scholarly journals Detection of qnrS and tetA resistance coding genes in Pseudomonas aeruginosaof egg-laying hens farmin Cianjur Regency, West Java

2021 ◽  
Vol 21 (2) ◽  
pp. 64-71
Author(s):  
FAUZAN ARISANDI ◽  
SAFIKA . SAFIKA ◽  
FACHRIYAN HASMI PASARIBU
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antibiotic Resistance ◽  
Laying Hens ◽  
Disease Incidence ◽  
Antibiotic Sensitivity ◽  
Cloacal Swab ◽  
Egg Laying ◽  
West Java ◽  
Resistance Level ◽  
Antibiotic Sensitivity Test

The use of antibiotics is an alternative to reduce disease incidence and is used to increase egg-laying hens. This study aims to detect the presence of antibiotic resistance to resistance coding genes in Pseudomonas aeruginosa bacteria. The cloacal swab samples were collected randomly as many 66 samples from several egg-laying hens farms in Cianjur Regency, West Java. The collected isolates were examined bacteriologically. The results of the antibiotic sensitivity test of 8 samples (12.1%) of the Pseudomonas aeruginosa showed the resistance level of antibiotics class tetracycline (tetracycline50%, oxytetracycline75%, and doxycycline50%), fluoroquinolone (enrofloxacin 12.5%), and phenicol (chloramphenicol 12.5%). Pseudomonas aeruginosa was resistant to tetracyclines, oxytetracyclines, doxycycline, enrofloxacin and is sensitive to chloramphenicol. The detection of resistance coding genes showed the genes amount of tetA (62.5%) and qnrS (75%). Efforts to determine the level of resistance and use of antibiotics in farms need regular surveillance and monitoring to ensure the wise use of antibiotics.

scholarly journals Phage steering of antibiotic-resistance evolution in the bacterial pathogen, Pseudomonas aeruginosa

2020 ◽  
Vol 2020 (1) ◽  
pp. 148-157 ◽  
Author(s):  
James Gurney ◽  
Léa Pradier ◽  
Joanne S Griffin ◽  
Claire Gougat-Barbera ◽  
Benjamin K Chan ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antibiotic Resistance ◽  
Bacterial Pathogen ◽  
Antibiotic Sensitivity ◽  
Resistant Bacteria ◽  
Phage Resistance ◽  
Antibiotic Resistant ◽  
Trade Off

Abstract Background and objectives Antimicrobial resistance is a growing global concern and has spurred increasing efforts to find alternative therapeutics. Bacteriophage therapy has seen near constant use in Eastern Europe since its discovery over a century ago. One promising approach is to use phages that not only reduce bacterial pathogen loads but also select for phage resistance mechanisms that trade-off with antibiotic resistance—so called ‘phage steering’. Methodology Recent work has shown that the phage OMKO1 can interact with efflux pumps and in so doing select for both phage resistance and antibiotic sensitivity of the pathogenic bacterium Pseudomonas aeruginosa. We tested the robustness of this approach to three different antibiotics in vitro (tetracycline, erythromycin and ciprofloxacin) and one in vivo (erythromycin). Results We show that in vitro OMKO1 can reduce antibiotic resistance of P. aeruginosa (Washington PAO1) even in the presence of antibiotics, an effect still detectable after ca.70 bacterial generations in continuous culture with phage. Our in vivo experiment showed that phage both increased the survival times of wax moth larvae (Galleria mellonella) and increased bacterial sensitivity to erythromycin. This increased antibiotic sensitivity occurred both in lines with and without the antibiotic. Conclusions and implications Our study supports a trade-off between antibiotic resistance and phage sensitivity. This trade-off was maintained over co-evolutionary time scales even under combined phage and antibiotic pressure. Similarly, OMKO1 maintained this trade-off in vivo, again under dual phage/antibiotic pressure. Our findings have implications for the future clinical use of steering in phage therapies. Lay Summary: Given the rise of antibiotic-resistant bacterial infection, new approaches to treatment are urgently needed. Bacteriophages (phages) are bacterial viruses. The use of such viruses to treat infections has been in near-continuous use in several countries since the early 1900s. Recent developments have shown that these viruses are not only effective against routine infections but can also target antibiotic resistant bacteria in a novel, unexpected way. Similar to other lytic phages, these so-called ‘steering phages’ kill the majority of bacteria directly. However, steering phages also leave behind bacterial variants that resist the phages, but are now sensitive to antibiotics. Treatment combinations of these phages and antibiotics can now be used to greater effect than either one independently. We evaluated the impact of steering using phage OMKO1 and a panel of three antibiotics on Pseudomonas aeruginosa, an important pathogen in hospital settings and in people with cystic fibrosis. Our findings indicate that OMKO1, either alone or in combination with antibiotics, maintains antibiotic sensitivity both in vitro and in vivo, giving hope that phage steering will be an effective treatment option against antibiotic-resistant bacteria.

