Fibrinolytic Enzyme – An Overview

2022 ◽  
Vol 23 ◽  
Author(s):  
Parveen. A ◽  
Devika. R
Keyword(s):  
Causes Of Death ◽  
Therapeutic Potential ◽  
Vital Signs ◽  
Circulatory System ◽  
Coronary Bypass ◽  
Antiplatelet Agents ◽  
Fibrinolytic Enzymes ◽  
Biochemical Processes ◽  
Common Causes ◽  
Rheumatic Heart

Cardiovascular diseases, like coronary heart disease or artery disorders (arteriosclerosis, including artery solidification), heart failure (myocardial infarction), arrhythmias, congestive heart condition, stroke, elevated vital signs (hypertension), rheumatic heart disorder, and other circulatory system dysfunctions are the most common causes of death worldwide. Cardiovascular disorders are treated with stenting, coronary bypass surgery grafting, anticoagulants, antiplatelet agents, and other pharmacological and surgical procedures; however, these have limitations due to their adverse effects. Fibrinolytic agents degrade fibrin through enzymatic and biochemical processes. There are various enzymes that are currently used as a treatment for CVDs, like Streptokinase, Nattokinase, Staphylokinase, Urokinase, etc. These enzymes are derived from various sources like bacteria, fungi, algae, marine organisms, plants, snakes, and other organisms. This review deals with the fibrinolytic enzymes, their mechanisms, sources, and their therapeutic potential.

Krajské mestá Slovenska v kontexte príčin smrti

2021 ◽  
Author(s):  
Katarína Vilinová ◽  
Jozef Kudlej
Keyword(s):  
Causes Of Death ◽  
Slovak Republic ◽  
Circulatory System ◽  
Economic Changes ◽  
Mortality And Morbidity ◽  
Circulatory System Diseases ◽  
Common Causes ◽  
Demographic Processes ◽  
External Causes ◽  
The Right

Interest in the health of the population is intensifying today. The main reasons include social, political and economic changes, but also the ongoing pandemic related to the spread of the COVID-19 virus. Due to many demographic changes in recent years, the study of the health status of the population emphasizes one of the demographic processes, which is mortality. The structure of the causes of death is very often monitored. After the stabilization of mortality and morbidity from infectious diseases in the eighties, civilization diseases such as circulatory system diseases and tumors came to the forefront of social interest in Slovakia. This indicator is also important in terms of the right direction in the field of regional development in relation to health care in individual regions. The aim of the paper is to characterize the structure of causes of death in regional cities of Slovakia. This paper will be based on data from the Statistical Office of the Slovak Republic for the period 1996-2017. The main methods used in the work will be methods of analysis, synthesis, as well as graphic and cartographic methods. In all regional cities of Slovakia, diseases of the circulatory system clearly dominated in men and women during the entire period under review. They were followed by cancer and external causes. The group of five most common causes was supplemented by diseases of the respiratory and digestive system.

Infections and demanding endocrine care contribute to increased mortality in patients with APECED

2021 ◽  
Author(s):  
Joonatan Borchers ◽  
Outi Mäkitie ◽  
Saila Laakso
Keyword(s):  
Cause Of Death ◽  
Causes Of Death ◽  
Clinical Course ◽  
Circulatory System ◽  
National Registry ◽  
Adrenal Crisis ◽  
Age At Death ◽  
Common Causes ◽  
Overall Mortality

Objective: Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) has variable clinical course. Overall mortality is increased but reasons for this remain largely unknown. Our objective was to assess the causes of death and factors contributing to increased mortality. Design: A follow-up study of the Finnish APECED cohort in 1970-2019. Methods: In 34 deceased patients with APECED, causes of death and clinical course preceding the death were analyzed using national registry data, death certificates, autopsy reports, and patient records. Results: Most common causes leading to death were infections (24%), oral and esophageal malignancies (15%; median age at death 36.7 years; median survival 1.5 years), and diseases of circulatory system (18%). Adrenal crisis was an independent cause of death in two patients. In addition, in four patients, adrenal crisis was a complicating factor during a fatal infection. Other APECED manifestations leading to death were hypoparathyroidism, diabetes, and hepatitis. Other causes of death included accidents (12%), alcohol related causes, and amyotrophic lateral sclerosis. Challenges in the overall, and especially in the endocrine, care contributed to deaths related to carcinomas and adrenal crisis. Age at death and year of death correlated (r = 0.345, P = 0.045), suggesting improved longevity. Conclusions: Infections, malignancies and diseases of circulatory system are the most common primary causes of death in patients with APECED. Adrenal crisis is an independent cause of death but more often a contributing factor in fatal infections. Despite the high overall mortality and the demanding care, our results suggest improved patient survival in recent years.

