scholarly journals Microstructural Control of Polymers Achieved Using Controlled Phase Separation During 3D Printing with Oligomer Libraries: Dictating Drug Release for Personalized Subdermal Implants

2020 ◽  
Author(s):  
Laura Ruiz-Cantu ◽  
Gustavo Trindade ◽  
Vincenzo Taresco ◽  
Zuoxin Zhou ◽  
Laurence Burroughs ◽  
...  
Keyword(s):  
Phase Separation ◽  
3D Printing ◽  
Drug Release ◽  
Material Properties ◽  
High Throughput Screening ◽  
Ink Jet ◽  
Versatile Tool ◽  
3D Printed ◽  
Subdermal Implants ◽  
Level Of Understanding

<p>Controlling the microstructure of materials by means of phase separation is a versatile tool for optimizing material properties. In this study, we show that ink jet 3D printing of polymer blends gives rise to controllable phase separation that can be used to tailor the release of drugs. We predicted phase separation using high throughput screening combined with a model based on the Flory-Huggins interaction parameter, and were able to show that drug release from 3D printed structures can be predicted from observations based on single drops of mixtures. This new understanding gives us hierarchical compositional control, from droplet to device, allowing release to be ‘dialed up’ without any manipulation of geometry. This is an important advance for implants that need to be delivered by cannula, where the shape is highly constrained and thus the usual geometrical freedoms associated with 3D printing cannot be exploited, bringing a hitherto unseen level of understanding to emergent material properties of 3D printing.</p>

scholarly journals Microstructural Control of Polymers Achieved Using Controlled Phase Separation During 3D Printing with Oligomer Libraries: Dictating Drug Release for Personalized Subdermal Implants

2020 ◽  
Author(s):  
Laura Ruiz-Cantu ◽  
Gustavo Trindade ◽  
Vincenzo Taresco ◽  
Zuoxin Zhou ◽  
Laurence Burroughs ◽  
...  
Keyword(s):  
Phase Separation ◽  
3D Printing ◽  
Drug Release ◽  
Material Properties ◽  
High Throughput Screening ◽  
Ink Jet ◽  
Versatile Tool ◽  
3D Printed ◽  
Subdermal Implants ◽  
Level Of Understanding

<p>Controlling the microstructure of materials by means of phase separation is a versatile tool for optimizing material properties. In this study, we show that ink jet 3D printing of polymer blends gives rise to controllable phase separation that can be used to tailor the release of drugs. We predicted phase separation using high throughput screening combined with a model based on the Flory-Huggins interaction parameter, and were able to show that drug release from 3D printed structures can be predicted from observations based on single drops of mixtures. This new understanding gives us hierarchical compositional control, from droplet to device, allowing release to be ‘dialed up’ without any manipulation of geometry. This is an important advance for implants that need to be delivered by cannula, where the shape is highly constrained and thus the usual geometrical freedoms associated with 3D printing cannot be exploited, bringing a hitherto unseen level of understanding to emergent material properties of 3D printing.</p>

scholarly journals 3D Printed Chromophoric Sensors

Chemosensors ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 317
Author(s):  
Zachary Brounstein ◽  
Jarrod Ronquillo ◽  
Andrea Labouriau
Keyword(s):  
Thermal Stability ◽  
3D Printing ◽  
Material Properties ◽  
Chemical Structure ◽  
Elevated Temperatures ◽  
Advanced Manufacturing ◽  
Color Changes ◽  
Printed Sensors ◽  
3D Printed ◽  
Manufacturing Techniques

Eight chromophoric indicators are incorporated into Sylgard 184 to develop sensors that are fabricated either by traditional methods such as casting or by more advanced manufacturing techniques such as 3D printing. The sensors exhibit specific color changes when exposed to acidic species, basic species, or elevated temperatures. Additionally, material properties are investigated to assess the chemical structure, Shore A Hardness, and thermal stability. Comparisons between the casted and 3D printed sensors show that the sensing devices fabricated with the advanced manufacturing technique are more efficient because the color changes are more easily detected.

scholarly journals Development and Evaluation of Amorphous Oral Thin Films Using Solvent-Free Processes: Comparison between 3D Printing and Hot-Melt Extrusion Technologies

Pharmaceutics ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1613
Author(s):  
Jiaxiang Zhang ◽  
Anqi Lu ◽  
Rishi Thakkar ◽  
Yu Zhang ◽  
Mohammed Maniruzzaman
Keyword(s):  
Thin Films ◽  
3D Printing ◽  
Drug Release ◽  
Hot Melt Extrusion ◽  
Dosage Forms ◽  
Solvent Free ◽  
Melt Extrusion ◽  
Physico Chemical ◽  
3D Printed ◽  
Hot Melt

