Pengaruh Pemberian Jus Terong Ungu terhadap Perlemakan Hati Tikus Wistar

2019 ◽  
Vol 18 (2) ◽  
pp. 59-63
Author(s):  
Dian Luthfiana Sufyan
Keyword(s):  
Fatty Liver ◽  
Solanum Melongena ◽  
Atherogenic Diet ◽  
Control Group ◽  
Test Design ◽  
Alcoholic Fatty Liver ◽  
Post Test ◽  
Post Hoc ◽  
Group Post ◽  
One Way Anova

ABSTRACT Non Alcoholic Fatty Liver Disease (NAFLD) is an infiltration of fat inside hepatocytes until exceeding 5% of the liver weight. Eggplant (Solanum melongena L.) contain high anthocyanin level, (8 - 85 mg per 100 gram edible portion) and pectin fiber. This study was aimed to determine the effect of eggplant juice to the fatty liver of Rattus novergicus strain Wistar that were given atherogenic diet. This study using control group post test design performed in wistar rat that placed in pharmacologic laboratory of Brawijaya University. Sampling was carried out by completely random sampling with 30 rats for total sample. Data were processed and analyzed using SPSS 16. Statictical test using one way ANOVA and post hoc tukey. The results showed there was significant correlation between dosage I (1,3 gr/3 ml), dosage II (2,6 gr/3 ml) and dosage III (5,2 gr/3 ml) of eggplant juice to fatty liver (p<0,001). Food intake of rat influenced the number of fatty liver cells. This reasearch conclusion is eggplant juice has effect to white rat fatty liver. Based on this study, it was recommended to consume eggplant as anthocyanin and pectin source to reduce fatty liver that induced by atherogenic diet. Key words: NAFLD, atherogenic diet, eggplant, anthocyanin, pectin   Perlemakan hati non alkohol adalah suatu infiltrasi dari lemak, terutama trigliserida di dalam hepatosit atau sel-sel hati hingga lebih dari 5% berat organ hati. Terong ungu (Solanum melongena L.) merupakan tanaman sayur yang mengandung pigmen antosianin cukup tinggi yakni 8 – 85 mg per 100 gram nya serta serat pektin. Penelitian ini bertujuan untuk mengetahui efek jus terong ungu terhadap perlemakan hati tikus wistar yang diberi diet aterogenik. Penelitian eksperimental ini menggunakan metode Control Group Post Test Design bertempat di laboratorium farmakologi FKUB. Pemilihan sampel dilakukan menggunakan metode RAL (Rancangan Acak Lengkap) dengan jumlah sampel total sebanyak 30 tikus putih. Data diolah dan dianalisis menggunakan SPSS 16. Uji statistik menggunakan one way ANOVA dilanjutkan Post Hoc Tukey. Hasil penelitian menunjukkan terdapat hubungan yang signifikan antara dosis I (1,3 gr/3 ml), dosis II (2,6 gr/3 ml) dan dosis III (5,2 gr/3 ml) jus terong ungu terhadap perlemakan hati (p<0,001). Berdasarkan penelitian ini dapat disimpulkan bahwa jus terong ungu memiliki efek terhadap perlemakan hati tikus putih. Dari penelitian ini, disarankan konsumsi terong ungu sebagai sumber antosianin dan pektin untuk menurunkan perlemakan hati yang dipicu oleh faktor diet aterogenik. Kata kunci:perlemakan hati non alkohol, diet aterogenik, terong ungu, antosianin, pektin

scholarly journals Tepung ulat sagu (Rhyinchophorus ferrugineus) imunomodulator Nitric Oxide (NO) sirkulasi mencit terapi antimalaria standar

2018 ◽  
Vol 6 (2) ◽  
pp. 131-138
Author(s):  
Ariani Ariani ◽  
Gemala Anjani ◽  
Muchlis Achsan Udji Sofro ◽  
Kis Djamiatun
Keyword(s):  
Control Group ◽  
Treatment Groups ◽  
Antimalarial Therapy ◽  
Post Test ◽  
The Mean ◽  
Randomized Control ◽  
Post Hoc ◽  
Group Post ◽  
One Way Anova

