The Effectiveness of Pilates Training and Vitamin D Intake on the hs-CRP and TSH in Overweight Men

Background: Vitamin D deficiency is known as a risk factor for various diseases and plays an important role in regulating systemic inflammation and thyroid function. Objective: The study was done to survey the effectiveness of Pilates training and vitamin D intake on serum high-sensitivity C-reactive protein (hs-CRP) and Thyroid-Stimulating Hormone (TSH) levels in overweight men. Methods: This clinical trial was conducted on 50 overweight men aged 45-55 years. Subjects were selected through available sampling and randomly assigned to the Pilates training, Pilates training with vitamin D, vitamin D, and control groups. The Pilates training was performed for eight weeks with the intensity of 50%-75% of reserve heart rate in 3 sessions/week. The supplement groups received 50000IU vitamin D weekly. The levels of hs-CRP and TSH were measured at first and eighth weeks after interventions. The data were analyzed by paired t-test and one-way ANOVA (p˂0.05). Findings: The results showed that 60% and 40% of the subjects had a vitamin D deficiency and insufficiency, respectively. Also, eight weeks of Pilates training, vitamin D intake, and the combined intervention resulted in a significant decrease in hs-CRP and TSH levels (p<0.05). Also, the combined intervention was associated with a stronger effect on the reduction of these factors compared with two other interventions (p˂0.05). Conclusion: It seems that abnormal levels of vitamin D are common in overweight men and vitamin D intake, Pilates training, and the combination can improve thyroid function and systemic inflammation in overweight men with abnormal vitamin D status. However, the combined intervention is associated with stronger effects.

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Supplementation with High Doses of Vitamin D to Subjects without Vitamin D Deficiency May Have Negative Effects: Pooled Data from Four Intervention Trials in Tromsø

ISRN Endocrinology ◽

10.1155/2013/348705 ◽

2013 ◽

Vol 2013 ◽

pp. 1-7 ◽

Cited By ~ 17

Author(s):

Rolf Jorde ◽

Moira Strand Hutchinson ◽

Marie Kjærgaard ◽

Monica Sneve ◽

Guri Grimnes

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Serum Lipids ◽

Randomized Clinical Trials ◽

High Sensitivity ◽

Vitamin D Supplementation ◽

High Dose ◽

Negative Effects ◽

The Mean ◽

Hs Crp

Data were pooled from four randomized clinical trials with vitamin D performed in Tromsø with weight reduction, insulin sensitivity, bone density, and depression scores as endpoints. Serum lipids, glycated hemoglobin (HbA1c), and high sensitivity C-Reactive Protein, (HS-CRP) were measured at baseline and after 6–12 months of supplementation with vitamin D 20 000 IU–40 000 IU per week versus placebo. A total of 928 subjects who completed the interventions were included. At baseline the mean serum 25-hydroxyvitamin D (25(OH)D) level in those given vitamin D was 55.9 (20.9) nmol/L and the mean increase was 82.4 (40.1) nmol/L. Compared with the placebo group there was in the vitamin D group at the end of the studies a slight, but significant, increase in HbA1c of 0.04%, an increase in HS-CRP of 0.07 mg/L in those with serum 25(OH)D < 50 nmol/L, and in those with low baseline HDL-C and serum 25(OH)D < 50 nmol/L a slight decrease serum HDL-C of 0.08 mmol/L (P<0.05). No serious side-effects were seen. In conclusion, in subjects without vitamin D deficiency, there is no improvement in serum lipids, HbA1c, or HS-CRP with high dose vitamin D supplementation. If anything, the effect is negative.