Conventional oral dosage forms may not always be optimal especially for those patients suffering from dysphasia or difficulty swallowing. Development of suitable oral thin films (OTFs), therefore, can be an excellent alternative to conventional dosage forms for these patient groups. Hence, the main objective of the current investigation is to develop oral thin film (OTF) formulations using novel solvent-free approaches, including additive manufacturing (AM), hot-melt extrusion, and melt casting. AM, popularly recognized as 3D printing, has been widely utilized for on-demand and personalized formulation development in the pharmaceutical industry. Additionally, in general active pharmaceutical ingredients (APIs) are dissolved or dispersed in polymeric matrices to form amorphous solid dispersions (ASDs). In this study, acetaminophen (APAP) was selected as the model drug, and Klucel™ hydroxypropyl cellulose (HPC) E5 and Soluplus® were used as carrier matrices to form the OTFs. Amorphous OTFs were successfully manufactured by hot-melt extrusion and 3D printing technologies followed by comprehensive studies on the physico-chemical properties of the drug and developed OTFs. Advanced physico-chemical characterizations revealed the presence of amorphous drug in both HME and 3D printed films whereas some crystalline traces were visible in solvent and melt cast films. Moreover, advanced surface analysis conducted by Raman mapping confirmed a more homogenous distribution of amorphous drugs in 3D printed films compared to those prepared by other methods. A series of mathematical models were also used to describe drug release mechanisms from the developed OTFs. Moreover, the in vitro dissolution studies of the 3D printed films demonstrated an improved drug release performance compared to the melt cast or extruded films. This study suggested that HME combined with 3D printing can potentially improve the physical properties of formulations and produce OTFs with preferred qualities such as faster dissolution rate of drugs.

scholarly journals A Study Based on Controlled Drug Release by 3D Printed Aloe-Vera Bi-Layer Tablet

2021 ◽  
pp. 522-531
Author(s):  
Anurag Verma ◽  
Piyush Mittal ◽  
Milind S. Pande ◽  
Neelanchal Trivedi
Keyword(s):  
3D Printing ◽  
Drug Release ◽  
Integral Functional ◽  
Aloe Vera ◽  
Controlled Drug Release ◽  
Immediate Release ◽  
Aloe Barbadensis ◽  
3D Printed ◽  
Medicinal Properties ◽  
Printing Techniques

Aloe-Vera or Aloe barbadensis (botanical name) is a plant with many medicinal properties and have great importance in Ayurveda. Its leaves are succulent, erect, forming a thick rosette. The internal translucent pulp of Aloe-Vera is bound to a waxy crust or cuticle, and its vascular tissues transport minerals as well as water from the soil. Aloe Vera is being used as a major skin rejuvenating product, although it has varied medicinal properties also. In the present study, an attempt to make a method to create bi-layer tablets of Aloe-Vera, utilizing 3D printing techniques is presented. The method created doesnt affect the integral functional characteristics of the tablet. The method here contains creating an immediate release and sustained release tablet for making the Aloe-Vera to be used directly by the person for its numerous health effects. The tablet is designed so to be consumed by vegans as well since it is completely herbal.

scholarly journals O22 3D printed polyethylene oxide oral doses with innovative ‘radiator-like’ design: impact of molecular weight on mechanical and rheological properties and drug release

2019 ◽  
Vol 104 (6) ◽  
pp. e10.1-e10 ◽  
Author(s):  
M Peak ◽  
K Baj ◽  
A Isreb ◽  
M Wojsz ◽  
I Mohammad ◽  
...  
Keyword(s):  
Molecular Weight ◽  
3D Printing ◽  
Drug Release ◽  
Rheological Properties ◽  
Oral Dosage ◽  
Parallel Plates ◽  
Fused Deposition ◽  
Plate Spacing ◽  
3D Printed ◽  
The Impact

