scholarly journals Results of application composite hydrogel coatings based on polyvinyl alcohol in the experiment

2021 ◽  
Vol 8 (3) ◽  
pp. 22-25
Author(s):  
V. I. Sil’vistrovich ◽  
A. A. Lyzikov
Keyword(s):  
Diabetes Mellitus ◽  
Polyvinyl Alcohol ◽  
Aspartic Acid ◽  
Healing Time ◽  
Composite Hydrogel ◽  
Wound Dressings ◽  
Control Group ◽  
Prolonged Action ◽  
The Third ◽  
Hydrogel Coatings

The results of the use in the experiment of composite hydrogel coatings of prolonged action based on polyvinyl alcohol are investigated.Objective. The aim of the study is a comparative clinical assessment of the effectiveness of the developed composite hydrogel coatings of prolonged action in an experiment in laboratory rats.Materials and research methods. After modeling alloxan diabetes mellitus and neuroischemic form of diabetic foot in laboratory white Wistar rats, the developed wound dressings were applied. A clinical analysis of their effectiveness was carried out and the optimal composition was determined. The animals were divided into three groups, 10 animals in each group, as follows: the first — control with self-healing of the wound, the second — with samples No. 1 (polyvinyl alcohol + chitosan + pectin + L-aspartic acid + gentamicin), the third — with samples No. 2 (polyvinyl alcohol + chitosan + pectin + L-aspartic acid + gentamicin + methyluracil). The first dressing change was carried out on the third day with the taking of histological material, then - every other day. When changing the dressing, such parameters as the nature and amount of wound discharge, the size of the ulcer, the presence of granulations and epithelialization were assessed. Dynamic assessment was performed on the 3rd, 7th, 14th and 21st days. The measurement of the area of the ulcer was carried out by transferring the contour of the ulcer to graph paper with manual counting.Research results. The healing rate of ulcers in the experimental groups was higher than in the control group. When comparing second and third groups, a significant increase in speed was noted by the seventh day in third group (p < 0.05), which reduced the overall healing time of ulcers by 7 days.Conclusion. The study showed that the healing time of ulcers in laboratory animals with the use of the developed wound dressings is significantly reduced in comparison with the control group. The proposed method of local treatment can be considered effective in the treatment of vascular etiology trophic ulcers against the background of diabetes mellitus.

A Trial of Hypoglycaemic Agents for Weight Increase in Psychiatric Patients

1962 ◽  
Vol 108 (454) ◽  
pp. 371-372
Author(s):  
Susanne Shafar
Keyword(s):  
Diabetes Mellitus ◽  
Weight Loss ◽  
Psychiatric Patients ◽  
Control Group ◽  
Prolonged Action ◽  
Oral Hypoglycaemic Agents ◽  
Once Daily ◽  
Hypoglycaemic Agents ◽  
Small Doses ◽  
Present Trial

Former attempts to restore weight loss in psychiatric patients have included hyperalimentation (Weir Mitchell, 8) and sub-coma insulin therapy (Debenham et al., 2; Sargant and Craske, 5; Sullivan, 7). The aim of the present trial was to compare weight gains in a group of patients given repeated small doses of insulin with two other groups to whom oral hypoglycaemic agents were administered, and with a control group. The drugs used were tolbutamide and chlorpropamide, both of which are sulphonylureas used in the management of diabetes mellitus, and known to induce hypoglycaemia in non-diabetic subjects (Hoenig and Gittleson, 4; Cardonnet et al., 1; Garcia Reyes et al., 3). Pharmacologically there are no qualitative differences in their mode of action. Stowers et al., (6) found the half-life of tolbutamide to be 3·5 hours and that of chlorpropamide 34·5 hours. The prolonged action of chlorpropamide permits once daily dosage, but tolbutamide, being a shorter acting drug, was given in divided doses to maintain depression of blood sugar over the 24 hours.