scholarly journals Microbial Pattern and Antibiotic Sensitivity Test Among Eye Infection Patients at Bali Mandara Eye Hospital Bali

2021 ◽  
Vol 6 (2) ◽  
pp. 57-60
Author(s):  
Patria Dewi Pande
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antibiotic Sensitivity ◽  
Health Care Facilities ◽  
Bacterial Conjunctivitis ◽  
Care Facilities ◽  
Antibiotic Sensitivity Test ◽  
Infection Disease ◽  
Eye Infection ◽  
Special Hospital ◽  
Keywords Infection

Abstract Infection disease of the eye usually found in health care facilities and can caused by viral,bacterial, parasite and fungi. Bali Mandara Eye Hospital was special hospital for eye disease in Bali. In this hospital infection disease of the eye dominated by bacterial conjunctivitis, viral conjunctivitis, corneal ulver, and endophtalmitis. This study was a restropective descriptive study using patient who are take eye secret culture in Bali Mandara Eye Hospital and sample were take from 2019 till 2020 It can be seen that was found seven microba and dominated disease was corneal ulcer 26 sample (86%) followed by endophtalmitis 4 sample (14%). The most microba were Pseudomonas aeruginosa. Pseudomonas aeruginosa found resistant in almost antibiotics and sensitive tolevofloxacin, gentamycin dan ceflazidime Keywords: infection, eye, culture, antibiotics

scholarly journals Correlation of biofilm production with antibiotic susceptibility pattern of Pseudomonas aeruginosa from various clinical specimens

2022 ◽  
Vol 13 (1) ◽  
pp. 88-92
Author(s):  
M Swapna ◽  
G Sumathi ◽  
M Anitha
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antibiotic Resistance ◽  
Biofilm Formation ◽  
Antibiotic Sensitivity ◽  
Microtiter Plate ◽  
Resistance Pattern ◽  
Sensitivity Testing ◽  
Clinical Specimens ◽  
Biofilm Production ◽  
Microbiological Methods

Background: Pseudomonas aeruginosa is one of the most prevalent nosocomial pathogens that cause a life-threatening infection. One of the important characteristics of P. aeruginosa is biofilm formation which leads to antibiotic resistance. Aims and Objectives: The aim of the study was to study the antibiotic resistance pattern of P. aeruginosa isolates and correlation with their biofilm-production. Materials and Methods: A total of 87 P. aeruginosa isolates from different clinical specimens were processed and confirmed by conventional microbiological methods as per standard methodology. Antibiotic sensitivity testing was done for all isolates. Biofilm producing isolates were identified by the microtiter plate method (MTPM). Results: Of 87 P. aeruginosa isolates, majority were from pus 33 (38%), followed by urine 26 (30%), sputum 19 (22%), body fluids 7 (8%), and blood 2 (2%). Biofilm producing isolates showed more resistance in comparison to non-biofilm producers. The observed difference between biofilm formation for multidrug resistant and susceptible isolates was found to be statistically significant. Conclusion: MTPM method was an effective test for detection of biofilm formation and was also able to verify biofilm production by P. aeruginosa. This indicated a higher propensity among the clinical isolates of P. aeruginosa to form biofilm and revealed a positive correlation between biofilm formation and antibiotic resistance. This indicates the need for testing of even susceptible isolates for virulence factors such as biofilm production.

scholarly journals Pola Kepekaan Bakteri terhadap Antibiotik di Ruang Rawat Intensif RSPI Prof. Dr. Sulianti Saroso Jakarta