Background : Sago worm flour (Rhyinchophorus ferrugineus)is a coconut beetle larvae that is processed into flour.This flour contains antioxidants as well as arginine, both of which play a role in modulating oxidative stress including NO involved in immunopathology of cerebral malaria.Objectives : To prove the immunomodulator role of sago worm flour in decreasing circulation  NO level at mice  who received standard antimalarial therapy  Dihydroartemisinin Piperaquine (DHP)Methods : This study was randomized control group post test only design by using 23 Swiss mice which divided into 5 group consist of : K(-) normal mice; K(+) inoculated woth Plasmodium berghei ANKA (PbA); X1 received DHP; X2 received sago worm flour; X3 received both of sago worm flour and DHP. All treatment groups X1,X2 and X3 were inoculated by PbA before treatmen were given. Serum circulation NO level was assessed by ELISA. statistical analysis used was One Way ANOVA followed by Bonferroni post hoc test.Results : The mean  NO level in K(-), K(+), X1, X2, and X3 were 1.008 μmol/mL, K(+) 1.338 μmol/mL; while at treatment X1 1.143 μmol/mL, X2 1.410 μmol/mL, dan X3 0.886 μmol/mL. One way ANOVA showed that they were significantly different (p=0.001). Bonferroni post hoc test of X2 was  proportional to K(+) (p=1.000), whole had NO level lower than either K(+)(p=0.009) or X2 (p=0.002). Conclusion : The immunomodulatory effects of sago worm flour (Rhyinchophorus ferrugineus) reduced circulating NO levels in standard antimalarial therapy recipients.

scholarly journals Pengaruh Pemberian Quercetin Terhadap Kematian Sel Endotel Aorta Pada Tikus Wistar Jantan (Rattus Norvegicus Strain Wistar) yang Diberi Diet Aterogenik

2018 ◽  
Vol 1 (2) ◽  
pp. 47
Author(s):  
Frenky Arif Budiman
Keyword(s):  
High Density Lipoprotein ◽  
Rattus Norvegicus ◽  
Density Lipoprotein ◽  
High Density ◽  
Control Group ◽  
Test Design ◽  
Post Test ◽  
Group Post ◽  
One Way Anova

Atherosklerosis merupakan suatu penyakit degeneratif. Proses Atherosklerosis terjadi melalui beberapa tahap. Kejadian awal yang berperan pada proses atherosklerosis adalah kerusakan atau disfungsi endotel karena kadar lemak LDL. LDL Lipoprotein) adalah kolesterol “jahat” yang potensial menyumbat pembuluh darah. Akan tetapi, hal tersebut dapat dicegah dengan pemberian antioksidan. Oleh karena itu, perlu adanya altermatif pengobatan yang bersifat preventif yang bahannya berasal dari buah-buahan. Quersetin adalah salah satu zat aktif kelas flavonoid yang secara biologis amat kuat. Antioksidan ini dapat mencegah kerusakan sel sel endotel atau jaringan pembuluh darah. Pada saat bersamaan, antioksidan akan meningkatkan koesterol “baik” (High Density Lipoprotein / HDL) yang bermanfaat untuk mencegah penyakit jantung dan pembuluh darah. Penelitian ini bertujuan mengetahui peranan quercetin sebagai antioksidan dalam mencegah penurunan jumlah sel endotel aorta tikus yang diberi diet aterogenik. Jenis penelitian ini menggunakan experimental laboratorik pada hewan coba tikus dengan menggunakan desain penelitian Control Group Post Test Design. Variabel penelitian ini adalah jumlah sel endotel aorta. Hasil uji statistik One Way Anova menunjukkan bahwa terdapat perubahan jumlah sel endotel aorta tiap taraf perlakuan yang signifikan. Kesimpulan dari penelitian ini adalah pemberian quercetin dengan dosis 56 mg paling potensial dalam pencegahan penurunan jumlah sel endotel aorta tikus. Kata Kunci : 

scholarly journals Pengaruh Senam Nifas terhadap Penurunan Tinggi Fundus Uteri dan Lochea pada Ibu Pasca Bersalin yang Mendapatkan Inisiasi Menyusu Dini dan Mobilisasi Dini

2020 ◽  
Vol 19 (03) ◽  
pp. 126-133
Author(s):  
Siska Toloan Toloan ◽  
Harimat Hendarwan
Keyword(s):  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
Group Design ◽  
Consecutive Sampling ◽  
Post Test ◽  
Post Hoc ◽  
One Way Anova

