scholarly journals Probiotics against alleviation of lead toxicity: recent advances

2019 ◽  
Vol 12 (2) ◽  
pp. 89-92 ◽  
Author(s):  
Sanjib Bhattacharya
Keyword(s):  
Heavy Metal ◽  
Clinical Study ◽  
Clinical Studies ◽  
Scientific Literature ◽  
Experimental Studies ◽  
Lead Toxicity ◽  
Literature Survey ◽  
Preclinical Studies ◽  
Significant Protection ◽  
Toxic Heavy Metal

Abstract Lead is a toxic heavy metal and there is no specific, safe and efficacious therapeutic management of lead toxicity. Scientific literature reported that some probiotic microorganisms alleviated experimentally induced lead toxicity. The present review attempts to collate the experimental studies on probiotics with ameliorative effects. Literature survey revealed that four (4) types of probiotic microorganisms exhibited significant protection from lead toxicity in experimental pre-clinical studies. No clinical study with significant outcome was found in the literature. From the outcomes of the preclinical studies it appears that probiotics are prospective for alleviation and treatment of lead toxicity.

scholarly journals Medicinal plants and natural products can play a significant role in mitigation of mercury toxicity

2018 ◽  
Vol 11 (4) ◽  
pp. 247-254 ◽  
Author(s):  
Sanjib Bhattacharya
Keyword(s):  
Natural Products ◽  
Medicinal Plants ◽  
Scientific Literature ◽  
Scientific Journal ◽  
Experimental Studies ◽  
Literature Survey ◽  
Mercury Toxicity ◽  
Journal Articles ◽  
Effective Agent ◽  
Clinical Investigations

Abstract Mercury is a heavy metal of considerable toxicity. Scientific literature reveals various plants and plant derived natural products, i.e., phytochemicals, which can alleviate experimentally induced mercury toxicity in animals. The present review attempts to collate those experimental studies on medicinal plants and phytochemicals with ameliorative effects on mercury toxicity. A literature survey was carried out by using Google, Scholar Google, Scopus and Pub-Med. Only the scientific journal articles found in the internet for the last two decades (1998–2018) were considered. Minerals and semi-synthetic or synthetic analogs of natural products were excluded. The literature survey revealed that in pre-clinical studies 27 medicinal plants and 27 natural products exhibited significant mitigation from mercury toxicity in experimental animals. Clinical investigations were not found in the literature. Admissible research in this area could lead to development of a potentially effective agent from the plant kingdom for clinical management of mercury toxicity in humans.

The lead toxicity and pollution with this element in Poland

2019 ◽  
Author(s):  
Angelika Charkiewicz ◽  
Jeffrey Backstrand
Keyword(s):  
Public Health ◽  
Heavy Metal ◽  
Public Health Problem ◽  
Lead Toxicity ◽  
The Body ◽  
Toxic Exposure ◽  
Important Public Health Problem ◽  
Toxic Heavy Metal ◽  
Sex Drive ◽  
Occupational And Environmental Exposure

Abstract Background The aim of this review is to describe lead’s toxic effects on the human body from conception through adulthood.Results One toxic heavy metal is lead. Pb is very dangerous when it is absorbed and accumulates in the main organs of the body where it can cause a range of symptoms that vary from person to person, the time of exposure and dose. Lead in adults can cause an increase in blood pressure, slow nerve conduction, fatigue, mood swings, drowsiness, impaired concentration, fertility disorders, decreased sex drive, headaches, constipation and in severe cases encephalopathy or death.Conclusions Toxic exposure to lead in Poland remains an important public health problem. This review will cover the range of lead exposures, from mild to heavy. Public health interventions and policies also are needed to reduce occupational and environmental exposure to this heavy metal.

Sex differences in experimental studies of depression: How can clinical research benefit?