2017 ◽  
Vol 1 (2) ◽  
pp. 23
Author(s):  
Putriana Indah Lestari ◽  
Ika Susanti ◽  
Huda Rahmawati
Keyword(s):  
Escherichia Coli ◽  
Pseudomonas Aeruginosa ◽  
Klebsiella Pneumoniae ◽  
Acinetobacter Baumannii ◽  
Antibiotic Sensitivity ◽  
Secondary Data ◽  
Sensitivity Pattern ◽  
Important Health ◽  
Antibiotic Sensitivity Test ◽  
Antibiotics Sensitivity

Abstrak : Penyakit infeksi merupakan salah satu masalah kesehatan yang penting. Penggunaan antibiotik yang tidak rasional dan tepat guna pada pasien penyakit infeksi beresiko menyebabkan terjadinya resistensi. Tujuan dari penelitian ini yaitu untuk mengetahui pola kepekaan bakteri terhadap antibiotik pada pasien Ruang Rawat Intensif (ICU) RSPI Prof. Dr. Sulianti Saroso (RSPI-SS) Jakarta. Penelitian dilakukan deskriptif dan retrospektif terhadap data sekunder hasil uji kepekaan antibiotik dan jenis bakteri dari 107 pasien dalam kurun waktu 2011. Hasil menunjukkan 68 (65,4%) pasien mendapatkan hasil kultur positif dan uji kepekaan bakteri terhadap antibiotik. Jenis bakteri patogen yang dominan yaitu Acinetobacter baumannii (29,4%), disusul oleh Pseudomonas aeruginosa (27,9%), Klebsiella pneumoniae (13,2%) dan Escherichia coli (8,8%). Sebagian besar bakteri pada pasien ICU RSPISS telah berkurang kepekaannya (resisten) terhadap beberapa antibiotik. A. baumannii dan P. aeruginosa merupakan bakteri yang paling resisten terhadap antibiotik uji. Pola kepekaannya menunjukkan bahwa bakteri patogen mempunyai resistensi tertinggi terhadap erythromycin dan terendah terhadap amikasin.Infectious diseases is an important health problem. Irrational antibiotics usage is a leading cause in initiating drugs resistances. A preliminary study was conducted on the sensitivity pattern of microorganisms against antibiotics at the intensive care unit of Sulianti Infectious Diseases Hospital Jakarta. Retrospective. Secondary data were collected on the results of antibiotics sensitivity tests and species of microorganisms of 107 patients during the year 2011. Sixty eight (65,4%) patients were positive on microorganism culture test and tested on antibiotic sensitivity test. Predominance pathogenic species found were Acinetobacter baumannii (29,4%), followed by Pseudomonas aeruginosa (27,9%), Klebsiella pneumoniae (13,2%) and Escherichia coli (8,8%). Most species were less sensitive (resistant) to several antibiotics. The pattern of sensitivity showed that pathogenic microorganisms were the most resistant against erythromycin and the most sensitive antibiotics was amikacin.

Antibiotic Susceptibility and Molecular Detection of Pseudomonas aeruginosa Isolated from Bovine Mastitis

2019 ◽  
Vol 43 (2) ◽  
pp. 77-85
Author(s):  
Ikram A.A. Al-Samarraae
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Bacterial Culture ◽  
Bovine Milk ◽  
Bovine Mastitis ◽  
Antibiotic Sensitivity ◽  
Culture Method ◽  
Resistance Rate ◽  
Good Choice ◽  
Choice Of Treatment ◽  
Antibiotic Sensitivity Test

This study aimed to isolate Pseudomonas aeruginosa from cattle (bovine) milk with mastitis to characterize its antimicrobial susceptibility against some antibiotics, and to identify aminoglycoside acetyltransferase (aac-3-Ib) gene.A total of 100 bovine milk samples were collected randomly from different local cow farms at districts of Wasit governorate, Iraq. Six P. aeruginosa isolates were obtained using bacterial culture method and further identified by Analytical Profile Index (API-20E). The antibiotic sensitivity test was performed by disc diffusion methods. Among the 5 antibiotics used, the highest resistance (100%) was found with Nalidixic acid andtetracycline, follow by gentamicin (50%) and the lowest resistance rate (16.6%, and 33.3%) was to the ciprofloxacin and cephalothin respectively. PCR was performed for all the gentamicin resistant isolates that be among the aminoglycoside family. The where the frequency of aac(3)-Ib gene have product (530bp) was to 3 of P. aeruginosa isolates. From the finding of present study we concluded that P.aeruginosa thatisolated from mastitic bovinehave been developed resistance against aminoglycosides through presence of aac(3)-Ibgene and the ciprofloxacin and cephalothin can be taken as good choice of treatment

scholarly journals A Study of Prevalence of Aerobic Bacteria and Fungi in Sputum Specimens of Patients with Post Tubercular Bronchiectasis

