Recent Advancements in lung cancer treatment using receptor targeting

2021 ◽  
Vol 14 ◽  
Author(s):  
Harjit Singh ◽  
Bharat Khurana ◽  
Sukhbir Kaur
Keyword(s):  
Lung Cancer ◽  
Targeted Therapy ◽  
The Body ◽  
Drug Uptake ◽  
Cell Toxicity ◽  
Cell Penetration ◽  
Cancerous Cell ◽  
The World ◽  
Rapid Clearance ◽  
Cancerous Cells

Background: In the cancer related deaths all over the world, lung cancer is at the top. The conventional treatment option available lacks specificity, causing cell toxicity, rapid clearance from the body and poor cancer cell penetration. Conclusion: The nano delivery has reformed the treatment of lung cancer as selective drug uptake to the cancerous cell has been achieved by ligand targeted therapy. The ligand targeted therapy has been used for diagnostic and therapeutic purposes. This approach is based on the concept that receptors are overexpressed in expression in cancerous state compared to normal cells. The nanomedicines can reach to the cancerous cells through leaky vasculature surrounding cell

scholarly journals Anti-VEGF Therapy in Breast and Lung Mouse Models of Cancers

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Di Domenico Marina ◽  
Ricciardi Carmela ◽  
Fusco Alfredo ◽  
Pierantoni Giovanna Maria
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Targeted Therapy ◽  
Blood Vessels ◽  
Blood Circulation ◽  
The Body ◽  
Vascular Endothelial ◽  
Murine Models ◽  
Body Tissues ◽  
The World ◽  
Endothelial Growth Factor

Cancer is the second leading cause of death in the world after cardiovascular diseases. Some types of cancer cells often travel to other parts of the body through blood circulation or lymph vessels, where they begin to grow. This process is recognized as metastasis. Angiogenesis is the formation of new blood vessels from existing vessel. Normally angiogenesis is a healthy process, that helps the body to heal wounds and repair damaged body tissues, whereas in cancerous condition this process supports new blood vessels formation that provide a tumor with its own blood supply, nutrients and allow it to grow. The most important proximal factor for angiogenesis is the vascular endothelial growth factor VEGF. Angioinhibition is a form of targeted therapy that uses drugs to stop tumors from making new blood vessels. Therefore, in this paper we analyse the importance of VEGF as target of cancer therapy, analysing murine models.

scholarly journals A brief Overview of a Fatal Disease Namely Cancer

2021 ◽  
Vol 11 (1) ◽  
pp. 19-23
Author(s):  
◽  
Pradumn Kumar Maddheshiya ◽  
Mukesh Kumar ◽  
◽  
Keyword(s):  
Daily Life ◽  
Sudden Change ◽  
The Body ◽  
Cancer Treatments ◽  
Fatal Disease ◽  
Cancer Disease ◽  
Normal Cells ◽  
The World ◽  
The Common ◽  
Cancerous Cells

In today era cancer is a dangerous and terrible disease which cause due to rapid increment of unusual cells within the body. Cancer is the second influential cause of death in the world. It has become very difficult overcome cancerous disease. 10 million people died per year from cancer. The major cause of cancer is sudden change in DNA within the cells. As a result normal cells convert into cancerous cells which enhance the process of metastasis. There are some treatments of this dangerous disease but cancer treatments are so expensive not everyone and the common man can get. So, it’s our responsibility to spread awareness and convince people about such a disease. Its simple purpose is that after reading people should know more about it. And whatever, things are follow in our daily life to avoid cancer disease. Keywords: Neoplasm, Carcinoma, Leukemia, Chemotherapy, Radiation therapy.

scholarly journals Detection of Distant Lung Cancer using Enhanced Transductive Support Vector Machines

2020 ◽  
Vol 9 (4) ◽  
pp. 672-677
Keyword(s):  
Lung Cancer ◽  
Support Vector Machines ◽  
Clinical Characteristics ◽  
Cell Cancer ◽  
The Body ◽  
Support Vector ◽  
Swarm Optimization ◽  
Glowworm Swarm Optimization ◽  
Vector Machines ◽  
The World