2017 ◽  
Vol 41 (S1) ◽  
pp. s905-s905
Author(s):  
N. Kokras ◽  
C. Dalla
Keyword(s):  
Clinical Trials ◽  
Sex Differences ◽  
Clinical Research ◽  
Clinical Studies ◽  
Rating Scales ◽  
Experimental Studies ◽  
Preclinical Studies ◽  
Antidepressant Response ◽  
Preclinical Research ◽  
Behavioral Indices

IntroductionSex differences in depression and antidepressant response in humans are modestly studied and results are controversial. Experimental studies using animal models may provide insights that could be useful in clinical trials.ObjectivesThe objective is to summarize findings from preclinical studies on sex differences and suggest how such preclinical research might be of use in clinical research.AimsSpecifically it is aimed to summarize evidence for both sexes in relation to the phenotype of depression, its endophenotype and the antidepressant response.MethodsA selection of experimental studies on sex differences in stress and antidepressant response was performed and their findings were linked to potential confounders or methodological issues that might obscure the results of clinical trials.ResultsIn preclinical studies, behavioral indices and models are adjusted for both sexes, in order to properly identify sex differences in primary outcomes. This is not routinely happening in clinical studies when using depression rating scales, which is the analogue of behavioral indices. Moreover, preclinical studies show sex differences at the baseline behavioral response and underlying mechanisms that often converge following antidepressant treatment. This is also a neglected issue in human studies. Finally, preclinical research suggests that when researching on potential biomarkers for depression and antidepressant response sex should be an important factor to consider.ConclusionsCautious exploitation of findings on sex differences from preclinical research could improve the design and quality of clinical studies for disease biomarkers and novel antidepressants and facilitate the drug development in a gender aware manner.Disclosure of interestNK has received honoraria and travel support from Janssen-Cilag, Lundbeck, Sanofi-Aventis, Medochemie Generics and Elpen S.A. CD has received honoraria from Janssen-Cilag and travel support from Boehringer Ingelheim. None of those is relevant to this study.

scholarly journals AMERLIORATIVE EFFECT OF CINNAMALDEHYDE AGAINST LEAD ACETATE INDUCED SPLENIC TOXICITY OF SWISS ALBINO MICE (MUS MUSCULUS)

2020 ◽  
pp. 61-63
Author(s):  
Papiya Datta ◽  
Soumosish Paul ◽  
Gobinda Chandra Sadhukhan ◽  
Nimai Chandra Saha ◽  
Soumendranath Chatterjee
Keyword(s):  
Heavy Metal ◽  
Mus Musculus ◽  
Lead Acetate ◽  
Lead Toxicity ◽  
Toxic Heavy Metal ◽  
Swiss Albino Mice ◽  
Ameliorative Effect ◽  
Herbal Plants ◽  
Albino Mice ◽  
Chronic Lead Exposure

Our mother India is full of various herbal plants with great medicinal importance. Cinnamaldehyde, an active component of Cinnamon, one of the widely used spice has antifungal, anti-microbial, anti-oxidative and many other properties. Our present study is aimed to investigate the ameliorative effect of Cinnamaldehyde upon the splenic toxicity induced by chronic lead exposure. For this lead acetate was applied on female Swiss albino mice (Mus musculus) continuously for 120 days. After treatment with lead, only selective dose of Cinnamaldehyde was applied on the mice for last 30 days. For observing the hazardous effects of this heavy metal and curative effect of Cinnamaldehyde, we explored various biological parameters like TBARS, GSH along with morphometric and histo-pathological analysis. Our observations clearly depicted the dose-dependent ill effects of this toxic heavy metal. Post –treatment of Cinnamaldehyde at a selective dose helped the tissue to get rid of this toxicity at certain level. All these findings disclosed the ameliorative effects of Cinnamaldehyde upon lead toxicity on spleen.

Exneriana – II – The Scientific Legacy of John E. Exner, Jr. 1Part of this paper was presented at the XIXth International Congress of Rorschach and Projective Methods, July 22–26, 2008, Louvain, Belgium.

