scholarly journals Aktivitas Antidiabetes Ekstrak Air-Etanol, n-Heksan, dan Etil Asetat Uwi Banggai (Dioscorea alata L.) Dengan Metode Induksi Aloksan Pada Mencit Jantan (Mus musculus)

2020 ◽  
Vol 6 (2) ◽  
Author(s):  
Khildah Khaerati ◽  
Delina Amini ◽  
Ihwan
Keyword(s):  
Blood Glucose ◽  
Ethyl Acetate ◽  
Ethyl Acetate Extract ◽  
Test Preparation ◽  
The Body ◽  
Hexane Extract ◽  
Dioscorea Alata ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Ethyl Acetate Extracts

Hyperglycemia is a condition of increased blood glucose levels caused by insufficient insulin enzymes produced to control blood sugar levels in the body. This study aimed to determine the activity of ethanol-water, nhexane, and ethyl acetate extracts of Dioscorea alata L. in reducing blood  glucose levels in hyperglycemia modeled mice that were given intraperitoneal alloxan induction. 25 white rats were divided into 5 groups of test animals. Each group consists of 5 mice. The first group was given 0.5% sodium carboxymethylcellulose solution as a placebo, the second group was given 0.65 mg/kg BW glibenclamide as a positive comparison group, the third group was given the suspension of ethanol-water extract, the fourth group was given n-hexane extract, and the fifth group was given ethyl acetate extract at a dose of 140 mg/kg BW. The test preparation was orally given within 14 days of testing. The test was measured as the initial blood glucose levels of mice after alloxan induction and after giving the test preparation suspension. The results of the qualitative analysis illustrate that the water-ethanol extract can reduce blood glucose levels by 31.39%, n-hexane extract by 51.11%, and ethyl acetate extract by 50.77%. The results of quantitative analysis using One Way ANOVA method showed that the water-ethanol, n-hexane, and ethyl acetate extracts significantly decreased the blood glucose levels of mice. The best antidiabetic activity was ethyl acetate extract with a decrease in rat blood glucose levels by 169 mg/kg BW.

scholarly journals The Dose Effect of Mangrove Leaf Extract (Rhizophora apiculata) on Anticancer Activity in HeLa Cells

2021 ◽  
Vol 5 (1) ◽  
pp. 1
Author(s):  
Dwi Mahfud Maulana
Keyword(s):  
Hela Cell ◽  
Cell Viability ◽  
Ethyl Acetate ◽  
Leaf Extract ◽  
Ethyl Acetate Extract ◽  
Ethanol Extract ◽  
Hexane Extract ◽  
Rhizophora Apiculata ◽  
Ic50 Value ◽  
Ethyl Acetate Extracts

