New approaches to the prevention of recurrent respiratory diseases in preschool age

Objective. To evaluate the effectiveness of the natural terpenoids complex in preschool children with recurrent acute respiratory infections (ARI).Material and methods. There were examined 7129 children of 3-7 years old, they were divided into 3 groups. In main group (n = 2400) there was endonasally (on the mucous membrane of the nasal cavity with cotton buds) used a complex of natural terpenoids 2 times a day (morning and evening) 5 days a week for 1 - 3 months. Prevention and treatment of children from the comparison group (n = 2,379) was carried out with dioxotetrahydroxy tetrahydronaphthalene. The control group consisted of children (n = 2,350), who received no therapy. Upon completion of the course of therapy, children were examined in dynamics.Results. The authors noted positive clinical effect of the natural terpenoid complex, as evidenced by a 1.6 times decrease in acute respiratory infections during the year and the duration of the acute episode of the disease by 2.5 days, as well as a positive effect on the elimination of Epstein Barr virusin frequently ill children when using drug for 65.51 ± 2.98 days. The authors observed a favorable clinical effect against the decrease in neutrophils and eosinophils in the rhinocytogram, as well as mixed flora and cocci, indicating a decrease in mucosal neutrophilic inflammation and prevention of bacterial complications.

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The role of multistraine probiotics in non-specific seasonal prevention of acute respiratory infections in children with recurrent URTI in organized teams

Medical Council ◽

10.21518/2079-701x-2021-1-220-226 ◽

2021 ◽

pp. 220-226

Author(s):

Lyudmila D. Panova Lyudmila D. Panova Lyudmila D. Panova

Keyword(s):

Treatment Group ◽

High Risk ◽

Randomized Clinical Trials ◽

Comparison Group ◽

Respiratory Infections ◽

Evidence Base ◽

Acute Respiratory Infections ◽

Infection Period ◽

Study Results

Introduction. A broad evidence base of numerous randomized clinical trials and meta-analyses asserts the role of intestinal microbiota dysbiosis in the development of various diseases, including those of infectious origin, in infancy and later stages of life.Purpose. Assessment of the efficacy of a multi-strain immuno-probiotic during rehabilitation of frequently ill children visiting organized groups during the period of epidemiological distress for acute respiratory diseases.Materials and methods.93 children older than 3 years of age were enrolled in an open comparative prospective clinical observation during the high-risk respiratory infection period – November, December. Children were observed for 1.5 months during administration of the multi-strain probiotic and 1 month after discontinuation of the probiotic. The subjects were randomized into two groups: the treatment group (60 children) received the multi-strain probiotic in the maximum age-specific dosage variances (children aged 3 to 12 years old – 1 capsule, older than 12 years of age – 2 capsules) once a day in the morning for 14 days and the comparison group (33 children) did not receive the multi-probiotic for the same period.Results and discussion. It was found that the incidence of disease in children receiving the multi-probiotic (the treatment group – 60 children) was statistically lower, and the disease severity was milder than in the group of children, who did not receive the probiotic (the comparison group – 33 children). Not a single child who received the multi-probiotic in the course of disease did not require antibiotic therapy during the entire observation period. Moreover, the incidence of respiratory infections in the treatment group within a month after discontinuation of the probiotic was 4.6 times lower than in the comparison group. No side effects were reported.Conclusions. The study results allowed the author to recommend the use of a multi-strain immuno-probiotic as a nonspecific immunomodulatory supplement for the seasonal prevention of acute respiratory infections, especially in frequently ill children at a high risk of infections.

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COMPARISON OF THE STATE OF THE MAXILLARY SINUSES IN A NEW CORONAVIRUS INFECTION COVID-19 AND ACUTE RESPIRATORY VIRAL INFECTION

The Bulletin of Contemporary Clinical Medicine ◽

10.20969/vskm.2021.14(5).28-33 ◽

2021 ◽

Vol 14 (5) ◽

pp. 28-33

Author(s):

ALEXANDER V. KOLSANOV ◽

◽

TATYANA JU. VLADIMIROVA ◽

PAVEL V. ZELTER ◽

OLESYA V. ZELYOVA ◽

...