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Vitamin D Deficiency is Associated With Higher Level of High Sensitivity C-reactive Protein (Hs-crp) in Patients Undergoing Elective Coronary Stenting

10.21203/rs.3.rs-73096/v1 ◽

2020 ◽

Author(s):

farzaneh foroughinia ◽

Shaghayegh Mottaghi ◽

Mohammad Reza Alimardani

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Inflammatory Diseases ◽

Inflammatory Marker ◽

Venous Blood ◽

High Sensitivity ◽

Vitamin D Status ◽

C Reactive Protein ◽

Reactive Protein ◽

Hs Crp

Abstract Background: Vitamin D deficiency, a prevalent worldwide concern, has been reported to have a pivotal role in many cardiovascular and inflammatory diseases. Percutaneous coronary intervention (PCI) is a therapeutic approach that may have several short-term and long-term cardiovascular complications, supposing to be mediated with high sensitive C-reactive protein (hs-CRP), an inflammatory marker. This study aimed to investigate the association between vitamin D status and hs-CRP level, as a prognostic marker, in patients undergoing elective PCI. Methods: The study population comprised of 150 patients who underwent elective coronary angioplasty. In order to measure vitamin D and hs-CRP levels, venous blood samples were obtained at baseline and 24 hours after PCI. Results: Our results showed a significant inverse relationship between post-PCI hs-CRP and also pre-post hs-CRP difference levels and vitamin D status. Conclusion: Hs-CRP content is higher in vitamin D deficient patients. Therefore, these patients, especially severely-deficient ones (25(OH)D<10ng/ml), may benefit from supplementation with vitamin D prior to PCI.

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Moderate Vitamin D Deficiency and Inflammation Related Markers in Overweight/Obese Schoolchildren

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000197 ◽

2014 ◽

Vol 84 (1-2) ◽

pp. 98-107 ◽

Cited By ~ 8

Author(s):

Elena Rodríguez-Rodríguez ◽

Aránzazu Aparicio ◽

Pedro Andrés ◽

Rosa M. Ortega

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

High Sensitivity ◽

High Serum ◽

Obese Children ◽

Reactive Protein ◽

Tnf Α ◽

Obese Subjects ◽

Hs Crp ◽

Necrosis Factor

Objective: Obesity has been associated with vitamin D deficiency and increased oxidative stress, which can lead to the dysregulation of adipokines and inflammation. The aim of the present work was to examine the association of vitamin D status [25(OH)D] on inflammatory related markers in overweight/obese children. Subjects/Methods: A total of 137 Spanish schoolchildren between 9 and 12 years of age (31.4 % with overweight/obesity) were studied. Being overweight was defined as BMI ≥ 85th percentile and obesity as BMI ≥ 97th percentile using the reference tables of Hernández. Serum 25(OH)D concentrations were measured by chemiluminescent assay. Plasma tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) were measured by immunoenzyme assay. Serum adiponectin was determined using an ELISA kit. Serum high-sensitivity C-reactive protein (hs-PCR) was tested by immunonephelometry. Results: IL-6 concentrations were higher in the overweight/obese children with deficient serum 25(OH)D (< 20 ng/mL) than in those in this group but whose serum 25(OH)D concentrations were adequate (≥ 20 ng/mL). Serum 25(OH)D was inversely associated with IL-6 concentrations in the overweight/obese subjects taking into account different covariates; thus, for every 1 ng/mL rise in the former, the latter fell by 0.160 pg/mL (β = - 0.160 ± 0.068; R2 = 0.131; p = 0.023). The obese subjects with concentrations of ≥ 25 ng/mL had lower hs-CRP values compared to those with concentrations of < 25 ng/mL (0.053 ± 0.035 vs. 0.356 ± 0.613 mg/dL; p = 0.035). Conclusion: Low serum 25(OH)D was significantly associated high serum IL-6 in overweight/obese children, and with increased hs-CRP in obese children.

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Implications of Vitamin D Research in Chickens can Advance Human Nutrition and Perspectives for the Future

Current Developments in Nutrition ◽

10.1093/cdn/nzab018 ◽

2021 ◽

Author(s):