BackgroundDespite regulatory advances, lack of age-appropriate formulations (AAFs) remains a challenge in paediatric practice. 3D-printing of oral dosage forms (ODFs) offers potential for AAFs for children. Optimising drug release from 3D-printed ODFs is an important technological step. Despite the abundant use of polyethylene oxides (PEOs) and their extensive use as an excipient, there have been no previous reports of applying this thermoplastic polymer species alone to fused deposition modelling (FDM) 3D printing. We assessed the impact of polymer molecular weight (MW) on the mechanical properties of the resultant filaments and their rheological properties. In the FDM 3D printing process, we also tested the effect of an innovative radiator-like design of the ODF on the acceleration of drug release patterns.MethodsBlends of PEO (MW: 100K, 200K, 300K, 600K or 900K) with PEG 6K (plasticiser) and a model drug (theophylline) were prepared by hot-melt extrusion. The resultant filaments were used as a feed for a FDM 3D printer to fabricate innovative designs of ODFs in a radiator-like geometry with inter-connected paralleled plates and inter-plate spacing of either 0.5mm, 1mm, 1.5mm or 2mm.ResultsVarying blends of PEO and PEG allowed formation of mechanically resistant filaments (maximum load at break of 357, 608, 649, 882, 781 N for filament produced with 100K, 200K, 300K, 600K or 900K, respectively). Filaments of PEO at a MW of 200K-600K were compatible with FDM 3D printing. Further increase in PEO MW resulted in elevated shear viscosity (>104 Pa.S) at the printing temperature and hindered material flow during FDM 3D printing. A minimum spacing (1 mm) between parallel plates of the radiator-like design was essential to boost drug release from the structure.ConclusionThese findings are essential in the development of next-generation personalised drug delivery doses using specialised polymer/polymer blends purposely optimised for FDM 3D printing.Disclosure(s)Nothing to disclose

3D-printed polypropylene transtibial sockets: Mechanical behavior

2020 ◽  
pp. 095440622094392
Author(s):  
MacArthur L Stewart
Keyword(s):  
3D Printing ◽  
Yield Strength ◽  
Tensile Test ◽  
Tensile Properties ◽  
Material Properties ◽  
Standard Test ◽  
Test Method ◽  
Material Behavior ◽  
Cross Sectional ◽  
3D Printed

This paper defines the tensile properties of a successfully worn 3D-printed transtibial socket. The socket was printed from a proprietary polypropylene filament and FDM 3D-printing process. Fused disposition modeling involves producing successive cross-sectional layers on top of one another and welding them together. Because of this, a notch is formed between the printed layers. As part of this investigation, tensile test specimens were die-cut perpendicular to the material direction and tested according to ASTM D638—Standard Test Method for Tensile Properties of Plastics. From the measured load–elongation data, stress–strain curves and the corresponding material properties were determined, including modulus of elasticity E, Poisson’s ratio ν, yield strength Sy, and ultimate strength Su. The average values for each of these material properties were 955 MPa, 0.35, 11.4 MPa, and 16.3 MPa, respectively. In addition to defining tensile properties, this work demonstrated a viable methodology for characterizing the as-built material behavior of 3D-printed sockets.

scholarly journals 3D-printed monolithic biofilters based on a polylactic acid (PLA) – hydroxyapatite (HAp) composite for heavy metal removal from an aqueous medium

RSC Advances ◽  
2021 ◽  
Vol 11 (51) ◽  
pp. 32408-32418
Author(s):  
Natalia Fijoł ◽  
Hani Nasser Abdelhamid ◽  
Binsi Pillai ◽  
Stephen A. Hall ◽  
Nebu Thomas ◽  
...  
Keyword(s):  
Heavy Metal ◽  
Phase Separation ◽  
3D Printing ◽  
Polylactic Acid ◽  
Metal Removal ◽  
Heavy Metal Removal ◽  
Three Dimensional ◽  
Thermally Induced Phase Separation ◽  
Thermally Induced ◽  
3D Printed

Water purification filters based on polylactic acid functionalised with hydroxyapatite were prepared by solvent-assisted blending and thermally induced phase separation (TIPS), extruded into filaments and processed via three-dimensional (3D) printing.

scholarly journals Real-Time Live-Cell Imaging Technology Enables High-Throughput Screening to Verify in Vitro Biocompatibility of 3D Printed Materials

Materials ◽  
2019 ◽  
Vol 12 (13) ◽  
pp. 2125 ◽  
Author(s):  
Ina G. Siller ◽  
Anton Enders ◽  
Tobias Steinwedel ◽  
Niklas-Maximilian Epping ◽  
Marline Kirsch ◽  
...  
Keyword(s):  
3D Printing ◽  
High Throughput Screening ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Live Cell ◽  
Post Processing ◽  
In Vitro Biocompatibility ◽  
3D Printed ◽  
Printed Materials