Keyword(s):

Mucous Membrane ◽

Paranasal Sinuses ◽

Chronic Sinusitis ◽

Respiratory Infections ◽

Control Group ◽

Acute Respiratory Infections ◽

Lower Wall ◽

Study Results ◽

Coronavirus Infection ◽

Maxillary Sinuses

The aim of the study was to identify possible changes in the maxillary sinuses during new coronavirus infection in comparison with the changes in the sinuses occurring during acute respiratory infections and to correlate the gender structure of the study groups. Material and methods. The study included 40 patients (18 women and 22 men) with a confirmed new coronavirus infection, hospitalized at the Covid Hospital Clinics of Samara State Medical University in 2020. All patients underwent multispiral computed tomography of the paranasal sinuses on a Ge revolution Evo 128 tomograph on the 10th day after the appearance of the first clinical symptoms. We also examined a control group of patients with acute respiratory infections with similar complaints of impaired sense of smell, rhinorrhea, and upper maxillary sinus discomfort. This group also included 40 people (24 women and 16 men). Statistical processing of the study results was performed using Microsoft Excel software package, the Mann – Whitney method of statistical significance calculation was used. Results and discussions. In 18 (45%) patients with a confirmed new coronavirus infection, a slight mucosal thickening along the lower wall of the maxillary sinuses was found symmetrically on both sides. Six (15%) of them were women and 12 (30%) were men. The age of the examined patients ranged from 31 to 83 years. Chronic sinusitis was noted in the history of 8 (20%) of the examined patients. In 6 (15%) patients with chronic sinusitis no abnormalities were detected in the maxillary sinuses at the time of examination. Two of them had parietal thickening of the mucous membrane along the lower wall of the maxillary sinuses. In the control group, there was significant symmetric parietal thickening of the mucous membrane of the paranasal sinuses in 24 (60%) examined patients (14 women and 10 men). There were no statistically significant differences in the prevalence of changes in the studied and control groups. Conclusion. According to the results of this study, there were no data on the pattern of occurrence of changes in the mucosa of the maxillary sinuses in new coronavirus infection with gender background or the presence of chronic inflammation of the maxillary sinuses in the history compared with the control group of examined patients after acute respiratory infections.

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Monostrain and multistrain probiotics for respiratory diseases in children

Russian Medical Inquiry ◽

10.32364/2587-6821-2020-4-11-698-704 ◽

2020 ◽

Vol 4 (11) ◽

pp. 698-704

Author(s):

E.S. Dzottsoeva ◽

◽

A.V. Gorelov ◽

◽

Keyword(s):

Respiratory Diseases ◽

Respiratory Infections ◽

Lactobacillus Rhamnosus ◽

Human Organism ◽

High Morbidity ◽

Acute Respiratory Infections ◽

Bifidobacterium Lactis ◽

Impaired Performance ◽

Vital Functions ◽

Multistrain Probiotics

Acute respiratory infections (ARIs) in children are common conditions characterized by high morbidity. ARIs account for up to 75% of all cases of antibiotic use. Dysbiosis results in the impaired performance of vital functions, i.e., digestion, synthesis, colonization resistance, and the regulation of immune system. Probiotics are one of the effective tools to affect the composition of gut microbiota and to restore its metabolic activity. Probiotics, their effects on human organism, and their use in various diseases have received an enormous attention. Meanwhile, the use of antibiotics and the etiological diversity of ARIs account for the lack and irrationality of extensive preventive measures (as in flu) and raise the interest in non-specific prophylaxis. Lactobacillus rhamnosus GG (LGG) and Bifidobacterium animalis subsp. Lactis BB-12 are well-studied strains. Lactobacillus plantarum LP01 and LP02, Lactobacillus rhamnosus LR04 and LR05, and Bifidobacterium lactis BS01 used as monostrain probiotics are also of interest. Multistrain probiotics are gaining traction. However, these probiotics are understudied and require more attention. KEYWORDS: microbiome, monostrain probiotics, multistrain probiotics, acute respiratory infections, antibiotic-associated diarrhea, antibiotic-associated syndrome, Lactobacillus rhamnosus, Bifidobacterium lactis. FOR CITATION: Dzottsoeva E.S., Gorelov A.V. Monostrain and multistrain probiotics for respiratory diseases in children. Russian Medical Inquiry. 2020;4(11):698–704. DOI: 10.32364/2587-6821-2020-4-11-698-704.

