scholarly journals Immune Functional Capability Dynamics Determine Disease Outcomes as in Cancer, Heart Diseases, COVID-19, Etc.

2021 ◽  
Author(s):  
Jianqing Wu ◽  
Ping Zha
Keyword(s):  
Industrial Revolution ◽  
Heart Diseases ◽  
Social Practices ◽  
Toxic Substances ◽  
Immune Functions ◽  
Functional Capabilities ◽  
Disease Outcomes ◽  
Vital Functions ◽  
Number Of Factors ◽  
Tissue Damages

Having proved flaws in using clinical trials to study weak factors, we want to investigate how life factors affect health and diseases. In this study, we show that cancer, heart disease and infectious diseases are inherently preventable and curable. We would like to find how life factors revolving around environment, emotion, activity, disease agents, diets, behaviors, etc. affect disease outcomes. We expand the scope of the immune functions to include functions for removing garbage and repairing tissue damages, and then identify six classes of health properties for evaluating the immune system’s actual functional capabilities. In this model, personal ability to resist infection depends on the immune system’s current functional capabilities, and the ability to resolve existing diseases depends on the immune system’s actual functional capabilities integrated over a relevant time. We show how each life factor affects the immune system’s current functional capabilities by examining its effects on any of the six classes of properties. Many seemingly irrelevant factors can affect disease outcomes because they share biological resources for removing garbage, repairing tissue damages and maintaining all vital functions. Thus, we found that rational strategies for conquering diseases are identifying disease causes, avoiding exposure to disease agents, detoxifying toxic substances, and using seemingly-irrelevant life factors to boost real-time immune functional capabilities and vital organ functions. All chronic diseases including personal resistance to SARS-CoV-2 are influenced by N and M factors, where N represents the number of factors related to disease causes, and M represents the number of factors that influence the immune functional capacities and organ capacities. Most of N factors are pollutants while most of M factors are created social practices that are formed after industrial revolution. It is time to address toxic substances and examine health-ruining social practices in education, employment, business, litigation, promotion, etc. which is responsible for switching on human stress hormones for months and years, with predictable adverse effects on human health.

The development of complications of community-acquired pneumonia of a severe course against the background of parenteral poisoning with a mixture of narcotic substances

2020 ◽  
Vol 22 (4) ◽  
pp. 59-66
Author(s):  
I. N. Gayvoronskiy ◽  
Yu. Sh Khalimov ◽  
S. V. Gayduk ◽  
T. V. Lyanginen ◽  
A. S. Partsernyak ◽  
...  
Keyword(s):  
Young Patient ◽  
Severe Pneumonia ◽  
Modern Medicine ◽  
Multiple Organ ◽  
Community Acquired Pneumonia ◽  
High Tech ◽  
Antibacterial Drug ◽  
Toxic Substances ◽  
Military Medical Academy ◽  
Vital Functions

Doctors of the clinic of military field therapy of the Military Medical Academy named after S.M. Kirov, the experience of successful treatment of community-acquired pneumonia of a severe course with the development of complications against the background of parenteral poisoning with a mixture of narcotic substances in a young patient was obtained. An important feature in the treatment tactics of this patient was the impossibility of antidote therapy with naloxone (a competitive opioid receptor antagonist) due to the presence of signs of respiratory failure, hypoxic and tissue hypoxia. As a result of the systemic treatment in the young patient, it was possible to arrest a significant septic process and multiple organ disorders of vital functions that arose due to severe endotoxic damage. An important factor in ensuring the survival of patients with severe pneumonia against a background of immune depression due to the use of toxic substances is the rational selection of an antibacterial drug or combinations of antibiotic therapy, constant monitoring of vital functions with prompt correction of emerging disorders, as well as the need to use modern high-tech treatment methods. This example clearly shows the need for urgent, systematic and complex intensive care in a number of manipulations performed in people with complications of community-acquired pneumonia, suffering from drug addiction. In addition, it is important to minimize the time from the detection of a poisoned person to the start of emergency measures, as well as their further evacuation to the stage of providing qualified and specialized medical care. Thus, modern medicine continues to face an extremely urgent problem of drug use by the population. A significant number of people with drug dependence syndrome do not seek medical help for various reasons, continuing to use illegal drugs.

