Oxidative stress in animals: role in oncogenesis from pathomorphologist view
Keyword(s):
Oxidative stress is a pathological accumulation of free radicals that contribute to the launch of intracellular damaging action mechanisms. Free radical is an atom possessing free or missing electron, and seeking to restore the lost electron, taking it from other molecules ― as a result a new free radical is formed. The mechanism is chain reaction-based. Hypoxia acts as an additional stimulus to the appearance of oxygen free radicals. Cell hypoxia develops following any type of cell damage: mechanical, bacteriological, chemical, etc. Cell hypoxia inevitably leads to the development of an inflammatory reaction, which is followed by the formation of oxygen free radicals and, as a result, by oxidative stress development.
2002 ◽
Vol 11
(6)
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pp. 543-551
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2018 ◽
Vol 21
(9)
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pp. 1274-1278
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2015 ◽
Vol 12
(4)
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pp. 269-274
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