scholarly journals Effect Observation of Clinical Treatment with Oxaliplatin and Tiggio for Biliary Tract Tumors on Advanced Stage

2021 ◽  
Vol 5 (3) ◽  
Author(s):  
Wei Zheng ◽  
Haibin Wang ◽  
Jiao Zhou
Keyword(s):  
Adverse Reaction ◽  
Survival Time ◽  
Biliary Tract ◽  
Clinical Efficacy ◽  
Adverse Reactions ◽  
Control Group ◽  
P Value ◽  
Chi Square ◽  
Biliary Tract Tumors ◽  
Experimental Group

Objective: To investigate the effect of oxaliplatin combined with tiggio in the treatment of advanced biliary tract tumors. Methods: The research period was from November 2019 to November 2020. 80 patients with advanced biliary tumor disease were enrolled. They were divided into groups according to the order of admission, with 40 cases in each group. The control group received oxaliplatin combined with gemcitabine, and the experimental group received oxaliplatin combined with tiggio. Incidence of adverse reactions, time to disease progression, survival time and clinical efficacy were checked and assessed. Results: Compared with the incidence of adverse reaction of the experimental group, which was 5.00% (2/40), the incidence of adverse reaction of the control group was 25.00% (10/40). The chi-square value = 6.2745, p-value = 0.0122. The time to progression and survival time of patients in the experimental group were shorter than those of the control group, with significant differences between the groups (p<0.05); the clinical efficacy of the experimental group and the control group were 97.50% (39/40) and 77.50% (31/ 40) respectively, the comparative chi-square value = 7.3143, p-value = 0.0068. Conclusion: The combined treatment of oxaliplatin and Tiggio in the treatment of advanced biliary tract tumors has higher safety and reduces the incidence of adverse reactions.

scholarly journals Ivermectin as Pre-exposure Prophylaxis for COVID-19 among Healthcare Providers in a Selected Tertiary Hospital in Dhaka – An Observational Study

2020 ◽  
Vol 2 (6) ◽  
Author(s):  
Mohammed Tarek Alam ◽  
Rubaiul Murshed ◽  
Pauline Francisca Gomes ◽  
Zafor Md. Masud ◽  
Sadia Saber ◽  
...  
Keyword(s):  
Observational Study ◽  
Large Scale ◽  
Statistical Significance ◽  
Healthcare Providers ◽  
Tertiary Hospital ◽  
Control Group ◽  
P Value ◽  
Chi Square ◽  
Exposure Prophylaxis ◽  
Experimental Group

Introduction: While multiple vaccines are undergoing clinical trial across the globe, we yearn for an FDA approved drug to protect us from the devastating pandemic for the time being. This study aims to determine the effectiveness of Ivermectin when administered as pre-exposure prophylaxis for COVID-19. Method: An observational study, with 118 healthcare providers who were enrolled purposively, was conducted in a tertiary hospital in Dhaka from May 2020 to August 2020. The subjects were divided into experimental and control groups; and the experimental group received an oral monthly dose of Ivermectin 12mg for 4 months. Both groups were exposed to COVID-19 positive patients admitted in the hospital during the course of study. The symptomatic subjects were evaluated by physical examination, COVID-19 RT-PCR and/or HRCT of chest. Differences between the variables were determined using the Chi-square test and the level of statistical significance was reached when p<0.05. Result: 73.3% (44 out of 60) subjects in control group were positive for COVID-19, whereas only 6.9% (4 out of 58) of the experimental group were diagnosed with COVID-19 (p-value < 0.05). Conclusion: Ivermectin, an FDA-approved, safe, cheap and widely available drug, should be subjected to large-scale trials all over the world to ascertain its effectiveness as pre-exposure prophylaxis for COVID-19.

scholarly journals Study on the Clinical Efficacy and Safety of Endostar Combined with Pemetrexed and Cisplatin in the Treatment of Lung Adenocarcinoma

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Yanbing Wang
Keyword(s):  
Lung Adenocarcinoma ◽  
Clinical Efficacy ◽  
Adverse Reactions ◽  
Treatment Plan ◽  
Specific Treatment ◽  
Control Group ◽  
Efficacy And Safety ◽  
Treatment Results ◽  
Significant Difference ◽  
Experimental Group