2017 ◽  
Vol 6 (2) ◽  
pp. 1468
Author(s):  
Gattu Suresh Kumar ◽  
Sabinkar Babu Lal ◽  
M. Laxmikanth
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antibiotic Resistance ◽  
Antibiotic Sensitivity ◽  
Aerobic Bacteria ◽  
Klebsiella Pneumonia ◽  
Culture Methods ◽  
Resistance Patterns ◽  
Bacteria And Fungi ◽  
One Year

<p><strong>Background:</strong> Patients with Post TB bronchiectasis colonize many aerobic bacteria and fungi and lead to an increase in exacerbations and decrease in quality of life.</p><p><strong>Objective:</strong> To study the prevalence of aerobic bacteria and fungi in sputum specimens of patients with post tubercular bronchiectasis and to find out the local antibiotic sensitivity and resistance patterns.</p><p><strong>Materials and Methods:</strong> This prospective observational study was carried out over a period of one year comprising of 50 patients with post Tubercular Bronchiectasis who were above 18 yrs, completed ATT smear negative and HRCT showing bronchiectactic changes. Identification of organisms from sputum samples were done by classical aerobic microbial staining and culture methods. Descriptive and inferential statistical analysis was carried out in this study.</p><p><strong>Results:</strong> This study comprises of the 50 patients with a larger group of individuals under the age group of 51-60 (30%), along with bronchial colonization of aerobic bacteria being 78% and growth of fungi being 2%.Among the 39 patients,16 patients (32%) had grown Pseudomonas aeruginosa, 12 patients(24%) had grown Klebsiella pneumoniae, 8 patients(16%) had grown Streptococcus species and rest 3 patients(6%) had grown staphylococcus species. The Antibiotic resistance noted highest being Amikacin (56.4%), piperacillin-tazobactam showing the least (2.6%) and highest sensitivity with imipenem(100%).</p><p><strong> Conclusion:</strong> This study signifies that prevalence of aerobic bacteria, especially Pseudomonas aeruginosa and Klebsiella pneumonia was common in patients with post tubercular bronchiectasis. The Antibiotic resistance noted highest being Amikacin (56.4%) and sensitivity with imipenem(100%). In patients colonizing Pseudomonas aeruginosa, there was significant decline in lung function.</p>

scholarly journals Prevalence and antibiotic resistance profile of Listeria spp. associated with seafoods from fish catchment areas in Kerala, India

2021 ◽  
Vol 14 (3) ◽  
pp. 777-783
Author(s):  
K. Vrinda Menon ◽  
B. Sunil ◽  
C. Latha
Keyword(s):  
Antibiotic Resistance ◽  
Antibiotic Sensitivity ◽  
Sensitivity Test ◽  
Isolation And Identification ◽  
Resistance Profile ◽  
Fresh Fish ◽  
Antibiotic Resistance Profile ◽  
Catchment Areas ◽  
Antibiotic Sensitivity Test ◽  
Serotype 4B

Background and Aim: Listeria monocytogenes is a ubiquitous, intracellular pathogen which has been implicated as a cause of several foodborne outbreaks. This study aimed to generate information on the prevalence and antibiotic resistance profile of Listeria species isolated from seafood. Materials and Methods: A total of 400 samples of fresh fish, 100 samples of dry fish and 200 samples each of crustaceans and mollusks were collected from the fish catchment areas. All the samples were subjected to isolation and identification of Listeria spp. by two-step enrichment in UVM broth and plating on selective agar media (PALCAM) and then subjected to molecular characterization. L. monocytogenes isolates obtained during the study were subjected to serotyping by multiplex polymerase chain reaction. The isolates were also subjected to antibiotic sensitivity test. Results: The prevalence of L. monocytogenes in seafoods in the present study was 0.55%. The isolates of L. monocytogenes were found to possess all virulence genes, namely, iap, hlyA, actA, prfA, plcA, and inlA. All the isolates belonged to serotype 4b. The occurrence of Listeria innocua was found to be more and was detected in 16.77% of seafoods samples. Antibiotic sensitivity test revealed that all isolates were resistant to cefixime but were sensitive to almost all other commonly used antibiotics. Conclusion: The presence of Listeria spp. in raw seafood samples augments the need for implementation of good hygienic practices during the handling and processing of seafoods to safeguard the health of the consumers.