Study of retinal blood flow in pregnant women with diabetes mellitus

2021 ◽  
pp. 117-120
Author(s):  
N.V. Pomytkina ◽  
◽  
E.L. Sorokin ◽  
Y.E. Pashentsev ◽  
◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Flow ◽  
Optical Coherence Tomography ◽  
Pregnant Women ◽  
Main Group ◽  
Retinal Blood Flow ◽  
Control Group ◽  
Vascular Density ◽  
Third Trimester ◽  
The Third

Purpose. To investigate changes in retinal blood flow in pregnant women with diabetes mellitus (DM) using optical coherence tomography in angiography (OCTA) mode. Material and methods. 60 pregnant women were examined. The main group consisted of 24 women with DM type 1 and type 2. The control group was represented by 36 healthy women with physiological pregnancy. Women underwent OCTA on an Optovue RTVue XR Avanti device (Optovue Inc., USA) using the HD Angio Retina 6.0 mm scanning protocol. The total vascular density (TVD), foveal vascular density (FVD), and the area of the foveal avascular zone (AFAZ) in the superficial retinal plexus were studied. The survey was carried out in all trimesters of pregnancy in the main group, in the control group – in the third trimester. Results. When conducting a comparative analysis, no significant differences in the values of TDV and AFAZ were found between the main group and the control group. FVD values in pregnant women with diabetes were statistically significantly lower relative to the control group (p=0.001). There were no significant differences in FVD values in the subgroups of pregnant women with diabetic retinopathy (DR) and with diabetes and the absence of DR in the third trimester (p=0.114). However, AFAZ indices in patients with DR were significantly higher (p=0.039), and TDV – significantly lower in comparison with pregnant women with diabetes and no DR (p=0.035). Conclusions. 1. In pregnant women with diabetes in the third trimester, a statistically significant decrease in FPS in the superficial retinal plexus was revealed in comparison with healthy women with physiological pregnancy, in the absence of significant differences in TDV and AFAZ. 2. In pregnant women with DR in the third trimester, a statistically significant expansion of AFAZ with a decrease in TDV in the superficial plexus was revealed in comparison with pregnant women with DM and no DR. Key words: diabetes mellitus, diabetic retinopathy, optical coherence tomography in angiography mode, retinal blood flow.

scholarly journals Effects of structured exercise regime on lipid profile and renal function tests in gestational diabetes mellitus patients-A pilot study

2020 ◽  
pp. 1-9
Author(s):  
Wardah Ajaz Qazi ◽  
Muhammad Naveed Babur ◽  
Arshad Nawaz Malik ◽  
Nadia Ahmed Bokhari ◽  
Mirza Shamim Baig ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Control Group ◽  
Third Trimester ◽  
The Third ◽  
Exercise Regime ◽  
Renal Function Tests

Abstract Objectives: To determine the effects of structured exercise regime on biochemical markers of patients of gestational diabetes mellitus during the third trimester. Methods: The two-arm pilot study was conducted at the Fauji Foundation Hospital, Rawalpindi, Pakistan, from March to July 2019, and comprised women aged 20-40 years with gestational age >20 weeks who were diagnosed with gestational diabetes mellitus and who were able to do 6min walk test under severity level on the 0-10 Borg scale. The subjects were randomized into two groups using the sealed envelope method. The intervention group received 5 weeks of structured exercise programme. including aerobics, stabilisation and pelvic floor muscle training, while the control group only received postural education. Data was noted at baseline and after intervention, and was analysed using SPSS 20. Results: Of the 16 subjects, there were 8(50%) in each of the two groups. The mean age was 31.5±4.17 years in the interventional group and it was 35.0±6.30 years in the control group. Serum low-density lipoprotein and serum creatinine showed significant differences between the groups (p<0.05), while the rest of markers were non-significant (p>0.05). Conclusion: Structured exercise regime was found to have a positive effect in reducing serum low-density lipoprotein and serum creatinine levels in gestational diabetes mellitus during the third trimester. Key Words: Gestational diabetes mellitus, Lipid profile, Renal function tests, Structured exercise regime, Third trimester.

scholarly journals Hyperglycemia Duration Impact On Anatomical Damage Level Of Osteoarthritic Articular Cartilage In Rat Models With Diabetes Mellitus Type 1

2021 ◽  
Vol 10 (3) ◽  
Author(s):  
Ibrahim Njoto
Keyword(s):  
Diabetes Mellitus ◽  
Articular Cartilage ◽  
Cruciate Ligament ◽  
Middle Layer ◽  
Diabetes Mellitus Type 1 ◽  
Male Rats ◽  
Control Group ◽  
Damage Level ◽  
The Third