scholarly journals Reviewing Effective Factors of Alimentary Deficiency in Animals Reproductive Functions

2021 ◽  
Vol 11 (2) ◽  
pp. 157-169
Author(s):  
Pavlo Skliarov ◽  
Serhiy Fedorenko ◽  
Svitlana Naumenko ◽  
Oleksandr Onyshchenko ◽  
Alina Pasternak ◽  
...  
Keyword(s):  
Reproductive Function ◽  
Optimal Level ◽  
The Body ◽  
Reproductive Capacity ◽  
Toxic Substances ◽  
Prevention Measures ◽  
Animal Reproduction ◽  
Number Of Factors ◽  
Wide Range ◽  
Negative Impacts

Animal reproduction is one of the main factors limiting the efficiency of livestock production. Its optimal level is possibly achieved when certain conditions are created for animals. As reproduction is a complex reflex process depending on neuroendocrine regulatory mechanisms, the character and strength of stimuli, which, in turn, is due to a number of factors. Under normal conditions, the body of animals is affected by many different factors, which are appropriately transformed and specified by positive or negative reactions. Inhibitory factors include air pool, saturated with harmful substances and gases, ionizing radiation, poor water quality along with altered redox properties, hypokinesia combined with poor unbalanced feeding, systematic chronic stress, presence of toxic substances in feed, and the deficiency of vitamins and other bioantioxidants in feed or their excessive spending. Of the wide range of genetic and paratypic factors of negative impacts on reproductive capacity, the most common one is alimentary, which causes impaired reproductive function due to deficiencies in the rules, regulations, and feeding regime of animals. In particular, the alimentary can be associated with both general malnutrition (starvation) and overfeeding (obesity). However, the alimentary form of infertility mostly occurs due to low-quality diets when the diet lacks vital components (mainly vitamins, macro-, and micronutrients) or the quantitative ratios of the ingredients are violated. This is possible even if the total nutritional value of the diet meets the established requirements for the physiological needs of the body. Vitamins, micro-, and macronutrients are ecologically deficient factors of disturbance of animal reproductive function, the influence of which is observed on all processes of reproduction, from fertilization to the postpartum period and the preservation of young animals. The pathogenesis of their insufficiency is associated with the violation of steroido-, gameto-, and embryogenesis and the emergence of ante-, intra-, neo- and postnatal pathologies, respectively. Therefore, treatments and prevention measures should be aimed at providing animals with biologically complete balanced feeding and replenishment of the body with vitamins and minerals. However, all these issues remain incompletely studied and need further research.

scholarly journals International Organizations: the Main Factors of Emergence and Development

2015 ◽  
pp. 102-110
Author(s):  
L. S. Voronkov
Keyword(s):  
International Relations ◽  
International Organizations ◽  
Regional Integration ◽  
Industrial Revolution ◽  
World Politics ◽  
Economic Life ◽  
Civil Society Organizations ◽  
Human Society ◽  
Vital Functions ◽  
Main Factors

The author argues that the emergence of the first permanent intergovernmental (IIGO) and non-governmental (INGO) organizationsin the second half of the XIX-th century was due to common causes. He tries to justify the need to consider them not as independent objects of study, but as the phenomenon, caused by the high level of internationalization of economic life of states and of socio-economic consequences of the industrial revolution, reached in this period. The emergence of IIGOs, based on international treaty, was accompanied by establishment of a large number of INGOs operating in similar fields of human activity, which performed supplementary functions and regulated areas of cooperation and public needs, not covered by interstate agreements. The article presents the main factors that in later stages of internationalization and development of contemporary international relations gave the impetus to emergence and development of international organizations, including the military-technological revolution, that gave birth to mass destruction weapons and avalanche-like growth of the number of human and material losses during wars and military conflicts, the Cold War between world communism and world capitalism, the collapse of the colonial system and formation ofa new main contradiction of the world politics between the "Club of rich countries" and states of the "global periphery", beginning of development of regional integration processes and, finally, the emergence of global problems. The article emphasizes that both IIGOs and INGOs evolved from the supportive tools in implementation of multilateral interaction of sovereign states towards becoming an integral part of contemporary international relations, fulfilling many vital functions of modern human society and its citizens. Given the involvement of the overwhelming majority of modern sovereign states and tens of thousands of civil society organizations in activity of numerical IIGOs and INGOs, none of the existing centers of world power can afford to trample down and to subordinate activities of all these international organizations. The development of IIGOs and INGOs makes any attempts to create a unipolar system of contemporary international relations impossible.