scholarly journals POLA KUMAN PENYEBAB OTITIS EKSTERNA DAN UJI KEPEKAAN ANTIBIOTIK DI POLIKLINIK THT-KL BLU RSUP PROF. Dr. R. D. KANDOU MANADO PERIODE NOVEMBER – DESEMBER 2013

e-CliniC ◽  
2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Monica Lie Sedjati ◽  
Oraetlabora Immanuel Palandeng ◽  
Olivia Claudia Pingkan Pelealu
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Otitis Externa ◽  
Antibiotic Sensitivity ◽  
Sensitivity Test ◽  
Age Group ◽  
Chronic Stage ◽  
Antibiotic Sensitivity Test ◽  
History Of ◽  
Pattern Sensitivity

Abstract: Otitis externa is an inflammation of the ear canal that occur in acute or chronic stage caused by an infection of bacteria, viruses or fungi. The extent of the use of antimicrobials in community can lead to resistant. This study aimed to know the bacteria pattern of otitis externa and the antibiotic sensitivity test at Otorhinolaryngology Departement Prof. Dr. R. D. Kandou Hospital Manado period of November - December 2013. This is a descriptive prospective study. A total of 22 otitis externa patients, the largest age group was adults 15-49 years old with 13 persons (59,1%). Most identified gender was female by 15 people (68.2%). All the patients diagnosed with a history of trauma. The most complained symptoms were pruritus 19 people (86,3%). There were 8 types of bacteria that has been identified and the most identified were 4 samples (18,2%) as Staphylococcus aureus and 4 samples (18,2%) as Pseudomonas aeruginosa. In susceptibility test, the most sensitive antibiotic were Levofloxacin and Ciprofloxacin by 20 samples (100%). The most resistant was Clindamycin 20 sampel (100%). Conclusions : The most identified bacteria were Staphylococcus aureus and Pseudomonas aeruginosa with 4 samples (18.2%). The most sensitive antibiotic were Levofloxacin and Ciprofloxacin 20 samples (100%). Keywords: otitis externa, bacterial pattern, sensitivity test.   Abstrak: Otitis eksterna merupakan peradangan pada liang telinga yang terjadi secara akut maupun kronis yang disebabkan infeksi oleh bakteri, virus maupun jamur. Luasnya penggunaan antimikroba di kalangan masyarakat dapat berujung pada keadaan resisten. Penelitian ini bertujuan untuk mengetahui pola kuman penyebab otitis eksterna dan uji kepekaan antibiotik di poliklinik THT-KL BLU RSUP Prof. Dr. R. D. Kandou Manado periode November-Desember 2013. Penelitian ini bersifat deskriptif prospektif. Dari 22 orang pasien otitis eksterna, diperoleh kelompok umur terbanyak adalah kelompok umur dewasa 15-49 tahun sebanyak 13 orang (59,1%). Jenis kelamin terbanyak adalah perempuan berjumlah 15 orang (68,2%). Semua pasien yang terdiagnosis memiliki riwayat trauma. Gejala yang terbanyak dikeluhkan pasien otitis eksterna adalah pruritus berjumlah 19 orang (86,3%). Terdapat 8 jenis bakteri yang teridentifikasi dan terbanyak adalah Staphylococcus aureus 4 sampel (18,2%) dan Pseudomonas aeruginosa 4 sampel (18,2%). Pada uji kepekaan, antibiotik dengan sensitivitas tertinggi adalah Levofloxacin dan Ciprofloxacin 20 sampel (100%). Angka resistensi tertinggi ditunjukkan oleh Clindamycin 20 sampel (100%). Kesimpulan : Bakteri terbanyak adalah Staphylococcus aureus dan Pseudomonas aeruginosa masing -masing 4 sampel (18,2%). Angka kepekaan tertinggi ditunjukkan oleh Levofloxacin dan Ciprofloxacin 20 sampel (100%). Kata Kunci: otitis eksterna, pola kuman, uji kepekaan.