Masa nifas adalah hal sangat penting untuk diperhatikan guna untuk menurunkan angka kematian ibu dan bayi di Indonesia. Penelitian ini bertujuan untuk Mengetahui Pengaruh Senam Nifas Terhadap Penurunan Tinggi Fundus Uteri Dan Lochea Pada Ibu Pasca Bersalin Yang Mendapatkan Inisiasi Menyusu Dini Dan Mobilisasi Dini Di Praktek Bidan Mandiri Kota Depok Tahun 2019. Penelitian ini menggunakan penelitian kuantitatif yang menggunakan desain penelitian Quasy Exsperimental dengan pendekatan post test only control group design. Populasi yang diambil yaitu 65 ibu pasca bersalin. Sampel diambil dengan metode consecutive sampling besar sampel ditentukan dengan menggunakan rumus Federer setiap variabel bebas terdiri atas 3 kelompok dan setiap kelompok sebanyak 9 sampel sehingga jumlah total sampel 27 ibu pasca bersalin. Pengumpulan data berupa data primer dan uji yang digunakan yaitu uji One Way Anova. Dapat dilihat dari nilai signifikan uji One Way Anova pada penurunan tinggi fundus uteri hari pertama sampai hari kesepuluh dengan nilai signifikan yaitu p-value < 0,05 yang artinya H0 ditolak atau ada perbedaan secara signifikan dan dilihat. Hasil post hoc test tidak terdapat perbedaan signifikan pada kelompok inisiasi menyusu dini, inisiasi menyusu dini dan mobilisasi dini dan kelompok inisiasi menyusu dini, mobilisasi dini dan senam nifas terhadap penurunan tinggi fundus uteri.

Effectiveness of website application (Sumiferos) for preventing anemia with pregnant women compliance in consuming Fe tablets

2020 ◽  
Vol 11 (3) ◽  
pp. 197-200
Author(s):  
Rosmaria . ◽  
Sri Yun Utama ◽  
Titik Hindriati ◽  
Diniyati .
Keyword(s):  
Pregnant Women ◽  
Health Workers ◽  
Intervention Group ◽  
Control Group ◽  
Test Design ◽  
Communication Tool ◽  
Care Services ◽  
Post Test ◽  
Quasi Experimental ◽  
Group Post

Background: The consumption of Fe tablets needs to be the attention of midwives as one of the spearheads in providing antenatal care services. Due to the low level of compliance of pregnant women to consume Fe tablets, it is necessary to provide appropriate counseling as an effort to increase compliance with Fe tablets. Objective: This study aimed to determine the effectiveness of the application model (Sumiferos) for preventing anemia with pregnant women compliance in consuming Fe tablets at Putri Ayu Health Center in Jambi city. Materials and methods: This study used a quasi-experimental research design with a post-test design by involving an intervention group and a control group (post-test), two group designs. With the total of 70 subjects;the intervention group, 35 respondents were given a website application (sumiferos), and a control group 35 respondents were given a leflet. After a month, the number of Fe tablets that have been consumed was monitored. Compliance of pregnant women in consuming Fe tablets required a monitoring or supervisioncarried out by health workers. Therefore, an intervention was given by using a website-based application (sumiferos) for pregnant women as a communication tool that has been created and designed previously by researchers. Results: Posttest statistical analysis showed that pregnant women who were given a website application (sumiferos) in the intervention group showed better compliance than pregnant women in the control group given lefket. Conclusion: Based on the results,a website application (sumiferos) is more effective than leaflets in improving maternal compliance to consume Fe tablets given by health workers.

scholarly journals UJI EFEK ANTI BAKTERI EKSTRAK BUNGA CENGKEH TERHADAP BAKTERI Streptococcus mutans SECARA IN VITRO

e-GIGI ◽  
2014 ◽  
Vol 2 (2) ◽  
Author(s):  
Juvensius R. Andries ◽  
Paulina N. Gunawan ◽  
Aurelia Supit
Keyword(s):  
Streptococcus Mutans ◽  
Control Group ◽  
Antibacterial Effects ◽  
Control Group Design ◽  
Group Design ◽  
Post Test ◽  
Clove Extract ◽  
Post Hoc ◽  
One Way Anova

