scholarly journals Pengaruh Pemberian Quercetin Terhadap Kematian Sel Endotel Aorta Pada Tikus Wistar Jantan (Rattus Norvegicus Strain Wistar) yang Diberi Diet Aterogenik

2018 ◽  
Vol 1 (2) ◽  
pp. 47
Author(s):  
Frenky Arif Budiman
Keyword(s):  
High Density Lipoprotein ◽  
Rattus Norvegicus ◽  
Density Lipoprotein ◽  
High Density ◽  
Control Group ◽  
Test Design ◽  
Post Test ◽  
Group Post ◽  
One Way Anova

Atherosklerosis merupakan suatu penyakit degeneratif. Proses Atherosklerosis terjadi melalui beberapa tahap. Kejadian awal yang berperan pada proses atherosklerosis adalah kerusakan atau disfungsi endotel karena kadar lemak LDL. LDL Lipoprotein) adalah kolesterol “jahat” yang potensial menyumbat pembuluh darah. Akan tetapi, hal tersebut dapat dicegah dengan pemberian antioksidan. Oleh karena itu, perlu adanya altermatif pengobatan yang bersifat preventif yang bahannya berasal dari buah-buahan. Quersetin adalah salah satu zat aktif kelas flavonoid yang secara biologis amat kuat. Antioksidan ini dapat mencegah kerusakan sel sel endotel atau jaringan pembuluh darah. Pada saat bersamaan, antioksidan akan meningkatkan koesterol “baik” (High Density Lipoprotein / HDL) yang bermanfaat untuk mencegah penyakit jantung dan pembuluh darah. Penelitian ini bertujuan mengetahui peranan quercetin sebagai antioksidan dalam mencegah penurunan jumlah sel endotel aorta tikus yang diberi diet aterogenik. Jenis penelitian ini menggunakan experimental laboratorik pada hewan coba tikus dengan menggunakan desain penelitian Control Group Post Test Design. Variabel penelitian ini adalah jumlah sel endotel aorta. Hasil uji statistik One Way Anova menunjukkan bahwa terdapat perubahan jumlah sel endotel aorta tiap taraf perlakuan yang signifikan. Kesimpulan dari penelitian ini adalah pemberian quercetin dengan dosis 56 mg paling potensial dalam pencegahan penurunan jumlah sel endotel aorta tikus. Kata Kunci : 

scholarly journals Uji Toksisitas Ekstrak Metanolik Kombinasi Daun Benalu Teh Dan Daun Benalu Mangga Terhadap Profil Lipid Tikus Betina (Rattus norvegicus) pada Paparan Sub-Kronik 28 Hari

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Tengku Anggun Lestari ◽  
Nour Athiroh ◽  
Nurul Jadid Mubarakati
Keyword(s):  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Rattus Norvegicus ◽  
Toxicity Test ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
One Way Anova