Objectives: To analyze and study the efficacy and safety of Endu combined with pemetrexed and cisplatin in the clinical treatment of lung adenocarcinoma. Methods: From August 2016 to September 2020, 32 patients with lung adenocarcinoma who were treated in our hospital were selected for group trials. According to their specific treatment plan, the patients were divided into control group and experimental group, with 16 cases in each group. The control group was treated with pemetrexed and cisplatin, and the experimental group was treated with Endostar combined with the treatment received by the control group. The clinical efficacy and safety of the two regimens were assessed by comparing the changes in symptoms and the incidence of adverse reactions between the two groups of patients after treatment. Results: The disease control rate of the experimental group was significantly higher than that of the control group, and there was no significant difference in the incidence of adverse reactions between the two groups. Conclusions: From the experimental results, we found that the treatment of patients with lung adenocarcinoma by Endostar combined with pemetrexed and cisplatin can effectively improve the treatment efficacy without increasing adverse reactions and therefore relevant chemotherapy regimens can be considered for wider clinical applications.

scholarly journals CARDIOMYOPATHY

2018 ◽  
Vol 25 (04) ◽  
pp. 497-501
Author(s):  
Ammar Asghar ◽  
Aneeqa Ilyas ◽  
Tuba Jamil ◽  
Umair Asghar
Keyword(s):  
Salt Intake ◽  
Heart Diseases ◽  
Control Group ◽  
P Value ◽  
Water Restriction ◽  
Chi Square ◽  
Peripheral Edema ◽  
The Mean ◽  
Group B ◽  
Experimental Group

Background: Peripheral edema is associated with cardiomyopathy. It iscommonly observed in patients of heart diseases. It is known that restriction of sodium productscan reduce edema. So it was planned to conduct the study and find the effectiveness of salt andwater restriction in cardiomyopathy patients having peripheral edema. Objectives: To comparethe peripheral edema by restricting salt and water consumption in patients with cardiomyopathy.Study Design: Randomized control trial. Setting: Department of Cardiology, Punjab Instituteof Cardiology, Lahore. Duration: Six months. Methodology: 50 cases of cardiomyopathy withperipheral edema were randomly divided in 2 groups. In group A, patients were instructed toreduce salt and water intake per day and in group B, no water and salt restriction was instructed.All patients were followed-up in OPD for 15 days. Then patients were assessed for peripheraledema. Chi square test was applied to compare the frequency of peripheral edema in bothgroups. P-value<0.05 was considered as significant. Results: The mean age of the patients was46.00±12.98 years. There were 48% males and 52% females. Mean duration of cardiomyopathywas 5.56±2.98 years. The mean reduction in salt intake was 0.57±0.22 grams in experimentalgroup and 0.42±0.21 grams in control group (P<0.05). The mean reduction in water intakewas 0.72L in experimental group and 0.53L in control group (P<0.05). Peripheral edema wasfound in 8% in experimental group and 44% in control group (P<0.05). Conclusion: Our studyresults concluded that salt and water restriction can reduce peripheral edema in patients withcardiomyopathy and thus improve condition of patient.

scholarly journals Maternal and fetal outcome in oligohydramnios after 34 weeks of gestation

2018 ◽  
Vol 7 (11) ◽  
pp. 4604
Author(s):  
Mahantappa A. Chiniwar ◽  
Joe Kaushik M. ◽  
Sharada B. Menasinkai
Keyword(s):  
Amniotic Fluid ◽  
Fetal Outcome ◽  
Morbidity And Mortality ◽  
Research Centre ◽  
Control Group ◽  
P Value ◽  
Study Group ◽  
Perinatal Morbidity ◽  
Amniotic Fluid Index ◽  
Chi Square

