scholarly journals Modern chemical disinfectants and antiseptics. Part I

2021 ◽  
Vol 19 (3(75)) ◽  
pp. 3-14
Author(s):  
Vasyl M. Britsun ◽  
Nataliya V. Simurova ◽  
Inna V. Popova ◽  
Oleksii V. Simurov
Keyword(s):  
Chemical Structure ◽  
Wide Spectrum ◽  
Active Compounds ◽  
Narrow Spectrum ◽  
Modern Chemical ◽  
Nitrofuran Derivatives ◽  
Alkylating Reagents

Aim. To generalize and systematize information on the properties of modern chemical disinfectants and antiseptic agents (DA and AA).Results and discussion. The review provides generalized and systematized information on the properties of modern chemical DA and AA – alkylating reagents, aldehydes, amides, amidines, bisguanidines, dyes, halogenated reagents, halogens and their complexes, 2-nitrofuran derivatives. The classification of DA and AA by their chemical structure was carried out. The activity spectra, possible application ways and forms of DA and AA were given. Their toxicity and impact on the environment were described as well.Conclusions. On the basis of the analysis carried out it was shown that aldehydes, halogen-active compounds and halogen-containing complexes are modern effective DA and AA with a wide spectrum of biocidal action. Amides, amidines and bisguanidines are characterized by a narrow spectrum of activity. Dyes and 2-nitrofuran derivatives are old-fashioned antiseptics.

scholarly journals Modern chemical disinfectants and antiseptics. Part II

2021 ◽  
Vol 19 (4(76)) ◽  
pp. 20-32
Author(s):  
Vasyl M. Britsun ◽  
Nataliya V. Simurova ◽  
Inna V. Popova ◽  
Oleksii V. Simurov
Keyword(s):  
Hydrogen Peroxide ◽  
Quaternary Ammonium ◽  
Wide Spectrum ◽  
Quaternary Ammonium Salts ◽  
Ammonium Salts ◽  
Phenol Derivatives ◽  
Modern Chemical ◽  
Average Action ◽  
The Impact

Aim. To generalize and systematize information on the properties of modern chemical disinfectants and antiseptic agents (DA and AA) – peroxide compounds, surfactants, salts of heavy metals and metals of variable valence in the highest oxidation state, alcohols, phenols and quaternary ammonium salts.Results and discussion. The classification of DA and AA by the chemical structure was performed. The spectrum of their activity, directions and forms of DA and AA were given. Toxicity and the impact on the environment were described.Conclusions. The results of the study conducted allow us to state that modern DA and AA of a wide spectrum of action are peracetic acid and, to a certain extent, hydrogen peroxide. However, they are unstable in dilute solutions. Other reagents are chemically stable, but they are characterized by a weak or average action against spores and viruses. The most effective DA and AA are mixtures (combinations) of compounds belonging to different classes. The examples of these combinations are “surfactants + biguanidine derivatives”; “quaternary ammonium salts + phenol derivatives”; “surfactants + aldehydes”; “quaternary ammonium salts + hydrogen peroxide”. These mixtures combine the advantages and compensate for the disadvantages of individual DA and AA.

Alpine vegetation of the Ivanovskiy, Prokhodnoy and Rossypnoy Ridges (Western Altai)

2015 ◽  
pp. 96-124
Author(s):  
E. G. Zibzeev ◽  
T. A. Nedovesova
Keyword(s):  
Plant Communities ◽  
Wide Spectrum ◽  
Climate Forcing ◽  
High Mountain ◽  
Air Mass ◽  
Rich Diversity ◽  
Mountain Systems ◽  
Mountain Vegetation ◽  
Coenotic Diversity

The mountain systems are characterized by diverse ecological conditions (climate, geomorphological, soil, etc.). The wide spectrum of environmental conditions entails a rich diversity of plant communities growing on the small territory and determines the different flora and vegetation geneses. The uniqueness of floristic and coenotic diversities of the high-mountain vegetation of the south of Western Altai (Ivanovskiy, Prokhodnoi, and Rossypnoi Ranges) are associated with the effect of two climate-forcing factors such as the westerly humid air mass and dry warm airflow from the inner Kazakhstan regions. The paper summarizes the data on coenotic diversity (Zibzeev, 2010, 2012) and gives a syntaxonomic analysis of the high-mountain vege­tation in the Ivanovskii, Prokhodnoi, and Rossypnoi Ranges (Western Altai, Kazakhstan). The classification of plant communities was carried out using the Braun-Blanquet approach (Westhoff, van der Maarel, 1973). The relevés records were stored in the TURBOVEG database and classified by ­TWINSPAN (Hill 1979).