Abstrak: Minyak cengkeh berguna sebagai antibakteri alami. Minyak esensial dari cengkeh mempunyai fungsi anestetik dan antimikrobial. Zat yang terkandung dalam cengkeh yang bernama eugenol dapat membunuh bakteri termasuk bakteri yang resisten terhadap antibiotika, salah satunya adalah bakteri Streptococcus mutans. Bakteri ini merupakan mikroorganisme penyebab utama terjadinya karies. Tujuan dari penelitian ini yaitu untuk mengetahui efek antibakteri ekstrak cengkeh terhadap bakteri Streptococcus mutans secara in vitro. Penelitian ini merupakan penelitian eksperimental menggunakan post test only control group design. Penelitian ini menggunakan bahan coba ekstrak cengkeh dengan konsentrasi 40%, 60%, dan 80%, Ciprofloxacin, aquades dengan pengulangan sebanyak lima kali. Data dikumpulkan dan dianalisis dengan one-way ANOVA dan post-hoc uji LSD ( = 0,05). Berdasarkan hasil uji statistik penelitian uji efek antibakteri ekstrak cengkeh terhadap bakteri streptococcus mutans secara in vitro, dapat disimpulkaan bahwa ekstrak cengkeh memiliki efek antibakteri dalam menghambat pertumbuhan bakteri Streptococcus mutans secara in vitro. Hasil uji lanjut post-hoc uji LSD menunjukan daya hambat ekstrak cengkeh 40%, 60%, 80%, lebih kecil (p<0,05) dalam menghambat Streptococcus mutans secara in vitro dibandingkan Ciprofloxacin. Kata Kunci: Ekstrak cengkeh, Streptococcus mutans.   Abstract: Clove oil is useful as a natural antibacterial agent, essential oil of clove has anesthetic and antimicrobial effect. Substances contained in clove called eugenol can kill bacteria including antibiotic resistant bacteria, one of which is the bacteria Streptococcus mutans. This bacteria is a major cause for caries. The purpose of this study was to mengetahui clove extrack antibacterial effects againts Streptococcus mutans bacteria in vitro. This study is an experimental study using a post test only control group design. This research try using clove extract with a concentration of 40%, 60%, and 80%, Ciprofloxacin, aquades repetition five times. Data collected and analyzed by one-way ANOVA and post-hoc LSD test (α = 0.05). Based on the results of the statistical test to test the effects of anti-bacterial research clove extracts against Streptococcus mutans bacteria in vitro, can disimpulkaan that clove extracts have antibacterial effects in inhibiting the growth of Streptococcus mutans bacteria in vitro.further test result post-hoc LSD test shoved its inhibitory clove extract 40%, 60%, 80% smaller (p<0,05)in hibiting Streptococcus mutans in vitro compared Ciprofloxacin. Keywords: clove extract, Streptococcus mutans

scholarly journals PENINGKATAN KEMAMPUAN KERJASAMA MELALUI MODEL PROJECT BASED LEARNING (PjBL) BERBANTUAN METODE EDUTAINMENT PADA MATA PELAJARAN ILMU PENGETAHUAN SOSIAL

2018 ◽  
Vol 8 (2) ◽  
Author(s):  
Ika Ari Pratiwi ◽  
Sekar Dwi Ardianti ◽  
Moh. Kanzunnudin
Keyword(s):  
Project Based Learning ◽  
Control Group ◽  
Test Design ◽  
Post Test ◽  
Model Project ◽  
Group Post

Tujuan penelitian ini untuk mendeskripsikan kemampuan kerjasama dan hasil belajar siswa menggunakan model project based learning berbantuan edutainment. Metode penelitian yang digunakan control group post-test  design, yang terdiri dari kelompok kontrol dan kelompok eksperimen. Hasil uji-t analisis kemampuan kerjasama menunjukkan bahwa nilai t-hitung 3,279 > t-tabel 2,011 dan  analisis hasil belajar siswa dengan uji-t menunjukkan bahwa nilai t-hitung 2,854 > t- tabel 2, 011. Maka terdapat perbedaan yang signifikan kemampuan kerjasama dan nilai post test siswa kelompok ekperimen dengan kelompok kontrol. Dengan demikian model project based learning (PjBL) berbantuan metode edutainment dapat meningkatkan kemampuan kerjasama dan hasil belajar siswa kelas IV SD Muhammadiyah Kudus.

scholarly journals Review: Effect of Red Cabbage Juice (Brassica oleracea var. Capitata f. Rubra) on SGPT Level

2020 ◽  
Vol 3 (1) ◽  
pp. 172-177
Author(s):  
Hesty Wahyuningsih ◽  
Andina Putri Aulia
Keyword(s):  
Liver Injury ◽  
Brassica Oleracea ◽  
Control Group ◽  
Drug Induced ◽  
Red Cabbage ◽  
Drug Induced Liver Injury ◽  
Post Test ◽  
Male Wistar Rats ◽  
Post Hoc ◽  
One Way Anova