2008 ◽  
Vol 29 (2) ◽  
pp. 81-107 ◽  
Author(s):  
Anne Andronikof
Keyword(s):  
Clinical Studies ◽  
Experimental Studies ◽  
Scientific Work ◽  
International Congress ◽  
Response Process ◽  
Scientific Legacy ◽  
Projective Test ◽  
Projective Methods ◽  
Comprehensive Picture ◽  
Complex Mechanisms

Based on an analysis of John Exner’s peer-reviewed published work from 1959 to 2007, plus a brief comment for an editorial in Rorschachiana, the author draws a comprehensive picture of the scientific work of this outstanding personality. The article is divided into three sections: (1) the experimental studies on the Rorschach, (2) the clinical studies using the Rorschach, and (3) Exner’s “testament,” which we draw from the last paper he saw published before his death (Exner, 2001/2002). The experimental studies were aimed at better understanding the nature of the test, in particular the respective roles of perception and projection in the response process. These fundamental studies led to a deeper understanding of the complex mechanisms involved in the Rorschach responses and introduced some hypotheses about the intentions of the author of the test. The latter were subsequently confirmed by the preparatory sketches and documents of Hermann Rorschach, which today can be seen at the H. Rorschach Archives and Museum in Bern (Switzerland). Exner’s research has evidenced the notion that the Rorschach is a perceptive-cognitive-projective test.

ASSESSMENT OF HEAVY METAL CONCENTRATION IN COCONUT WATER

1970 ◽  
pp. 07-10
Author(s):  
MdDidarul Islam, Ashiqur Rahaman, Aboni Afrose
Keyword(s):  
Heavy Metals ◽  
Heavy Metal ◽  
Heavy Metal Concentration ◽  
Coconut Water ◽  
Toxic Heavy Metals ◽  
High Concentration ◽  
Toxic Heavy Metal ◽  
Low Concentration ◽  
Wet Ashing ◽  
Aas Method

This study was based on determining concentration of essential and toxic heavy metal in coconut water available at a local Hazaribagh area in Dhaka, Bangladesh. All essential minerals, if present in the drinking water at high concentration or very low concentration, it has negative actions. In this study, fifteen samples and eight heavy metals were analyzed by Atomic Absorption Spectroscopy (AAS) method which was followed by wet ashing digestion method. The concentration obtained in mg/l were in the range of 0.3 to 1.5, 7.77 to 21.2, 0 to 0.71, 0 to 0.9, 0 to 0.2, 0.9 to 17.3, 0.1 to 0.9, 0 to 0.9 and 0 to 0.7 for Fe, Ni, Cu, Cd, Cr, Zn, Pb and Se respectively. From this data it was concluded that any toxic heavy metals like Cd, Cr, Pb and Ni exceed their toxicity level and some essential nutrients were in low concentration in those samples. 

Applications of Bentonite to Soil Decontamination

2018 ◽  
Vol 69 (7) ◽  
pp. 1695-1698
Author(s):  
Marin Rusanescu ◽  
Carmen Otilia Rusanescu ◽  
Gheorghe Voicu ◽  
Mihaela Begea
Keyword(s):  
Heavy Metals ◽  
Heavy Metal ◽  
Laboratory Experiments ◽  
Experimental Studies ◽  
Heavy Metal Concentration ◽  
Polluted Soil ◽  
Raw Material ◽  
Soil Decontamination ◽  
Metal Retention ◽  
Removal Of Heavy Metals

A calcium bentonite from Orasu Nou deposit (Satu Mare Romania) was used as raw material. We have conducted laboratory experiments to determine the influence of bentonite on the degree of heavy metal retention. It has been observed that the rate of retention increases as the heavy metal concentration decreases. Experimental studies have been carried out on metal retention ( Zn) in bentonite. In this paper, we realized laboratory experiments for determining the influence of metal (Zn) on the growth and development of two types of plants (Pelargonium domesticum and Kalanchoe) and the effect of bentonite on the absorption of pollutants. These flowers were planted in unpolluted soil, in heavy metal polluted soil and in heavy metal polluted soil to which bentonite was added to observe the positive effect of bentonite. It has been noticed that the flowers planted in unpolluted soil and polluted with heavy metals to which bentonite has been added, the flowers have flourished, the leaves are still green and the plants whose soils have been polluted with heavy metals began to dry after 6 days, three weeks have yellowish leaves and flowers have dried. Experiments have demonstrated the essential role of bentonite for the removal of heavy metals polluted soil.

