scholarly journals On the way to COVID-19 vaccine development: tireless efforts and outcomes

2020 ◽  
Vol 1 (2) ◽  
pp. 3-8
Author(s):  
Tapas Pramanik ◽  
Tapas Kumar Sur
Keyword(s):  
Vaccine Development ◽  
Viral Vector ◽  
Virus Disease ◽  
Large Population ◽  
Pharmaceutical Companies ◽  
Protein Subunit ◽  
Huge Number ◽  
Vaccine Candidates ◽  
Corona Virus ◽  
The World

Novel corona virus disease (COVID-19), since its emergence in November 2019, took the toll of a huge number of human lives. It is a β-corona-virus also known as SARS-CoV2. The safest and most effective way to prevent the disease is definitely vaccination amongst the large population. To the best of our knowledge, more than 200 vaccine candidates for COVID-19 were developed by the scientists of research institutions and pharmaceutical companies and nearly 52 candidates were in human trials. Till now, only 15 vaccines are being offered to the general population in the world, out of which 2 vaccines are RNA, 6 are conventional inactivated, 5 viral vector and 2 protein subunit. Here, we tried to unfold the events and efforts behind the successes of new innovations of COVID-19 vaccines, the world has achieved yet.

scholarly journals Eksistensi Perjanjian Ditengah Pandemi Covid-19

2020 ◽  
Vol 1 (1) ◽  
pp. 33
Author(s):  
Kunarso Kunarso ◽  
A Djoko Sumaryanto
Keyword(s):  
Research Method ◽  
Virus Disease ◽  
Human Life ◽  
Large Population ◽  
The State ◽  
Legal Research ◽  
Conceptual Approach ◽  
Corona Virus ◽  
Force Majeure ◽  
The World

Corona Virus Disease-19 (COVID-19) has a significant impact on all aspects of human life in the world, especially in Indonesia which is very large in area and has a large population (around 267 million people) with different kinds of professions. The purpose of this study is to focus on civil matters, with more emphasis on the problem of agreements that are influenced by Covid-19. The normative legal research method uses a statutory approach, and a conceptual approach to force majeure and describes an analysis (analytical descriptive). The results showed that the agreement in the state of the Covid-19 outbreak greatly influenced the implementation of the agreement set and agreed upon by the parties, because the agreement binds the parties, so the parties are subject to the contents of the agreement.

scholarly journals COVID-19: Insights into Potential Vaccines

2021 ◽  
Vol 9 (3) ◽  
pp. 605
Author(s):  
Ke-Yan Loo ◽  
Vengadesh Letchumanan ◽  
Hooi-Leng Ser ◽  
Siew Li Teoh ◽  
Jodi Woan-Fei Law ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Viral Vector ◽  
Phase Iii ◽  
Effective Vaccine ◽  
Pharmaceutical Companies ◽  
Protein Subunit ◽  
Subunit Vaccines ◽  
Vaccine Candidates ◽  
Phase Iii Clinical Trials ◽  
Positive Results

People around the world ushered in the new year 2021 with a fear of COVID-19, as family members have lost their loved ones to the disease. Millions of people have been infected, and the livelihood of many has been jeopardized due to the pandemic. Pharmaceutical companies are racing against time to develop an effective vaccine to protect against COVID-19. Researchers have developed various types of candidate vaccines with the release of the genetic sequence of the SARS-CoV-2 virus in January. These include inactivated viral vaccines, protein subunit vaccines, mRNA vaccines, and recombinant viral vector vaccines. To date, several vaccines have been authorized for emergency use and they have been administered in countries across the globe. Meanwhile, there are also vaccine candidates in Phase III clinical trials awaiting results and approval from authorities. These candidates have shown positive results in the previous stages of the trials, whereby they could induce an immune response with minimal side effects in the participants. This review aims to discuss the different vaccine platforms and the clinical trials of the candidate vaccines.

scholarly journals The Recent Updates on Approaches and Clinical Trials Status of Covid-19 Vaccines Developed Globally