Red cabbage (Brassica oleracea var. Capitata f. Rubra) is a vegetable widely used in Indonesian cuisine. Red cabbage is rich in anthocyanins to reduce SGPT levels in drug-induced liver injury (DILI). This study aims to determine the effect of red cabbage juice on SGPT levels in acetaminophen-induced liver injury. In this post-test, only the control group study, male Wistar rats (300g), were randomly divided into 5 groups (K1-K2-K3-K4-K5). Acetaminophen was given to induce liver injury in rats. The rats were treated with the cabbage juice (at the dose of 0.5g/ml or 0.7g/ml or 0.9g/ ml. Data were analyzed using One way ANOVA and LSD post hoc test. Mean SGPT levels for K1, K2, K3, K4, K5 was 58.43 ± 7.18 UI / L, 71.20 ± 9.13 UI/L, 55.73 ± 9.51 UI / L, 72.80 ± 3.47 UI /L, 72.63 ± 3.01 UI /L, respectively. One way ANOVA resulted in p=0.00 (p <0.05). The post hoc LSD test showed significant differences (P <0.05) between all groups except between groups K1-K3, K2-K4, and K2-K5 (p> 0.05). Red cabbage juice can reduce SGPT in acetaminophen-induced liver injury in rats. The most effective dose was 0.5 g/ml.

scholarly journals Efek perendaman rebusan Daun Sirih Merah (Piper crocatum) terhadap kekerasan permukaan resin komposit

2016 ◽  
Vol 2 (2) ◽  
pp. 60
Author(s):  
Devi Puspita Handayani ◽  
Dewi Puspitasari ◽  
Nurdiana Dewi
Keyword(s):  
Composite Resin ◽  
Surface Hardness ◽  
Control Group ◽  
Mouth Rinse ◽  
Control Group Design ◽  
Treatment Groups ◽  
Betel Leaf ◽  
Post Test ◽  
Post Hoc ◽  
One Way Anova

The effect of immersion of decoction water of Red Betel Leaf (Piper crocatum) on the surface hardness of composite resin. The purpose of this study was to determine the effect of immersion of decoction water of red betel leaf on the surface hardness of composite resin compared to alcoholic mouth rinse. It was a pure experimental study with post-test only with control group design. The total samples were 27 samples divided into 2 treatment groups and 1 control group, each of which consisted of 9 samples. The treatment groups were immersed in the decoction water of red betel leaf and alcoholic mouth rinse. The control group was immersed in aquadest. After the immersion, the samples were measured using Vickers Micro hardness Tester. Analysis with one way anova and post hoc Bonferroni showed a significant difference (p<0.05) on the surface hardness of composite resin after being immersed in decoction water of red betel leaf(79,81±3,76) kg/mm2 and alcoholic mouth rinse (67,11±2,51) kg/mm2. Based on this research, it can be concluded that there was an effect of immersion of decoction water of red betel leaf if compared with alcoholic mouth rinse. The value of surface hardness of composite resin immersed in alcoholic mouth rinse was lower than the decoction water of red betel leaf.ABSTRAKPenelitian ini bertujuan untuk mengetahui efek perendaman dalam rebusan daun sirih merah terhadap kekerasan permukaan resin komposit bila dibandingkan dengan obat kumur beralkohol. Penelitian ini merupakan penelitian eksperimental murni dengan post-test only with control group design. Jumlah sampel sebanyak 27 yang dibagi dalam 2 kelompok perlakuan dan 1 kelompok kontrol dengan masing-masing kelompok sebanyak 9 sampel. Kelompok perlakuan direndam dengan air rebusan daun sirih merah dan obat kumur beralkohol. Kelompok kontrol direndam dengan akuades steril. Setelah itu dilakukan pengukuran menggunakan Vickers Microhardness Tester. Hasil uji One Way Anova dan Post Hoc Bonferroni menunjukkan bahwa terdapat perbedaan bermakna nilai kekerasan permukaan resin komposit yang direndam dengan air rebusan daun sirih merah (79,81±3,76) kg/mm2 dan obat kumur beralkohol (67,11±2,51) kg/mm2 dengan nilai kemaknaan (p<0,05). Berdasarkan penelitian yang dilakukan dapat diambil kesimpulan bahwa terdapat efek lebih rendah pada perendaman dalam rebusan daun sirih merah terhadap kekerasan permukaan resin komposit bila dibandingkan dengan obat kumur beralkohol. Nilai kekerasan permukaan resin komposit yang direndam obat kumur beralkohol lebih rendah dibandingkan air rebusan daun sirih merah.