scholarly journals Toxic Animal-Based Medicinal Materials Can Be Effective in Treating Endometriosis: A Scoping Review

Toxins ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 145
Author(s):  
Su-In Hwang ◽  
Young-Jin Yoon ◽  
Soo-Hyun Sung ◽  
Ki-Tae Ha ◽  
Jang-Kyung Park
Keyword(s):  
Side Effects ◽  
Clinical Studies ◽  
Malignant Tumors ◽  
Experimental Studies ◽  
Herbal Medicines ◽  
Treatment Method ◽  
Reproductive Age ◽  
Dependent Growth ◽  
Gynecological Disorder ◽  
Preclinical And Clinical Studies

Animal toxins and venoms have recently been developed as cancer treatments possessing tumor cell growth-inhibitory, antiangiogenesis, and proapoptotic effects. Endometriosis is a common benign gynecological disorder in reproductive-age women, and no definite treatment for this disorder is without severe side effects. As endometriosis and malignant tumors share similar characteristics (progressive, invasive, estrogen-dependent growth, and recurrence), animal toxins and venoms are thought to be effective against endometriosis. The objective of this study was to outline studies using toxic animal-based medicinal materials (TMM) as endometriosis treatment and to explore its clinical applicability. Preclinical and clinical studies using TMM were searched for in four databases from inception to October 2020. A total of 20 studies of TMM on endometriosis were included. In eight clinical studies, herbal medicines containing TMM were effective in relieving symptoms of endometriosis, with no side effects. In twelve experimental studies, the main therapeutic mechanisms of TMM against endometriosis were proapoptotic, antiangiogenesis, estrogen level-reducing, and possible anti-inflammatory effects. TMM are thus considered promising sources for the development of an effective treatment method for endometriosis. Further studies are needed to clarify the therapeutic mechanism of TMM against endometriosis and to provide sufficient grounds for clinical application.

scholarly journals Application of nanoscale zero-valent iron in hexavalent chromium-contaminated soil: A review

2020 ◽  
Vol 9 (1) ◽  
pp. 736-750
Author(s):  
Xilu Chen ◽  
Xiaomin Li ◽  
Dandan Xu ◽  
Weichun Yang ◽  
Shaoyuan Bai
Keyword(s):  
Heavy Metal ◽  
Hexavalent Chromium ◽  
Contaminated Soil ◽  
Zero Valent Iron ◽  
Toxic Heavy Metal ◽  
Factors Affecting ◽  
Metal Pollutants ◽  
Nanoscale Zero Valent Iron ◽  
Low Toxicity ◽  
Heavy Metal Pollutants

AbstractChromium (Cr) is a common toxic heavy metal that is widely used in all kinds of industries, causing a series of environmental problems. Nanoscale zero- valent iron (nZVI) is considered to be an ideal remediation material for contaminated soil, especially for heavy metal pollutants. As a material of low toxicity and good activity, nZVI has been widely applied in the in situ remediation of soil hexavalent chromium (Cr(vi)) with mobility and toxicity in recent years. In this paper, some current technologies for the preparation of nZVI are summarized and the remediation mechanism of Cr(vi)-contaminated soil is proposed. Five classified modified nZVI materials are introduced and their remediation processes in Cr(vi)-contaminated soil are summarized. Key factors affecting the remediation of Cr(vi)-contaminated soil by nZVI are studied. Interaction mechanisms between nZVI-based materials and Cr(vi) are explored. This study provides a comprehensive review of the nZVI materials for the remediation of Cr(vi)-contaminated soil, which is conducive to reducing soil pollution.

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