2021 ◽  
Vol 14 (3) ◽  
pp. 1109-1124
Author(s):  
Sachin Chaudhary ◽  
Abdel-Nasser El-Shorbagi ◽  
Ramesh Kumar Gupta ◽  
Amit Kumar
Keyword(s):  
Clinical Trial ◽  
Vaccine Development ◽  
Viral Vector ◽  
Human Life ◽  
World Health ◽  
Protein Subunit ◽  
The World ◽  
Precautionary Measures ◽  
Health Organization ◽  
Trial Phase

The Covid-19 pandemic since 2019 has imparted a massive influence on the human life around the world, irrespective of all the precautionary measures followed worldwide it is strongly suggested that only the effective and safer vaccine can control this vicious pandemic. Nevertheless, the vaccine development strategies for Covid-19 was initiated firstly in china after the outbreak of Covid-19 and then globally after it was declared as pandemic by World Health Organization. Currently, numerous platforms have been designed for developing the most efficacious and safe vaccines designed by different technologies including protein subunit, viral vector, RNA, DNA, inactivated, and live attenuated approach. Here, this review will illustrates the detailed information on above mentioned Covid-19 vaccines development technologies, protocols and their clinical trial phase status. Additionally, this review also includes the details of vaccines failed to progress further.

scholarly journals SARS-CoV-2 vaccines strategies: a comprehensive review of phase 3 candidates

npj Vaccines ◽  
2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Nikolaos C. Kyriakidis ◽  
Andrés López-Cortés ◽  
Eduardo Vásconez González ◽  
Alejandra Barreto Grimaldos ◽  
Esteban Ortiz Prado
Keyword(s):  
Neutralizing Antibodies ◽  
Large Scale ◽  
Vaccine Development ◽  
Rna Virus ◽  
Protein S ◽  
Effective Vaccine ◽  
Phase 3 ◽  
Vaccine Candidates ◽  
Advantages And Disadvantages ◽  
The World

AbstractThe new SARS-CoV-2 virus is an RNA virus that belongs to the Coronaviridae family and causes COVID-19 disease. The newly sequenced virus appears to originate in China and rapidly spread throughout the world, becoming a pandemic that, until January 5th, 2021, has caused more than 1,866,000 deaths. Hence, laboratories worldwide are developing an effective vaccine against this disease, which will be essential to reduce morbidity and mortality. Currently, there more than 64 vaccine candidates, most of them aiming to induce neutralizing antibodies against the spike protein (S). These antibodies will prevent uptake through the human ACE-2 receptor, thereby limiting viral entrance. Different vaccine platforms are being used for vaccine development, each one presenting several advantages and disadvantages. Thus far, thirteen vaccine candidates are being tested in Phase 3 clinical trials; therefore, it is closer to receiving approval or authorization for large-scale immunizations.

Hospitalitas Kristen Yang Hampir Hilang Pada Kasus Kematian Salah Satu Anggota Masyarakat Di Dusun Beringin, Luwu Utara, Sulawesi Selatan Akibat Covid-19

2021 ◽  
Author(s):  
desna rura sarapang
Keyword(s):  
Virus Disease ◽  
Social Distancing ◽  
Indonesian Government ◽  
Risk Of Death ◽  
The Earth ◽  
Corona Virus ◽  
The World ◽  
Global World ◽  
The Impact ◽  
Christian Hospitality

The emergence of a new virus in the global world at the end of 2019, namely Corona Virus Disease 2019, brought tremendous excitement to all inhabitants of the earth. The emergence of this virus brings tremendous concern and fear to the world because the spread of this virus is quite fast, even the most frightening is that the risk of death of people exposed to this virus is very large. Indonesia itself, cannot avoid the impact of this Covid-19 case. As a form of efforts to prevent and minimize transmission of the virus, the Indonesian government has issued a social distancing / physical distancing recommendation. This situation also causes the interaction between communities to be very limited. This situation seems to be able to eliminate hospitality among the community. This paper aims to emphasize the importance of maintaining the value of Christian hospitality in society amid the Covid-19 pandemic.

