scholarly journals ASSOCIATION BETWEEN AGES AND GLUCOCORTICOID-INDUCED DIABETES MELLITUS INCIDENCE IN INTRACRANIAL TUMOR PATIENTS

2020 ◽  
Vol 7 (7) ◽  
pp. 17-22
Keyword(s):  
Diabetes Mellitus ◽  
Brain Tumors ◽  
Age Groups ◽  
Intracranial Tumor ◽  
Age Group ◽  
Test Results ◽  
Metastatic Brain Tumors ◽  
Tumor Patients ◽  
Cohort Design ◽  
Sugar Levels

Background: glucocorticoids are the main therapy for treating peritumoral edema in patients with intracranial tumors. The use of glucocorticoids has side effects, one of which is hyperglycemia or what is called Glucocorticoid-Induced Diabetes Mellitus (GIDM). Hyperglycemia in brain tumor patients is associated with decreased survival, increased recurrence and degeneration to malignancy. Objective: to determine the association between age and the incidence of GIDM in intracranial tumor patients. Method: this study uses a cohort design. Sampling was conducted at Ruang Rawat Inap Terpadu (Rindu) H. Adam Malik General Hospital Medan. Samples were taken as many as 30 subjects consecutively. Blood sugar levels were checked twice a day on days 4 and day 5. Data analysis used the fisher test and eta correlation test. Results: demographic characteristics of the study subjects were an average age of 51 years, high school education level, housewife occupation. As many as 46.7% were primary brain tumors and 53.3% were metastatic brain tumors with the most metastases originating from the lungs (56.3%). There was no difference in the proportion of age groups for the incidence of GIDM (p> 0.05). There was no significant relationship between age and the incidence of GIDM (p> 0.05). Conclusion: there is no difference in the proportion of the age group to the incidence of GIDM and there is no significant association between age and the incidence of GIDM.

scholarly journals HYPERTENSIVE PATIENTS;

2013 ◽  
Vol 20 (03) ◽  
pp. 341-347
Author(s):  
SHAHANA ARSHI ◽  
FAKHRA NAHEED ◽  
MAZHAR BADSHAH ◽  
Farah Naz ◽  
Kamran Sardar
Keyword(s):  
Diabetes Mellitus ◽  
Impaired Fasting Glucose ◽  
Fasting Glucose ◽  
Age Groups ◽  
Age Group ◽  
Medical Sciences ◽  
Blood Samples ◽  
Hypertensive Patients ◽  
Glucose Levels ◽  
Secondary Causes

Objective: To see the frequency of diabetes mellitus and impaired fasting glucose levels in hypertensive patients. Design:Descriptive study. Place of Study: OPD / Filter clinic. Pakistan Institute of Medical Sciences. Islamabad. Patients and Methods: Thisstudy was carried out on 116 hypertensive patients during the period from August to September '2008. Out of 116 patients, 64 werefemales and 52 were males with age group between 20 to 70 years. Secondary causes are ruled out on the basis of history and physicalexamination. Blood samples were sent to PIMS laboratory for fasting glucose. Data and results were analyzed in SPSS. Results:According to this study, out of 116 patients, there were18 patients who had diabetes mellitus while 33 had hypertension with impairedfasting glucose tolerance which is statistically significant. The females as compared to males were increased in number who had bothdiabetes mellitus and impaired fasting glucose. According to age diabetes mellitus increased in age groups between 41-50 and 61-70years while impaired fasting glucose were increased in age group between 31-60 yrs. The results indicate that impaired fasting glucose ispresent in significant number of hypertensive patients. Conclusions: Hypertension is associated with diabetes mellitus and impairedfasting glucose.

scholarly journals Estimating the disease burden of Korean type 2 diabetes mellitus patients considering its complications

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0246635
Author(s):  
Juyoung Kim ◽  
Seok-Jun Yoon ◽  
Min-Woo Jo
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Markov Model ◽  
Burden Of Disease ◽  
Age Groups ◽  
Years Of Life Lost ◽  
Age Group ◽  
Disease Study