Keys to the Trematoda. Volume II (ed. Jones, A., Bray, R. A. and Gibson, D. I.), pp. 768. Commonwealth Agricultural Bureau International (CABI Publishing), UK and The Natural History Museum, London, UK, 2005. ISBN 0 85199 587 X. £150.00.

Parasitology ◽  
2006 ◽  
Vol 132 (1) ◽  
pp. 153-154
Author(s):  
TOMÁš SCHOLZ
Keyword(s):  
Natural History ◽  
Wide Spectrum ◽  
Animal Health ◽  
Life Cycles ◽  
Huge Number ◽  
History Museum ◽  
Cabi Publishing ◽  
Vertebrate Hosts ◽  
Commonwealth Agricultural Bureau

Trematodes (flukes or digeneans) are by far the most abundant group of parasitic flatworms (Neodermata), and their importance for human and animal health is indisputable. In addition, they exhibit a variety of unique adaptations to parasitism and, probably most remarkably, possess extraordinarily complicated life-cycles. Classification of trematodes represents a very difficult task due to the huge number of existing species and variety of morphological forms, sites of infection within invertebrate and vertebrate hosts and ability to infect a wide spectrum of animals. Therefore, identification of any trematode may represent a problem even for an experienced specialist. This is the reason why I appreciated so much the publication of the first volume of the Keys to the Trematoda in 2002.

scholarly journals Molecular genetic changes in gastric carcinoma

2021 ◽  
Vol 6 ◽  
pp. 30-46
Author(s):  
Juhi Singh ◽  
Puneet Kumar ◽  
Khushi Verma ◽  
Satyender Kumar Tiwary ◽  
Gopeshwar Narayan ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gastric Carcinoma ◽  
Wide Spectrum ◽  
Molecular Genetic ◽  
Survival Rates ◽  
High Throughput Analysis ◽  
Genetic Changes ◽  
Genetic Level ◽  
New Biomarkers

Gastric cancer remains highly prevalent and accounts for a notable proportion of global cancer mortality and this is associated with poor survival rates. Understanding the molecular genetic changes of gastric carcinoma may offer an insight into its pathogenesis helps in identifying new biomarkers, aid prognostication, and novel treatment targets. Over a past few decades, advances in technology and high throughput analysis have improved understanding of the molecular genetic aspects of gastric cancer. In this article, hierarchy of the changes at genetic and molecular level including several aspects which are heterogenous and represents a wide spectrum such as tumor suppressor genes, oncogenes, cellcycle regulators, apoptosis, cell-adhesion molecules, loss of heterozygosity, microsatellite instability, and epigenetic changes. The classification of gastric carcinoma at molecular and genetic level as well as hereditary gastric carcinoma is elaborated. The molecular genetic aspects regarding pathogenesis, changes and aberrations of all genes and pathways which are involved in gastric cancer are addressed in this review.

scholarly journals Wetting - Display Capacity of Some New Superficial Active Salefied Polyether ( =3–20) Primary Amides in Food Hygienization

2011 ◽  
Vol 68 (2) ◽  
Author(s):  
G. UIVAROSAN ◽  
C. JIANU ◽  
I. JIANU
Keyword(s):  
Food Chain ◽  
Plant Protection ◽  
Wide Spectrum ◽  
Structural Units ◽  
Ecological Agriculture ◽  
Active Compounds ◽  
New Class ◽  
Low Toxicity

Colloidal features (wetting) of conditioning auxiliaries (additives) of plant protection active principles constitute, together with toxicity, a decisive technical index in forming administering receipts in modern ecological agriculture and foodstuff processing all during the agroalimentary processing and consumption chain. In this paper we show the results of a study on a new class of superficial active compounds salefied polyether ( =3–20) primary amides. Structures have real colloidal and bacteriostatical abilities compared to a wide spectrum of microrganisms (tested in studies related to this paper). Low toxicity of polyoxyethylene chains (PEO) together with that of other structural units in provide the studied glymes with a high compatibility in relation to environment and to plant and animal organisms of the food chain.

scholarly journals Classification of mucinous appendiceal neoplasm and pseudomyoxma peritonei

2018 ◽  
Vol 8 (1) ◽  
pp. 1301-1307
Author(s):  
Arnab Ghosh
Keyword(s):  
Goblet Cell ◽  
Wide Spectrum ◽  
Low Grade ◽  
Controversial Issues ◽  
High Grade ◽  
Goblet Cell Carcinoid ◽  
Signet Ring Cells ◽  
Mucinous Neoplasm ◽  
Signet Ring

