scholarly journals Effect of Phytase Application to Rape Cake Diet on Nutrient Deposition and Bone Quality in Broiler Chickens

2012 ◽  
Vol 56 (4) ◽  
pp. 663-668
Author(s):  
Teresa Banaszkiewicz
Keyword(s):  
Total Phosphorus ◽  
Broiler Chickens ◽  
Control Diet ◽  
Nutrient Content ◽  
Feed Consumption ◽  
Nutrient Deposition ◽  
Group Iii ◽  
Group I ◽  
Low Phosphorus

Abstract The aim of the study was to evaluate the effect of high rape cake content and microbial phytase added to low-phosphorus diet on deposition of nutrients and energy in body of broiler chickens and quality of their bones. At the beginning, seven 1-day-old Ross 308 chickens were weighed, slaughtered, dried, and their bodies were analysed for gross energy and nutrient content. Next, 90 one-day-old chickens were randomly divided into three groups. The group I was fed control diet (RC), which contained 15% (starter) and 20% (grower) of rape cake of Lirajet cultivar with P (7.5 g kg-1) and Ca (10 g.kg-1). The group I I was fed diet denoted as RC LP, which contained less P and Ca (5.8 g.kg-1 and 6.8 g.kg-1, respectively) than the control diet. The diet for group III, denoted RC LP+ Phy, contained 5.8 g.kg-1 of P and 6.8 g.kg-1of Ca, and was supplemented with enzyme preparation containing 0.35g.kg-1 of phytase. On the 21st d of life, the chickens were weighed and six birds from each group were slaughtered, dried, and analysed. The rest of the chickens were fed grower mixtures to 49 d of age and then six chickens were slaughtered and the quality of their bones was evaluated. The reduction of P and Ca contents in diets and phytase application did not influence body weight and feed consumption, but significantly improved the deposition of total phosphorus in chicken body at 1-21 d of age. The highest content of total phosphorus was stated in the femur of the chickens fed diet with normal P and Ca contents. The application of phytase to low-phosphorus diet did not influence the quality of bones.

scholarly journals LIVE WEIGHT, SAFETY, SLAUGHTER YIELD AND MEAT QUALITY OF BROILER CHICKENS WHEN FED WITH COMBINED BLOOD-FEATHER FEED ADDITIVE

2018 ◽  
Vol 56 ◽  
pp. 71-76
Author(s):  
I. I. Murzha ◽  
V. G. Кеbkо ◽  
Yu. P. Polupan ◽  
M. G. Porhun ◽  
L. O. Dedova ◽  
...  
Keyword(s):  
Broiler Chickens ◽  
Raw Materials ◽  
Live Weight ◽  
Feed Additive ◽  
Control Group ◽  
Group Iii ◽  
Technological Line ◽  
Group I ◽  
Combined Feed

