scholarly journals Prospects for the use of exogenous polyprenols in the complex therapy and prevention of pathologies of the hepatobiliary system. Updating scientific data

2020 ◽  
pp. 170-175
Author(s):  
Emilia Mikhailova ◽  
Denis Lokoshko ◽  
Elizaveta Bolshakova
Keyword(s):  
Medical Practice ◽  
Liver Diseases ◽  
Scientific Data ◽  
Basic Information ◽  
Plant Origin ◽  
Hepatobiliary System ◽  
Complex Therapy

The article presents the basic information about polyprenols of plant origin, as well as summarizes the scientific experience accumulated to date of their use as hepatoprotectors and means of preventing liver diseases. The conclusion is made about the relevance of their use in everyday medical practice.

Hepatocorbidity in psoriasis

2021 ◽  
pp. 7-11
Author(s):  
M. A. Koroleva
Keyword(s):  
Diabetes Mellitus ◽  
Psoriatic Arthritis ◽  
Mental Disorders ◽  
Cardiovascular System ◽  
Liver Damage ◽  
Liver Diseases ◽  
Hepatobiliary System ◽  
Immunological Mechanisms ◽  
Bowel Diseases ◽  
Comorbid Diseases

Тhe well-known manifestations in psoriasis include psoriatic arthritis and psoriasis of the nails, however, at present, other conditions comorbid to psoriasis have begun to be actively studied: such as liver diseases, diabetes mellitus, diseases of the cardiovascular system, obesity, mental disorders, inflmmatory bowel diseases. and joints. In addition to similar immunological mechanisms, genes have been found that are common to psoriasis and the comorbid diseases associated with it. The article provides data on dysfunctions of the hepatobiliary system in patients with psoriasis. The article reveals the results of studies conducted by foreign and domestic authors, which have shown signifiant relationships in the severity of liver damage in psoriasis.

scholarly journals Biochemical study of hepatoprotective collection of plant origin

2019 ◽  
Vol 59 (7) ◽  
pp. 134-141
Author(s):  
Anatoly A. Lapin ◽  
◽  
Irek G. Garifullin ◽  
Valery N. Zelenkov ◽  
◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Liver Diseases ◽  
Biochemical Study ◽  
Water Extract ◽  
Total Antioxidant Activity ◽  
Plant Origin ◽  
Treatment And Prevention ◽  
Total Antioxidant ◽  
The Individual ◽  
Metabolic Regulators

The article presents the results of biochemical studies of the total antioxidant activity of the hepatoprotective collection of plant origin and its individual components, which show that it consists of birch leaves (Betulae folia), tansy flowers (Tanaceti flores), phytohepatol No. 2 (choleretic collection No. 2) and individual its components have pronounced antioxidant activity. More antioxidant activity founded in tansy and true hepatoprotective collection. Comparative tests of the flowers of meadowsweet, with the highest antioxidant activity, showed the promise of their use in the collections of medicinal plants as effective natural metabolic regulators. The total antioxidant activity of the water extract collection at 13.56% rel. exceeded the calculated value obtained by summing the activities of the individual components of the collection, which indicates the presence of synergism in their action, which may be of value for use in the treatment and prevention of liver diseases. When all components of the drug collection are finished, the indicator increases by 11-24 % rel., which indicates the thermal stability of the antioxidant substances that make up their composition. In the oxidation of aqueous extracts of the components of hepatoprotective collection with hydrogen peroxide, the most stable were antioxidants of birch leaves. It was found that collection only at a ratio of 7.7 g per liter of water shows synergism (15 % rel.), and the rest of all the samples we tested are antagonistic. The detected increase in the antioxidant activity of the new collection compared with the effects of its individual components allows us to consider it as a promising dosage form for use in the treatment and prevention of liver diseases.

scholarly journals Investigation of the hepatoprotective properties of “Phytovenol” capsules on the model of medicamentous hepatitis in rats

