scholarly journals The Analytical Applications And Biological Activity of Hydroxamic acids

2014 ◽  
Vol 10 (1) ◽  
pp. 2118-2125 ◽  
Author(s):  
M. J. A. Abualreish ◽  
M. A. Abdein
Keyword(s):  
Biological Activity ◽  
Literature Review ◽  
Physical Properties ◽  
General Structure ◽  
Analytical Techniques ◽  
Hydroxamic Acids ◽  
Vital Role ◽  
Historical Background ◽  
Analytical Applications ◽  
Methods Of Synthesis

Hydroxamic acids play a vital role in applied chemistry , the present literature review is an investigation on the analytical applications and biological activity of hydroxamic acids .The review includes a survey of  the historical background of hydroxamic acids , their general structure , classification , physical properties , stability and occurrence in nature .  In addition the review discuss the synthesis and  identification of hydroxamic acids ,in which different methods of synthesis and different analytical techniques for identification were outlined .The review also includes the wide use of hydroxamic acids , mainly their analytical applications and a summarized account of the biological activity of hydroxamic acids.

Instant 99mTc Compounds

1971 ◽  
Vol 10 (03) ◽  
pp. 245-251 ◽  
Author(s):  
P. Richards ◽  
W. C. Eckelman
Keyword(s):  
Physical Properties ◽  
High Purity ◽  
Analytical Techniques ◽  
Full Potential ◽  
Labeled Compounds ◽  
Ph Adjustment ◽  
One Step ◽  
Stannous Ion ◽  
99Mtc Radiopharmaceuticals ◽  
Potential Use

SummaryThe full potential use of technetium has not been achieved despite its ideal physical properties, dosimetry and availability because of the complex preparations required for 99mTc radiopharmaceuticals. One of the goals of our work is to develop techniques for the preparation of high-purity 99mTc compounds which can be easily prepared, ideally by adding pertechnetate to a prepared solution.The use of stannous ion as reducing agent for technetium makes it possible to obtain such one-step, high-purity products. All non-radioactive components can be premixed in a single vial before addition of the radioactive pertechnetate. No final pH adjustment, further chemical manipulation or purification is required.Procedures for two instantly labeled compounds have been developed to date: 99mTc DTPA and 99mTc HSA. The 99mTc DTPA is prepared by adding pertechnetate to a previously prepared solution of stannous ion and CaNa3 DTPA which has been stored at pH 4. The 99mTc HSA is prepared by adding pertechnetate to a solution of stannous ion and HSA. The parametric variations and analytical techniques involved in formulating these procedures are described. It appears that development of kits for other biologically interesting compounds may be possible using similar procedures.

Synthesis and Biological Potentials of Quinoline Analogues: A Review of Literature

2019 ◽  
Vol 16 (7) ◽  
pp. 653-688 ◽  
Author(s):  
Leena Kumari ◽  
Salahuddin ◽  
Avijit Mazumder ◽  
Daman Pandey ◽  
Mohammad Shahar Yar ◽  
...  
Keyword(s):  
Biological Activity ◽  
Heterocyclic Compounds ◽  
Building Blocks ◽  
Vital Role ◽  
Review Of Literature ◽  
Drug Discovery Process ◽  
Active Compounds ◽  
Lead Compounds ◽  
Synthetic Approaches ◽  
Derivatives Of

Heterocyclic compounds are well known for their different biological activity. The heterocyclic analogs are the building blocks for synthesis of the pharmaceutical active compounds in the organic chemistry. These derivatives show various type of biological activity like anticancer, antiinflammatory, anti-microbial, anti-convulsant, anti-malarial, anti-hypertensive, etc. From the last decade research showed that the quinoline analogs plays a vital role in the development of newer medicinal active compounds for treating various type of disease. Quinoline reported for their antiviral, anticancer, anti-microbial and anti-inflammatory activity. This review will summarize the various synthetic approaches for synthesis of quinoline derivatives and to check their biological activity. Derivatives of quinoline moiety plays very important role in the development of various types of newer drugs and it can be used as lead compounds for future investigation in the field of drug discovery process.

scholarly journals Comparison of Osmotic Resistance, Shape and Transmembrane Potential of Erythrocytes Collected from Healthy and Fed with High Fat-Carbohydrates Diet (HF-CD) Pigs—Protective Effect of Cistus incanus L. Extracts

Materials ◽  
2021 ◽  
Vol 14 (4) ◽  
pp. 1050
Author(s):  
Sylwia Cyboran-Mikołajczyk ◽  
Robert Pasławski ◽  
Urszula Pasławska ◽  
Kacper Nowak ◽  
Michał Płóciennik ◽  
...  
Keyword(s):  
Biological Activity ◽  
Physical Properties ◽  
Plasma Lipid ◽  
Membrane Lipid ◽  
Osmotic Resistance ◽  
High Fat ◽  
Atherosclerotic Lesions ◽  
Cistus Incanus ◽  
Osmotic Resistance Of Erythrocytes ◽  
The Impact