Mortality among Male Disability Pensioners

1977 ◽  
Vol 5 (2) ◽  
pp. 73-75 ◽  
Author(s):  
Asbjörn Medhus ◽  
Hans Kristenson
Keyword(s):  
Respiratory System ◽  
Disability Pension ◽  
Causes Of Death ◽  
Circulatory System ◽  
Basic Material ◽  
Post Mortem ◽  
Permanent Disability ◽  
Common Causes ◽  
Expected Mortality ◽  
First Time

The basic material consists of all 235 men who were granted temporary or permanent disability pension in Malmö for the first time in 1964. By the end of 1974, 111 had died; the expected mortality was 42. The most common causes of death were diseases of the circulatory system, neoplasms, and diseases of the respiratory system. The post-mortem diagnoses of the 111 deceased usually agreed with the main diagnoses at the time of the pension award.

Suicidal Death Autopsy Analysis at Dhaka Medical College

1970 ◽  
Vol 40 (1) ◽  
pp. 18-21 ◽  
Author(s):  
MN Hossain ◽  
Z Rahman ◽  
S Akhter
Keyword(s):  
Forensic Medicine ◽  
Causes Of Death ◽  
Cross Sectional Study ◽  
Age Group ◽  
Sectional Study ◽  
Cross Sectional ◽  
Medical College ◽  
Autopsy Report ◽  
Common Causes ◽  
Suicidal Death

A cross sectional study was carried out at the department of Forensic Medicine in Dhaka Medical College during the period of January 2008 to December 2009. Data were collected from 3rd copy of the post mortem reports which were preserved in the department of Forensic Medicine with the verbal consent of the doctors who performed autopsy report. During this period total 5114 autopsies were conducted. Out of this 970 cases (19%) were suicidal in nature. It was noticed that all suicidal deaths occurred from 10 years to all age group respectively, but top amongst age group of suicidal deaths occurred in between 21 to 30 years of people. Suicidal deaths are more common in female than male. Suicidal deaths due to hanging is highest, next common causes of death due to organophosphorus compund poisoning. Suicidal deaths by hanging is more in female than male but in poisoning cases male are more lvictimised than female. Objectives of our study are to see the occurrence and methods of suicidal death. DOI: http://dx.doi.org/10.3329/bmj.v40i1.9957 BMJ 2011; 40(1): 18-21

scholarly journals Advances in the understanding of trauma-induced coagulopathy

Blood ◽  
2016 ◽  
Vol 128 (8) ◽  
pp. 1043-1049 ◽  
Author(s):  
Ronald Chang ◽  
Jessica C. Cardenas ◽  
Charles E. Wade ◽  
John B. Holcomb
Keyword(s):  
Animal Studies ◽  
Causes Of Death ◽  
Endothelial Activation ◽  
The United States ◽  
Trauma Patients ◽  
Platelet Dysfunction ◽  
Intracranial Injury ◽  
Trauma Induced Coagulopathy ◽  
Common Causes

Abstract Ten percent of deaths worldwide are due to trauma, and it is the third most common cause of death in the United States. Despite a profound upregulation in procoagulant mechanisms, one-quarter of trauma patients present with laboratory-based evidence of trauma-induced coagulopathy (TIC), which is associated with poorer outcomes including increased mortality. The most common causes of death after trauma are hemorrhage and traumatic brain injury (TBI). The management of TIC has significant implications in both because many hemorrhagic deaths could be preventable, and TIC is associated with progression of intracranial injury after TBI. This review covers the most recent evidence and advances in our understanding of TIC, including the role of platelet dysfunction, endothelial activation, and fibrinolysis. Trauma induces a plethora of biochemical and physiologic changes, and despite numerous studies reporting differences in coagulation parameters between trauma patients and uninjured controls, it is unclear whether some of these differences may be “normal” after trauma. Comparisons between trauma patients with differing outcomes and use of animal studies have shed some light on this issue, but much of the data continue to be correlative with causative links lacking. In particular, there are little data linking the laboratory-based abnormalities with true clinically evident coagulopathic bleeding. For these reasons, TIC continues to be a significant diagnostic and therapeutic challenge.

scholarly journals Causes of Mortality in Older People With Intellectual Disability: Results From the HA-ID Study