Background: Cancer disease is the second largest disease after heart-attack in the world. Cancer is an abnormal growth of normal cell. Cancer is classified based on the cell type where it is mainly affected .There are different types of cancer like blood cancer, brain cancer, small intestine cancer, lung cancer, liver cancer etc. According to ICMR, among 1.27 billion Indian populations, the incidence of cancer is 70 – 90% per 100,000 populations and 70% of cancer is identified in the last stage accounting for high mortality. Though there are hundred form of cancer, the prognosis of bronchogenic carcinoma (lung cancer) is very poor because it can be identified only at a final stage. The beginning tumors are not more dangerous but the malignant tumors are more risky which spread to further portions of the body over blood stream or the lymph vessels. Prognosis and remedy is the biggest provocations in cancer for the medical field and physicians in the past few years. The CT scans support the doctors to detect cancer at early stage. When cancer is prognoses at benign stage, millions of human life across the world gets saved every year. Method: Noise in the CT scan input image is reduced by traditional adaptive median filtering and segmented by Region Based Neural Networks to extract a region of interest. To reduce the unwanted texture and noises and to detect wide-ranged images, Improved Canny Edge detector is implemented. The clinical characteristics of the patient were included as a feature reference. The considered features in clinical characteristics are status of patient smoking ,age of the patient, classification of tumor and T, N staging. Feature selection using Improved Glowworm Swarm Optimization and Classification Enhanced Transductive Support Vector Machines (ETSVM) is utilized to diagnose the distant metastasis of lung cancer. Result: Experimental results shows that ETSVM and Improved Glowworm Swarm Optimization achieved the best performance with an accuracy 90.7% and sensitivity 94.7%.

Scanning electron microscopy of freeze-fractured prescapular lymph node of caprine

1984 ◽  
Vol 42 ◽  
pp. 244-245
Author(s):  
O. Faroon ◽  
F. Al-Bagdadi ◽  
T. G. Snider ◽  
C. Titkemeyer
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Lymphatic System ◽  
Three Dimensional ◽  
Meat Products ◽  
The Body ◽  
Morphological Data ◽  
The World ◽  
Cellular Constituent ◽  
Scanning Electron

The lymphatic system is very important in the immunological activities of the body. Clinicians confirm the diagnosis of infectious diseases by palpating the involved cutaneous lymph node for changes in size, heat, and consistency. Clinical pathologists diagnose systemic diseases through biopsies of superficial lymph nodes. In many parts of the world the goat is considered as an important source of milk and meat products.The lymphatic system has been studied extensively. These studies lack precise information on the natural morphology of the lymph nodes and their vascular and cellular constituent. This is due to using improper technique for such studies. A few studies used the SEM, conducted by cutting the lymph node with a blade. The morphological data collected by this method are artificial and do not reflect the normal three dimensional surface of the examined area of the lymph node. SEM has been used to study the lymph vessels and lymph nodes of different animals. No information on the cutaneous lymph nodes of the goat has ever been collected using the scanning electron microscope.

HIPEREMESIS GRAVIDARUM PADA IBU HAMIL DI KLINIK BIDAN SUPRIYATI SRIBIT BERBAH SLEMAN

2019 ◽  
Vol 14 (1) ◽  
pp. 51
Author(s):  
Pramukti Dian Setianingrum ◽  
Farah Irmania Tsani
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Hyperemesis Gravidarum ◽  
Unwanted Pregnancy ◽  
The Body ◽  
Nausea And Vomiting ◽  
Daily Activities ◽  
World Health ◽  
The World