Matthew F Warren ◽

Kimberly A Livingston

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Vitamin D Supplementation ◽

The Body ◽

Human Nutrition ◽

Vitamin D Metabolites ◽

Vitamin D Metabolism ◽

Related Research ◽

Vitamin D Intake ◽

Increased Risk

Abstract The risk of vitamin D insufficiency in humans is a global problem that requires improving ways to increase vitamin D intake. Supplements are a primary means for increasing vitamin D intake, but without a clear consensus on what constitutes vitamin D sufficiency, there is toxicity risk with taking supplements. Chickens have been used in many vitamin D-related research studies, especially studies involving vitamin D supplementation. Our state-of-the-art review evaluates vitamin D metabolism and how the different hydroxylated forms are synthesized. We provide an overview with how vitamin D is absorbed, transported, excreted, and what tissues in the body store vitamin D metabolites. We also discuss a number of studies involving vitamin D supplementation with broilers and laying hens. Vitamin D deficiency and toxicity are also described and how they can be caused. The vitamin D receptor (VDR) is important for vitamin D metabolism. However, there is much more that can be understood with VDR in chickens. Potential research aims involving vitamin D and chickens should explore VDR mechanisms which could lead to newer insights with VDR. Utilizing chickens in future research to help with elucidating vitamin D mechanisms has great potential to advance human nutrition. Finding ways to increase vitamin D intake will be necessary because the coronavirus 2019 disease (COVID-19) pandemic is leading to increased risk of vitamin D deficiency in many populations. Chickens can provide a dual purpose with addressing pandemic-caused vitamin D deficiency: 1) vitamin D supplementation gives chickens added value with possibly leading to vitamin D-enriched meat and egg products; and 2) chickens’ use in research provides data for translational research. Expanding vitamin D-related research in chickens to include more nutritional aims in vitamin D status has great implications with developing better strategies to improve human health.

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Comparative analysis of vitamin D content in population of different climatic zones of Carpathian region

Bukovinian Medical Herald ◽

10.24061/2413-0737.xviii.4.72.2014.206 ◽

2014 ◽

Vol 18 (4 (72)) ◽

Author(s):

V. V. Povorozniuk ◽

I. V. Pankiv

Keyword(s):

Vitamin D ◽

Comparative Analysis ◽

High Altitude ◽

Vitamin D Deficiency ◽

Sea Level ◽

Severe Form ◽

Climatic Zones ◽

Vitamin D Intake ◽

Carpathian Region ◽

Low Altitude

The adequate vitamin D intake is found only in 19,5 % of inspected habitants of Carpathian region. The vitamin D deficiency is marked in 135 (80,5 %) and among them severe form is detected in 48 (28,4 %) of the inspected people. Frequency of vitamin D deficiency depends on a residence and increases with the height above a sea level. 25 (ОН) D level is higher among the ihabitants of low altitude region (27,14±1,26 nmol/l) comparatively with data of middle altitude region (21,37±1,34 nmol/l) and high altitude region (15,56±1,04 nmol/l).

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Obese patients with higher TSH levels had an obvious metabolic improvement after bariatric surgery

Endocrine Connections ◽

10.1530/ec-21-0360 ◽

2021 ◽

Vol 10 (10) ◽

pp. 1326-1336

Author(s):

Nannan Bian ◽

Xiaomeng Sun ◽

Biao Zhou ◽

Lin Zhang ◽

Qiu Wang ◽

...

Keyword(s):

Insulin Resistance ◽

Bariatric Surgery ◽

Thyroid Function ◽

Fasting Blood Glucose ◽

Thyroid Stimulating Hormone ◽

Morbidly Obese ◽

Obese Patients ◽

Free Triiodothyronine ◽

The Relationship ◽

Tsh Levels

Objective Bariatric surgery has become the most effective treatment for morbid obesity. Increasing evidence showed that bariatric surgery can alleviate insulin resistance and influence thyroid function. This study aimed to investigate the relationship between changes in thyroid function and adipose tissue insulin resistance (adipo-IR) after bariatric surgery. Methods A total of 287 non-diabetic participants with regular thyroid function were recruited and divided into the lean, overweight and obese groups. Among them, 50 morbidly obese patients submitted to bariatric surgery. Results The obese group had a higher level of adipo-IR, thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), FT3/free thyroxine (FT4) and metabolism disorders than the lean and overweight groups. BMI was correlated with TSH, FT3, FT3/FT4 and adipo-IR (r = 0.309, 0.315, 0.322 and 0.651, respectively, all P < 0.001). Adipo-IR was significantly correlated with TSH (r = 0.402, P < 0.001), FT3 (r = 0.309, P < 0.001), and FT3/FT4 (r = 0.228, P < 0.05). Bariatric surgery resulted in a sharp decline in BMI, adipo-IR, TSH, FT3 and FT3/FT4 levels, meanwhile, metabolic disorders improved. The decrease in BMI after bariatric surgery was significantly correlated with reductions in adipo-IR (r = 0.577, P < 0.001) and TSH (r = 0.401, P = 0.005). Interestingly, the fasting blood glucose, fasting insulin, adipo-IR and TSH in the higher TSH group decreased more remarkably than in the lower TSH group. Conclusion Obese individuals with higher TSH levels had an obvious metabolic improvement after bariatric surgery.