2018 ◽  
Vol 123 (1) ◽  
pp. 61-71 ◽  
Author(s):  
Alyt Oppewal ◽  
Josje D. Schoufour ◽  
Hanne J.K. van der Maarl ◽  
Heleen M. Evenhuis ◽  
Thessa I.M. Hilgenkamp ◽  
...  
Keyword(s):  
Older Adults ◽  
Intellectual Disability ◽  
Cause Of Death ◽  
Causes Of Death ◽  
Circulatory System ◽  
Bacterial Diseases ◽  
Specific Mortality ◽  
Causes Of Mortality ◽  
Insight Into

Abstract We aim to provide insight into the cause-specific mortality of older adults with intellectual disability (ID), with and without Down syndrome (DS), and compare this to the general population. Immediate and primary cause of death were collected through medical files of 1,050 older adults with ID, 5 years after the start of the Healthy Ageing and Intellectual Disabilities (HA-ID) study. During the follow-up period, 207 (19.7%) participants died, of whom 54 (26.1%) had DS. Respiratory failure was the most common immediate cause of death (43.4%), followed by dehydration/malnutrition (20.8%), and cardiovascular diseases (9.4%). In adults with DS, the most common cause was respiratory disease (73.3%), infectious and bacterial diseases (4.4%), and diseases of the digestive system (4.4%). Diseases of the respiratory system also formed the largest group of primary causes of death (32.1%; 80.4% was due to pneumonia), followed by neoplasms (17.6%), and diseases of the circulatory system (8.2%). In adults with DS, the main primary cause was also respiratory diseases (51.1%), followed by dementia (22.2%).

scholarly journals Paediatric brought-in-dead at a tertiary health facility in South western Nigeria: Patterns and drivers

2021 ◽  
Vol 48 (2) ◽  
pp. 66-73
Author(s):  
Oladele S. Olatunya ◽  
Adefunke O. Babatola ◽  
Adewuyi T. Adeniyi ◽  
Adebukola B. Ajite ◽  
Isaac O. Oluwayemi ◽  
...  
Keyword(s):  
Health Facility ◽  
Causes Of Death ◽  
Severe Anaemia ◽  
Hospital Treatment ◽  
Cross Sectional ◽  
Over The Counter ◽  
Pediatric Health Care ◽  
Duration Of Illness ◽  
Common Causes ◽  
Southwest Nigeria

Background: ‘Brought- in-dead’ (BID) refers to the demise of an individual before presentation to a health facility. This study assessed the pattern of paediatric BID cases seen at a tertiary health facility in southwest Nigeria. Method: A cross-sectional, descriptive study was done at the Children Emergency Ward (CEW) of the hospital between January 2014 and December 2018. The patterns of BID cases and presumed causes of death were determined using a standardized checklist adapted from the WHO verbal autopsy instrument. Results: Ninety-eight BID cases were seen during the study, constituting 2.5% of total patients seen during the period. The median (IQR) age of cases was 24.0 (8.75 – 63.0) months and 72.4% were under-fives. Most had symptoms related to the haematologic (36.7%), respiratory (24.5%) or digestive (20.4%) systems. Severe anaemia 31(31.6%), gastroenteritis 19 (19.4) and aspiration 17 (17.3%) were the most common causes of death. The median (IQR) duration of illness before presentation was 3.0 (1.0 – 7.0) days but most presented from 4 – 7 days of illness. A significant relationship was found between the duration of illness and whether or not pre-hospital treatment was received (p < 0.0001). Unprescribed drugs purchased over the counter were the most commonly used treatment in 79.1% of cases (p < 0.0001). Conclusion: This study has highlighted the prevalence and pattern of paediatric BID in a tertiary health facility in southwest Nigeria and the factors that were associated with it. More efforts need to be geared towards community sensitization and pediatric health care to prevent factors drivingits menace.

scholarly journals PENYULUHAN PENTINGNYA PEMERIKSAAN IVA PADA WUS (Wanita Usia Subur) DI DESA SUKAMAJU KABUPATEN MUARO JAMBI TAHUN 2018

2020 ◽  
Vol 1 (1) ◽  
pp. 1-4
Author(s):  
Lia Artika Sari ◽  
Enny Susilawati
Keyword(s):  
Cervical Cancer ◽  
Community Service ◽  
Causes Of Death ◽  
Hpv Infection ◽  
Reproductive Age ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Women Of Reproductive Age ◽  
Common Causes ◽  
Post Test