Background The burden of diabetes is considerable not only globally but also nationally within Korea. The Global Burden of Disease study derived the disability-adjusted life years (DALYs) of diabetes depending on its complications as individual severity using prevalence-based approach from 2017. Conversely, the Korean National Burden of Disease study based on an incidence-based approach does not incorporate the severity of diseases. This study aimed to simulate incidence-based DALYs of type 2 diabetes mellitus (T2DM), given diabetic complications as disease severity using a Markov model. Methods We developed a model with six Markov states, including incident and existing prevalent cases of diabetes and its complications and death. We assumed that diabetes and its complications would not be cured. The cycle length was one year, and the endpoint of the simulation was 100 years. A 5% discount rate was adopted in the analysis. Transition cases were counted by 5-year age groups above 30 years of age. Age- and sex-specific transition probabilities were calculated based on the incident rate. Results The total DALY estimates of T2DM were 5,417 and 3,934 per 100,000 population in men and women, respectively. The years of life lost in men were relatively higher than those in women in most age groups except the 80–84 age group. The distribution of years lived with disability by gender and age group showed a bell shape, peaking in the 55–59 age group in men and 65–69 age group in women. Conclusions The burden of T2DM considering its complications was larger compared to the outcomes from previous studies, with more precise morbid duration using the Markov model.

scholarly journals Evaluation Of Clinical, Laboratory And Radiological Findings In Pediatric Covid-19 Cases And Their Relation With RT-PCR Result

2021 ◽  
Author(s):  
Muhammet Asena ◽  
ilyas yolbaş ◽  
murat Kanğın
Keyword(s):  
Computed Tomography ◽  
Respiratory Distress ◽  
Clinical Laboratory ◽  
Age Groups ◽  
Age Group ◽  
Test Results ◽  
Rt Pcr ◽  
Radiological Findings ◽  
Laboratory Findings ◽  
Pcr Test

Background: The pandemic of the new coronavirus disease (COVID-19) continues to be a major health problem globally. In this study, clinical findings, radiological findings, laboratory findings and polymerase chain reaction (PCR) test results were evaluated according to age groups in pediatric patients with COVID-19. Methods: In this study, PCR (+) and PCR (-) 278 cases diagnosed with COVID-19 between March 15, 2020 and September 30, 2020 were assessed considering clinical symptoms, radiological and laboratory findings and RT-PCR test results. Results: 43.9% of the cases consisted of RT-PCR (+) and 56.1% of RT-PCR (-) cases. Fever was observed at the rate of 64.7%, cough 53.2%, respiratory distress 12.2%, myalgia 24.5%, diarrhea 12.9%, chest X-ray findings 48.2% and computed tomography findings 43.6%. Diarrhea and cough, alanine aminotransferase, aspartate aminotransferase, leukocyte and lymphocyte elevation were determined as significantly higher in younger age group cases, while high myalgia and neutrophilia was observed in older age group children (p <0.05). Fever, high CRP, leukocytosis frequency, high neutrophil, were significantly higher in PCR(-) cases and the frequency of respiratory distress, high lymphocyte and chest computed tomography findings in PCR(+) cases (p <0.05). Conclusion: COVID-19 infection may indicate different nonspecific clinical, laboratory and radiological findings in children according to both adults and pediatric age groups. In addition, the results of the PCR test may give erroneous results in cases due to conditions such as fever, respiratory distress, high CRP, leukocytosis, high neutrophil and CT finding. Keywords: pediatric, COVID-19, RT-PCR

Brain tumors: Regulation of angiogenesis.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e13540-e13540 ◽  
Author(s):  
Eduard Evgenevich Rostorguev ◽  
Elena Mikhaylovna Frantsiyants ◽  
Yulia A. Pogorelova ◽  
Natalia D. Cheryarina ◽  
Larisa Kozlova ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Test Results ◽  
Metastatic Brain Tumors ◽  
Metastatic Tissue ◽  
Pathological Angiogenesis ◽  
Important Mediator ◽  
Student’S T ◽  
G 14 ◽  
Student’S T Test