Backgroud: The World Health Organization (WHO) explained that the number of Hyperemesis Gravidarum cases reached 12.5% of the total number of pregnancies in the world and the results of the Demographic Survey conducted in 2007, stated that 26% of women with live births experienced complications. The results of the observations conducted at the Midwife Supriyati Clinic found that pregnant women with hyperemesis gravidarum, with a comparison of 10 pregnant women who examined their contents there were about 4 pregnant women who complained of excessive nausea and vomiting. Objective: to determine the hyperemesis Gravidarum of pregnant mother in clinic. Methods: This study used Qualitative research methods by using a case study approach (Case Study.) Result: The description of excessive nausea of vomiting in women with Hipermemsis Gravidarum is continuous nausea and vomiting more than 10 times in one day, no appetite or vomiting when fed, the body feels weak, blood pressure decreases until the body weight decreases and interferes with daily activities days The factors that influence the occurrence of Hyperemesis Gravidarum are Hormonal, Diet, Unwanted Pregnancy, and psychology, primigravida does not affect the occurrence of Hyperemesis Gravidarum. Conclusion: Mothers who experience Hyperemesis Gravidarum feel nausea vomiting continuously more than 10 times in one day, no appetite or vomiting when fed, the body feels weak, blood pressure decreases until the weight decreases and interferes with daily activities, it is because there are several factors, namely, hormonal actors, diet, unwanted pregnancy, and psychology.

‘A pinch of unseen, unguarded dust’: The World and Self in Thomas Hardy's Poems

2018 ◽  
Vol 8 (1) ◽  
pp. 49-66
Author(s):  
Monika Szuba
Keyword(s):  
The Body ◽  
The Self ◽  
Phenomenological Philosophy ◽  
The Earth ◽  
The World ◽  
The Universe ◽  
Recurrent Theme ◽  
Body Subject

The essay discusses selected poems from Thomas Hardy's vast body of poetry, focusing on representations of the self and the world. Employing Maurice Merleau-Ponty's concepts such as the body-subject, wild being, flesh, and reversibility, the essay offers an analysis of Hardy's poems in the light of phenomenological philosophy. It argues that far from demonstrating ‘cosmic indifference’, Hardy's poetry offers a sympathetic vision of interrelations governing the universe. The attunement with voices of the Earth foregrounded in the poems enables the self's entanglement in the flesh of the world, a chiasmatic intertwining of beings inserted between the leaves of the world. The relation of the self with the world is established through the act of perception, mainly visual and aural, when the body becomes intertwined with the world, thus resulting in a powerful welding. Such moments of vision are brief and elusive, which enhances a sense of transitoriness, and, yet, they are also timeless as the self becomes immersed in the experience. As time is a recurrent theme in Hardy's poetry, this essay discusses it in the context of dwelling, the provisionality of which is demonstrated in the prevalent sense of temporality, marked by seasons and birdsong, which underline the rhythms of the world.

An ayurvedic tablet formulation for ulcer protection

2020 ◽  
Vol 10 (4) ◽  
pp. 35-38
Author(s):  
Shiva Kumar K ◽  
Purushothaman M ◽  
Soujanya H ◽  
Jagadeeshwari S
Keyword(s):  
Pharmacological Activity ◽  
The Body ◽  
Gastric Ulcers ◽  
Antiulcer Activity ◽  
Herbal Drugs ◽  
Human Beings ◽  
Synthetic Drugs ◽  
Scientific Investigations ◽  
System A ◽  
The World

Gastric ulcers or the peptic ulcer is the primary disease that affects the gastrointestinal system. A large extent of the population in the world are suffering from the disease, and the age group of people those who suffer from ulcers are 20-55years. Herbs are known to the human beings that are useful in the treatment of diseases, and there are a lot of scientific investigations that prove the pharmacological activity of herbal drugs. Practitioners have been using the herbal material to treat the ulcers successfully, and the same had been reported scientifically. Numerous publications have been made that proves the antiulcer activity of the plants around the world. The tablets were investigated for the antiulcer activity in two doses 200 and 400mg/kg in albino Wistar rats in the artificial ulcer those are induced by the ethanol. The prepared tablets showed a better activity compared to the standard synthetic drug and the marketed ayurvedic formulation. The tablets showed a dose-dependent activity in ulcer prevention and treatment. Many synthetic drugs are available for the ulcer treatment, and the drugs pose the other problems in the body by showing the side effects and some other reactions. This limits the use of synthetic drugs to treat ulcers effectively. Herbs are known to the human beings that are useful in the treatment of diseases, and there are a lot of scientific investigations that prove the pharmacological activity of herbal drugs.

