scholarly journals Preventive effect of hydroalcoholic extract of Vetiveria zizanoides roots on paracetamol induced hepatotoxicity in Wistar albino rats

2018 ◽  
Vol 4 (1) ◽  
pp. 70-73
Author(s):  
Chakradhar T. ◽  
Sarath Babu K.
Keyword(s):  
Albino Rats ◽  
Preventive Effect ◽  
Hydroalcoholic Extract ◽  
Wistar Albino Rats

scholarly journals PREVENTIVE EFFECT OF PHASEOLUS VULGARIS SEED COATS ON PENTYLENETETRAZOLE (PTZ) INDUCED KINDLING AND BEHAVIORAL COMORBIDITIES

2021 ◽  
Vol 3 (4) ◽  
pp. 20-25
Author(s):  
Sarika Chaudhary ◽  
Sagarika Majhi ◽  
Madhu Verma
Keyword(s):  
Phaseolus Vulgaris ◽  
Albino Rats ◽  
Glutathione Level ◽  
Preventive Effect ◽  
Hydroalcoholic Extract ◽  
Nitric Oxide Level ◽  
Anti Oxidant ◽  
Wistar Albino Rats ◽  
The Brain ◽  
Seed Coats

Introduction: To investigate the preventive effect of Phaseolus vulgaris seed coats on pentylenetetrazole-induced kindling and behavioral comorbidities. Material and Methods: Thirty Wistar albino rats were categorized into five groups. The first group received regular saline (0.9 % w/v NaCl) p.o.; the second group received PTZ (35 mg/kg b.w.) i.p.; the third group received valproic acid (200 mg/kg b.w.) p.o.; the fourth group received P. vulgaris extract (100 mg/kg b.w.) p.o.; the fifth group received P. vulgaris extract (200 mg/kg b.w.) p.o. on an alternate day for 21 days. PTZ improved lipid peroxidase levels, decreased Glutathione level, decreased superoxide dismutase activity, increased Nitric Oxide level. Result: This study revealed that P. vulgaris (Hydroalcoholic extract) increased the anti-oxidant level of both 100 mg/kg and 200 mg/kg compared to the PTZ category. Histopathological findings revealed that the hippocampal section of the brain of rats receiving P. vulgaris extract had improved relative to the receiving PTZ group. Conclusion: Based on the result, it is proposed that Phaseolus vulgaris has anti-oxidant properties. This is useful for the treatment of epilepsy.

PHYTOREMEDIAL POTENTIAL OF HYDROALCOHOL EXTRACT OF SEEDS OF SORGHUM BICOLOR AGAINST DRUG-INDUCED NEPHROTOXICITY

INDIAN DRUGS ◽  
2021 ◽  
Vol 58 (07) ◽  
pp. 46-52
Author(s):  
Sreedevi Adikay ◽  
Sai Sruthi Kaveripakam ◽  
Keyword(s):  
Sorghum Bicolor ◽  
Albino Rats ◽  
Prophylactic Regimen ◽  
Drug Induced ◽  
Hydroalcoholic Extract ◽  
Novel Approach ◽  
Nephroprotective Activity ◽  
Wistar Albino Rats ◽  
Immunohistochemical Studies ◽  
The Impact

The gravity of the impact of drug induced nephrotoxicity is more prominent in society. The present study was undertaken to evaluate the potential of hydroalcoholic extract of seeds of Sorghum bicolor against cisplatin and doxorubicin- induced nephrotoxicity in Wistar albino rats. The nephrotoxicity was modeled by intraperitoneal injection of cisplatin (5 mg/kg b.w.) in cisplatin model and doxorubicin (15 mg/kg b.w.) in doxorubicin-induced model in rats. Nephroprotection of hydroalcoholic extract of seeds of S. bicolor was evaluated at two different doses of 200 and 400mg/kg b.w. The nephroprotective activity was assessed by the determination of various serum and urinary parameters, anti-oxidant studies, histological and immunohistochemical studies. The results indicated that injection of cisplatin and doxorubicin led to marked nephrotoxicity in animals. Treatment with extract in cisplatin-induced model resulted in significant nephroprotective activity in a curative regimen whereas in prophylactic regimen the extract prevented the induction of nephrotoxicity only up to a considerable level. But the extract failed to attenuate the doxorubicin induced nephrotoxicity, as evident by biochemical, histological and immunohistochemical studies. From the findings, it is concluded that the seeds of S. bicolor can be used as a novel approach in the treatment of cisplatin-induced nephrotoxicity.