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Kadar High Sensitivity C-Reactive Protein Berkaitan dengan Lingkar Pinggang pada Lansia

Indonesian Journal of Human Nutrition ◽

10.21776/ub.ijhn.2021.008.01.3 ◽

2021 ◽

Vol 8 (1) ◽

pp. 21

Author(s):

Deny Yudi Fitranti ◽

Bunga Syifarahmi ◽

Martha Ardiaria ◽

Nurmasari Widyastuti

Keyword(s):

Physical Activity ◽

Vitamin D ◽

International Physical Activity Questionnaire ◽

High Sensitivity ◽

C Reactive Protein ◽

Cross Sectional ◽

Reactive Protein ◽

Consecutive Sampling ◽

Hs Crp ◽

Activity Questionnaire

Proses penuaan mempengaruhi peningkatan distribusi lemak abdominal dengan indikator lingkar pinggang (LP) dan rasio lingkar pinggang panggul (RLPP). Penimbunan lemak abdominal menyebabkan disfungsi jaringan adiposa sehingga mempengaruhi biomarker proinflamasi yaitu kadar serum high-sensitivity C-reactive Protein (hs-CRP). Penelitian bertujuan untuk mengetahui hubungan LP dan RLPP dengan kadar hs-CRP lansia wanita. Rancangan penelitian cross sectional pada 53 subjek dipilih secara consecutive sampling. Antropometri yang diukur adalah LP dan RLPP. Pengukuran kadar serum hs-CRP dianalisis dengan metode enyme-linked immunosorbent assay (ELISA). Wawancara yang dilakukan yaitu data diri, asupan, aktivitas fisik, dan riwayat konsumsi obat. Data asupan diperoleh dengan metode food recall 3x24 jam. Aktivitas fisik diperoleh menggunakan International Physical Activity Questionnaire (IPAQ). Analisis data digunakan uji korelasi Spearman. Hasil penelitian menunjukkan bahwa persentase LP pada lansia wanita yang berisiko sebesar 90,6%, RLPP yang berisiko sebesar 98,1%, dan kadar hs-CRP tinggi sebesar 30,2%. Terdapat hubungan positif antara LP dengan kadar serum hs-CRP (r=0,417 ; p=0,002). Dalam penelitian ini RLPP, aktivitas fisik, asupan energi, karbohidrat, protein, lemak, serat, vitamin A, vitamin C, vitamin D,vitamin E, dan selenium tidak berkorelasi dengan kadar hs-CRP. Simpulan penelitian ini adalah LP berkorelasi positif dengan kadar serum hs-CRP, namun RLPP tidak berkorelasi dengan kadar serum hs-CRP

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Evaluation of Vitamin D Deficiency and Its Relationship with Body Mass Index in Children 1 To 16 Years

Tabari Biomedical Student Research Journal ◽

10.18502/tbsrj.v3i2.6667 ◽

2021 ◽

Author(s):

Elham Nozari Mirarkolaei ◽

Mahdi Gholami ◽

Elham Rostami ◽

Azita Aliakbarniya ◽

Massoumeh Hotelchi ◽

...