scholarly journals Impairment of T cells’ antiviral and anti-inflammation immunities dominates the death from COVID-19

2021 ◽  
Author(s):  
Luhao Zhang ◽  
Rong Li ◽  
Gang Song ◽  
Gregory D. Scholes ◽  
Zhen-Su She
Keyword(s):  
T Cells ◽  
Clinical Data ◽  
Inflammatory Responses ◽  
Dominant Role ◽  
Cell Number ◽  
Immune Functions ◽  
Virus Clearance ◽  
Cytokine Inhibition ◽  
Tissue Damages ◽  
Positive Correlations

AbstractClarifying key factors dominating the immune heterogeneity from non-survivors to survivors is crucial for therapeutics and vaccine developments against COVID-19. The main difficulty is to quantitatively analyze the multi-level clinical data of viral dynamics, immune response, and tissue damages. Here, we adopt top-down modeling to quantify key functional aspects and their dynamical interplays in the virus-immune system battle, yielding an accurate description of real-time clinical data involving hundreds of patients for the first time. The quantification of antiviral responses demonstrates T cells’ dominant role in the virus clearance relative to antibodies, especially for mild patients (96.5%). Moreover, the anti-inflammatory responses, namely cytokine inhibition rate and tissue repair rate also have positive correlations with T cell number, and are significantly suppressed in non-survivors. Simulations show that impaired immune functions of T cells leads to greater inflammation (thus dominates the death), explaining the monotonous increase of COVID-19 mortality with age and higher mortality for males. We conclude that T cells play the role of crucial immunity that saves the death from COVID-19, which points out a new direction to advance current prevention and treatment by incorporating the vaccines, drugs and health care activities that aim to improve T cells’ number and functions.

scholarly journals PROPOSAL OF THE MODULE FOR EXPERIMENTAL WORKPLACE BASED ON PLATFORM INDUSTRY 4.0

2018 ◽  
pp. 201-209
Author(s):  
Visnovsky Martin ◽  
Rakay Robert ◽  
Galajdova Alena ◽  
Simsik Dusan
Keyword(s):  
Industry 4.0 ◽  
Industrial Revolution ◽  
Automation System ◽  
Laboratory System ◽  
Sensors And Actuators ◽  
Functional Capabilities ◽  
Automation Systems ◽  
Modular Production ◽  
Automation Control ◽  
The Individual

Urgency of the research. New modern trends in the cable industrial communication and exchange of data focus on implementation of new communication standards, protocols and reduced costs. Communication in every automation systems is crucial. Functions of these systems is very important for the correct function of automation system. Target setting. For designing sensor and actuator systems for automation and solving connection between different devices, developers solved this problem with standardized communication like technology IO-Link. This communication technology together with industrial bus create solution for modern communication with quantity of benefits like quick design and diagnostic, unified interface, cost and work reduction. Actual scientific researches and issues analysis. To prepare this paper, we analyzed different solutions for communication between sensors and actuators, different control systems and mechanical solutions. We used knowledge from our previous experiments and choose optimal components and systems for our project. Uninvestigated parts of general matters defining. There are many different types of sensors, actuators, communication interfaces and industrial busses. This paper is insufficient to describe them all. That’s why we’ve only described those, which will be used. The research objective. This article describe the design of a machining module for the FESTO FMS 500 Modular Laboratory System. This module will be physically implemented as part of the revitalization and modernization of the FMS 500 laboratory system at the Department of Automation, Control and Human-Machine Interactions. The statement of basic materials. We follow the trends in industrial automation and the requirements of the 4th Industrial Revolution. This is reason why we use IO-Link technology in combination with Profinet bus for communication with sensors and actuators. Conclusions. The main objective of this article is to approach the design of the Machining Module with Industry 4.0 elements for the Modular Production System FMS 500. This design describe the individual components which will be used. The functions and purpose of the module are also describe, as well as its functional capabilities in terms of diagnostics.