scholarly journals EFFECT OF ARTHROSPIRA PLATENSIS AS A FOOD SUPPLEMENT AGAINST SODIUM FLUORIDEINDUCED INTOXICATION ON SOFT TISSUES OF MALE WISTAR ALBINO RATS

2017 ◽  
Vol 10 (11) ◽  
pp. 133
Author(s):  
Ravindra Reddy Kandula ◽  
Narasimha Jayaveera Korlakunta ◽  
Raghavendra Mitta
Keyword(s):  
Body Weight ◽  
Soft Tissues ◽  
Radical Scavenging ◽  
Arthrospira Platensis ◽  
Albino Rats ◽  
Hydroalcoholic Extract ◽  
Group I ◽  
Liver And Kidney ◽  
Wistar Albino Rats

  Objective: The objective of the present study was to explore the in vitro antioxidant and effect of hydroalcoholic extract of Arthrospira platensis (ASP) against sodium fluoride (NaF)-induced toxic effects on soft tissues (heart, liver, and kidney).Methods: In vitro antioxidant activity was assessed using 1,1-diphenyl-2-picrylhydrazyl radical scavenging, 2,2’-azino-bis(3-ethylbenzothiazoline- 6-sulphonic acid) radical scavenging, metal chelation, total antioxidant and reducing power assays, and total flavonoid and phenol content. In this study, 36 male Wistar albino rats were divided into six groups of six animals each. Animals were served as Group I - normal control, Group II - toxic control, and Groups III, IV, and V - treatment groups, which received hydroalcoholic extract of ASP at doses of 100, 200, and 400 mg/kg body weight (p.o), respectively. Group VI served as plant control received hydroalcoholic extract of ASP at a dose of 400 mg/kg body weight (p.o). All groups except Groups I and VI received NaF (100 ppm) through drinking water for 30 days.Results: Results showed that intoxication of NaF caused significant elevation of serum biomarkers of the heart, liver, and kidney and altered tissue oxidative stress markers’ levels. Administration of hydroalcoholic extract of ASP significantly normalized elevated serum levels of heart (p<0.001), liver (p<0.001, p<0.05), and kidney biomarkers (p<0.001). Decrease in lipid peroxidation and increase in reduced glutathione and catalase enzyme levels in a dose-dependent manner were observed in soft tissues (p<0.001, p<0.01, and p<0.05).Conclusion: The study revealed that ASP has good antioxidant and mitigative action against NaF intoxication on soft tissues.

scholarly journals Protective Effect of Cucurbita maxima against Maximal Electroshock Induced Convulsions

2021 ◽  
pp. 91-101
Author(s):  
Nagnath R. Kadam ◽  
P. K. Mohanty ◽  
Ashish Jain
Keyword(s):  
Protective Effect ◽  
Albino Rats ◽  
Anticonvulsant Effect ◽  
Maximal Electroshock ◽  
Cucurbita Maxima ◽  
Hydroalcoholic Extract ◽  
Indigenous Plant ◽  
Wistar Albino Rats ◽  
Electroshock Seizures ◽  
Different Doses

In the present investigation, an indigenous plant, Cucurbita maxima was studied for its protective effect against maximal electroshock (MES) induced convulsions in Wistar albino rats. The rats were pretreated with different doses (100, 200, 400 mg/kg) of hydroalcoholic extract of seeds of Cucurbita maxima for 14 days and then, they were subjected to maximal electroshock seizures (40 mA for 0.2 sec) treatment. Hydroalcoholic extract of Cucurbita maxima seeds at 200 and 400 mg/kg doses significantly reduced the duration of hind limb extension along with the protection of rats against maximal electroshock induced seizures. The reference standard i.e., phenytoin (20 mg/kg) provided complete protection. Thus, present study revealed anticonvulsant effect of Cucurbita maxima against maximal electroshock-induced convulsions in rats.