Background — Diabetes mellitus caused alteration of chondrocytes morphology of superficial layer on osteoarthritic articular (OA) cartilage in an articular cartilage rat model. These results need to be analyzed in relation to hyperglycemia duration. Objective — This study evaluates the influence of hyperglycemia on microscopic anatomical damage progression in OA cartilage. Material and Methods — Thirty-five adult male rats were divided into seven groups: control group, three OA groups, and three OA groups with type 1 diabetes mellitus (DMT-1). For OA groups, the first, second, and third group was sacrificed on the third, fourth, and sixth week respectively after two months maintenance. OA with DMT-1 groups were performed anterior cruciate ligament transaction (ACLT) and were injected streptozotocin intraperitoneally to promote DMT-1 for one-month maintenance. DMT-1.1, DMT-1.2, and DMT-1.3 group was sacrificed on the third, fourth, and sixth week respectively after two months maintenance. The right knee cartilage was taken and processed for histopathology with hematoxylin and eosin staining, then analyzed using a Pritzker scale. Results — In OA group with DMT-1, hyperglycemia duration (6th>4th>3th weeks exposure) increased the level of damage in the OA cartilage compared with the OA group. Pritzker scale observe on deeper abrasiveness of the superficial articular layer, cartilage fissure reaching the middle layer, a more severe decrease in the chondrocytes columnar pattern, changing of matrix integrity, and many sclerotic conditions were provoked by increasing the hyperglycemia duration. Conclusion — Hyperglycemia duration influenced the damage level in the articular cartilage, increasing the progression of OA disease in animal models.

scholarly journals Conservative treatment of facial burns

2020 ◽  
Vol 11 (2) ◽  
pp. 129-133
Author(s):  
I. V. Chmyrev ◽  
Ya. L. Butrin
Keyword(s):  
Healing Time ◽  
Main Group ◽  
The Body ◽  
Water Soluble ◽  
Control Group ◽  
Plant Origin ◽  
Antibacterial Drugs ◽  
Burn Wounds ◽  
The Third ◽  
The Face

Objective: compare the effectiveness of using a moisturizer containing antibacterial drugs of plant origin with a water-soluble ointment that includes the antibiotic chloramphenicol in the treatment of victims with burns of the face II-IIIа degrees.Materials and methods: The results of treatment of 27 victims (12 men and 15 women) with burns of the face and other areas of the body of I – II degree with a total area of 1 to 6 % of the body surface at the age of 18 – 60 years were analyzed. In the main group (13 patients), a cream containing antibacterial drugs of plant origin was used. In the control group (14 patients), bandages with a water-soluble ointment containing an artificial synthesized antibiotic chloramphenicol were used. Visually evaluated the course of the wound process, the nature and volume of exudate, the healing time of burn wounds when using ointments. Seeding of the wound discharge was done on the day of admission, on the 5th and 10th day of treatment. The structure and number of microflora of burn wounds were studied.Results: in the third seeding of the main group, the concentration of bacteria was (2.4 ± 0.04) x103 CFU / g. in the third seeding of the control group, the concentration of microorganisms was (5.9 ± 0.03)×105 CFU / g. the duration of hospitalization in the main group was 18.1 ± 1.5 days, in the control group — 23.8 ± 1.9 days.Conclusions: cream containing antibacterial preparations of plant origin, in comparison with a water-soluble ointment that includes an artificial synthesized antibiotic chloramphenicol, reduces the bacterial contamination of wounds in victims with superficial burns of the face by 2×102 times, the duration of inpatient treatment for 5 days (p < 0.05).

The effects of Cyclosporin-A (CYA) on the Ultrastructure of Gingival Mast Cells (GMC) in Behcet's disease (BD)

1990 ◽  
Vol 48 (3) ◽  
pp. 358-359
Author(s):  
Oktay Arda ◽  
Ulkü Noyan ◽  
Selgçk Yilmaz ◽  
Mustafa Taşyürekli ◽  
İsmail Seçkin ◽  
...  
Keyword(s):  
Unknown Etiology ◽  
Control Group ◽  
Target Cells ◽  
Gingival Hyperplasia ◽  
Cellular Activity ◽  
Direct Relation ◽  
Immune Disease ◽  
Genital Ulceration ◽  
Functional Changes ◽  
The Third

Turkish dermatologist, H. Beheet described the disease as recurrent triad of iritis, oral aphthous lesions and genital ulceration. Auto immune disease is the recent focus on the unknown etiology which is still being discussed. Among the other immunosupressive drugs, CyA included in it's treatment newly. One of the important side effects of this drug is gingival hyperplasia which has a direct relation with the presence of teeth and periodontal tissue. We are interested in the ultrastructure of immunocompetent target cells that were affected by CyA in BD.Three groups arranged in each having 5 patients with BD. Control group was the first and didn’t have CyA treatment. Patients who had CyA, but didn’t show gingival hyperplasia assembled the second group. The ones displaying gingival hyperplasia following CyA therapy formed the third group. GMC of control group and their granules are shown in FIG. 1,2,3. GMC of the second group presented initiation of supplementary cellular activity and possible maturing functional changes with the signs of increased number of mitochondria and accumulation of numerous dense cored granules next to few normal ones, FIG. 4,5,6.