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Woman and Child: The Penitentiary Aspect

Baikal Research Journal ◽

10.17150/2411-6262.2018.9(4).15 ◽

2018 ◽

Vol 9 (4) ◽

Author(s):

Boris Spasennikov

Keyword(s):

Medical Care ◽

Respiratory Diseases ◽

Comparison Group ◽

Mixed Feeding ◽

Living Together ◽

Mother And Child ◽

Women And Children ◽

Breastfeeding Rates ◽

Positive Effect ◽

Joint Maintenance

The article analyzes the legal and medical significance of the child's living together with his mother in the Children's Houses of the penitentiary system. Materials for the study were the author's own observations, the materials of the Federal Service for Execution of Punishment (FSEP) of Russia reports on medical care for women and children over the period of five years; the data obtained as a result of targeted inquiries to the Children's Houses of the penitentiary system. The article generalizes the experience of the Children's House activities of the penitentiary system in this direction. It shows the positive effect of joint maintenance, first of all, in terms of the breastfeeding rates. Natural and mixed feeding constituted 67 % in the Children's Houses, including 85 % in the Children's Houses with joint stay of the newborns, and 42 % in other Children's Houses, which is statistically lower. In the Children's Houses with the expanded co-residence department, the primary morbidity of children was 1678 ‰, while in the comparison group - 2015 ‰, which is significantly higher. According to the primary incidence rate, there was a decrease in the pool of respiratory diseases from 1000 to 870 per 1000 children, thanks to placing into operation of the joint co-residence hostel for mother and child. The co-residence of the mother, convicted to imprisonment, and the newborn will contribute to the childs physical, neuropsychic development, its harmonious growth, as well as to manifesting the maternity feelings, which can be an important factor of the resocialization of the convicted person. The author propose to introduce a normative compulsory co-residence of mother and child in the Children's Houses of the penitentiary system.

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Optimization of rehabilitation measures after artificial abortion as the result of immunomodulator aminodihydrophthalasindione sodium apply in comprehensive therapy

Medical Council ◽

10.21518/2079-701x-2018-21-156-161 ◽

2019 ◽

pp. 156-161

Author(s):

E. A. Voroshilova

Keyword(s):

Marked Reduction ◽

Clinical Effect ◽

Comparison Group ◽

Clinical Symptoms ◽

Randomized Study ◽

Main Group ◽

Control Group ◽

Comprehensive Therapy ◽

Effect Of Treatment ◽

Artificial Abortion

The article presents the results of a comparative randomized study, the purpose of which was to evaluate the effectiveness of the use of aminodihydrophthalasindione sodium (Galavit, LLC SELVIM, Russia) in the treatment of patients undergoing an abortion. Included in the study, 48 women were divided into two groups, 24 patients of the main group in addition to the standard rehabilitation were treated with aminodihydrophthalasindione sodium in the comparison group – 24 patients underwent only standard rehabilitation. In this study, all patients (100%) of the main group who were treated with aminodihydrophthalasindione sodium in addition to the standard therapy marked reduction of the clinical symptoms of the disease and positive dynamics was observed at ultrasound. In the control group, the full clinical effect of treatment was observed only in 10 patients (52.6%). 9 women (47,4%) required repeated therapy. Ultrasound studies in 12 patients (63.2%) showed changes equivalent to endometritis.

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Influence of vitamin D provision on the course of acute respiratory infections in children

Modern pediatrics. Ukraine ◽

10.15574/sp.2021.119.73 ◽

2021 ◽

pp. 73-80

Author(s):

Yu.V. Marushko ◽

◽

S.I. Esipova ◽

T.V. Gishchak ◽

◽

...