2014 ◽  
Vol 27 (4) ◽  
pp. 240-242
Author(s):  
Oleg Gerush ◽  
Olena Lenytska ◽  
Larysa Yakovleva ◽  
Liudmyla Gladkova ◽  
Igor Gerush
Keyword(s):  
Pharmacological Activity ◽  
Medical Practice ◽  
Liver Diseases ◽  
Scientific Paper ◽  
Hepatoprotective Effect ◽  
Experimental Conditions ◽  
Medical Preparation ◽  
Quality Of Treatment ◽  
First Time

Abstract This scientific paper is an investigation of the pharmacological activity of the new medical preparation “Phytovenol” (capsules in the dose of 150 mg/kg) on the pattern of hepatitis in rats induced by paracetamol administration. The authors of the article, for the first time under experimental conditions, detected a hepatoprotective effect that was brought about by “Phytovenol” capsule administration. This is realized due to the antioxidant, antitoxic and anticytolytic activity of the examined medicine. The study found that its efficacy is not lower than the classical hepatoprotector - “Silibor” tablets. The results obtained suggest that it is possible to extend the range of available hepatoprotectors and improve the quality of treatment for liver diseases, by introducing “Phytovenol” capsules into medical practice.

SWEET SAWBERRY (Comarum Palustre L.) IN MEDICAL PRACTICE (literature review)

2020 ◽  
Vol 5 (4) ◽  
pp. 66-70 ◽  
Author(s):  
V. Platonov ◽  
Aleksandr Hadarcev ◽  
Elena Belyaeva
Keyword(s):  
Chemical Composition ◽  
Medical Practice ◽  
Clinical Medicine ◽  
Biologically Active ◽  
General Description ◽  
Plant Origin ◽  
Comarum Palustre ◽  
Practice Literature ◽  
Active Substances

The review substantiates the use of biologically active substances of plant origin, derived from marsh saber, common on the territory of Russia – in various sections of clinical medicine. The General description and zones of its distribution, possibilities of extraction of Sabel-nick rhizomes are given. The chemical composition was charac-terized and the role of proanthocyanidins in the anti-inflammatory effects of sabelnik was clarified. The possibility of obtaining various medicinal forms of drugs from the rhizomes of sabelnik is shown. A well-known range of applications in medical practice for lesions of the musculoskeletal system, arthrosis and arthritis, nephropathy, after transurethral resection of the prostate, etc.

L-CARNITINE IN MEDICAL PRACTICE: NEW VIEWS ON THE USE IN THE CURRENT REALITY AND FOR THE FUTURE (LITERATURE REVIEW AND OWN DATA)

Fitoterapia ◽  
2020 ◽  
Vol 3 (3) ◽  
pp. 5-11
Author(s):  
A. I. Voloshуn ◽  
◽  
L. A. Voloshуnа ◽  
V. L. Vasyuk ◽  
N. V. Bachuk-Ponуch ◽  
...  
Keyword(s):  
Medical Practice ◽  
Age Groups ◽  
Scientific Data ◽  
Scientific Databases ◽  
Complex Agent ◽  
Wide Range ◽  
Almost All ◽  
Positive Effect ◽  
Positive Results ◽  
Current Reality

Keywords: L-carnitine, poly- and comorbidity, postcoid syndrome, application prospects. Purpose – to analyze scientific data on the use of drugs with L-carnitine in medical practice and the prospects for its use in patients with poly- and comorbidity. Material and methods. Conducted scientific search in printed and electronic publications, search scientific databases using methods of analysis, comparison and generalization. Preliminary results of the use of one of the L-carnitine agents in patients with postcoid syndrome are presented. Results. Information material testifies to a wide range of applications of drugs with L-carnitine in various fields of medicine, age groups from newborns to old age, with the most common lesions of almost all organs and systems. The thorough mechanisms of the positive effect of L-carnitine , including dysfunctions of cellular mitochondria, have been disclosed and give grounds for widespread use in patients with poly- and comorbidity or other systemic diseases.In this aspect, the use of multicomponent preparations based on L-carnitine with qualities complementary to its properties seems promising. The authors used a complex agent of L-carnitine, zinc and selenium in patients with postcovid syndrome and obtained significant positive results. Conclusion. Mono- and multi-component L-carnitine agents, reinforced by other active factors, are promising in the complex treatment of patients with poly- and comorbidity, symptoms of postcoid syndrome as adjuvants.