scholarly journals The Effect of COVID-19 on Hospitalized Cancer Patients and Their Healthcare

2021 ◽  
pp. 699-703
Author(s):  
Jahnvi Garg ◽  
Ranjit S. Ambad ◽  
Nandkishor Bankar
Keyword(s):  
Cancer Patients ◽  
Virus Disease ◽  
Rt Pcr ◽  
Vulnerable Group ◽  
Healthcare Facilities ◽  
Corona Virus ◽  
Global Pandemic ◽  
The World ◽  
Utmost Care ◽  
Staying At Home

Introduction: This article includes the effect of Corona virus disease on cancer patients and their healthcare facilities. The global pandemic mentioned around the world has impacted the most vulnerable group of patients- cancer. With the assistance of RT PCR tests and HRCT, oncologists and doctors have tried to provide treatment to Covid-19 patients. Cancer patients are more susceptible to Covid-19 than non-cancer or non-survivor patients, according to reports. To avoid the prevalence and infection of cancer victims, WHO has suggested staying at home and continuing their treatment through telemedicine unless the situation is critical for which they might require therapy and/or surgery. Covid-19 is here to stay so we should practice with utmost care and precaution.

Coronavirus and Fingerprint Technology

2021 ◽  
Vol 13 (4) ◽  
pp. 1-16
Author(s):  
Gabriel B. Iwasokun
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Viral Infection ◽  
Virus Disease ◽  
High Rate ◽  
Corona Virus ◽  
The World ◽  
Almost All

The corona virus disease, otherwise known as COVID-19, is an extremely communicable and pathogenic viral infection caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), which emerged in Wuhan, China in December 2019 and has spread to almost all the countries in the world. The transmission of the virus is through touching of the nose, eyes, or mouth by a finger that has been contaminated through droplets on a surface when a carrier sneezes or coughs. Since the existing fingerprint devices are predominantly contact based, it implies that they can aid in the transmission of the virus. This paper discusses the application of fingerprint devices in notable places with high rate of COVID-19 infection as well as the threats to fingerprint technologies and the countermeasures. The need to change focus and orientation towards contactless biometric technologies as sure solution to the fear and animosity expressed towards contact-based fingerprint technology is also expatiated.

Challenges in the Management of COVID-19 Patients with Metabolic Syndrome with Special Emphasis on Gender and Age - A Review

2021 ◽  
Vol 8 (38) ◽  
pp. 3401-3405
Author(s):  
Arunima Chaudhuri ◽  
Suhrita Paul ◽  
Tapas Ghosh
Keyword(s):  
Metabolic Syndrome ◽  
Virus Disease ◽  
Adult Population ◽  
Density Lipoprotein ◽  
Blood Stream ◽  
Low Grade ◽  
Corona Virus ◽  
Gender And Age ◽  
The World ◽  
Low Grade Inflammation