ABSTRAK Latar Belakang: Kanker merupakan salah satu penyebab kematian yang paling utama di dunia, sekitar 40 wanita tiap harinya terdiagnosa kanker leher rahim. Kanker leher rahim disebabkan oleh virus HPV, infeksi HPV sendiri sering kali tidak menimbulkan gejala. Desa Suka Maju merupakan salah satu desa yang terdapat di Kabupaten Muaro Jambi dan mempunyai jumlah wanita usia subur berjumlah 820 orang, namun hanya 17,11% wanita usia subur yang baru memanfaatkan pelayanan IVA.Metode: Dengan memberikan penyuluhan kepada wanita usia subur dengan (WUS) sebanyak 40 orang, dan diberikan pre dan post test untuk mengevaluasi pengetahuan wanita usia subur mengenai pemeriksaan IVA Hasil: terjadi kenaikan pengetahuan wanita usia subur di Desa Sukamaju sebesar 87,5%.Kesimpulan: Penyuluhan dapat meningkatkan pengetahuan wanita usia subur terhadap pentingnya pemeriksaan IVA. ABSTRACT Background: Cancer is one of the most common causes of death in the world. About 40 women are diagnosed with cervical cancer every day. Cervical cancer is caused by the HPV virus, HPV infection itself often causes no symptoms. Suka Maju Village is one of the villages in Muaro Jambi Regency that has 820 women of childbearing age, but only 17.11% of women of childbearing age have just used IVA services.Methods: employed in community service was to provide counseling to women of reproductive age with (WUS) as 40 women, and then given pre and posttests to evaluate the knowledge of women of childbearing age After being given counseling on IVA examinations. In brief,Result: There was an increase in the knowledge of women of childbearing age in Sukamaju Village by 87.5 %. Conclusion: Health education can increasedthe knowledge of women of childbearing age on the importance of IVA Chencking

scholarly journals Mortality in Russia: the second epidemiological revolution that never was

2015 ◽  
pp. 4-33 ◽  
Author(s):  
Anatoly Vishnevsky
Keyword(s):  
Life Expectancy ◽  
Causes Of Death ◽  
Age Distribution ◽  
Circulatory System ◽  
Developed Countries ◽  
Significant Rise ◽  
Past Half Century ◽  
External Causes Of Death ◽  
External Causes ◽  
Age Of Death

The article looks at different approaches to the conceptualization of the modern stage of mortality reduction (the "new stages” of the epidemiological transition, "the second epidemiological revolution”, the “health transition”). During this stage, which has lasted for at least half a century, revolutionary changes have taken place in most developed countries. These changes manifest themselves in the drastic expansion of the degree of control over non-infectious causes of death—particularly over diseases of the circulatory system, neoplasms, and other non-communicable diseases, as well as over external causes of death. As a consequence of these changes, there has been a rapid shift of deaths from the abovementioned causes to older ages, an increase in the mean age of death from these causes, and, ultimately, a significant rise in life expectancy. Russia, unfortunately, is watching this revolution from the outside, without taking any part in it. The age distribution of deaths from major classes of causes of death in Russia has not changed over the past half-century, life expectancy has stagnated, and Russia has increasingly lagged behind the majority of developed countries with respect to this indicator. Thus, the “second epidemiological revolution” has not yet to occur in Russia.

scholarly journals Mortality from external causes in Russia over half a century

2015 ◽  
pp. 85-108
Author(s):  
Ekaterina Kvasha ◽  
Tatiana Kharkova ◽  
Valeriy Yumaguzin
Keyword(s):  
Life Expectancy ◽  
Causes Of Death ◽  
Circulatory System ◽  
Developed Countries ◽  
Large Contribution ◽  
Mortality Trends ◽  
Undetermined Intent ◽  
External Causes Of Death ◽  
Excess Number ◽  
External Causes

The article discusses long-term mortality trends (since 1956) from external causes of death in Russia. Russia has long lagged behind developed countries in this domain. The level of mortality from external causes of death remains high and its structure is still archaic with large contribution of homicides, alcohol poisoning and injuries of undetermined intent. Excess number of deaths from life tables of Russia and Western European countries is compared. It is shown that in Russia the greatest excess losses are associated with mortality from poisonings among both sexes, suicide among men and homicide among women. Mortality from external causes, along with mortality from diseases of the circulatory system, has had a significant impact on life expectancy. In general, over the period 1956-2012 the increase in mortality from external causes in the 15-64 age group reduced life expectancy by 2.6 years for males and 0.7 years for females. The decline, starting in 2003, of mortality from external causes of death has slightly reduced the gap between Russia and developed countries, bringing the current Russian level closer to those levels reached in Russia in the mid-1960s and 1980s. However, given the fluctuations of mortality from external causes, it is premature to say whether the current decline in mortality is robust.

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