Keyword(s):

Body Mass Index ◽

Vitamin D ◽

Children And Adolescents ◽

Vitamin D Deficiency ◽

Body Mass ◽

Body Weight Gain ◽

Thyroid Stimulating Hormone ◽

Overweight And Obesity ◽

Mazandaran Province ◽

Significant Difference

Introduction: Body weight gain in children and teenagers is one of the major challenges that cause undesirable health outcomes. Simultaneously with the prevalence of overweight and obesity, children and adolescents are diagnosed with 25-hydroxyvitamin D (25(OH)D) deficiency in different sides of the world. The present study aimed to assess 25(OH)D status among Iranian volunteers aged 1-16 years and find the correlation between 25(OH)D status and body mass index (BMI) subjects. Material and Methods: The total volunteers included 807 Iranian children aged 1 to 16 referred to the general and endocrinology clinics in Babol city, Mazandaran Province. A trained physician determined anthropometric characteristics. Serum levels of calcium (Ca), phosphate (P), creatinine (Cr), urea, thyroxine (T4), thyroid-stimulating hormone (TSH), and 25(OH)D were assessed in all children. Results: 25.27% of the children were 25(OH)D deficient, and 59.1% were insufficient. There was no significant difference in serum 25(OH)D level between girls and boys (P=0.13). A significant negative correlation was found in serum 25(OH)D level with weight (P=0.000, r=-0.12), BMI (P=0.000, r=-0.13), and age (P=0.000, r=-0.13). Conclusion: These data displayed that 25(OH)D insufficiency is highly prevalent among children in the north of Iran. Serum 25(OH)D levels are affected by age and BMI value. Improving vitamin D deficiency helps to maintain the health of children and adolescents during this critical period.

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Studying Depression Status and Possible Association with Vitamin D Deficiency and the Level of Thyroid Stimulating Hormone among Jordanian Patients with Addiction

Journal of the Royal Medical Services ◽

10.12816/0052896 ◽

2019 ◽

Vol 26 (1) ◽

pp. 31-36

Author(s):

Maher , Alasasleh ◽

Bashir , Nabil A. ◽

Alkhatib , Ahed J. ◽

Alomary , Mohammadnoor ◽

Aburumman , Raafat

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Thyroid Stimulating Hormone ◽

Depression Status ◽

Stimulating Hormone

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Abnormal Thyroid Function and Recurrent Pregnancy Loss

Nepal Journal of Obstetrics and Gynaecology ◽

10.3126/njog.v9i1.11184 ◽

2014 ◽

Vol 9 (1) ◽

pp. 29-32

Author(s):

A Shrestha ◽

CD Chawla

Keyword(s):

Longitudinal Study ◽

Thyroid Function ◽

Autoimmune Thyroiditis ◽

Pregnancy Loss ◽

Recurrent Pregnancy Loss ◽

Thyroid Stimulating Hormone ◽

Thyroid Disorder ◽

Positive Message ◽

Effect Of Treatment ◽

Tsh Levels

Aims: The aim of our study was to observe the benefit of screening for thyroid function amongst women with recurrent pregnancy loss and effect of treatment for thyroid disorder on pregnancy outcome. Methods: This was a longitudinal study conducted from June 2012 to December 2013. One hundred and three patients with recurrent pregnancy loss without features of thyroid disorder were included. They were investigated for thyroid stimulating hormone (TSH), free tri iodothyronin (FT3), free thyroxine (FT4) levels and for auto-antibodies against thyroperoxidase (anti TPO). The patients with abnormal TSH levels were treated with thyroxine depending on the level of TSH. Results: TSH, FT3, FT4 and anti TPO levels were measured. Amongst 103 ladies, thirty-eight (36.89%) had high levels of TSH. Thirty-five (33.98%) of them underwent test for anti TPO, of which two (5.71%) had autoimmune thyroiditis. Nine (8.73%) out of 103 had high FT4 levels. Ladies with diagnosis of hypothyroidism underwent treatment and 17 (44.73%) out of 38 had conceived. Conclusions: Of 103 women with recurrent pregnancy loss, abnormal thyroid function was detected in 47. Seventeen (44.73%) of them with increased TSH level conceived after treatment with thyroxine, which gives a positive message that hypothyroidism is a treatable cause for recurrent pregnancy loss. DOI: http://dx.doi.org/10.3126/njog.v9i1.11184 NJOG 2014 Jan-Jun; 2(1):29-32

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