e13540 Background: Cancer implicates pathological angiogenesis. The problem of treatment for primary and metastatic brain tumors is still unsolved. In addition to main angiogenic functions, VEGF family performs important mediator functions in the immune system. The role of VEGF family in central nervous system tumors is poorly studied. Our purpose was to study the levels of factors of angio- and lymphangiogenesis in tissues of glioblastomas (G), brain metastases (MTS), meningiomas and corresponding peritumoral area. Methods: Tissues of tumor and peritumoral zone (PZ) obtained during the surgery from 22 patients with G, 14 patients with brain MTS from breast cancer and 12 meningioma patients, mean age 39.2±4.8 years, were studied. Levels of VEGF-A, VEGFR-1, VEGF-C and VEGFR-3 were determined by ELISA. The data were processed using Statistica 10 program. The significance of differences was determined by Student's t-test. Results: VEGF-A levels in tissues of G and MTS were higher than in meningioma tissues by 74.7 and 94.5 times, respectively; levels of VEGF-R1 were 2.7 and 3.9 higher, and the VEGF-A/VEGF-R1 coefficient was 28.1 and 24.1 times higher, respectively. Levels of VEGF-C and VEGF-R3 were escalated only in G tissues compared to meningiomas (by 1.7 times on average). The VEGF-С/VEGF-R3 coefficient was similar in all studied tumors. VEGF-A levels were higher in PZ of G and MTS compared to PZ of meningiomas – by 78.2 and 110.7 times, respectively, while VEGF-R1 level was higher in G PZ only (by 5.5 times). The VEGF-A/VEGF-R1 coefficient was 14.5 and 128.5 times higher, respectively. VEGF-C level in PZ of G was escalated compared to meningiomas by 6.5 times, in MTS – by 1.6 times. VEGFR-3 contents did not differ significantly in all PZ samples, but the VEGF-С/VEGF-R3 coefficient was higher in PZ in G by 9 times and in MTS by 2 times. Conclusions: Compared to benign meningiomas, angio- and lymphangiogenesis are activated in glioblastoma tissue and angiogenesis – in metastatic tissue. Lymphangiogenesis is more active in peritumoral zone of glioblastomas compared to metastatic tissue, and angiogenesis is more active in peritumoral zone of metastases.

Incidence and Prevalence of Pregnant Women with Gestational Diabetes Mellitus, Thyroid Disorders and Eclampsia in Khammam Region, Telangana State

2017 ◽  
Vol 3 (4) ◽  
pp. 367-371
Author(s):  
. Ravali ◽  
B. Sravani ◽  
P. Suresh Kumar
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Age Groups ◽  
Tertiary Hospital ◽  
Thyroid Disorders ◽  
Rural And Urban ◽  
Telangana State ◽  
Sugar Levels

Objective: The aim of this study was to estimate the incidence and prevalence of Gestational Diabetes Mellitus (GDM), Thyroid dysfunction and Eclampsia in pregnant women prior to delivery. Methods: An observational retrospective study was conducted between December 2016 and June 2017 in a District Headquarters Hospital and two other tertiary antenatal care centers on pregnant women who delivered between 37 and 42 weeks of gestational age. The study participants data was collected prior delivery who were diagnosed as GDM with Random Blood Sugar levels ≥ 140mg/dl, hyperthyroidism with ≤1.1 µIU/ml and hypothyroidism with ≥ 5.5 µIU/ml and Eclampsia in women who had a grand mal seizure with features of preeclampsia. Results: A total of 265 pregnant women was included whose information was sampled. A prevalence of 10.5% (n = 28) was identified with GDM, 77.7% (n = 206) was identified with Thyroid Disorders and 11.6% (n = 31) with Eclampsia who were categorized into rural and urban communities based on age groups. Conclusion: Ignorance regarding antenatal check-up, lack of transport and lack of early communication with a tertiary hospital play an important role for high incidence and prevalence of complications in pregnancy in Khammam region, Telangana State.

scholarly journals Mindfulness: Age and gender differences on a Bosnian sample

2017 ◽  
Vol 10 (1) ◽  
pp. 155-166 ◽  
Author(s):  
Sabina Alispahic ◽  
Enedina Hasanbegovic-Anic
Keyword(s):  
Gender Differences ◽  
General Population ◽  
Age Groups ◽  
Age Group ◽  
Test Results ◽  
Age And Gender ◽  
Significant Difference ◽  
Age And Gender Differences ◽  
And Gender ◽  
Acting With Awareness