With growing advances in three-dimensional (3D) printing technology, the availability and diversity of printing materials has rapidly increased over the last years. 3D printing has quickly become a useful tool for biomedical and various laboratory applications, offering a tremendous potential for efficiently fabricating complex devices in a short period of time. However, there still remains a lack of information regarding the impact of printing materials and post-processing techniques on cell behavior. This study introduces real-time live-cell imaging technology as a fast, user-friendly, and high-throughput screening strategy to verify the in vitro biocompatibility of 3D printed materials. Polyacrylate-based photopolymer material was printed using high-resolution 3D printing techniques, post-processed using three different procedures, and then analyzed with respect to its effects on cell viability, apoptosis, and necrosis of adipogenic mesenchymal stem cells (MSCs). When using ethanol for the post-processing procedure and disinfection, no significant effects on MSCs could be detected. For the analyses a novel image-based live-cell analysis system was compared against a biochemical-based standard plate reader assay and traditional flow cytometry. This comparison illustrates the superiority of using image-based detection of in vitro biocompatibility with respect to analysis time, usability, and scientific outcome.

DLP 3D printing of Dexamethasoneincorporated PEGDA-based photopolymers: compressive properties and drug release

2020 ◽  
Vol 6 (3) ◽  
pp. 406-409
Author(s):  
Robert Mau ◽  
Thomas Reske ◽  
Thomas Eickner ◽  
Niels Grabow ◽  
Hermann Seitz
Keyword(s):  
Mechanical Properties ◽  
3D Printing ◽  
Drug Release ◽  
Drug Loading ◽  
Patient Specific ◽  
Burst Release ◽  
Compressive Properties ◽  
Drug Load ◽  
Polyethylene Glycol Diacrylate ◽  
3D Printed

AbstractPhotopolymerizing, high-resolution 3D printing methods such as Stereolithography (SLA) or Digital Light Processing (DLP) are very promising for the manufacturing of drug-incorporated, patient specific implants. However, a drug-load may be limited by adequately solubility of the active pharmaceutical ingredient (API) in the photopolymer. Furthermore, a drug-load may affect the mechanical properties of the material negatively. Here, we investigate the DLP 3D printing of drugincorporated photopolymers. Polyethylene glycol diacrylate (PEGDA, Mn = 700 g/mol) is used as matrix polymer and Dexamethasone (DEX) is used for drug-loading (10 g/L and 20 g/L). Compressive properties, drug release and drug stability of 3D printed test samples were analyzed. DEX was found to be sparingly soluble in the PEGDA-based photopolymer. Not all drug particles can be dissolved at a concentration of 20 g/L and a slurry-like suspension is formed. Drug-incorporated photopolymers of 10 g/L (solution) and 20 g/L (suspension) were processed successfully via DLP. The higher the drug-load, the lower the compressive strength. Mechanical properties can be improved via a post-curing in a UV light curing box. Drug-incorporated 3D printed test samples show burst-release of DEX. The post-curing process does not affect drug release. DEX degrades in 3D-printed test samples significantly (~ 30 %) over a several days time period.

scholarly journals Formulation and Evaluation of 3D Printed Pregabalin Tablets Targeted For Neuropathic Pain By Qbd Approach For Personalized Medicine

2021 ◽  
Vol 11 (6) ◽  
pp. 1-13
Author(s):  
Bhusnure omprakash Gadgeppa ◽  
Mule Shrikrishna Tukaram ◽  
Gholvesachin Baburo ◽  
Giram padamja Sidram ◽  
Gaurav Agarwal Prof.(Dr) ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
3D Printing ◽  
Drug Release ◽  
Thermo Gravimetric Analysis ◽  
Processing Condition ◽  
Gravimetric Analysis ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Fused Deposition ◽  
3D Printed

The 3D printing technology has been newly employed in the design and formulation of different dosage forms with the aim formulation and evaluation of 3D printed Pregabalin tablets for the treatment of neuropathic pain by QbD approach. Drug (Pregabalin) together with other excipients, were mixed and extruded into filaments by hot melt extrusion. Then with the help of fused deposition modeling these obtained filaments were printed into tablets. Due to the use of different polymers in the printed formulation different release profiles for the 3D printed tablets were obtained. Drug release characteristics change the infill or the size of the printed tablets, allowing the personalization of the tablets. Filaments and tablets were characterized by means of Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), X- RAY powder diffraction (XRPD), and thermo gravimetric analysis (TGA). The results showed that after printing, the processing condition did not have a significant impact on the stability of the drug and the crystalline nature of the drug remained. FDM 3D printing makes it possible not only to formulate 3D printing Pregabalin tablets for the treatment of neuropathic pain but also to modify the potential of additive manufacturing in the development of personalized dose medicines. This study presents novel formulations containing Pregabalin for prevention of neuropathic pain and investigates 3D printing technology for personalized production of oral solid dosage from enabling adjustable dose as well as drug release properties.

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