BACKGROUND The corona virus disease-19 (Covid-19) pandemic has put human civilization into a huge challenge, especially in the field of medicine in the management of patients with co-morbidities. Health authorities across the world depend greatly on reliable data to make major decisions and this is especially true during this global pandemic. The present review was conducted to estimate the challenges in the management of Covid-19 patients with metabolic syndrome with special emphasis on gender and age. Patients having pre-existing health conditions e.g., heart disease, diabetes are at higher risk of morbidity and mortality due to COVID-19. According to the WHO newsletter, COVID-19 has tragically claimed more than 1.5 million lives. The burden of obesity across the world has nearly tripled since 1975. In 2016, 1.9 billion adults, were overweight; 650 million were obese; 13 % of the world's adult population (11 % of males and 15 % of females) were obese in 2016. Obesity has been observed to be a high-risk factor for COVID-19 severity. Severe acute respiratory syndrome-corona virus-2 (SARS-CoV-2) targets the angiotensinconverting enzyme 2 (ACE2) for cell entry and ACE2 is highly expressed in adipose tissue. This suggests an important role for the tissue in determining COVID-19 disease severity in obese individuals.1-2 There has been an increase in death from diabetes by 70 % globally between 2000 and 2019, and an 80 % rise in deaths among males has been observed. Metabolic syndrome comprises three or more of the following factors: increased waist circumference; hypertriglyceridemia; elevated blood pressure; reduced high-density lipoprotein cholesterol; hyperglycemia.1-2 Visceral fat is known to produce higher concentrations of proinflammatory cytokines. These are then released in the bloodstream. Release of proinflammatory markers in blood stream may cause auto-amplifying cytokine production (“cytokine storms”) and low-grade inflammation. Cytokine storm and low-grade inflammation can contribute to worsening of COVID-19 patients with obesity. Components of metabolic syndrome such as hypertension, type 2 diabetes mellitus (T2DM), and obesity are highly prevalent among the general population and have been observed to significantly increase the risk of hospitalization and mortality in COVID-19 patients.1-2 KEYWORDS Covid-19 Pandemic, Metabolic syndrome, Aging, Gender

Dampak Wabah Corona Virus Disease Terhadap Budaya Ibadah Umat Muslim Dan Kebijakan Pemerintah

2020 ◽  
Vol 1 (2) ◽  
pp. 131-143
Author(s):  
Rif’at Ayu Wijdan Irham ◽  
A. Khawarizmi Siregar ◽  
Hasse Jubba
Keyword(s):  
Qualitative Study ◽  
Virus Disease ◽  
Religious Leaders ◽  
Corona Virus ◽  
Islamic Jurisprudence ◽  
The World ◽  
The Government

This paper aims to see how the response of Muslims and the government related to the Covid-19 pandemic that occurred throughout the world. This research is a qualitative study of document studies using sources consisting of publications. Muslims believe in this pandemic originating from Allah SWT, but Muslims are expected not to react to it too much and make this phenomenon to increase the capital of God for the Almighty God, Islamic jurisprudence can help find solutions to overcome it. Covid-19 Pandemic. The government as a leader in this country has implemented a policy related to the reduction of Covid-19. Many people who respond to the policies set by the government do not believe also because they oppose the government because of the lack of education by the government and Indonesian religious leaders.

Psychosocial Effects and Panic Regarding Corona Virus

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1689-1694
Author(s):  
Amir Ali
Keyword(s):  
Virus Disease ◽  
Medical Services ◽  
Way Of Life ◽  
Psychosocial Effects ◽  
Web Based ◽  
Corona Virus ◽  
Economic Weight ◽  
The World ◽  
Novel Coronavirus

After the hike of the Coronavirus from the country of China in the end of the previous year, Novel Coronavirus accounts for a total of about 46 million cases all around the world with the death of more than 1.28 million individuals & 31.8 million recoveries. Besides its extraordinary infectivity & casualty rates, Corona Virus Disease has caused widespread panic, economic weight & budgetary misfortunes. Mass terror of CORONA VIRUS, named as "corona phobia", has made an adequate mental indications in over-all population. Along these lines, this audit has been embraced to characterize panic consequence of CORONA Virus. The quarantine can create extreme anger, nervousness, accumulating, psychological illness & sadness. Strengthened through an "infodemic" extent through a various foundation in web-based broadcasting. Upheavals bigotry, defamation, & tolerance against specific networks remain additionally being broadly detailed. All things considered, bleeding-edge medical services laborers are at higher danger of getting the illness just as encountering unfriendly mental results in a type of burnout, tension, fear of communicating contamination, a sentiment of contrariness, wretchedness, & extended substance-reliance. Network-based alleviation projects to battle coronavirus will upset youngster normal way of life & may cause flowery psychological depression. Networks remain pretentious by disease in several manners & want exceptional consideration. 

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