The goal of this research was to examine age and gender differences in mindfulness on Bosnian general population. The study was conducted on a sample of 441 participants from the general population, from twelve cities in Bosnia and Herzegovina. As a measure of mindfulness we used Five Factor Mindfulness Questionnaire. Results showed that older participants’ scores were higher than for younger participants for all aspects of mindfulness. There was found a statistically significant difference between the three age groups on the subscales of Acting with awareness F(2, 435) = 7.39, p < .01 and of Non-judging of inner experience F(2, 428) = 5.67, p < .01. We found statistically significant difference for the Acting with awareness between 20-32 age group (M = 28.57, SD = 5.66) and 33-49 age group (M = 31.01, SD = 5.00, t(292) = -3.91, p < .001), and between 20-32 age group and 50+ group (M = 30.14, SD = 5,86, t(290) = -2.32, p < .05). Also, there was a significant difference for the Non-judging between 20-32 age group (M = 24.77, SD = 5.80) and 33-49 age group (M = 26.65, SD = 5.09, t(288) = -2.94, p < .01), and between 20-32 age group and 50+ group (M = 26.49, SD = 4.90, t(287) = -2,71, p < .05). According to the t-test results, there was statistically significant gender difference between the subscales Observing (t(432) = -2.259, p < .05) and Acting with awareness (t(432) = 2.197, p < .05), women scored higher than men on the subscale Observing, while men exhibited higher scores on the subscale Acting with awareness. Results of this research showed that there were found significant age and gender differences for some aspects of mindfulness in the sample of Bosnian general population.

scholarly journals Evaluation of child preference for dentist attire and usage of camouflage syringe in reduction of anxiety

2017 ◽  
Vol 11 (04) ◽  
pp. 531-536 ◽  
Author(s):  
Prashant Babaji ◽  
Pavni P. Chauhan ◽  
Vikram Rathod ◽  
Swapnil Mhatre ◽  
Uttam Paul ◽  
...  
Keyword(s):  
Dental Anxiety ◽  
Age Groups ◽  
Anxiety Level ◽  
White Coat ◽  
Age Group ◽  
Test Results ◽  
Chi Square ◽  
Younger Age ◽  
Cartoon Character ◽  
Chi Square Test

ABSTRACT Objectives: The aim of this study is to evaluate the child preference for dentist attire and camouflage versus conventional syringe in reduction of anxiety. Materials and Methods: A total of 600 children aged 6–14 years were made to look at a set of six photos of an individual dressed with different colored apron of pink, green, blue, white colors, formal dress, and cartoon character along with conventional syringe and camouflage syringe with a toy-like appearance to permit injection of local anesthesia. Children's anxiety level during injections and with colored coat was assessed and recorded using the Modified Child Dental Anxiety Scale faces version. Statistical Analysis Used: SPSS statistical software version 21 and using Chi-square test. Results: Among age group of 6–8 years, 65.33% selected colorful apron, while other age groups 9–10, 11–12 years, and 13–14 years selected 47.34%, 57.34%, and 50.67% white coat, respectively (P < 0.05). For syringe, 78% of younger age group (6–10 years) preferred camouflage syringe, whereas 71% of older age group (11–14 years) preferred conventional syringe. Anxiety level of all children for syringe was more compared to that of white coat. Conclusion: Younger children prefer colorful attire of dentist and camouflage syringe over conventional compared to older one.

Iodine-131-labeled antitenascin monoclonal antibody 81C6 treatment of patients with recurrent malignant gliomas: phase I trial results.

1998 ◽  
Vol 16 (6) ◽  
pp. 2202-2212 ◽  
Author(s):  
D D Bigner ◽  
M T Brown ◽  
A H Friedman ◽  
R E Coleman ◽  
G Akabani ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Brain Tumor ◽  
Brain Tumors ◽  
Phase I ◽  
Phase I Trial ◽  
Hematologic Toxicity ◽  
Metastatic Brain Tumors ◽  
Tumor Patients ◽  
Iodine 131 ◽  
Dose Limiting Toxicity

PURPOSE To determine the maximum-tolerated dose (MTD) of iodine 131 (131I)-labeled 81C6 monoclonal antibody (mAb) in brain tumor patients with surgically created resection cavities (SCRCs) and to identify any objective responses to this treatment. METHODS In this phase I trial, eligible patients were treated with a single injection of 131I-labeled 81C6. Cohorts of three to six patients were treated with escalating dosages of 131I (starting dose of 20 mCi with a 20-mCi escalation in subsequent cohorts) administered through an Ommaya reservoir in the SCRC. Patients were followed up for toxicity and response until death or for a minimum of 1 year after treatment. The SCRC patients, who were previously irradiated, were followed up without additional treatment unless progressive disease was identified. RESULTS We administered 36 treatments of 131I doses up to 120 mCi to 34 previously irradiated patients with recurrent or metastatic brain tumors. Dose-limiting toxicity was reached at 120 mCi and was limited to neurologic or hematologic toxicity. None of the patients treated with less than 120 mCi developed significant neurologic toxicity; one patient developed major hematologic toxicity (MHT). The estimated median survival for patients with glioblastoma multiforme (GBM) and for all patients was 56 and 60 weeks, respectively. CONCLUSION The MTD for administration of 131I-labeled 81C6 into the SCRCs of previously irradiated patients with recurrent primary or metastatic brain tumors was 100 mCi. The dose-limiting toxicity was neurologic toxicity. We are encouraged by the minimal toxicity and survival in this phase I trial. Radiolabeled mAbs may improve the current therapy for brain tumor patients.