Keyword(s):

Vitamin D ◽

Respiratory Diseases ◽

Conflicts Of Interest ◽

Respiratory Infections ◽

Vitamin D Supplementation ◽

The Body ◽

Skeletal System ◽

D3 Receptors ◽

The Relationship ◽

Positive Effect

The review article provides data from modern studies confirming the multifaceted effect of vitamin D in the human body. Vitamin D3 receptors (VDRs) have been shown to be present in most organs and tissues of the body. This confirms the importance of vitamin D not only in the formation of the skeletal system, but also in many of its extraosseous effects. Calcitriol affects the modulation of cell growth, neuromuscular conduction, inflammation processes, and is also an important stimulator of innate immunity due to the synthesis of antimicrobial peptides that provide protection against bacteria and viruses. In recent years, the relationship between the concentration of vitamin D in the blood and the incidence of respiratory infections in children has been actively studied. Many studies have shown that low vitamin D status is characteristic of most children with respiratory infections, and an adequate level of 25(OH)D in serum has a positive effect on the frequency of these infections and the severity of their course. Most authors demonstrate the benefits of vitamin D supplementation in the prevention of respiratory diseases in children, but there is no consensus regarding the frequency and dosage of vitamin D. The authors declare that they have no conflicts of interest. Key words: vitamin D, children, deficiency, respiratory diseases, prevention.

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A prognostic model to calculate the probability of severe preeclampsia in healthy young reproductive age woman

GYNECOLOGY ◽

10.26442/20795696.2020.5.200173 ◽

2020 ◽

Vol 22 (5) ◽

pp. 17-21

Author(s):

Nataly I. Frolova ◽

Tatiana E. Belokrinitskaya ◽

Kristina A. Kolmakova

Keyword(s):

Predictive Models ◽

Prognostic Model ◽

Respiratory Infections ◽

Severe Preeclampsia ◽

Reproductive Age ◽

Prognostic Models ◽

Individual Risk ◽

Control Group ◽

Acute Respiratory Infections ◽

Quality Model

Aim.To develop the prognostic model to calculate the probability of severe preeclampsia in healthy young reproductive age woman. Materials and methods.This study included two groups of healthy women aged 1835 years with spontaneous singleton pregnancy: 100 patients with severe preeclampsia (patient group), and 100 women with non-complicated pregnancy (control group). All women had not a risk factors of preeclampsia such as history of hypertension, autoimmune, metabolic, renal, or cardiac diseases, and family or individual history preeclampsia or thromboembolism before this pregnancy. Their body mass index in the 1-st trimester of gestation was 35 kg/sq. m. Gene polymorphisms were detected using the polymerase chain reaction-real time technique. The data were analyzed with methods of binary and multifactorial mathematical statistics. Our analysis of the predictive models was performed by using logistic regression. To determine the diagnostic value of the predictive models used the ROC-curve is followed by determining the area under it (AUC). Results.Some prognostic models to calculate the probability of severe preeclampsia were build using an anamnestic, clinical and genotypic characteristics and multifactorial analysis. Combination of genotypesAGTR2-1675АA/eNOS3-786СC; tobacco smoking; bacteriuria; acute respiratory infections and/or acute vulvovaginitis during 23 trimester of gestation were determinate as most informative predictors of severe preeclampsia. Logistic model included three predictors: bacteriuria; acute respiratory infections and/or acute vulvovaginitis during 23 trimester of gestation had higher prognostic value. ROC analysis identified a high specificity (89.58%) and sensitivity (76.47%) of the model, and the integral index of the effectiveness of predictive markers (AUC=0.885), according to the expert scale of values which is indicative of a very high quality model. Conclusion.It is recommended to use this elaborated predictive model for the purpose of individual risk assessment of severe preeclampsia in healthy young reproductive age woman.