Introduction. In recent years, the production of feed additives of animal origin in Ukraine has declined sharply, and the cost of imported additives is very high. At the same time, in our country, the industry of industrial poultry farming has recently received intensive development, in particular, the cultivation and processing of broiler chickens for meat. At the same time, a significant amount of non-food waste from poultry slaughter in many poultry farms is not processed for feed purposes. Currently, an urgent problem is the organization of processing of non-food waste of poultry for feed purposes at poultry farms of industrial type of cultivation for meat of broiler chickens, primarily from blood and hydrolyzed raw materials. Processing of these wastes for feed purposes will not only give the opportunity to increase the production of high-grade protein feed, but also to significantly improve environmental safety. The purpose of our research is to study the meat productivity, safety, slaughter yield and quality of broiler chicken meat when feeding a combined feed additive from blood and hydrolyzed raw materials. Materials and methods of research. Development of an innovative technological line for the production of a combined feed additive from blood and hydrolyzed raw materials was carried out in LLC "Complex Agromars" (village of Havrylivka, Vyshgorod district of Kyiv region), and research on the effectiveness of feeding a combined feed additive from blood and hydrolyzed raw materials was performed in the production conditions of LLC "Bila Hora" Sniatynskyi district of Ivano-Frankivsk region. Research result. Development of innovative technological line was carried out in cooperation with engineering and technical staff of LLC "Complex Agromars". The innovative technological line is designed and installed using devices and mechanisms of the company "Haarslev Industries". In order to study the effectiveness of feeding a combined blood-feather feed additive for the experiment, four groups of broiler chickens of the Cobb 500 cross were formed, 50 heads in each, according to the following scheme: one group of broiler chickens was taken as a control group, and the next three groups – as research groups. Cultivation of broiler chickens in the experiment was carried out according to the traditional technology of feeding on standard compound feeds adopted in industrial broiler poultry farming, which, depending on the age and growth of chickens, includes 3 phases: "Start" – 14 days, "Growth" – 18 days, "Finish" – 12 days. According to the scheme of experience, the control group of chickens received standard feed without blood-feather feed additive. The difference in feeding of the broiler chickens of the experimental groups was in different levels of feeding with experimental combined feed additive from blood and hydrolyzed feather raw materials, which, depending on the age and growth of chickens, included in the feed of the I group from 4 to 12%, of the II group – from 3 to 10%, of the III group – from 2 to 8%. As a result of the studies it was found that at the end of the experiment at 44-day age the average live weight of broiler chickens of the control group was 2630 g, of the experimental group I – 2885 g, of the group II –2790 g, of the group III – 2680 g. For 44 days of experience the following amounts died: in the control group – 2 chickens, in the experimental group I – 1 chicken, in the group II – no chickens, in the group III – 1 chicken. Slaughter of broiler chickens and meat tasting was carried out in the company "Bilyi Bereh" of Ternopil region at the age of 44 days. It was established that the average slaughter yield of 1 carcass of broiler chicken meat was: in the control group – 1920, in the experimental group I – 2106 g, in the group II – 2037 g, in the group III – 1956 g. The difference in quality of meat of broiler chickens of control and experimental groups by results of tasting was not revealed. Summary: In LLC "Complex Agromars" (village of Havrylivka, Vyshgorod district of Kyiv region) designed and implemented an innovative technological line for production of ecologically safe combined feed additive from blood and hydrolyzed feather raw materials from non-food waste slaughter of broiler chickens when growing for meat. In the course of scientific and economic experiment it was found that the inclusion in the standard traditional feed in different phases of cultivation of broiler chickens for meat of about 4 to 12% of the combined feed additive from blood and hydrolyzed feather raw materials increased their average live weight from 2630g in the control group to 2885 g, and the average slaughter yield of 1 meat carcass – from 1920 g in the control group to 2106 g.

ВЛИЯНИЕ ПРОДОЛЖИТЕЛЬНОСТИ ПРОИЗВОДСТВЕННОГО ЦИКЛА И УРОВНЯ КОРМЛЕНИЯ НА ПРОДУКТИВНЫЕ КАЧЕСТВА БЫЧКОВ АБЕРДИН АНГУССКОЙ ПОРОДЫ

2019 ◽  
pp. 5-8
Author(s):  
M.M. SHAKHMURZOV ◽  
F.A. SHEVKHUZHEV ◽  
V.A. POGODAEV ◽  
N.V. TSURIKOVА
Keyword(s):  
Live Weight ◽  
Specific Weight ◽  
Feed Consumption ◽  
Production Cycle ◽  
Cattle Breeding ◽  
Average Mass ◽  
Group Iii ◽  
Group I ◽  
Different Levels