Tea Benalu (Scurrula atropurpurea [Bl.] Dans.) and Mango Benalu (Dendrophthoe pentandra L. miq.) containssecondary metabolites with potential antioxidant potential. Antioxidants can inhibit the oxidation process and reduce Total Cholesterol, Triglycerides, Low-Density Lipoprotein (LDL) and increase High-Density Lipoprotein (HDL). The safety of the preparations for the combination of parasites of tea and mango leaves was tested to obtain toxic effects after repeated treatment tests over some time. The purpose of this study was to determine the toxic effects of a combination of methanolic extracts of a combination of tea parasites and mangoes in female rats (Rattus norvegicus) subchronically for 28 days by looking at the results of the clinical biochemical examination on lipid profiles, namely total cholesterol levels, triglycerides, high-density lipoproteins (28%). HDL), and Low-Density Lipoprotein (LDL). The method of this study was experimental with a combination dose of methanol extract of tea parasite leaves and mango parasite leaves at a dose of 250 mg / KgBB, 500 mg / KgBB and 1000 mg / KgBB with 5x replications each treatment. The subjects used white rats (Rattus norvegicus) female Wistar strains aged 6-8 weeks with a minimum body weight of 100 grams. The treatment in this study was in the form of each dose given 5 times a week for 28 days (subchronic toxicity test) orally. Lipid profile levels were analyzed using the one-way ANOVA test. The results showed that the level of control blood lipid profile with a treatment dose of 250 mg / KgBW, 500 mg / KgBW, and 1000 mg / KgBW was not significantly different. The toxicity test of combined extracts of tea leaves and mango parasite leaves of female rat Rattus novergicus on subchronic exposure 28 days with those doses showed no difference tangible between treatments of controls. This means it is safe and does not cause toxic properties in the lipid profile of female wistar rats.Keywords: Lipid Profile, Scurrula atropurpurea, Dendophthoe pentandra, Sub-Chronic Toxicity, Rattus norvegicus ABSTRAKBenalu Teh (Scurrula atropurpurea [Bl.] Dans.) dan  Benalu Mangga (Dendrophthoe pentandra L. miq.) mengandung metabolit sekunder berpotensi sebagai antioksidan. Antioksidan dapat memperhambat proses oksidasi dan menurunkan Cholesterol Total, Trigliserida, Low Density Lipoprotein (LDL) dan menaikkan High Density Lipoprotein (HDL). Keamanan sediaan kombinasi daun benalu teh dan mangga diuji memperoleh tentang efek toksik setelah uji perlakuan berulang dalam jangka waktu tertentu. Tujuan dari penelitian ini untuk mengetahui efek toksik kombinasi ekstrak metanolik kombinasi daun benalu teh dan mangga pada tikus betina (Rattus norvegicus) secara subkronik selama 28 hari dengan melihat hasil pemeriksaan biokimia klinis pada profil lipid, yaitu kadar Cholesterol Total, Trigliserida, High Density Lipoprotein (HDL), dan Low Density Lipoprotein (LDL). Metode penelitian ini adalah eksperimental dengan perlakuan dosis kombinasi ekstrak metanol daun benalu teh dan daun benalu mangga dosis 250 mg/KgBB, 500 mg/KgBB dan 1000 mg/KgBB dengan ulangan 5x tiap perlakuan. Subjek menggunakan tikus putih (Rattus norvegicus) betina strain wistar yang berumur 6-8 minggu dengan berat badan minimal 100 gram. Perlakuan dalam penelitian ini berupa setiap dosis  diberikan 5 kali seminggu selama 28 hari (uji toksisitas subkronik) secara per-oral. Kadar profil lipid dianalisis menggunakan uji One-way ANOVA. Hasil penelitian menunjukkan bahwa kadar profil lipid darah kontrol dengan perlakuan dosis 250 mg/KgBB, 500 mg/KgBB dan 1000 mg/KgBB tidak berbeda nyata. Uji”toksisitas”ekstrak kombinasi daun benalu teh dan daun benalu mangga  tikus betina Rattus novergicus pada paparan subkronik 28 hari dengan”dosis”tersebut menunjukkan hasil tidak”beda”nyata antara perlakuan terhadap”kontrol. ”Hal ini berarti aman dan tidak menimbulkan sifat toksik pada profil lipid tikus wistar betina.Kata Kunci : Profil Lipid, Scurrula atropurpurea, Dendophthoe pentandra, Subkronik, Rattus norvegicus

scholarly journals JUS PEPAYA (CARICA PAPAYA L) DAPAT MENURUNKAN KADAR LDL DAN KOLESTEROL TOTAL PADA USIA 40-70 TAHUN

2018 ◽  
pp. 153-161
Author(s):  
Junendri Ardian ◽  
Ari Natalia Probandari ◽  
K Kusnandar
Keyword(s):  
High Density Lipoprotein ◽  
Carica Papaya ◽  
Low Density Lipoprotein ◽  
Intervention Group ◽  
Density Lipoprotein ◽  
High Density ◽  
Control Group ◽  
Low Density ◽  
Post Test ◽  
Research Show

  ABSTRAK Hiperkolesterolemia merupakan suatu kondisi dimana kolesterol dalam darah meningkat melebihi ambang normal yang ditandai dengan meningkatnya kadar kolesterol total terutama Low Density Lipoprotein (LDL) dan diikuti dengan penurunan kadar High Density Lipoprotein (HDL) darah, Tujuan penelitian adalah menganalisis pengaruh pemberian asupan jus pepaya terhadap kadar LDL dan kolesterol total pada ibu rumah tangga usia 40-70 tahun yang menderita hiperkolesterolemia. Metode: Jenis penelitian ini merupakan penelitian true eksperimental dengan desain penelitian pre and post test with control group. Total subjek sebanyak 20 orang yang dibagi kedalam dua kelompok, yaitu Intervensi Jus pepaya dan kelompok kontrol. Hasil penelitian menunjukkan bahwa kadar kolesterol total pada kelompok jus pepaya mengalami penurunan yang bermakna (p<0,05). Sedangkan pada kelompok kontrol tidak bermakna (p>0,05). Kadar LDL pada kelompok jus pepaya mengalami penurunan yang bermakna (p<0,05). Sedangkan pada kelompok kontrol tidak bermakna (p>0,05). Kesimpulan jus pepaya (carica papaya l) dapat menurunkan kadar LDL (Low Density Lipoprotein) dan kolesterol total.   Kata kunci: jus pepaya, kolesterol total, LDL.       ABSTRACT Hypercholesterolemia is a conditions where cholesterol in the bloods increased beyond the normal standard, its showed with cholesterol total level’s was increased especially Low Density Lipoprotein (LDL) and followed by the decreasing of High Density Lipoprotein (HDL) in blood, The purpose of this research is analyzing the influence’s of papaya juice intake for LDL’s levels and cholestrol’s total at the age of 40 – 70 years old for housewives with hypercholesterolemia. The method this research is true experimental researchs with pre and post test control group designs. The subject in this research are 20 people and separated into two groups, the first group is papaya juice’s intervention group, and the second is control group. The result of this research show that papaya juice’s has significant result for decreasing cholesterol’s total with p value’s < 0,05 , while the control group has no significant result because its p value’s >0,05. The result for LDL’s levels show that papaya juice’s has significant result too for decreasing LDL’s levels with p value’s < 0,05, while the control group has no significant result because its p value’s >0,05. The conclusion in this research is papaya juice (carica papaya l) can decreased ldl’s levels and cholesterol’s total.   Keywords: cholesterol’s total, LDL, papaya juice.  