Toxicological Investigation of Drug-Related Cases in Greece: Interpretation of Analytical Findings

2007 ◽  
Vol 26 (3) ◽  
pp. 231-236 ◽  
Author(s):  
Maria Stefanidou ◽  
Constantine Maravelias ◽  
Artemis Dona ◽  
Sotiris Athanaselis ◽  
Hara Spiliopoulou
Keyword(s):  
Drug Metabolism ◽  
Matrix Effect ◽  
Drug Concentration ◽  
Toxic Substances ◽  
Psychoactive Substances ◽  
Chemical Changes ◽  
Vast Number ◽  
Toxicological Analysis ◽  
Number Of Factors ◽  
Toxicological Investigation

The process of toxicological analysis of postmortem specimens can reveal some special difficulty compared to the clinically derived specimens. Many drugs are not stable and the chemical changes that occur in the specimens, due to the hydrolysis processing, the time passed, the drug metabolism, and matrix effect, even when the postmortem interval is short, may affect the interpretation of the toxicological results. This interpretation may be critical, not only to the thorough investigation of different kind of forensic cases, but also to clinical or other cases as it provides very significant challenges to the scientists. This article reviews (a) particular toxicological issues associated with some toxic substances responsible for common lethal or nonlethal poisonings, such as opiates, cannabis, and cocaine and the vast number of factors that affect drug concentration; and (b) focuses on toxicological issues associated with the analytical findings of certain postmortem specimens. The toxic substances cited in the present paper are the most commonly found in forensic cases in Greece. The investigation of these drug-related deaths has revealed that heroin, alone or in combination with other psychoactive substances, such as cannabis and cocaine, is the main drug involved in these deaths.

scholarly journals The role of STIM and ORAI proteins in phagocytic immune cells

2016 ◽  
Vol 310 (7) ◽  
pp. C496-C508 ◽  
Author(s):  
Nicolas Demaurex ◽  
Paula Nunes
Keyword(s):  
Dendritic Cells ◽  
Immune Cells ◽  
Adaptive Immune System ◽  
Innate Immune ◽  
Toxic Substances ◽  
Immune Functions ◽  
Phagocytic Cells ◽  
Major Pathway ◽  
Physiological Impact ◽  
Molecular Components

Phagocytic cells, such as neutrophils, macrophages, and dendritic cells, migrate to sites of infection or damage and are integral to innate immunity through two main mechanisms. The first is to directly neutralize foreign agents and damaged or infected cells by secreting toxic substances or ingesting them through phagocytosis. The second is to alert the adaptive immune system through the secretion of cytokines and the presentation of the ingested materials as antigens, inducing T cell maturation into helper, cytotoxic, or regulatory phenotypes. While calcium signaling has been implicated in numerous phagocyte functions, including differentiation, maturation, migration, secretion, and phagocytosis, the molecular components that mediate these Ca2+signals have been elusive. The discovery of the STIM and ORAI proteins has allowed researchers to begin clarifying the mechanisms and physiological impact of store-operated Ca2+entry, the major pathway for generating calcium signals in innate immune cells. Here, we review evidence from cell lines and mouse models linking STIM and ORAI proteins to the control of specific innate immune functions of neutrophils, macrophages, and dendritic cells.