Эффективность специализированного мясного скотоводства можно повысить за счет реализации интенсивных технологий. Целью нашей работы было изучение влияния различных уровней кормления бычков абердин ангусской породы по периодам выращивания, откорма, длительности производственного цикла на продуктивность и качество говядины. Длительность периодов и продолжительность производственного цикла были следующие: первый период колебался по I, II, III группам — 138, 155, 178 дней; второй — 145, 163, 186 дней; третий — 143, 161, 182 дня. Удельный вес концентратов по питательности составлял по группам 30, 40, 50%, а питательность израсходованных кормов за цикл соответственно 3233, 3045, 2914 ЭКЕ. В целом за весь производственный цикл выращивания и откорма бычки достигли одинаковой живой массы (441,5—445,3 кг). При этом животные III группы по среднесуточному приросту превосходили своих сверстников из I группы на 205 г, или на 28,7% (Р<0,001), а бычков II группы на 112 г, или на 15,7% (Р<0,001). Расход кормов на 1 кг прироста колебался от 7,7 корм. ед. в I группе до 7,0 корм. ед. в III (разница 11,0%), в то время как затраты концентратов в I группе по сравнению с III были меньше на 31% и во II — на 15,4%. Средняя масса парной туши по группам составила 235,8—240,4 кг, они имели хороший жировой полив туш (16,8—18,5 баллов) и убойный выход (53,4—54,0%). Наибольший уровень рентабельности получен при реализации бычков III группы (36,8%).The effectiveness of specialized beef cattle breeding can be improved through the implementation of intensive technologies. The aim of our work was to study the influence of different levels of feeding Angus breed Aberdeen bulls on the periods of cultivation, fattening, duration of the production cycle on the productivity and quality of beef. The duration of the periods and the duration of the production cycle were as follows: the first period ranged in groups — 138, 155, 178 days; the second — 145, 163, 186 days; the third period — 143, 161, 182 days. The specific weight of concentrates on nutrition was in groups of 30, 40, 50%, and the nutritional value of consumed feed per cycle, respectively, 3233, 3045, 2914 EKE. In General, for the entire production cycle of growing and fattening bulls reached the same live weight (441.5—445.3 kg). At the same time, animals of group III exceeded their peers from group I by 205 g, or by 28.7% (P<0.001), and bulls of group II by 112 g, or by 15.7% (P<0.001). Feed consumption per 1 kg of growth ranged from 7.7 feed. units in group I up to 7.0 feed. units in III (difference 11,0%), while the costs of concentrates in group I compared to III were less by 31% and in II — by 15,4%. The average mass of steam carcass of the groups was made amounting to 235.8—240,4 kg, they had a good watering fatty carcasses (16,8—18,5 points) and slaughter yield (53,4—54,0%). The greatest level of profitability obtained with the implementation of the calves of group III (36.8 per cent).

scholarly journals Effects of Lactobacillus reuteri and Streptomyces coelicolor on Growth Performance of Broiler Chickens

2021 ◽  
Vol 9 (6) ◽  
pp. 1341
Author(s):  
Sarayu Bhogoju ◽  
Collins N. Khwatenge ◽  
Thyneice Taylor-Bowden ◽  
Gabriel Akerele ◽  
Boniface M. Kimathi ◽  
...  
Keyword(s):  
Broiler Chickens ◽  
Lactobacillus Reuteri ◽  
Body Weight Gain ◽  
Streptomyces Coelicolor ◽  
Control Diet ◽  
Probiotic Bacteria ◽  
Feed Consumption ◽  
Feed Conversion ◽  
Wheat Middlings ◽  
Dietary Treatments

There are well documented complications associated with the continuous use of antibiotics in the poultry industry. Over the past few decades, probiotics have emerged as viable alternatives to antibiotics; however, most of these candidate probiotic microorganisms have not been fully evaluated for their effectiveness as potential probiotics for poultry. Recent evaluation of a metagenome of broiler chickens in our laboratory revealed a prevalence of Lactobacillus reuteri (L. reuteri) and Actinobacteria class of bacteria in their gastrointestinal tract. In this study Lactobacillus reuteri and Streptomyces coelicolor (S. coelicolor) were selected as probiotic bacteria, encapsulated, and added into broiler feed at a concentration of 100 mg/kg of feed. In an 8-week study, 240 one day-old chicks were randomly assigned to four dietary treatments. Three dietary treatments contained two probiotic bacteria in three different proportions (L. reuteri and S. coelicolor individually at 100 ppm, and mixture of L. reuteri and S. coelicolor at 50 ppm each). The fourth treatment had no probiotic bacteria and it functioned as the control diet. L. reuteri and S. coelicolor were added to the feed by using wheat middlings as a carrier at a concentration of 100 ppm (100 mg/kg). Chickens fed diets containing L. reuteri and S. coelicolor mixture showed 2% improvement in body weight gain, 7% decrease in feed consumption, and 6–7% decrease in feed conversion ratios. This research suggests that L. reuteri and S. coelicolor have the potential to constitute probiotics in chickens combined or separately, depending on the desired selection of performance index.