Long-term high fat-carbohydrates diet (HF-CD) contributes to the formation of irreversible changes in the organism that lead to the emergence of civilization diseases. In this study, the impact of three-month high-fat diet on the physical properties of erythrocytes (RBCs) was studied. Furthermore, the biological activity of Cistus incanus L. extracts, plant known with high pro-health potential, in relation to normal and HF-CD RBCs, was determined. Obtained results have shown that, applied HF-CD modified shape, membrane potential and osmotic resistance of erythrocytes causing changes in membrane lipid composition and the distribution of lipids. The impact of HF-CD on physical properties of RBCs along with atherosclerotic lesions of the artery was visible, despite the lack of statistically significant changes in blood morphology and plasma lipid profile. This suggests that erythrocytes may be good markers of obesity-related diseases. The studies of biological activity of Cistus incanus L. extracts have demonstrated that they may ameliorate the effect of HF-CD on erythrocytes through the membrane-modifying and antioxidant activity.

scholarly journals Chemical Diversity and Biological Activity of Secondary Metabolites from Soft Coral Genus Sinularia since 2013

Marine Drugs ◽  
2021 ◽  
Vol 19 (6) ◽  
pp. 335
Author(s):  
Xia Yan ◽  
Jing Liu ◽  
Xue Leng ◽  
Han Ouyang
Keyword(s):  
Biological Activity ◽  
Secondary Metabolites ◽  
Coral Species ◽  
Soft Coral ◽  
Biological Activities ◽  
Vital Role ◽  
Chemical Diversity ◽  
Pharmacological Activities ◽  
Lead Compounds ◽  
Coral Genus

Sinularia is one of the conspicuous soft coral species widely distributed in the world’s oceans at a depth of about 12 m. Secondary metabolites from the genus Sinularia show great chemical diversity. More than 700 secondary metabolites have been reported to date, including terpenoids, norterpenoids, steroids/steroidal glycosides, and other types. They showed a broad range of potent biological activities. There were detailed reviews on the terpenoids from Sinularia in 2013, and now, it still plays a vital role in the innovation of lead compounds for drug development. The structures, names, and pharmacological activities of compounds isolated from the genus Sinularia from 2013 to March 2021 are summarized in this review.

scholarly journals Extraction Techniques and Analytical Methods for Characterization of Active Compounds in Origanum Species

Molecules ◽  
2020 ◽  
Vol 25 (20) ◽  
pp. 4735
Author(s):  
Maša Knez Hrnčič ◽  
Darija Cör ◽  
Jana Simonovska ◽  
Željko Knez ◽  
Zoran Kavrakovski ◽  
...  
Keyword(s):  
Biological Activity ◽  
Abiotic Stresses ◽  
Plant Protection ◽  
Analytical Techniques ◽  
Extraction Techniques ◽  
Isolation And Identification ◽  
Activity Assessment ◽  
Current Contribution ◽  
Pharmaceutical Industries

Phytochemical research based on ethnopharmacology is gaining interest in industries such as functional food, nutraceuticals, cosmetics and pharmaceutical industries. Plants and plant extracts are a rich source of bioactive secondary metabolites. These compounds are often involved in plant protection against biotic or abiotic stresses. The exploitation of available technologies should be oriented and intensified to extend and enhance the continued usefulness of the plants as renewable sources of chemicals, especially medicinal compounds. This current contribution is focused on extraction and analytical techniques for their isolation from the oregano species, their characterization and their potential antioxidative, as well as their antimicrobial, antifungal and anticarcinogenic properties. The work is structured rendering to the different steps involved in the research; starting with extraction and sample preparation, followed by discussing the analytical techniques employed for the isolation and identification of compound/s responsible for the biological activity and methods and techniques for biological activity assessment.

scholarly journals Rethinking SME default prediction: a systematic literature review and future perspectives

2021 ◽  
Author(s):  
Francesco Ciampi ◽  
Alessandro Giannozzi ◽  
Giacomo Marzi ◽  
Edward I. Altman
Keyword(s):  
Literature Review ◽  
Systematic Literature Review ◽  
Global Financial Crisis ◽  
Analytical Techniques ◽  
Future Research ◽  
Finance Management ◽  
Default Prediction ◽  
Emerging Issues ◽  
Medium Enterprise ◽  
Modern Analytical