scholarly journals Effect of stem bark hydroalcoholic extract of cocoa (T. Cacao) on liver function of Wistar albino rats induced with anaemia

2021 ◽  
Vol 25 (9) ◽  
pp. 1715-1720
Author(s):  
I.M. George-Opuda ◽  
O.A. Adegoke ◽  
O.B. Oluwatayo ◽  
O.B. Odeghe ◽  
J. Ndibe
Keyword(s):  
Liver Function ◽  
Total Protein ◽  
Theobroma Cacao ◽  
Total Bilirubin ◽  
Stem Bark ◽  
Bark Extract ◽  
Albino Rats ◽  
Serum Total Protein ◽  
Hydroalcoholic Extract ◽  
Wistar Albino Rats

The study investigated the effect of stem bark hydroalcoholic extract of cocoa (Theobroma cacao) on liver function of phenlyhydrazine (PHZ)-induced forty anaemic (treated) and normal albino rats divided into 8 groups of five rats each in the study. The activities of marker enzymes such as aspartate amino transferase (AST), alanine amino transferase (ALT) and alkaline phosphatase (ALP), were assayed. In addition serum total protein, total bilirubin, albumin were determined. There was a significantly (p<0.05) decrease in AST of anaemic not treated rats compared to normal control rats with the exception of serum total protein, total bilirubin, direct bilirubin, albumin, ALT and ALP where no significant (p>0.005) change was recorded. In the group (anaemic rats) treated with bark extract of Theobroma cacao at the doses of 100, 200, and 500mg/kg, AST was significantly (p<0.05) reduced while there was significant (p>0.05) increase in serum total protein, total bilirubin, albumin, ALT and ALP. In the group (non anaemic rats) treated with graded doses of the extract 200mg, 500mg and 1000mg, there was a significant (p<0.05) of total bilirubin diect bilirubin, and AST while no significant (p>0.05) change was recorded. The study illustrate that the bark extract of Theobroma cacao possess antioxidant and membrane permeability properties. Dose of Theobroma cacao at 500mg does not have antianaemic potentials.

scholarly journals Protective Effect of Hydroalcoholic Extract of Aloe Vera Supplemented by Zinc on the Testis of Wistar Albino Rats Exposed to Cadmium

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 2128-2133
Author(s):  
Sushanth N K ◽  
Vijayalakshmi S ◽  
Dayanand Reddy G ◽  
Sunil Kumar K N ◽  
Shakila R
Keyword(s):  
Body Weight ◽  
Protective Effect ◽  
Environmental Pollutants ◽  
Aloe Vera ◽  
Reproductive Organs ◽  
Health Concern ◽  
Control Group ◽  
Albino Rats ◽  
Hydroalcoholic Extract ◽  
Wistar Albino Rats

Infertility is a major health concern that may be caused due to inadequate fertility hormones or poor quality of reproductive parameters. The environmental pollutants such as cadmium is one of the causative factors for inducing infertility in men. Cadmium accumulates in various tissues and affects reproductive organs, especially testis which is highly sensitive to cadmium poisoning. In this experiment, protective effect of hydroalcoholic extract (HAE) of Aloe vera with and without zinc has been evaluated. Zinc, protects the testes from damages resulting due to cadmium. Aloe vera is a very good source of antioxidants such as vitamin C and E. In this experiment male Wistar albino rats were grouped into 5. The control group received only the vehicle. Experimental groups were administered in Cd group with 10mg/Kg body weight of CdCl2, in Cd+Zn group 40mg/Kg body weight of CdCl2 and 40mg/Kg bodyweight of ZnCl2, in Cd+AV group 10mg/Kg body weight of CdCl2 and 200mg/Kg body weight of HAE of Aloe vera and in Cd+AV+Zn 10mg/Kg body weight of CdCl2, 200mg/Kg body weight of HAE of Aloe vera and 40mg/Kg bodyweight of ZnCl2. The results showed that cadmium caused extensive testicular damage which was protected by HAE of Aloe vera and zinc. Hence, protective effect of HAE of Aloe vera  was exhibited clearly in cadmium treated rats, however, supplementing Aloe vera with zinc provided better protection.

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