scholarly journals Effectiveness of pharmacopuncture by “alloplant” biomaterial in complex therapy of knee joint osteoarthritis

2020 ◽  
Vol 19 (1) ◽  
pp. 45-49
Author(s):  
Ruslan K. Urazbakhtin ◽  
Raushaniya N. Kildebekova ◽  
Lira T. Gilmutdinova ◽  
Vadim T. Kaybyshev ◽  
Ravil Sh. Mirkhaydarov ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Drug Therapy ◽  
Knee Joint ◽  
Well Being ◽  
Biologically Active ◽  
Basic Drug ◽  
Group Iii ◽  
Group I ◽  
Immunological Mechanisms

Background. Osteoarthritis is characterized by a decrease in the quality of life, which is currently considered as the main measure of well-being of an individual and a criterion for the effectiveness of treatment and rehabilitation measures. Modern research emphasizes the need for an integrated approach to the treatment of osteoarthritis, which should include pharmacological and non-drug methods of treatment. Aim. The purpose of the study was to evaluate the effectiveness of pharmacopuncture administration of Alloplant biomaterial by patients with osteoarthritis of the knee joint from the standpoint of influencing the immunological mechanisms of the disease. Methods. The randomization methodology was divided into 3 groups, comparable in terms of clinical and functional characteristics. Group I patients (n = 39) have standard basic drug therapy according to the federal clinical guidelines Osteoarthritis approved by the Association of Rheumatologists of Russia (2013), with additions from 2016; in patients of group II (n = 39), in addition to drug therapy, dispersed Alloplant biomaterial was used according to the original method; group III patients (n = 39) against the background of basic drug therapy are additionally prescribed a combination of dispersed Alloplant biomaterial at biologically active points and magnetic therapy with a pulsed magnetic field. Results. Against the background of the treatment of patients with osteoarthritis using pharmacopuncture with Alloplant biomaterial and magnetotherapy, there was a positive dynamics in clinical data with a significant decrease in pain intensity when walking and at rest, stiffness, with the restoration of immune status parameters and an improvement in the quality of life in the field of physical and psychological health . A more pronounced and lasting positive dynamics was observed in patients of group III against the background of the combined effects of pharmacopuncture with Alloplant biomaterial and magnetotherapy. Conclusion. The Alloplant biomaterial has a positive effect in the treatment of patients with stage III osteoarthritis according to the KellgrenLawrens classification. The similarity of the mechanism of action with drugs with a structurally modifying effect on cartilage allows us to recommend pharmacopuncture with Alloplant biomaterial for widespread use in the treatment of osteoarthritis.

EFFECTS OF BIOLOGICAL THERAPY ON QUALITY OF LIFE AND PSYCHOEMOTIONAL STATUS OF PATIENTS WITH ULCERATIVE COLITIS

2021 ◽  
Vol 74 (10) ◽  
pp. 2610-2613
Author(s):  
Antonina V. Varvarynets
Keyword(s):  
Quality Of Life ◽  
Ulcerative Colitis ◽  
Biological Therapy ◽  
Old Patients ◽  
Group Iii ◽  
Group I ◽  
Sf 36 ◽  
Nonspecific Ulcerative Colitis ◽  
Social Introversion