scholarly journals Pengaruh Hepatokuratif Ekstrak Daun Kenikir (Cosmos caudatus) terhadap Kadar SGPT Tikus Wistar yang Diinduksi Parasetamol

2020 ◽  
Vol 3 (1) ◽  
pp. 32
Author(s):  
Syaema Maulida ◽  
Yanuarita Tursinawati ◽  
Ardhea Jaludamascena
Keyword(s):  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Cosmos Caudatus ◽  
Post Test ◽  
Post Hoc ◽  
One Way Anova

Penggunaan parasetamol dosis tinggi menjadi pemicu kerusakan hepar yang ditandai dengan peningkatan SGPT. Daun kenikir mengandung flavonoid, saponin, dan tanin yang berfungsi sebagai hepatokuratif. Tujuan penelitian ini adalah untuk mengetahui pengaruh ekstrak daun kenikir terhadap kadar SGPT darah tikus galur wistar yang diinduksi parasetamol. Penelitian ini merupakan studi eksperimen laboratorium dengan rancangan post test only control group design. Sampel sebanyak 30 ekor tikus jantan galur wistar yang dibagi dalam 5 kelompok secara random. Perlakuan dilakukan selama 15 hari, kelompok K- hanya diberi pakan standar selama masa perlakuan, kelompok KT diinduksi parasetamol dosis tunggal 270mg/200grBB tanpa diberikan intervensi, kelompok  K+, PI, dan PII diinduksi parasetamol, K+ diberi N-asetilsistein 2,52mg/kgBB, PI diberi ekstrak daun kenikir 62,5mg/kgBB, PII ekstrak daun kenikir 125mg/kgBB sampai hari ke-14 dan  hari ke-15 diperiksa kadar SGPT. Analisa data dengan uji one-way ANOVA dan dilanjutkan Post-hoc. Rerata kadar SGPT yaitu K- 47,0±0,82 IU/L, KT 78,0±0,97 IU/L, K+ 40,2±2,27 IU/L, PI 55,3±1,74 IU/L, dan PII 69,3±1,48 IU/L. Terdapat perbedaan signifikan rerata SGPT antar seluruh kelompok (p=0,000).Perbedaan signifikan juga ditemukan antar kelompok K- dengan KT (p=0,000), K- dengan K+ (p=0,023), K- dengan P1 (p=0,001), K- dengan P2 (p=0,000), KT dengan K+ (p=0,000), KT dengan P1 (p=0,000), KT dengan P2 (p=0,000), K+ dengan P1 (p=0,000), K+ dengan P2 (p=0,000), dan P1 dengan P2 (p=0,000). Ekstrak daun kenikir (Cosmos caudatus) dapat mempengaruhi kadar SGPT darah tikus galur wistar yang diinduksi parasetamol

scholarly journals Gambaran Histopatologi Paru Mencit (Mus musculus) Setelah Pemaparan Paraquat

2018 ◽  
Vol 11 (2) ◽  
pp. 7
Author(s):  
Aulia Wiradi ◽  
Wiwit Ade Fidiawati ◽  
Sri Melati Munir
Keyword(s):  
Experimental Study ◽  
Treatment Group ◽  
Mus Musculus ◽  
Lung Fibrosis ◽  
Control Group ◽  
Post Test ◽  
Lung Histopathology ◽  
Post Hoc ◽  
One Way Anova

Paraquat destroys organs including lung. Purpose of this study was to determine the effect of paraquat on histopathologyof lung, exspecially fibrosis in mice (Mus musculus). This study was an experimental study with post-test only withcontrol design and using 15 mice as sample. Samples were divided into 5 groups consist of one control group and fourdifferent doses of paraquat treatment group (25 mg / kg / day, 50 mg / kg / day, 75 mg / kg / day and 100 mg / kg / day for7 days with spraying). Analysis of the data have used One-Way ANOVA then post-hoc test with tukey to assesseddifferences of each groups. The results showed increasing of lung fibrosis with increasing doses and have significantcorrelations (p = 0.000). In conclusion, there are significant changes in lung histopathology of mice (Mus musculus)after paraquat exposure for 7 days.

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