Myriad Aspects of Secular Thinking on Malayali Cuisine

GIS Business ◽  
2019 ◽  
Vol 14 (3) ◽  
pp. 202-206
Author(s):  
SAJITHA M
Keyword(s):  
Social Status ◽  
Daily Life ◽  
Social Indicators ◽  
The Body ◽  
Human Being ◽  
Healthy Life ◽  
The Social ◽  
The World ◽  
History Of ◽  
Civilized Society

Food is one of the main requirements of human being. It is flattering for the preservation of wellbeing and nourishment of the body.  The food of a society exposes its custom, prosperity, status, habits as well as it help to develop a culture. Food is one of the most important social indicators of a society. History of food carries a dynamic character in the socio- economic, political, and cultural realm of a society. The food is one of the obligatory components in our daily life. It occupied an obvious atmosphere for the augmentation of healthy life and anticipation against the diseases.  The food also shows a significant character in establishing cultural distinctiveness, and it reflects who we are. Food also reflected as the symbol of individuality, generosity, social status and religious believes etc in a civilized society. Food is not a discriminating aspect. It is the part of a culture, habits, addiction, and identity of a civilization.Food plays a symbolic role in the social activities the world over. It’s a universal sign of hospitality.[1]

Differenzierungen im Begriff, Gegenwart‘ bei Husserl und Merleau-Ponty

2017 ◽  
Vol 2017 (1) ◽  
pp. 39-54
Author(s):  
Jörg Zimmer
Keyword(s):  
Modern Philosophy ◽  
The Body ◽  
Fundamental Concept ◽  
Phenomenological Description ◽  
Philosophy Of Time ◽  
Phenomenology Of Perception ◽  
The World ◽  
Classical Philosophy ◽  
The Moment ◽  
Empty Time

In classical philosophy of time, present time mainly has been considered in its fleetingness: it is transition, in the Platonic meaning of the sudden or in the Aristotelian sense of discreet moment and isolated intensity that escapes possible perception. Through the idea of subjective constitution of time, Husserl’s phenomenology tries to spread the moment. He transcends the idea of linear and empty time in modern philosophy. Phenomenological description of time experience analyses the filled character of the moment that can be detained in the performance of consciousness. As a consequence of the temporality of consciousness, he nevertheless remains in the temporal conception of presence. The phenomenology of Merleau-Ponty, however, is able to grasp the spacial meaning of presence. In his perspective of a phenomenology of perception, presence can be understood as a space surrounding the body, as a field of present things given in perception. Merleau-Ponty recovers the ancient sense of ‘praesentia’ as a fundamental concept of being in the world.

Unmaking and Remaking the World in Long-Term Solitary Confinement

2018 ◽  
Vol 1 (1) ◽  
pp. 16
Author(s):  
Lisa Guenther
Keyword(s):  
The Body ◽  
Solitary Confinement ◽  
Hunger Strike ◽  
State Prison ◽  
Legal Documents ◽  
The Social ◽  
The World ◽  
Collective Resistance ◽  
Civil Death

In The Body in Pain, Elaine Scarry analyzes the structure of torture as an unmaking of the world in which the tools that ought to support a person’s embodied capacities are used as weapons to break them down. The Security Housing Unit (SHU) of California’s Pelican Bay State Prison functions as a weaponized architecture of torture in precisely this sense; but in recent years, prisoners in the Pelican Bay Short Corridor have re-purposed this weaponized architecture as a tool for remaking the world through collective resistance. This resistance took the form of a hunger strike in which prisoners exposed themselves to the possibility of biological death in order to contest the social and civil death of solitary confinement. By collectively refusing food, and by articulating the meaning and motivation of this refusal in articles, interviews, artwork, and legal documents, prisoners reclaimed and expanded their perceptual, cognitive, and expressive capacities for world-making, even in a space of systematic torture.

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