The aim: To compare the effects of tofacitinib, adalimumab and budesonide on the quality of life and psychoemotional status of patients with moderate UC. Materials and methods: The study included 104 patients with moderately severe UC aged between 18 and 75 years old. Patients were divided into 3 groups. Group I consisted of patients with UC treated with budesonide 9 mg 1 g / d (BUD; n = 34). Group II – of patients receiving adalimumab at an initial dose of 160 mg and 80 mg at week 2, followed by maintenance dose of 40 mg weekly (ADA; n = 38) and group III, who received tofacitinib 10 mg 2p / d (TOF; n = 32). Evaluation of quality of life and psycho-emotional status of patients was performed using IBDQ, SF-36 and MMRI questionnaires. Results: According to the IBDQ-questionnaire, all groups after treatment had a statistically significant increase in their results: BUD (from 146,44 ± 2,23 to 151,36 ± 2,40), ADA (from 144,28 ± 3,10 to 172,36 ± 3,12), TOF (from 149,22 ± 2, 86 to 184.36 ± 2.88), respectively, p <0.05. Also, after treatment statistically significant changes were seen in patients of all groups in regards to the psychological and physical components of the SF-36 scale. Analysis of the personality profile using MMRI of all groups of patients showed a change in scales 2 (depression), 3 (hysteria), 5 (tenderness-femininity), 6 (paranoia) and 0 (social introversion), which significantly improved in the ADA and TOF groups. Conclusions: Tofacitinib and adalimumab in patients with nonspecific ulcerative colitis of moderate severity had a better effect on quality of life and psychoemotional status compared with budesonide treatment.

scholarly journals Growth Performance Meat Yield and Profitability of Broiler Chickens Fed Diets Incorporating Cassava Tuber Meal

2012 ◽  
Vol 5 (1) ◽  
pp. 47-53
Author(s):  
F Sultana ◽  
MA Ali ◽  
I Jahan
Keyword(s):  
Body Weight ◽  
Broiler Chickens ◽  
Control Diet ◽  
Live Weight ◽  
Dietary Treatment ◽  
Feed Consumption ◽  
Body Parts ◽  
Trial Period ◽  
Growth Responses ◽  
Meat Yield

A total of sixty, 14-day old broiler chickens (Cobb-500) of either sex were used in this study to assess the effects of processed cassava tuber meals (0, 15, 30, and 45 gkg-1) on growth responses, meat yield, and profitability of boilers; rearing from day 14 to day 33 of ages. The experimental diets were iso-caloric and iso-nitrogenous in nature, and were supplied the broilers ad libitum throughout the trial period. Broilers fed on control diet (i.e. exclusion of CTM) achieved higher (P<0.01) body weight, while the broilers offered diets with the highest amount (45 gkg-1) of CTM had the lowest body weight. Increased (P<0.01) feed intake was observed in the treatments of 21 d and 28 days of age when broilers fed diets with the supplementation of CTM, but no significant differences was found among the dietary treatments in the feed consumption of the broilers during 33 day of age. FCR differed significantly (P<.01) throughout the trial period, broilers fed diets without supplementation of CTM had the superior FCR than the others. Mortality was unaffected by all the dietary treatment groups. Moreover, different body parts (feather, head, neck, wing, viscera) and meat yields (thigh, drumstick, breast, back, giblet, dressing) were not influenced by treatments. Live weights were unaffected by all the dietary groups with/without incorporation of cassava tuber meals (CTM) up to day 21 and day 28 of  ages. Statistically significant (P<0.01) decreased live weight was observed among the treatments in 33-day old birds DOI: http://dx.doi.org/10.3329/jesnr.v5i1.11552 J. Environ. Sci. & Natural Resources, 5(1): 47- 53, 2012  

scholarly journals Selective Hematological, Biochemical and Pathological Alterations of Newcastle Virus in Naturally Infected and Vaccinated Broilers in Damietta Governorate of Egypt