Background: Oligohydramnios is one of the major causes of maternal and perinatal morbidity and mortality. It is a clinical condition characterized by Amniotic Fluid Index (AFI) ≤5 cm by sonographic assessment. The aim of present study is to know the maternal and fetal outcome in oligohydramnios after 34 weeks of gestation compared with women who had normal volume of amniotic fluid.Methods: Study was done for the period of 21 months from November 2014-July 2016 at Adichunchanagiri Institute of Medical Sciences, Hospital and Research Centre Bellur. 50 antenatal cases with > 34 weeks of gestation with AFI ≤5 cm by ultrasonographic estimation were included as study group and 50 women with normal AFI were included as control group. Maternal and fetal outcome of the women with oligohydramnios were analyzed and compared with control group.Results: Results were analyzed statistically using parameters like mean, SD, Chi Sq test, P value. Amniotic fluid was clear in 32% in study and 78% in control group, thin meconium stained in 30% in study group and 14%in control group and was thick meconium stained in 38% in study group and 8% in control group (Chi square =22.31, p<0.0001). Induction of labour was done in 54% in study group and 20% in control group. Cesarean delivery was done in 58% in study group women and 28% in control group women. Regarding the birth weight of babies 62% were < 2.5 kg in study group and 18% in control group with p<0.001. 10% of babies in study group required NICU admission and perinatal mortality was 2%.Conclusions: Due to increased perinatal morbidity and mortality and increased rate of LSCS, timely decision during labour is important to reduce perinatal morbidity and mortality.

scholarly journals Meta-Analysis of Clinical Efficacy and Safety of Ligustrazine in the Treatment of Idiopathic Pulmonary Fibrosis

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Xiaozheng Wu ◽  
Wen Li ◽  
Zhenliang Luo ◽  
Yunzhi Chen
Keyword(s):  
Idiopathic Pulmonary Fibrosis ◽  
Pulmonary Fibrosis ◽  
Clinical Efficacy ◽  
Adverse Reactions ◽  
Clinical Symptoms ◽  
Gas Analysis ◽  
Control Group ◽  
Efficacy And Safety ◽  
Arterial Blood Gas ◽  
Arterial Blood

Objective. To systematically review the efficacy and safety of Ligustrazine in the treatment of idiopathic pulmonary fibrosis (IPF). Methods. The electronic literature databases (PubMed, EMbase, CNKI, WanFang database, and VIP) were retrieved through a computer to find out the randomized controlled trials (RCT) of Ligustrazine in the treatment of IPF according to the inclusion/exclusion criteria screening test. Cochrane’s bias risk table was also used to evaluate the quality of the study and to extract effective data. RevMan 5.3 was used for statistical analysis. Results. A total of 7 RCTs (a total of 366 patients, including 196 in experimental and 170 in control group). Compared with the control group, Ligustrazine could improve the clinical symptoms ([OR] = 2.20, 95% CI [1.40, 3.46], P = 0.0006 ), lung function (VC % [MD] = 3.92, 95% CI [0.68, 7.17], P = 0.02 ), (TLC% [MD] = 4.94, 95% CI [0.37, 9.52], P = 0.03 ), the pulmonary diffusion function (DLCO % [MD] = 9.12, 95% CI [5.70, 12.55], P < 0.00001 ), and arterial blood gas analysis (PaO2 [MD] = 7.11, 95% CI [1.96, 12.25], P = 0.007 ) (PaCO2 [MD] = −2.42, 95% CI [−4.36, −0.49], P = 0.01 ) of IPF patients, respectively. However, FEV1/FVC % ([MD] = 9.37, 95% CI [−1.23, 19.97], P = 0.08 ) and adverse reactions ([MD] = 0.35, 95% CI [0.02, 5.36], P = 0.45 ) were not significantly improved. Conclusion. Ligustrazine has certain clinical efficacy in the treatment of IPF, but the safety of applying it and the adverse reactions need to be further analyzed and determined. It can be considered as a new alternative and complementary medicine to be promoted and recommended for use in medical units in various countries in the world and it solved the difficult problem of conventional drug treatment of IPF; therefore, more research strength can be put in the treatment of the pathological mechanism of IPF for further exploration. The study was registered under registration number CRD42020193626.

scholarly journals HUBUNGAN MEROKOK DENGAN KADAR GLUKOSA DARAH MAHASISWA FAKULTAS HUKUM UNIVERSITAS ISLAM AL-AZHAR TAHUN 2019

2019 ◽  
Vol 4 (2) ◽  
pp. 63
Author(s):  
Deny Sutrisna Wiatma ◽  
Muhlisin Amin
Keyword(s):  
Control Group ◽  
P Value ◽  
Chi Square ◽  
Equivalent Control