Disease cancer caused by abnormal growth of tissue where there has been an error, fast and out of control. Judging from the fact of gender, more than 270,000 women die every year caused by cervical cancer. To inhibit the growth of cancer cells, a compound is needed that causes the cell cycle to stop so that the ability of cell proliferation decreases. Alkaloid compounds can inhibit proliferation through oxidative inhibition processes that can cause cancer. Mangrove plants have potential as anticancer, antimicrobial, and antioxidant. The content of chemical compounds found in mangroves are flavonoids, steroids, alkaloids, phenolites, saponins and tannins. These compounds show high antioxidant activity and are shown to have a real relationship with the properties of the material's bioactivity against cancer cells. One of the mangrove species is Rhizophora apiculata. The purpose of this study was to determine the IC50 value produced by Rhizophora apiculata mangrove leaf extract on HeLa cell viability and to see the effect of Rhizophora apiculata mangrove leaf extract dosage on HeLa cell viability. The method used in this research is the experimental method. The research parameters included yield, proximate test, phytochemical test, toxicity test, total phenol test, cytotoxicity test and LC-MS test. The experimental design used was a simple and complex completely randomized design (CRD) with the Tukey test.The results of this study showed that the highest yield was in the ethanol extract of 5.91%, while the n-hexane and ethyl acetate extracts respectively had yields of 1.18% and 1.31%. The results of the proximate test on the water content of leaves and powder were 64.53% and 13.86%, respectively, the results of the ash content in the leaves and powder of Rhizophora apiculata were 3.94% and 8.41%, respectively. while the water content in the extract obtained the highest yield in the ethanol extract of 21.42%, while the n-hexane extract and ethyl acetate extract were 11.08% and 15.42%, respectively. For phytochemical results, it was found that n-hexane extract only contained alkaloids, flavonoids and steroids. Ethyl acetate extract contains steroid compounds. Meanwhile, the ethanol extract contains the most bioactive compounds, namely saponins, flavonoids, tannins and triterpenoids. The toxicity test using the Brine Shrimp Lethality Test (BSLT) method resulted in the lowest IC50 of ethanol extract at 49.45 ppm while the n-hexane and ethyl acetate extracts were 251.63 ppm and 920.45 ppm respectively. In the total phenol test, the n-hexane extract was 66.79 mg GAE / 100 gr, 222.97 mg GAE / 100 gr ethyl acetate extract and 929.04 mg GAE / 100 gr ethanol extract. HeLa cell cytotoxicity testing using the MTT method (3- (4,5-dimethiltiazol-2-yl) -2,5-dipheniltetra zolium bromide) assay resulted in the highest cell viability value at a dose of 125 ppm of 46.97%. As for the doses of 250 ppm, 500 ppm 1000 ppm, and 2000 ppm resulted in a percentage of viability of 42.95% 37.70% 35.82% and 32.12%, respectively. The IC50 value of Rhizophora apiculata leaf extract was 64.42 ppm. This value indicates that the Rhizophora apiculata extract is toxic to HeLa cells.

scholarly journals Non-Invasive Determination of Blood Glucose Levels by Optical Waveguide

2021 ◽  
Author(s):  
Mohsen Askarbioki ◽  
Mojtaba Mortazavi ◽  
Abdolhamid Amooee ◽  
Saeid Kargar ◽  
Mohammad Afkhami-Ardekani ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Optical Waveguide ◽  
Interstitial Fluid ◽  
Evanescent Waves ◽  
The Body ◽  
Statistical Population ◽  
Glucose Levels ◽  
Non Invasive ◽  
Blood Glucose Levels

Objective: Today, there are various non-invasive techniques available for the determination of blood glucose levels. In this study, the level of blood glucose was determined by developing a new device using near-infrared (NIR) wavelength, glass optical waveguide, and the phenomenon of evanescent waves. Materials and Methods: The body's interstitial fluid has made possible the development of new technology to measure the blood glucose. As a result of contacting the fingertip with the body of the borehole rod, where electromagnetic waves are reflected inside, evanescent waves penetrate from the borehole into the skin and are absorbed by the interstitial fluid. The electromagnetic wave rate absorption at the end of the borehole rod is investigated using a detection photodetector, and its relationship to the people's actual blood glucose level. Following precise optimization and design of the glucose monitoring device, a statistical population of 100 participants with a maximum blood glucose concentration of 200 mg/dL was chosen. Before measurements, participants put their index finger for 30 seconds on the device. Results: According to this experimental study, the values measured by the innovative device with Clark grid analysis were clinically acceptable in scales A and B. The Adjusted Coefficient of Determination of the data was estimated to be 0.9064. Conclusion: For future investigations, researchers are recommended to work with a larger statistical population and use error reduction trends to improve the accuracy and expand the range of measurements.

scholarly journals Assessment of Blood Glucose and Electrolytes during Cardiopulmonary Bypass in Diabetic and Non-Diabetic Patients of Pakistan

2016 ◽  
Vol 8 (9) ◽  
pp. 159
Author(s):  
Muhammad Bilal ◽  
Abdul Haseeb ◽  
Mohammad Hassaan Khan ◽  
Akash Khetpal ◽  
Muhammad Saad ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Cardiopulmonary Bypass ◽  
Repeated Measures ◽  
Artery Bypass ◽  
The Body ◽  
Diabetic Patients ◽  
Blood Electrolytes ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Significant Difference