scholarly journals Detection of blaCTX-M gene among Pseudomonas aeruginosa isolated from water samples in Baghdad

2017 ◽  
Vol 28 (1) ◽  
pp. 35
Author(s):  
Saba R. Khdair
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Tap Water ◽  
Antibiotic Sensitivity ◽  
Penicillin G ◽  
Dilution Method ◽  
Agar Dilution Method ◽  
M Gene ◽  
Antibiotic Sensitivity Test ◽  
Agar Dilution ◽  
Esbl Producers

A total of 50 environmental Pseudomonas aeruginosa isolates were collected from sewage and tap water in Baghdad, Iraq. The MICs of Cefotaxime and Ceftazidime were determined by using agar dilution method, The MIC ranged from 2 to 256 µg/ml.The results of antibiotic sensitivity test showed that among sewage P. aeruginosa isolates, resistance was observed most often to Ticarcillin (92%), Penicillin G (84%), Ceftazidime (12%), (8%) for each of Cefotaxime and Ticarcillin. On the other hand, all tap water isolates were sensitive to Ofloxacin and Levofloxacin, Except (5%) of isolates were resistant to Cefotaxime (25%) to Ceftazidime and (95%) to Ticarcillin. All isolates were tested for Extended-Spectrum β-Lactamase (ESBL) production. Ten isolates (20%) were found to be ESBL producers. All environmental P. aeruginosa isolates were screened for the presence of the blaCTX-M genes by application PCR, Only (30%) of them were positive for this test.

scholarly journals Clinical Characteristics of Bacterial Spectrum and Antimicrobial Resistance in Urine and Stone Cultures From Patients With Kidney Stone Disease

2021 ◽  
Author(s):  
Min Lei ◽  
Zheng Jiang ◽  
Peng Xu ◽  
Lingyue An ◽  
Zhenglin Chang ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Clinical Characteristics ◽  
Bacterial Species ◽  
Antibiotic Sensitivity ◽  
Stone Disease ◽  
Bacterial Spectrum ◽  
The Two Cultures ◽  
Positive Rate ◽  
Antibiotic Sensitivity Test ◽  
Middle Stream

Abstract Background It is important to understand the clinical characteristics of bacterial spectrum and antibiotic resistance of urine and stone pathogens for the prevention and treatment of urolithiasis and perioperative infection. Methods Consecutive patients with kidney stones treated by percutaneous nephrolithotomy (PCNL) from September 2016 to September 2018 were included. The bacterial species and antibiotic sensitivity test of the germs cultured from clean middle-stream urine and from stones intraoperatively were evaluated. Results In 1055 patients, the rate of positive bacterial test was higher in stones than in urine (337, 31.0% vs. 221, 20.9%, p=0.016). 167(15.8%) patients had both positive urine culture (UC) and stone culture (SC), of which 137 (82.0%) had identical bacteria in both cultures. In infection stone patients, the positive rate of bacteria was 34.7% (91/262) in urine and 52.3% (137/262) in stone, and in non-infection stone patients, was 16.4% (130/793) and 25.2% (200/793). The positive rate of SC in patients with different types of stones were higher than that of UC. E. coli was the most common organism not only in both UC (54.3% ,120/221) and SC (43.9%,148/337) but also in urine and stones from patients with infection stones (44.0%,32.8%) or non-infection stones (61.5%,51.8%). Furthermore, the pathogens isolated from urine and stones showed high resistance to fluoroquinolones, ceftriaxone, cefazolin, cefuroxime, β-lactamases and sulfonamides (all resistance>20%). Conclusions The bacterial spectra demonstrated in stones and urine samples were significantly different. Positive SC was more commonly encountered than positive UC. Compared with non-infection stones, infection stones were accompanied by higher rates of positive tests in both cultures. The antibiotic resistance was comparable between bacteria in the two cultures. A combination of antibiotic sensitivity results in urine and stones might be a useful guide for selection of effective and appropriate treatment aiming at reduced problems with bacterial antibiotic resistance.

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