ESTIMATION OF SERUM FERRITIN LEVELS IN TYPE 2 DIABETIC PATIENTS AND ITS RELATION WITH HbA1C LEVEL.

2019 ◽  
Vol 3 (8) ◽  
Author(s):  
Shah Namrata Vinubhai ◽  
Pardeep Agarwal ◽  
Bushra Fiza ◽  
Ramkishan Jat
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Sugar ◽  
Serum Ferritin ◽  
Inflammatory Marker ◽  
Control Group ◽  
Diabetic Patients ◽  
Positive Correlation

Background: Serum ferritin is known as an index for body iron stores also as an inflammatory marker and it is influenced by several disease. We were looking for a correlation between HbA1c and S. Ferritin in type 2 DM. Methodology: The present study a total of 150 participants were enrolled of which 100 were confirmed cases of Type 2 Diabetes Mellitus and rest 50 age and sex matched healthy subjects constituted the control group. All were screened for HbA1c, Fasting blood sugar, Post prandial blood sugar and S.Ferritin. Results: A highly significant variation and positive correlation was observed with respect to S.Ferritin and HbA1c levels. Mean S.Ferritin was high in the subgroup with poor glycemic control. Conclusion: The fasting, post prandial sugar levels, HbA1c and S.Ferritin were significantly higher in the diabetic subjects. This study shows a positive correlation between HbA1c and S. Ferritin levels. So we can conclude that in diabetic patients S. Ferritin may serve as an independent marker of poor glycemic and metabolic control. Keywords: Serum ferritin, Type 2 Diabetes Mellitus, HbA1c.

SUPPORTIVE EDUCATIVE SYSTEM DALAM MENINGKATKAN KEMANDIRIAN MERAWAT KAKI PADA PASIEN DIABETES MELLITUS TIPE II

2019 ◽  
Vol 9 (2) ◽  
pp. 63-72
Author(s):  
Nova Nurwinda Sari ◽  
Herlina Herlina
Keyword(s):  
Diabetes Mellitus ◽  
Health Center ◽  
Intervention Group ◽  
T Test ◽  
Control Group ◽  
P Value ◽  
Type Ii ◽  
Foot Care ◽  
Control Group Design ◽  
Patients With Diabetes

Diabetes mellitus dapat menyebabkan cukup banyak komplikasi seperti kelainan mata, kelainan ginjal, kelainan pembuluh darah dan kelainan pada kaki. Penderita diabetes mellitus yang mengalami komplikasi kronis perlu diberikan upaya preventif untuk mencegah komplikasi, salah satunya adalah kemampuan perawatan kaki. Penelitian ini dilakukan untuk menguji efektivitas supportive educative system dalam meningkatkan kemandirian perawatan kaki pada pasien dengan diabetes mellitus Tipe II di Puskesmas Permata Sukarame, Bandar Lampung. Penelitian ini menggunakan metode quasy eksperimen dengan desain pretest-posttest with control group dengan total masing-masing kelompok sebanyak 18 responden. Pengumpulan data dilakukan dengan menyebarkan kuesioner kepada responden yang memenuhi kriteria inklusi penelitian. Penelitian ini diuji menggunakan analisis univariat, bivariat dan uji T-test. Hasil penelitian menunjukkan bahwa terdapat perbedaan rata-rata dalam kemandirian perawatan kaki pada kelompok intervensi dan kelompok kontrol dengan p-value 0,000. Pendidikan dan praktik perawatan kaki harus diberikan sejak dini sebagai upaya pencegahan untuk komplikasi.   Kata kunci : Supportive educative system, kemandirian perawatan kaki   SUPPORTIVE EDUCATIVE SYSTEM IN IMPROVING INDEPENDENCE OF FOOT CARE IN PATIENTS WITH DIABETES MELLITUS TYPE II   ABSTRACT Diabetes mellitus can cause quite a lot of complications such as eye disorders, kidney disorders, vascular disorders and abnormalities in the legs. Patients with diabetes mellitus who have chronic complications need to be given a preventive effort to prevent complications, one of which is foot care ability. This research was conducted to examine the effectiveness of supportive educative systems in increasing the independence of foot care in patients with Type II diabetes mellitus in the Permata Sukarame Health Center Bandar Lampung Working Area. This study used a quasi-experimental method with pretest-posttest with control group design with a total of 18 respondents each. Data collection is done by distributing questionnaires to respondents who meet the research inclusion criteria. This study was tested using univariate, bivariate, T-Test analysis. The results showed that the mean differences in the independence of foot care in the intervention group and the control group in the Permata Sukarame Community Health Center work area with a p-value of 0,000. Education and practice of foot care should be given early as a preventative effort for complications.   Keywords: Supportive educative system, independence of foot care