<p><strong>INTRODUCTION: </strong>Perioperative hyperglycemia has been shown to be related to higher levels of morbidity and mortality in patients on cardiopulmonary bypass (CPB) undergoing coronary artery bypass grafting (CABG), both diabetic and non-diabetic. Blood electrolytes, like sodium, potassium, calcium, and chloride play a very important role in the normal functioning of the body and can lead to a variety of clinical disorders if they become deficient. A minimal number of studies have been conducted on the simultaneous perioperative changes in both blood glucose and electrolyte levels during CPB in Pakistan. Therefore, our aim is to record and compare the changes in blood glucose and electrolyte levels during CPB in diabetic and non-diabetic patients.</p><p><strong>MATERIALS &amp; METHODS: </strong>This was a prospective, observational study conducted on 200 patients who underwent CABG with CPB, from October 2014 to March 2015. The patients were recruited from the Cardiac Surgery Ward, Civil Hospital Karachi after they complied with the inclusion criteria. Repeated-measures analysis of variance (ANOVA) was used to compare the trend of the changes perioperatively for the two groups.</p><p><strong>RESULTS: </strong>There was no significant difference in changes in blood glucose between the two groups (<em>P</em> = 0.62). The only significant difference detected between the two groups was for PaCO<sub>2</sub> (<em>P</em> = 0.001). Besides, further analysis revealed insignificant group differences for the trend changes in other blood electrolytes (<em>P</em> &gt; 0.05).</p><p><strong>CONCLUSION: </strong>Our findings highlighted that there is no significant difference in blood electrolytes changes and the increase in blood glucose levels between diabetic and non-diabetic patients.</p>

scholarly journals GIVING RED RICE (ORIZA NIVARA) TO CHANGE GLUCOSE LEVELS IN DIABETES MELLITUS PATIENTS IN KENDARI CITY

2021 ◽  
Vol 3 (1) ◽  
pp. 38-44
Author(s):  
La Ode Ardiansyah ◽  
Nawawi Nawawi
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Brown Rice ◽  
Secondary Data ◽  
The Body ◽  
P Value ◽  
Red Rice ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Quasi Experimental

Background:Diabetes mellitus (DM) is a phenomenon which the body  cannot  produce insulin supply which is indicated by increasing blood glucose levels. Red Rice (Oriza nivara) contains flavonoid compounds which have antidiabetic abilities. It can  reduce blood glucose by increasing insulin secretion and preventing insulin resistance. This study aims to determine the effect of giving brown rice (Oriza nivara) to change   blood glucose levels in people with diabetes mellitus in Kendari City. Methods: This research method was carried out with a quasi-experimental design with pre-post test design for 1 week with primary and secondary data collection techniques. The respondents  were  determined by proportional random sampling. Respondents in this study were 33 people with DM. Result:The results of the study on checking blood glucose levels before and after giving brown rice (oriza nivara) within 1 week obtained P value = 0.000 <  alpha 0.05. Conclusion: there is a  significant  effect of giving brown rice (oriza nivara) on changes in blood glucose level in diabetes mellitus people  in Kendari City.

scholarly journals Blood glucose regulating hormones and their physiological and biochemical roles

2020 ◽  
pp. 44-49
Author(s):  
Maqsuduulah Mujtahid
Keyword(s):  
Nervous System ◽  
Blood Glucose ◽  
Normal Level ◽  
Endocrine System ◽  
The Body ◽  
Regulatory Mechanisms ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Multicellular Organisms ◽  
Physiological And Biochemical

Regulation and coordination of different body organs is important in multicellular organisms. Hormones and the nervous system participate in this synchronization. Hormones are the compounds and chemical messengers produced by cells, glands, or special tissues called the endocrine system and released into the bloodstream. In addition to the hormones, blood is consist of proteins, sugars, lipids, vitamins, etc. Blood sugar is glucose which produces energy in the body. Regular blood glucose levels vary at different ages and exceed 120-170 mg / dl. It is harmful and even fatal to increase or decrease it from the normal level, so the concentration of glucose dissolved in plasma was subject to tight regulation and various regulatory mechanisms were developed thereon. Hormones cortisol, glucagon, adrenaline, and glucocorticoids are the major regulators. These substances are tracked regularly to prevent blood glucose from rising and dropping. Insulin consists of hyperglycemia, as well as other hormones. The mechanism by which it affects the metabolism of the food (carbohydrates, lipids, proteins) prevents hypoglycemia in several respects.