2017 ◽  
Vol 74 (2) ◽  
pp. 139
Author(s):  
Shefaa A. M. EL-MANDRAWY ◽  
Shimaa A. A. ISMAIL
Keyword(s):  
Newcastle Disease ◽  
Broiler Chickens ◽  
Histopathological Examination ◽  
Hypochromic Anemia ◽  
Nasal Discharge ◽  
Tissue Samples ◽  
Group Iii ◽  
Group I ◽  
Liver And Kidney ◽  
G Ratio

Newcastle disease (ND) remains one of the most harmful poultry diseases that threaten the poultry industry producers all over the world, thus the present work was planned to investigate the hematological, biochemical, and pathological changes in vaccinated and non-vaccinated broiler chickens naturally infected with ND. The study was conducted on 45 broiler chickens, 35-days-old, from a private farm in Damietta governorate and used in this work, 15 chickens were clinically healthy (Group I), 30 chickens with ND symptoms divided into 15 non-vaccinated (Group II) and the other 15 chickens (Group III) were vaccinated with La Sota strain of NDV with a titre of 106.5 EID50. The disease was diagnosed by hem agglutination test as ND. Blood and tissue samples were collected for clinical-pathological and histopathological examination. The infected broiler chickens showed cyanosis, nasal discharge, edema of eyelid and white pasty diarrhea with nervous manifestations. Furthermore, microcytic hypochromic anemia with leukocytosis was observed. Biochemical studies revealed a significant decrease in serum total proteins, albumin and A/G ratio, with significant increases in serum activities of aspartate aminotransferase, creatinine, and uric acid and glucose concentration in addition to several histological alterations were significantly seen in brain, intestine, liver and kidney of the infected birds. All these disturbances were less severe in the vaccinated group than the non-vaccinated one. In conclusion, La Sota vaccine can increase the bird resistant against Newcastle disease virus induced blood disorders and hepatic-renal insufficiency in broiler chickens.

scholarly journals PRODUCTIVE QUALITIES OF THE SIMMENTAL BREED BULLS BY PROBIOTICS VETOSPORIN SUSPENSION FEEDING

2018 ◽  
pp. 34-39
Author(s):  
Фаргат Вагапов ◽  
Fargat Vagapov ◽  
Наталья Гизатова ◽  
Natal'y Gizatova
Keyword(s):  
Live Weight ◽  
Group Iv ◽  
Feed Additive ◽  
Control Group ◽  
Dominant Position ◽  
Group Iii ◽  
Group I ◽  
Leading Position ◽  
Different Doses

The purpose of research is increase of beef productivity and beef quality of Simmental calves at introduc-tion in a diet of feeding different doses of the drug Vetosporin suspension. Of the half-yearly animals, 40 males were selected and formed into group IV for the experiment. The differences were only in feeding. The young were fed the studied additive Vetosporin suspension. In this case, the supplement was an addi-tion to the basic diet of animals of the experimental II-IV groups. The volume of the additive added was 0.1; 1.0; and 2 ml per 10 kg of live weight, respectively. Control group I, consumed exclusively a diet that does not contain an additive. Based on the results of the experiment at the age of 18 months. The prevalence of bulls of the experimental live weight over peers was observed, which was 4.4-25.3 kg (0.78-4.67%). The study of the studied indicators after control slaughter in the context of groups showed the superiority of bulls of experimental groups in all the periods studied. It is established that at the age of 15 months. The size of the removable live weight of the youngest of the control group was less by 8.0-19.7 kg (1.75-4.29%) than in the animals of the test groups. In this case, the leading position was occupied by the youngest of group III, the prevalence of which was 0.7-11.7 (0.14 -2.51%). It should be noted that after 3 months a simi-lar picture of the distribution of the studied quantities was observed. As for the output of carcass, we can note the following. Outsider among the animals of the experimental groups was the control group. So the bulls of group I were inferior to those who received the additive by 0.7-1.3%. At 18 months, as well as at 15 months, the dominant position was occupied by gobies of experimental groups. It should be noted that among the animals of the experimental groups the leading place was occupied by the bulls receiving the feed additive in a dose of 1.0 ml per 10 kg of live weight, that is, the youngest of the III group.