scholarly journals Physiological and Immune Functions of Punicalagin

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2150
Author(s):  
Eva Venusova ◽  
Adriana Kolesarova ◽  
Pavel Horky ◽  
Petr Slama
Keyword(s):  
Tumor Cells ◽  
Antiproliferative Activity ◽  
Punica Granatum ◽  
Toxic Substances ◽  
Immune Functions ◽  
Immune Reactions ◽  
Inflammatory Pathways ◽  
Anti Inflammatory ◽  
Antioxidant Effects

The aim of this publication is to compile a summary of the findings regarding punicalagin in various tissues described thus far in the literature, with an emphasis on the effect of this substance on immune reactions. Punicalagin (PUN) is an ellagitannin found in the peel of pomegranate (Punica granatum). It is a polyphenol with proven antioxidant, hepatoprotective, anti-atherosclerotic and chemopreventive activities, antiproliferative activity against tumor cells; it inhibits inflammatory pathways and the action of toxic substances, and is highly tolerated. This work describes the source, metabolism, functions and effects of punicalagin, its derivatives and metabolites. Furthermore, its anti-inflammatory and antioxidant effects are described.

scholarly journals Initiatives for Building Infrastructure For Preventing and Curing 90% of Chronic Diseases and Saving Lives on The Planet

2021 ◽  
Author(s):  
Jianqing Wu
Keyword(s):  
Chronic Diseases ◽  
Heart Diseases ◽  
Toxic Substances ◽  
Infectious Agents ◽  
Human Beings ◽  
Joint Effort ◽  
Human Survival ◽  
The Past ◽  
Mental Diseases ◽  
Harsh Climate

This proposal is presented to several states to explore the possible joint effort to establish a health infrastructure in support of a health culture that will enable state residents and U.S. Citizens to avoid more than 90% of chronic diseases including heart diseases, cancer, mental diseases, rare diseases, etc. As shown in the proposal, the proposed infrastructure or its equivalent is the only measure for addressing challenging human health problems. This infrastructure will enable human beings to survive from overwhelming disease agents from toxic substances to infectious agents to harsh climate. Our researches have firmly established that adverse effects of all disease agents in our planet are one to several orders of magnitude larger than what has been recognized and understood in the past. Past studies failed to provide strong warning on the danger of the massive disease agents on human survival. The proposed measure is not an option, and nor a political choice, but a required measure for finding cures for chronic diseases and human survival.

Critical Study Of Ischemic Heart Disease W.S.R. To Ayurvedokta Shatkriyakala

2019 ◽  
Vol 7 (01) ◽  
Author(s):  
Subhash Waghe ◽  
Sanjay P. Deshmukh ◽  
Pradnya P. Thakre
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Heart Diseases ◽  
Point Of View ◽  
Ischemic Heart ◽  
Critical Study ◽  
Unhealthy Lifestyle ◽  
Number Of Factors ◽  
Fatty Food ◽  
Principles Of Treatment

The death due to ischemic heart disease is increasing in Indian population at an alarming rate and accounts for around 15-20% of all deaths. The number of factors play role in the development of ischemic heart diseases but over consumption of oily fatty food and unhealthy lifestyle (mithya ahar vihar) with mental stress are the important basic factors enumerated by both the science. Shatkriya Kala is a unique pathological concept in Ayurveda developed with aim of treating the diseases at various stages of pathogesnesis. Ancient Ayurvedic acharyas had stated 6 such stages of therapeutic intervention with reference to six stages of pathogenesis namely sanchaya, prakopa, prasara, sthansanshraya, vyakti and bheda.. If disease is treated in early stages, it does not lead to complications. Hence, it is essential to apply the Ayurvedic concept of pathogenesis like ‘Shat Kriyakala’  to ischemic heart disease so as to study it from Ayurvedic pathological point of view and to evolve a strategy to deal with it, based on the Ayurvedokta principles of treatment particularly in terms of shatkriyakalas. The study of ischemic heart disease with reference to Shat Kriyakala, showed that the pathogenesis of ischemic heart disease can very well be arranged in Ayurvedokta  six stages of Shat Kriyakala and treatment could be framed as per different stages. With the help of modern investigations, these six stages could be confirmed.

Sign in / Sign up

Export Citation Format

Share Document