scholarly journals PENGARUH ZUMBA TERHADAP KADAR GULA DARAH

2014 ◽  
Vol 2 (2) ◽  
Author(s):  
Novia P. I. Benaino ◽  
S. H. R. Ticoalu ◽  
Djon Wongkar
Keyword(s):  
Blood Glucose ◽  
Glucose Level ◽  
Physical Activities ◽  
T Test ◽  
The Body ◽  
Paired Sample ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Post Test ◽  
Hands And Feet

Abstract: Glucose is the result of carbohydrate metabolism that is converted and absorbed by bloodstream and placed to several organs and body tissues that functions as the main source of energy for muscles, physical activities of the body, central nervous system and brain work. A normal glucose level value is maintained by the body in a narrow range which is about 70-120 mg/dl. Glucose that has formed in its use as an energy source requires physical activities and insulin to stimulate permeability of the fiber muscle. This research aims at finding the effect of zumba to the blood glucose levels. Method: This research is an experiment with a one group pre and post test design that fulfill the criteria such as normal body mass index (18,5-22,9), people with no exercise routine, no diabetes mellitus, no asthma, no heart disease, no broken bones on hands and feet, and not being injured in muscle joints. The research samples are twenty students of nursing program study batch 2013, Faculty of Medicine, Sam Ratulangi University. the blood glucose level is measured before and after zumba exercise. The data are analyzed by Paired Sample-T test using SPSS. Conclusion: Based on the research done on the twenty research subjects, the result shows that there is no significant change of blood glucose levels after the two-week zumba exercise. Keywords: zumba, blood glucose.     Abstrak: Gula darah adalah hasil metabolisme karbohidrat yang terkonversi kemudian terabsorbsi oleh aliran darah dan ditempatkan ke berbagai organ dan jaringan tubuh dengan fungsi sebagai sumber energi utama bagi otot, aktivitas fisik tubuh, sistem saraf pusat dan kerja otak. Nilai kadar glukosa normal dipertahankan oleh tubuh dalam suatu rentangan nilai yang sempit yaitu sekitar 70-120 mg/dl. Glukosa yang telah terbentuk dalam penggunaannya sebagai sumber energi memerlukan aktivitas fisik dan kerja insulin untuk merangsang permebealitas dari serabut otot.Penelitian ini bertujuan untuk mengetahui pengaruh zumba terhadap kadar gula darah. Metode: Penelitian ini bersifat eksperimental dengan rancangan one group pre and post test yang memenuhi kriteria-kriteria yaitu tidak rutin berolahraga, IMT normal (18,5-22,9), bukan penderita penyakit diabetes melitus, bukan penderita penyakit asma, bukan penderita penyakit jantung, bukan penderita patah tulang pada kaki dan tangan, tidak sedang mengalami cedera otot dan sendi. Sampel penelitian yaitu mahasiswi Program Studi Ilmu Keperawatan Fakultas Kedokteran angkatan 2013 Universitas Sam Ratulangi Manado yang berjumlah 20 orang. Kadar gula darah diperiksa sebelum dan sesudah zumba. Data dianalisis dengan Paired Sample T-test menggunakan SPSS. Simpulan: Berdasarkan penelitian yang telah dilakukan pada subjek penelitian diperoleh hasil yaitu tidak terjadi perubahan kadar gula darah yang bermakna setelah melakukan zumba selama dua minggu. Kata kunci: zumba, gula darah.

Perbedaan Kadar Glukosa Darah 2 Jam Post Prandial

2017 ◽  
Vol 1 (1) ◽  
pp. 51
Author(s):  
Linda Triana ◽  
Maulidiyah Salim
Keyword(s):  
Blood Glucose ◽  
Comparative Study ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
T Test ◽  
The Body ◽  
Oral Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Simple Carbohydrates