AbstractOver the last dozen years, the topic of small and medium enterprise (SME) default prediction has developed into a relevant research domain that has grown for important reasons exponentially across multiple disciplines, including finance, management, accounting, and statistics. Motivated by the enormous toll on SMEs caused by the 2007–2009 global financial crisis as well as the recent COVID-19 crisis and the consequent need to develop new SME default predictors, this paper provides a systematic literature review, based on a statistical, bibliometric analysis, of over 100 peer-reviewed articles published on SME default prediction modelling over a 34-year period, 1986 to 2019. We identified, analysed and reviewed five streams of research and suggest a set of future research avenues to help scholars and practitioners address the new challenges and emerging issues in a changing economic environment. The research agenda proposes some new innovative approaches to capture and exploit new data sources using modern analytical techniques, like artificial intelligence, machine learning, and macro-data inputs, with the aim of providing enhanced predictive results.

scholarly journals Physical properties, ligand substitution reactions, and biological activity of Co(iii)-Schiff base complexes

2019 ◽  
Vol 48 (18) ◽  
pp. 5987-6002 ◽  
Author(s):  
A. Paden King ◽  
Hendryck A. Gellineau ◽  
Samantha N. MacMillan ◽  
Justin J. Wilson
Keyword(s):  
Biological Activity ◽  
Schiff Base ◽  
Physical Properties ◽  
Ligand Exchange ◽  
Ligand Substitution ◽  
Schiff Base Complexes ◽  
Substitution Reactions ◽  
Anticancer Properties ◽  
Ligand Substitution Reactions

A subset of fluorinated Co(iii) Schiff base complexes was synthesized, and their structural, ligand exchange, and anticancer properties were investigated.

scholarly journals Pictorial Statistics Following the Vienna Method

ARTMargins ◽  
2017 ◽  
Vol 6 (1) ◽  
pp. 108-118 ◽  
Author(s):  
Otto Neurath
Keyword(s):  
General Structure ◽  
Vienna Circle ◽  
Historical Background ◽  
Basic Knowledge ◽  
Educational Achievements ◽  
Historical Significance ◽  
Visual Pedagogy ◽  
Austrian Tradition ◽  
Philosophical Debates ◽  
International Social

This text introduces a programmatic text of Otto Neurath on the educational use of the method of pictorial statistics. Neurath emphasizes the importance of a visual method to transfer scientific knowledge to popular audiences. At the same time, his Vienna Method attempts to adapt the popular educational strategy to an increasingly visual modernity. The specific educational interest of Neurath's Vienna Method consists in political education, in transferring basic knowledge about the general structure and dominant developments of society. His program thus echoes his contemporaries’ debates on the possibilities of social realism. To understand the historical significance of Neurath the introductory text accentuates three lines of possible discussion. It points out the importance of Neurath's visual pedagogy for the tradition of contemporary discussions around the so-called Bildwissenschaften. It also contextualizes Neurath's visual pedagogy in the Austrian tradition of Second International Social Democracy and in the context of the philosophical debates of the Vienna circle. Against this double historical background, the text eventually tries to understand the educational achievements and political pitfalls of Neurath's attempt to represent general societal developments visually.

Synthesis, Characterization, Applications, and Toxicity of Green Synthesized Nanoparticles

2021 ◽  
Vol 22 ◽  
Author(s):  
João Marcos Pereira Galúcio ◽  
Sorrel Godinho Barbosa de Souza ◽  
Arthur Abinader Vasconcelos ◽  
Alan Kelbis Oliveira Lima ◽  
Kauê Santana da Costa ◽  
...  
Keyword(s):  
Green Synthesis ◽  
Low Cost ◽  
Chemical Properties ◽  
Analytical Techniques ◽  
Industrial Applications ◽  
Synthesis Methods ◽  
Methods Of Synthesis ◽  
Food Applications ◽  
Living Organisms ◽  
Harmful Effects

: Nanotechnology is a cutting-edge area with numerous industrial applications. Nanoparticles are structures that have dimensions ranging from 1–100 nm which exhibit significantly different mechanical, optical, electrical, and chemical properties when compared with their larger counterparts. Synthetic routes that use natural sources, such as plant extracts, honey, and microorganisms are environmentally friendly and low-cost methods that can be used to obtain nanoparticles. These methods of synthesis generate products that are more stable and less toxic than those obtained using conventional methods. Nanoparticles formed by titanium dioxide, zinc oxide, silver, gold, and copper, as well as cellulose nanocrystals are among the nanostructures obtained by green synthesis that have shown interesting applications in several technological industries. Several analytical techniques have also been used to analyze the size, morphology, hydrodynamics, diameter, and chemical functional groups involved in the stabilization of the nanoparticles as well as to quantify and evaluate their formation. Despite their pharmaceutical, biotechnological, cosmetic, and food applications, studies have detected their harmful effects on human health and the environment; and thus, caution must be taken in uses involving living organisms. The present review aims to present an overview of the applications, the structural properties, and the green synthesis methods that are used to obtain nanoparticles, and special attention is given to those obtained from metal ions. The review also presents the analytical methods used to analyze, quantify, and characterize these nanostructures.

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