EXPERIENCE OF USING A CELLULAR ENERGY PROTECTOR IN THE COMPLEX TREATMENT OF ACUTE KIDNEY INJURY IN AN ADOLESCENT WITH METAMIZOLE POISONING

2021 ◽  
Vol 100 (3) ◽  
pp. 283-288
Author(s):  
L.А. Kovalenko ◽  
◽  
O.L. Chugunova ◽  
G.N. Sukhodolova ◽  
O.I. Yaroshevskaya ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Renal Function ◽  
Conservative Treatment ◽  
Effective Treatment ◽  
Medical Practice ◽  
Pediatric Patients ◽  
Kidney Injury ◽  
Complex Treatment ◽  
Cellular Energy ◽  
Complex Therapy

Every year, 1,700–1,850 pediatric patients apply to the Department of Toxicology of Filatov Children's City Clinical Hospital for specialized medical care. More than 56% of hospitalizations are caused by medicinal poisoning. One of the serious complications of drug intoxication is acute kidney injury (AKI). The incidence of AKI in acute chemical poisoning in childhood is from 10 to 57,6% according to various authors, therefore, the issues of effective treatment of AKI in the medical practice of doctor of any specialty are extremely relevant. The article presents the case of conservative treatment of AKI stage 3 according to the KDIGO classification in a teenager with metamizole poisoning, including inclusion of «Cytoflavin» cellular energy protector as a part of complex therapy. As a result of the treatment, the level of proteinuria and azotemia in the child has decreased. The rate of tuber filtration has increased from 20,0 to 62,4 ml/min/1,73 m2. Thus, the use of a cellular energy protector contributed to effective restoration of renal function.

scholarly journals Effect of complex therapy with Cortexin on the state of the body’s regulatory systems in patients with rosacea

2020 ◽  
Vol 6 (1) ◽  
pp. 21-27
Author(s):  
Alexandra A. Bobrakova
Keyword(s):  
Immune System ◽  
Antioxidant System ◽  
Clinical Effect ◽  
Clinical Manifestations ◽  
The State ◽  
Interleukin 12 ◽  
Traditional Treatment ◽  
Corrective Effect ◽  
Hepatobiliary System ◽  
Complex Therapy

Introduction: For treating patients with rosacea, it is important to study the effectiveness of drugs with both neuromodulating activity and immunomodulatory properties. The aim of the study is to examine the nature of biochemical parameters, the state of the blood antioxidant system, and the state of the immune system in patients with rosacea before and after a traditional treatment and the treatment using Cortexin. Materials and methods: 216 people participated in the study. All the patients received a traditional therapy. The patients in the study group additionally received Cortexin at a dose of 10 mg intramuscularly № 10. The clinical examination of the patients included a thorough collection of complaints, life histories, medical histories, and physical examination. The state of the skin, the hepatobiliary system, the blood antioxidant system, the immune and the endocrine systems were studied in detail. Results and discussion: The therapy using Cortexin made it possible to achieve a better clinical effect in terms of dermatological status. Thanks to the innovative treatment, 40% of the patients got rid of the clinical manifestations of the disease, and none of patients was reъъported to have no clinical effect. The patients with rosacea had disorders in the hepatobiliary system, an imbalance in the lipid peroxidation system and in the blood antioxidant system, as well as hyperactivation of the cellular and humoral parts of the immune system. The therapy with Cortexin did not have a significant advantage over the traditional treatment in the processes of normalization of the hepatobiliary system and the antioxidant system of the blood. However, Cortexin, being a complex of natural low-molecular-weight peptides, had a corrective effect on the cellular and humoral parts of the immune system. Unlike the traditional treatment, which maintained elevated levels of helper T-lymphocytes, lymphocytic index and interleukin 12, against the background of a slightly reduced level of T-lymphocyte suppressors. Conclusion: As a result of the Cortexin use in complex therapy, the patients with rosacea had a faster normalization of their dermatological and immune statuses.