Abstract: One of the simple carbohydrates is glucose that acts as the main energy producer. The function of the body will be felicitous when blood glucose levels are within normal limits. Glucose removal levels are considered normal if glucose levels return to normal within 2 hours after it rises in the first hour. If the blood glucose level within 2 hours after given fed is abnormal, it can be done by Oral Glucose Tolerance Test to get additional information about the presence of carbohydrate metabolism disorders. This study was aimed to determine the difference of blood glucose levels within 2 hours postprandial between samples who given fed with loads of 75 grams glucose. The type of research used in this research was analytic observational with comparative study approach. Samples obtained 33 samples with treatment 4 times in each sample. The method used in this research was an enzymatic method. The results of this study showed the average blood glucose level within 2 hours postprandial which given fed with loads was 10.10% while the average measurement of blood glucose level within 2 hours postprandial loaded with 75 grams glucose was 7.61%. T-test obtained t value of 1.092 with a significant level at p = 0.284 (p> 0.05) so the conclusion there was no difference of blood glucose level within 2 hours postprandial between who given fed with loads of 75-gram glucose.Abstrak: Salah satu karbohidrat sederhana adalah glukosa yang berperan sebagai penghasil energi utama. Fungsi dari tubuh akan menjadi sangat baik apabila kadar glukosa darah berada pada batas yang normal. Kadar pembuangan glukosa dianggap normal jika kadar glukosa kembali normal dalam waktu 2 jam setelah kenaikan pada 1 jam pertama. Apabila kadar glukosa darah dalam waktu 2 jam setelah makan abnormal, maka dapat dilakukan Tes Toleransi Glukosa Oral untuk mendapatkan keterangan tambahan tentang adanya gangguan metabolisme karbohidrat. Penelitian ini bertujuan untuk mengetahui perbedaan kadar glukosa darah 2 jam post prandial antara yang diberi beban makanan dengan beban glukosa 75 gram. Jenis penelitian yang digunakan dalam penelitian ini adalah observasional analitik dengan pendekatan comparative study. Sampel didapatkan 33 sampel dengan perlakuan 4 kali pada setiap sampelnya. Metode yang digunakan dalam penelitian ini adalah metode enzimatik. Hasil penelitian ini menunjukan rata-rata kadar glukosa darah 2 jam post prandial yang diberi beban makanan yaitu 10,10% sedangkan hasil pengukuran rata-rata kadar glukosa darah 2 jam post prandial yang diberi beban glukosa 75 gram yaitu 7,61%. Uji T-test didapatkan nilai t hitung sebesar 1,092 dengan tingkat signifkan pada p = 0,284 (p>0,05) sehingga Ha ditolak dengan kesimpulan tidak ada perbedaan kadar glukosa darah 2 jam post prandial antara yang diberi beban makanan dengan beban glukosa 75 gram.

scholarly journals Ascorbic Acid-Rich Moringa oleifera Lam. Extract Inhibits Hepatorenal Toxicity and Enhances the Endogenous Antioxidant Levels in Streptozotocin-Induced Type II Diabetes

2019 ◽  
pp. 25-35
Author(s):  
Vikas Kumar ◽  
Ankit Sahoo ◽  
Prakash Khadka ◽  
Deeksha Chauhan ◽  
Azizah Salim Bawadood ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Plasma Insulin ◽  
Moringa Oleifera ◽  
Density Lipoprotein ◽  
Diabetic Rats ◽  
The Body ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Treatment Of Diabetes ◽  
Moringa Oleifera Lam

Background. The cases of diabetes increase day by day due to unhealthy lifestyle, food habit, and less food intake. Novel drugs for the treatment of diabetes are urgently needed. Most researchers are looking for alternative drugs (plant-based drugs) for the treatment of diabetes. Objective. The current experiment was designed to examine the hepatic and renal beneficial effect of Moringa oleifera Lam. (MO) extract in the streptozotocin (STZ)-induced diabetes. Methods. Antidiabetic potential of the MO extract was estimated in terms of blood glucose levels, plasma insulin, hexokinase, and glucose-6-phosphate. Antihyperlipidemic effects of MO extract were evaluated through the estimation of low-density lipoprotein (LDL) cholesterol, total cholesterol (TC), triglyceride (TG), very LDL (VLDL) cholesterol, and high-density lipoprotein (HDL) level whereas the antioxidant effects were evaluated through estimation of catalase (CAT), superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione peroxidase (GPx) levels in diabetic rats. Results. Dose-dependent treatment using MO extract significantly increased the body weight, hexokinase, plasma insulin, HDL, SOD, CAT, and GPx levels (P < 0.001) and significantly decreased the levels of fasting blood glucose, TC, TGs, LDL, VLDL, MDA, fructose-1,6-bisphosphate, glucose-6-phosphate, and glycated hemoglobin in STZ-induced diabetic rats (P < 0.001). Conclusion. MO can be used as a therapeutic agent in the management of elevated blood glucose levels through the alterations in the blood glucose level, plasma level of insulin, and various biochemical parameters.