Rheumatoid Factor in Type 2 Male Diabetes Mellitus Patients in a Tertiary Care Hospital of Bangladesh

2018 ◽  
Vol 4 (2) ◽  
pp. 58-62
Author(s):  
Roksana Yeasmin ◽  
MA Muttalib ◽  
Kazi Nazneen Sultana ◽  
Nizamul Hoque Bhuiyan ◽  
Md Jamil Hasan Karami ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Rheumatoid Factor ◽  
Serum Uric Acid ◽  
Control Group ◽  
Healthy Male ◽  
Male Patients

Background: Type 2 diabetes mellitus is a chronic disease characterized by relative or absolute deficiency of insulin, resulting in glucose intolerance.Objectives: The present study was planned to see the associations of serum uric acid with positive Rheumatoid factor in type 2 male diabetes mellitus patients. Methodology: This case control study was carried out at the department of Biochemistry at Ibrahim Medical College, Dhaka, Bangladesh. The duration of the study was from June 2015 to June 2016 for a period of one year. In this present study, male patients with type 2 diabetes mellitus were taken as case group and age and sex matched healthy male were taken as control group. Rheumatoid factor was measured from the blood of all case and control group respondents. Others blood para meters were also measured for the correlation with the diabetes mellitus patients.Results: In this present study, 110 male patients presented with type 2 diabetes mellitus were recruited as case and age and sex matched healthy male were recruited as control. More rheumatoid factor positive in type 2 DM male patients with the uric acid range between 6.5 to 9.5 mg/dL. The number of patients was 5 out of total 9 rheumatoid factor positive cases. In this study serum uric acid was significantly correlated with rheumatoid factor in type 2 male diabetic patients. Rheumatoid factor positive cases were taking insulin among 9 and it was statistically significantly associated (p<0.001). Conclusion: In this study serum uric acid is significantly associated with positive rheumatoid factor in type 2 male diabetic patients.Journal of Current and Advance Medical Research 2017;4(2):58-62

THE EFFECT OF APPLYING DEMONSTRATION METHOD ON STUDENTS’ ACHIEVEMENT IN SPEAKING SKILL AT THE THIRD GRADE OF SMK PAB 3 MEDAN ESTATE

2015 ◽  
Vol 4 (2) ◽  
Author(s):  
Meryanti Napitupulu And Anni Holila Pulungan
Keyword(s):  
High School ◽  
Control Group ◽  
Vocational High School ◽  
Control Groups ◽  
Speaking Test ◽  
The Third ◽  
Speaking Skill ◽  
The Subject ◽  
And Control ◽  
Experimental Group

This study was conducted as an attempt to discover the effect of applying Demonstration Method on students’ achievement in speaking skill. It was an experimental research. The subject was students of Grade XII, Vocational High School (Sekolah Menengah Kejuruan: SMK), which consisted of 79 students. The research was divided into two groups: experimental and control groups. The instrument used to collect the data was speaking test. To obtain the reliability of the test, the writer applied Kuder Richardson 21 formula. The result of the reliability was 0.7, and it was found that the test was reliable. The data were analyzed by using t-test formula. The analysis showed that the scores of the students in the experimental group were significantly higher than the scores of the students in the control group at the level of significant m = 0.05 with the degree of freedom (df) 77, t-observed value 8.9 > t-table value 1.99. The findings indicate that using Demonstration Method significantly affected the students’ achievement in speaking skill. So, English teachers are suggested to use Demonstration Method in order to improve students’ achievement in speaking skill.

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