scholarly journals SERO-EPIDEMIOLOGICAL STUDY OF HEPATITIS B, C, HIV AND TREPONEMA PALLIDUM AMONG BLOOD DONORS IN HODEIDA CITY- YEMEN

2019 ◽  
Author(s):  
Ahmed Mohsen Al-kadassy ◽  
Abdulmalik Faisal Saleh Al-Ashiry ◽  
Hassan Abdulwahab Al-Shamahy
Keyword(s):  
Blood Transfusion ◽  
Blood Donors ◽  
Blood Donation ◽  
Age Groups ◽  
Treponema Pallidum ◽  
Research Center ◽  
Age Group ◽  
Test Results ◽  
Current Prevalence

Infections transmitted in blood transfusions are the most significant concern associated with blood donation. The purpose of this study was to establish the current prevalence of hepatitis viruses (B and C), HIV and T.pallidium among blood donors at National Blood Transfusion and Research Center (NBTRC) Hodeida Branch, Hodeida city, Yemen. Serological markers of HBV, HCV, HIV 1, 2, T. pallidium antibodies were studied in 25446 (males) using commercially available kits, over a period of 3 years from January 2016 to April 2018 at National Blood Transfusion and Research Center (NBTRC) Hodeida Branch , Hodeida city, Yemen. Also, the prevalence of confirmed-positive test results of these infections was evaluated among different ages. The sero-prevalence of HBV and HCV, HIV, T. pallidium infections based on confirmation tests, were 0.74%, 0.19%, 0.38% and 0.18% respectively. The prevalence of HBV was significantly higher in age groups 37-46 years and 47-56 years with significant associated OR equal to 2.3 (p<0.001) and OR=2.7 (p=0.02) respectively. The prevalence of HCV was significantly higher in age groups 47-56 years with significant associated OR equal to 6.5 (p=0.003). The prevalence of T.pallidium was significantly higher in age group 37-46 years with significant associated OR equal to 3.6 (p<0.001). In conclusion: this study highlights the prevalence of HBV, HCV, HIV, and T. pallidium among different male ages. The prevalence varies from one age group to another, being the lowest among younger and very older age groups. Therefore, extensive recruitment of young donors should help ensure a long-term increase in the blood supply without jeopardizing safety.

scholarly journals CNS Tumors in Adolescents and Young Adults: The Need for a Holistic Specialized Approach

2020 ◽  
Vol 16 (4) ◽  
pp. 155-162 ◽  
Author(s):  
Georgios I. Papageorgiou ◽  
Evangelia D. Razis
Keyword(s):  
Young Adults ◽  
Brain Tumors ◽  
Age Groups ◽  
Unmet Need ◽  
Young Patients ◽  
Adolescents And Young Adults ◽  
Cns Tumors ◽  
Age Group ◽  
Increased Risk ◽  
Common Causes

CNS tumors are one of the most common causes of cancer-related death in the 15- to 39-year-old age group. The management of adolescents and young adults (AYAs) who are diagnosed with brain tumors presents unique endocrine, developmental, and psychosocial issues. AYAs are frequently diagnosed late, after a prolonged period of misdiagnosis. The epidemiology, biology, prognosis, and overall management of these tumors differ from those of both older and younger age groups. AYAs are usually in a transitional phase in their lives, and brain tumors in this age group carry a better prognosis than in older adults; thus, special attention should be paid to survivorship care. Fertility and other treatment-related sequelae that affect the quality of life, as well as the increased risk of secondary malignancies in long-term survivors, are such examples. Although most AYAs are managed by adult or, to a lesser extent pediatric, oncologists, a multidisciplinary approach in the setting of specialized centers with increased participation in clinical trials is preferable. End-of-life and palliative care remain an unmet need for these patients, because most physicians lack the training to discuss such issues with young patients.

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