Conclusions: The serological test showed high specificity and moderate sensitivity in comparison to the stool antigen test. The increased risk of H. pylori infection associated with smoking and blood grouping.

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Hemmkörperentwicklung bei Hämophilie-Patienten nach Präparate wechsel

Hämostaseologie ◽

10.1055/s-0037-1619773 ◽

2012 ◽

Vol 32 (S 01) ◽

pp. S39-S42 ◽

Cited By ~ 1

Author(s):

S. Kocher ◽

G. Asmelash ◽

V. Makki ◽

S. Müller ◽

S. Krekeler ◽

...

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Observational Study ◽

Retrospective Observational Study ◽

Frequent Change ◽

Patient Age ◽

Treatment Regimens ◽

Patient Âgé ◽

The Relationship ◽

Observation Period

SummaryThe retrospective observational study surveys the relationship between development of inhibitors in the treatment of haemophilia patients and risk factors such as changing FVIII products. A total of 119 patients were included in this study, 198 changes of FVIII products were evaluated. Results: During the observation period of 12 months none of the patients developed an inhibitor, which was temporally associated with a change of FVIII products. A frequent change of FVIII products didn’t lead to an increase in inhibitor risk. The change between plasmatic and recombinant preparations could not be confirmed as a risk factor. Furthermore, no correlation between treatment regimens, severity, patient age and comorbidities of the patients could be found.

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Haematocrit: Relationships with Blood Lipids, Blood Pressure and other Cardiovascular Risk Factors

Thrombosis and Haemostasis ◽

10.1055/s-0038-1648811 ◽

1994 ◽

Vol 72 (01) ◽

pp. 058-064 ◽

Cited By ~ 14

Author(s):

Goya Wannamethee ◽

A Gerald Shaper

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Blood Pressure ◽

Body Mass Index ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Alcohol Intake ◽

Blood Lipids ◽

The Other ◽

The Relationship

SummaryThe relationship between haematocrit and cardiovascular risk factors, particularly blood pressure and blood lipids, has been examined in detail in a large prospective study of 7735 middle-aged men drawn from general practices in 24 British towns. The analyses are restricted to the 5494 men free of any evidence of ischaemic heart disease at screening.Smoking, body mass index, physical activity, alcohol intake and lung function (FEV1) were factors strongly associated with haematocrit levels independent of each other. Age showed a significant but small independent association with haematocrit. Non-manual workers had slightly higher haematocrit levels than manual workers; this difference increased considerably and became significant after adjustment for the other risk factors. Diabetics showed significantly lower levels of haematocrit than non-diabetics. In the univariate analysis, haematocrit was significantly associated with total serum protein (r = 0*18), cholesterol (r = 0.16), triglyceride (r = 0.15), diastolic blood pressure (r = 0.17) and heart rate (r = 0.14); all at p <0.0001. A weaker but significant association was seen with systolic blood pressure (r = 0.09, p <0.001). These relationships remained significant even after adjustment for age, smoking, body mass index, physical activity, alcohol intake, lung function, presence of diabetes, social class and for each of the other biological variables; the relationship with systolic blood pressure was considerably weakened. No association was seen with blood glucose and HDL-cholesterol. This study has shown significant associations between several lifestyle characteristics and the haematocrit and supports the findings of a significant relationship between the haematocrit and blood lipids and blood pressure. It emphasises the role of the haematocrit in assessing the risk of ischaemic heart disease and stroke in individuals, and the need to take haematocrit levels into account in determining the importance of other cardiovascular risk factors.

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