scholarly journals Antidiabetic Effects of NRDT50, the Enzyme Composition for Regulating Sugar Metabolism, in Db/db Mice

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A317-A317
Author(s):  
Daham Kim ◽  
Cheol Ryong Ku ◽  
Jung Seung Kim ◽  
Jihwan Hwang ◽  
Yoon Hee Cho ◽  
...  
Keyword(s):  
Blood Glucose ◽  
The Body ◽  
Postprandial Blood Glucose ◽  
Standard Diet ◽  
Meal Test ◽  
Mixed Meal ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Mixed Meal Test ◽  
Antidiabetic Effects

Abstract Objective: The enzyme composition (NRDT50) which includes glucosyl transferase, fructosyl transferase, amylase, glucose oxidase, and catalase can regulate the absorption of glucose into the body by converting the carbohydrates in food to a form of sugar that is not absorbed in the stomach before being decomposed in the small intestine into glucose. The aim of this study was to evaluate the antidiabetic effects of repeated oral administration of NRDT50 in db/db mice. Methods: The 7-week-old db/db mice were divided into 3 groups; control, NRDT50 (300mg/kg/day), and voglibose (0.3mg/kg/day). Mice received a standard diet containing drugs for 1 month. Fasting and postprandial glucose level was measured every week. Mixed meal test, biochemical assays, and fecal microbiota analysis were performed. Results: There were no significant differences in body weight or food intake between the three groups. However, NRDT50 treatment led to a significant reduction in fasting and postprandial blood glucose levels compared to control after 3, 4 weeks. The blood glucose levels during the mixed meal test were significantly lower in NRDT50 group compared to control group. NRDT50 treatment reduced triglyceride level, tend to reduce LDL level, and increased relative Bacteroidetes-Firmicutes ratio. NRDT50 treatment did not demonstrate any negative side effects on biochemical and histopathological examination. Conclusion: NRDT50 is expected to be useful for people who are at risk of hyperglycemia or diabetes and thus need to regulate blood sugar with safe. It may also improve the gut microbiota profile by inducing the production of oligosaccharides in the alimentary tract.

scholarly journals Efek Pemberian Buah Naga Merah (Hylocereus Polyrhizus) Terhadap Penurunan Kadar Glukosa Darah Pada Penderita Diabetes Tipe 2

2021 ◽  
Vol 5 (2) ◽  
pp. 97-103
Author(s):  
Yhurike Diah Pitaloka ◽  
Siti Juwariyah
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Communicable Disease ◽  
Public Health Problem ◽  
The Body ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Dragon Fruit ◽  
Reduce Blood Glucose

Diabetes Mellitus is a non-communicable disease and is an important public health problem. Diabetes mellitus is a chronic disease in which the pancreas does not produce enough insulin or when the body is ineffective in using it (WHO, 2016). One of the non-pharmacological management of diabetes mellitus is the administration of red dragon fruit. Dragon fruit is rich in antioxidants and contains many substances such as calcium, beta-carotene, vitamin B1, vitamin B2, vitamin C, phosphorus and flavonoid substances so that it can be used as a therapy to reduce blood glucose levels by preventing apoptosis due to oxidative reactions. The purpose of this case study is to compile a resume of nursing care in giving red dragon fruit to reduce blood glucose levels. This type of research is descriptive with a case study method in the form of a one group pretest posttest design. The subject of this study was 1 patient with diabetes mellitus. The results of the study showed that there was a change in the patient's condition after being given red dragon fruit for 10 days. Conclusion Dragon fruit has the effect of lowering blood glucose levels in people with type 2 diabetes mellitus because it contains fiber that is able to bind water in the intestines, and contains antioxidants and bioactive compounds and is able to inhibit free radical compounds. Keywords: diabetes mellitus, adults, red dragon fruit

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