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Newer Virus Diseases: Clinical Differentiation of Acute Respiratory Infections

PEDIATRICS ◽

10.1542/peds.27.1.44 ◽

1961 ◽

Vol 27 (1) ◽

pp. 44-44

Author(s):

DAVID T. KARZON

Keyword(s):

Respiratory Diseases ◽

Small Volume ◽

Respiratory Infections ◽

Daily Practice ◽

Clinical Aspects ◽

Acute Respiratory Infections ◽

Viral Etiology ◽

Virus Diseases ◽

Acute Respiratory Diseases ◽

Basic Concepts

Acute respiratory diseases, especially those of viral etiology, occupy a goodly proportion of the attention of the pediatrician in his daily practice. In this small volume, Dr. Adams attempts to bring together the rapidly appearing information regarding recent discoveries and innovations in virology and correlate them with clinical aspects of respiratory infection. Sections are devoted to introducing basic concepts in virology and to anatomic and physiologic aspects of the respiratory system in relation to infection.

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Efficacy of probiotics on digestive disorders and acute respiratory infections: a controlled clinical trial in young Vietnamese children

European Journal of Clinical Nutrition ◽

10.1038/s41430-020-00754-9 ◽

2020 ◽

Author(s):

Truong Tuyet Mai ◽

Pham Thi Thu ◽

Hoang Thi Hang ◽

Tran Thi Thu Trang ◽

Shintaro Yui ◽

...

Keyword(s):

Nutritional Status ◽

Respiratory Infections ◽

Daily Intake ◽

Fermented Milk ◽

Control Group ◽

Controlled Clinical Trial ◽

Acute Respiratory Infections ◽

Intervention Period ◽

Probiotic Group

Abstract Objectives To evaluate the efficacy of fermented milk containing Lactobacillus casei strain Shirota (LcS) on the incidence of constipation, diarrhea, acute respiratory infections (ARI), and nutritional status of young Vietnamese children. Methods A controlled field trial was conducted with 1003 children (3–5 years old) in Thanh Hoa province in Vietnam. The probiotic group (n = 510) consumed fermented milk 65 mL/day containing 108 CFU/mL of LcS for the 12-week intervention period, whereas the control group (n = 493) was not given any. The incidence of constipation, diarrhea, ARI, and anthropometry in children was determined at baseline, after 4, 8, and 12-week intervention, and after the 4-week follow-up period. Results Probiotic drink decreased the incidence of constipation after the 12-week intervention period (12.0% vs. 32.0%, OR = 0.28 (95% CI: 0.21–0.40), p < 0.001), tended to decrease the incidence of diarrhea (4.9% vs. 7.9%, OR = 0.60 (95% CI: 0.35–1.01), p = 0.068), and prevented the occurrence of ARI (15.9% vs. 24.5%, OR = 0.58 (95% CI: 0.42–0.79), p < 0.001), when compared with the control group. In contrast, no probiotic effects were observed for the duration of diarrhea or ARI. Weight gain was higher in the probiotic group than in the control group after 4, 8, and 12-week intervention and after the 4-week follow-up period (p < 0.05). Conclusions Daily intake of fermented milk containing LcS strongly prevented the incidence of constipation and ARI in Vietnamese children. This study also revealed the potential effects of the use of a probiotic drink on diarrhea prevention as well as nutritional status improvement.

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The herbal preparations in the treatment of cough in children with respiratory infections

Medical Council ◽

10.21518/2079-701x-2019-2-82-86 ◽

2019 ◽

pp. 82-86 ◽

Cited By ~ 1

Author(s):

V. М. Deliagin

Keyword(s):

Herbal Medicine ◽

Respiratory Diseases ◽

Respiratory Infections ◽

Symptomatic Treatment ◽

Common Symptom ◽

Acute Respiratory Infections ◽

It Use ◽

Herbal Preparations ◽

Outpatient Practice ◽

Common Infection

Acute respiratory infections (ARI, commen cold) are the most common infection diseases in children. They account for up 75% of all cases of respiratory diseases. In most cases, ARI are selfterminating diseases that require only symptomatic treatment. The most common symptom of ARI is cough. In outpatient practice justified the use of herbal medicine. As an antisussive well eastablished syrup Gedelix. The effectivnesses of the medicine, the possibility of accuracy dosing, pleasant taste facilitate it use in children.

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