Mucinous appendiceal tumors are uncommon and include a wide spectrum of tumors whose classification remained controversial. Some of these mucin producing appendiceal tumors can disseminate to the peritoneal cavity leading to pseudomyxoma peritonei (PMP). Despite several attempts to classify mucinous tumors of appendix and PMP by different authors in the past, no universally accepted classification system was present. The controversial issues were discussed at the 2012 World Congress of the Peritoneal Surface Oncology Group International (PSOGI) in Berlin. A panel of 71 experts from 13 different countries was formed under the lead co-ordinator Norman J. Carr. A total of 4 rounds of questionnaires and one meeting were held. The opinion of the majority was taken into account. Importance of intactness of muscularis mucosae, pushing invasion and infiltrative invasion were emphasized. The entities Low grade appendiceal mucinous neoplasm (LAMN) and High grade appendiceal mucinous neoplasm (HAMN) were defined.. The terminologies suggested for Goblet cell carcinoid and adenoneuroendocrine carcinoma were goblet cell tumor and adenocarcinoma ex goblet cell carcinoid. Acellular mucin in peritoneum was not classified under PMP which was classified into 3 categories depending upon low grade , high grade cytologic features and presence of signet ring cells. It was suggested to report the extent of mucin and cells separately. A reporting format solely for mucinous appendiceal tumors was formulated by the panel. However, there are some grey areas which may have to be addressed in future.

The Toxicity and Attenuation Methods of Toxic Chinese Materia Medica for its Reasonable Application: A Review

2021 ◽  
pp. 1-27
Author(s):  
Jun-Yan Xiang ◽  
Yan-Yu Chi ◽  
Jin-Xin Han ◽  
Hongyu Xiang ◽  
Qiuhong Xie
Keyword(s):  
Clinical Practice ◽  
Chemical Structure ◽  
Structural Modification ◽  
Chinese Materia Medica ◽  
Materia Medica ◽  
Rational Application ◽  
Health Products ◽  
Ancient Times ◽  
Toxic Components

Over a millennia, traditional Chinese medicine (TCM) has been used to treat various diseases in China. In recent years, more and more Chinese materia medica (CMM) have been studied in scientific research projects, applied in clinical practice, and their extracts have even appeared in some health products. However, the toxicity of some CMM is often overlooked, including hepatotoxicity, nephrotoxicity, neurotoxicity, cardiotoxicity, etc. In this review, the toxic components and their toxicological mechanisms of some toxic CMM were listed according to the chemical structure classification of toxic components. Afterwards, the traditional methods (processing and compatibility) and modern methods (structural modification, biotransformation, etc.) of attenuation of CMM were discussed. Since ancient times, it has been said that “fight fire with fire, fight poison with poison,” and toxic CMM are of great significance in the treatment of difficult and severe diseases. The rational application of toxic CMM and their components in clinical practice was also exemplified in this review. While the pharmacological effects of TCMs have been emphasized, the scientific attenuation and rational application of toxic components should be concerned. We hope this review can provide a reference for future related research.

scholarly journals Bladder Cancer in the Genomic Era

2019 ◽  
Vol 143 (6) ◽  
pp. 695-704 ◽  
Author(s):  
Charles C. Guo ◽  
Bogdan Czerniak
Keyword(s):  
Bladder Cancer ◽  
Molecular Mechanisms ◽  
Complex Disease ◽  
Human Cancer ◽  
Wide Spectrum ◽  
Clinicopathologic Features ◽  
Pathologic Features ◽  
Genomic Characterization

Context.— Bladder cancer is a heterogeneous disease that exhibits a wide spectrum of clinical and pathologic features. The classification of bladder cancer has been traditionally based on morphologic assessment with the aid of immunohistochemistry. However, recent genomic studies have revealed that distinct alterations of DNA and RNA in bladder cancer may underlie its diverse clinicopathologic features, leading to a novel molecular classification of this common human cancer. Objective.— To update recent developments in genomic characterization of bladder cancer, which may shed insights on the molecular mechanisms underlying the origin of bladder cancer, dual-track oncogenic pathways, intrinsic molecular subtyping, and development of histologic variants. Data Sources.— Peer-reviewed literature retrieved from PubMed search and authors' own research. Conclusions.— Bladder cancer is likely to arise from different uroprogenitor cells through papillary/luminal and nonpapillary/basal tracks. The intrinsic molecular subtypes of bladder cancer referred to as luminal and basal exhibit distinct expression signatures, clinicopathologic features, and sensitivities to standard chemotherapy. Genomic characterization of bladder cancer provides new insights to understanding the biological nature of this complex disease, which may lead to more effective treatment.

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