Latar Belakang :Rokok sangatlah berbahaya bagi kesehatan, salah satu kandungannya yakni nikotin telah diketahui dapat menjadi faktor resiko kejadian diabetes, nikotin dapat merusak sel β pankreas dan menghambat insulin. Tujuan :untuk mengetahui hubungan merokok dengan kadar glukosa darah mahasiswa Fakultas Hukum Universitas Islam Al-Azhar Mataram tahun 2019. Metode Penelitian : Populasi pada penelitian ini adalah 52 orang mahasiswa perokok aktif Fakultas Hukum Universitas Islam Al-Azhar periode 2015-2019, sampel diambil dengan teknik total sampling yakni jumlah sampel sama dengan jumlah populasi, dan menggunakan metode pre-eksperimental design dengan rancangan non equivalent control group, hasil pada penelitian ini selanjutnya di analisis dengan uji Chi-Square. Hasil : Hasil yang didapatkan dari uji Chi-Squarediperoleh nilai signifikan dengan rerata kadar glukosa darah pretest dan posttest kelompok eksperimen adalah 107,73 mg/dL dan 112,65 mg/dL sedangkan pada kelompok kontrol adalah 123,27 mg/dL dan 112,40 mg/dL serta didapatkan p value 0,001 (P <0,05). Kesimpulan :Terdapat Hubungan yang Signifikan antara merokok dengan kadar glukosa darah.

scholarly journals Factors Related to the Incidence of Typhoid Fever in the Work Area Health Office of Jayawijaya Regency

2021 ◽  
Vol 5 (1) ◽  
pp. 49-56
Author(s):  
Rahmad Suryawan Ura ◽  
Yuly Peristiowati
Keyword(s):  
Typhoid Fever ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
District Health Office ◽  
District Health ◽  
Chi Square ◽  
Work Area ◽  
Chi Square Test ◽  
Test Result

Typhoid fever is a disease that is prone to occur in Indonesia, because of the characteristics of the climate that is very prone to diseases related to the seasons. The purpose of this study is to analyze factors related to the incidence of typhoid fever in the Working Area of the Jayawijaya District Health Office. The research design used is quantitative analytics method using quantitative data. The type of approach used is case control. The population is 74 patients with typhoid fever. The large sample taken as many as 37 respondents, with a large comparison of samples between the number of respondents in the case group is 37 respondents, and 37 respondents as a control group, so the total number of samples is 74 respondents. Sampling techniques used in this study is a simple random sampling technique. Based on the results of the study, it is known that there is no relationship between age and the incidence of typhoid fever in the Working Area of the Jayawijaya District Health Office. Chi-square test result obtained p-Value Sig (0.445) > α (0.05). While it is known that there is a relationship between the level of knowledge, the level of education, hygiene of individual respondents with the incidence of typhoid fever in the Work Area of the Health Office of Jayawijaya Regency. Chi-square test results obtained p- value (0.000) < α (0.05) and environmental sanitation with the incidence of Typhoid Fever in the Work Area of the Jayawijaya District Health Office. Chi-square test result obtained p-value (0.001) < α (0.05). Based on the results of the study is expected to increase kinship with patients as well as by providing health services visits to the patient's home.

scholarly journals Pengaruh Pijat Bayi terhadap Peningkatan Berat Badan

2020 ◽  
Vol 1 (3) ◽  
pp. 144-150
Author(s):  
Yuyuk Eva Fitriyanti ◽  
Gusman Arsyard ◽  
Sumiaty Sumiaty
Keyword(s):  
Weight Gain ◽  
Health Workers ◽  
Sampling Technique ◽  
Child Growth ◽  
Control Group ◽  
P Value ◽  
Infant Massage ◽  
Chi Square ◽  
Control Group Design ◽  
Quasi Experimental

Indicator of child growth is weight. At the age of 1-3 months is a period of rapid growth, so it is necessary to maintain a baby's weight according to age. Touch therapy or massage is one of technique that combines the physical benefits of human touch with emotional benefits such as bounding and increasing weight. The purpose of this study was to determine the effect of infant massage on weight gain in infants aged 1-3 months in the work area of the Sangurara Health Center in Palu. This type of research was a Quasi-experimental design with pretest and Posttest control group design. The sample in this study was 30 months old infants as many as 30 infants with sampling technique consecutive sampling. Data analysis used test Chi-square with a confidence level of 95% (α = 0.05). The results show that babies who were massaged had more weight gain, which was 24.07%, while babies who were not massaged had a weight gain of 18.28%. This is evidenced by the value of p value: 0.03 (p.value≤0.05). In conclusion, there was the effect of Baby Massage on Increased Body Weight. Suggestions for researchers for health workers to socialize and suggest baby massage to reduce the case of BGM weight (Under the Red Line) in infants.