scholarly journals A Review of Hepatoprotective Plants Used in Saudi Traditional Medicine

2014 ◽  
Vol 2014 ◽  
pp. 1-22 ◽  
Author(s):  
Abdulrahman K. Al-Asmari ◽  
Abdulrahman M. Al-Elaiwi ◽  
Md Tanwir Athar ◽  
Mohammad Tariq ◽  
Ahmed Al Eid ◽  
...  
Keyword(s):  
Traditional Medicine ◽  
Liver Diseases ◽  
Chemical Constituents ◽  
Scientific Data ◽  
Toxicity Data ◽  
Herbal Products ◽  
Medicinal Uses ◽  
Safety And Efficacy ◽  
The World ◽  
New Compounds

Liver disease is one of the major causes of morbidity and mortality across the world. According to WHO estimates, about 500 million people are living with chronic hepatitis infections resulting in the death of over one million people annually. Medicinal plants serve as a vital source of potentially useful new compounds for the development of effective therapy to combat liver problems. Moreover herbal products have the advantage of better affordability and acceptability, better compatibility with the human body, and minimal side effects and is easier to store. In this review attempt has been made to summarize the scientific data published on hepatoprotective plants used in Saudi Arabian traditional medicine. The information includes medicinal uses of the plants, distribution in Saudi Arabia, ethnopharmacological profile, possible mechanism of action, chemical constituents, and toxicity data. Comprehensive scientific studies on safety and efficacy of these plants can revitalise the treatment of liver diseases.

scholarly journals Cholelithiasis: epidemiological data, key aspects of the pathogenesis and comorbidity, relevant therapeutic targets

2020 ◽  
Vol 4 (5) ◽  
pp. 290-296
Author(s):  
I.G. Nikitin ◽  
◽  
A.V. Volnukhin ◽  
◽  
◽  
...  
Keyword(s):  
Ursodeoxycholic Acid ◽  
Glycyrrhizic Acid ◽  
Therapeutic Targets ◽  
Epidemiological Data ◽  
Scientific Data ◽  
The Body ◽  
Bile Acid Metabolism ◽  
Therapy Effect ◽  
Complex Therapy ◽  
Key Aspects

The article is devoted to current scientific data on the cholelithiasis pathogenesis and opportunities for optimizing litholytic therapy. It is shown that cholelithiasis should be considered as a topical manifestation of systemic disorders of metabolic and inflammatory genesis throughout the body. The article shows the key role in the development of its insulin resistance, imbalanced cholesterol and bile acid metabolism, biliary dyskinesia, and the production of inflammatory mediators. There are factors that cause cholelithiasis comorbidity with cardiovascular diseases, cerebrovascular diseases, gastrointestinal cancer of various localization, and liver diseases. The role of cholelithiasis as a risk factor and a criterion for an adverse prognosis is justified. Pathogenetically justified method for improving oral litholysis, which provides a complex therapy effect, is considered; the rationality of using a fixed combination of ursodeoxycholic acid and glycyrrhizic acid is justified. KEYWORDS: gallstone disease, cholelithiasis, cholesterol stones, oral litholysis, ursodeoxycholic acid, glycyrrhizic acid, complex therapy, metabolic disorders. FOR CITATION: Nikitin I.G., Volnukhin A.V. Cholelithiasis: epidemiological data, key aspects of the pathogenesis and comorbidity, relevant therapeutic targets. Russian Medical Inquiry. 2020;4(5):290–296. DOI: 10.32364/2587–6821–2020–4-5-290-296.

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