scholarly journals INFLUENCE OF PHYSICAL REHABILITATION ON QUALITY OF LIFE AFTER RENAL TRANSPLANTATION

2015 ◽  
Vol 69 (3-4) ◽  
pp. 65-70 ◽  
Author(s):  
T. Y. Zhirnova ◽  
E. E. Аchkasov ◽  
O. M. Tsirulnikova ◽  
E. M. Shilov ◽  
O. B. Dobrovolskiy
Keyword(s):  
Quality Of Life ◽  
Kidney Transplantation ◽  
Organ Transplant ◽  
Rehabilitation Program ◽  
Physical Rehabilitation ◽  
Group Iii ◽  
Results Of Treatment ◽  
Group I ◽  
Group Ii

Background: Aim of this study was to evaluate the role of physical rehabilitation to improve the quality of life (QOL) of people after kidney transplantation. Patients and methods: Analyzes the results of treatment of 57 recipients (mean age 35±9,65 years) donor kidney at different times of the postoperative period. Depending on the physical rehabilitation program allocated 3 groups of patients: group II — physical rehabilitation was carried out only in the first week after surgery to prevent early postoperative complications, in group I — during the year; in group III combined 30 relatively healthy people do not need an organ transplant and with a mean age 33,7±8,7 years, leading a normal life, not engaged in regular recreational physical culture. Quality of life was assessed using a questionnaire SF36 at 1, 3, 6 and a 12 months after surgery. Results: One year after surgery in both groups compared with preoperative indicators marked improvement according to all scales of the questionnaire. However, in group I indicators of quality of life were higher than in group II from 11,4 to 19,7%, and even some items questionnaire SF-36 is higher than in group III which is associated with the physical rehabilitation. Conclusion: It has been shown that exercises is an important component of treatment and rehabilitation after kidney transplantation and help improve both the psychological and the physical component of quality of life.

scholarly journals Dynamics of Quality of Life Indices in Case of Metabolic Syndrome in Patients with Paranoid Schizophrenia on the Background of Atypical Neuroleptic Agents Application and Improvement of Comorbidity

2019 ◽  
Author(s):  
Ivan Romash ◽  
Mykhailo Vynnyk
Keyword(s):  
Quality Of Life ◽  
Metabolic Syndrome ◽  
Short Form ◽  
Paranoid Schizophrenia ◽  
Atypical Neuroleptic ◽  
Group Iii ◽  
Neuroleptic Therapy ◽  
Group I ◽  
The Impact

The objective of the research was to study the features of quality of life dynamics depending on clinical and psychopathological symptoms in patients with paranoid schizophrenia asso ciated with metabolic syndrome on the background of long-term neuroleptic therapy and to study the eff ectiveness of concomitant corrective therapy. 140 patients with paranoid schizophrenia (F20.0) were examined and divided into three groups. Group I included 40 patients who received haloperidol at an ave rage daily dose of 4.6 ± 1.3 mg/day, Group II consisted of 40 patients who received risperidone (3.7 ± 1.8 mg/day), Group III included 40 patients who received quetiapine (413 ± 116 mg/day). Half of the patients in each of the presented groups continued to receive neuroleptic therapy according to the above mentioned regimen, and the other half of the patients received metformin hydro chloride at a dose of 500 mg/day in addition to the standard therapy. The cont rol group consisted of 20 patients diag nosed with "paranoid schizophrenia, remission", without metabolic syndrome signs, who had not received neuroleptics for the past six months. The Positive and Negative Syndrome Scale (PANSS) and the Medical Outcomes Study 36-Item Short-Form Health Status Questionnaire (SF-36) were used to study the patients’ mental health in detail. In this research, we monitored the impact of comorbidity on quality of life indices in the patients with long-lasting treatment of schizophrenia by neuroleptic agents, and noted that concomitant corrective therapy was appropriate in terms of compliance increase and quality of life indices improvement in the studied category of patients. Keywords: paranoid schizophrenia, metabolic syndrome, atypical neuroleptic agents, quality of life

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