scholarly journals An observation of the clinical efficacy of combining Riluzole with mannitol and hyperbaric oxygen in treating acute spinal cord injury

2021 ◽  
Vol 37 (2) ◽  
Author(s):  
Huan-xia Li ◽  
Jing Cui ◽  
Jing-shi Fan ◽  
Jian-zhou Tong
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Hyperbaric Oxygen ◽  
Clinical Efficacy ◽  
Acute Spinal Cord Injury ◽  
Sensory Function ◽  
Control Group ◽  
Thoracolumbar Fractures ◽  
Cord Injury ◽  
Experimental Group

Objective: To examine the clinical efficacy of combining Riluzole with mannitol and hyperbaric oxygen therapy in treating thoracolumbar vertebral fracture-induced acute spinal cord injury (ASCI). Methods: From June 2015 to May 2018, 80 patients with thoracolumbar fractures and ASCI who were treated at Baoding First Central Hospital were selected. All patients underwent posterior laminectomy and screw fixation, and they were randomly divided into two groups using a random number table method. The control group received conventional postoperative treatment, while the experimental group was treated with riluzole combined with mannitol and hyperbaric oxygen on the basis of conventional treatment. The recovery of nerve function which included motor function and sensory function, and the changes of serum IL-6, CRP, BDNF, BFGF and other factors before treatment and four weeks after treatment of the two groups of patients were observed and evaluated. Results: After treatment, the motor function scores and sensory function scores of the two groups of patients were improved compared with those before treatment (p<0.05). Compared with the control group, the experimental group improved significantly, and the difference was statistically significant (p<0.05). The levels of IL-6, BDNF and NFGF in the experimental group were significantly lower than those in the control group (p<0.05). Conclusions: For patients with thoracolumbar fractures and ASCI undergoing laminar decompression and fixation, the comprehensive treatment plan of riluzole combined with mannitol and hyperbaric oxygen has certain advantages. Compared with the conventional therapy, it may significantly improve the movement and sensory functions of patients, relieve the inflammatory response of spinal cord, and promote recovery from the injury. doi: https://doi.org/10.12669/pjms.37.2.3418 How to cite this:Li H, Cui J, Fan J, Tong J. An observation of the clinical efficacy of combining Riluzole with mannitol and hyperbaric oxygen in treating acute spinal cord injury. Pak J Med Sci. 2021;37(2):---------. doi: https://doi.org/10.12669/pjms.37.2.3418 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Senam Irama Lagu Gizi Seimbang Meningkatkan Kebugaran Pada Anak Sekolah

2020 ◽  
Vol 5 (1) ◽  
pp. 22-29
Author(s):  
Een Juliasti ◽  
Mury Kuswari ◽  
Idrus Jus’at
Keyword(s):  
Physical Activity ◽  
Elementary School ◽  
Test Group ◽  
Wilcoxon Test ◽  
Control Group ◽  
P Value ◽  
Fitness Level ◽  
Rhythmic Gymnastics ◽  
Post Test ◽  
Experimental Group

Physical activity on students in Jakarta is the lowest if it is compared to various regions in Indonesia. The low physical activity has an impact on the declining of health and fitness so that it affects toward the risk of various non-communicable diseases. The purpose of this research is to know the influence of gymnastics rhythm of Gizi Seimbang’s song to the level of fitness on students in State Elementary School Kebon Jeruk 08 Pagi West Jakarta. The type of research uses design experimental quasi research with design of Pre test - post test group control design. This design involves two groups of subjects, one is given an experimental group and one group is not enforced (control group). The population of this study are children aged 10-12 years old with 60 respondents (30 students of gymnastic group and 30 control group students) with gymnastics 3x/week for 12 times. Data analysis use t-dependent test, wilcoxon test because the data is not normally distributed. The result of the research shows that there is the influence of rhythmic gymnastics of Gizi Seimbang’s song to the significant fitness level (p value = 0.0001). Based on the results of this study, gymnastics rhythm of Gizi Seimbang’s song increases the level of fitness compared with control group on students in State Elementary School Kebon Jeruk 08 Pagi West Jakarta.

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