scholarly journals Pengaruh pemberian kombinasi minyak rami dengan minyak wijen terhadap kadar kolesterol high density lipoprotein (HDL) pada tikus sprague dawley dislipidemia

2017 ◽  
Vol 6 (1) ◽  
pp. 35
Author(s):  
Bike Meisyahputri ◽  
Martha Ardiaria
Keyword(s):  
High Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Control Group ◽  
Sprague Dawley ◽  
Control Group Design ◽  
Group Design ◽  
Post Test ◽  
Randomized Control ◽  
Paired T Test

Latar Belakang: Dislipidemia merupakan faktor risiko dari penyakit kardiovaskular (CVD) seperti penyakit jantung koroner (PJK) dan artherosklerosis. Dislipidemia adalah kelainan metabolisme lipid dalam darah. Salah satu kelainan komponen lipid yaitu menurunnya kadar kolesterol High Density Lipoprotein (HDL). Minyak rami dan minyak wijen yang mengandung asam linolenat, asam linoleat dan antioksidan yang berpotensi dalam meningkatkan kadar kolesterol HDL darah. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian kombinasi minyak rami dengan minyak wijen terhadap kadar kolesterol HDL pada tikus dislipdemia.Metode : Penelitian true experimental dengan pre-post test randomized control group design terhadap 24 ekor tikus Sprague dawley dislipidemia dibagi secara acak menjadi 4  kelompok yaitu kelompok kontrol diberikan pakan standar dan tinggi kolesterol dan tiga kelompok perlakuan diberikan pakan tinggi kolesterol dan kombinasi minyak rami dengan minyak wijen dosis 1 ml/200 gBB, 2 ml/200 gBB, 3 ml/200 gBB selama 14 hari. Kadar kolesterol HDL diperiksa dengan metode CHOD-PAP. Data dianalisis dengan uji Paired t-test dan Anova.Hasil : Terdapat perbedaan penurunan kolesterol HDL secara bermakna sebelum dan sesudah perlakuan pada kelompok kontrol sebesar 1,43% (p=0,003). Kelompok P1, P2, P3 mengalami peningkatan kolesterol HDL secara bermakna (p<0,05) berturut-turut yaitu sebesar 18,49% (p=0,000), 29,21% (p=0,000), dan 50,85% (p=0,000).Simpulan : Ketiga kelompok perlakuan dengan pemberian kombinasi minyak rami dengan minyak wijen selama 14 hari terbukti dapat meningkatkan kadar kolesterol HDL. Kelompok perlakuan  dosis 3 ml/200 gBB paling efektif meningkatkan kolesterol HDL pada tikus dislipidemia.

Pengaruh Pemberian Jus Terong Ungu terhadap Perlemakan Hati Tikus Wistar

2019 ◽  
Vol 18 (2) ◽  
pp. 59-63
Author(s):  
Dian Luthfiana Sufyan
Keyword(s):  
Fatty Liver ◽  
Solanum Melongena ◽  
Atherogenic Diet ◽  
Control Group ◽  
Test Design ◽  
Alcoholic Fatty Liver ◽  
Post Test ◽  
Post Hoc ◽  
Group Post ◽  
One Way Anova

ABSTRACT Non Alcoholic Fatty Liver Disease (NAFLD) is an infiltration of fat inside hepatocytes until exceeding 5% of the liver weight. Eggplant (Solanum melongena L.) contain high anthocyanin level, (8 - 85 mg per 100 gram edible portion) and pectin fiber. This study was aimed to determine the effect of eggplant juice to the fatty liver of Rattus novergicus strain Wistar that were given atherogenic diet. This study using control group post test design performed in wistar rat that placed in pharmacologic laboratory of Brawijaya University. Sampling was carried out by completely random sampling with 30 rats for total sample. Data were processed and analyzed using SPSS 16. Statictical test using one way ANOVA and post hoc tukey. The results showed there was significant correlation between dosage I (1,3 gr/3 ml), dosage II (2,6 gr/3 ml) and dosage III (5,2 gr/3 ml) of eggplant juice to fatty liver (p<0,001). Food intake of rat influenced the number of fatty liver cells. This reasearch conclusion is eggplant juice has effect to white rat fatty liver. Based on this study, it was recommended to consume eggplant as anthocyanin and pectin source to reduce fatty liver that induced by atherogenic diet. Key words: NAFLD, atherogenic diet, eggplant, anthocyanin, pectin   Perlemakan hati non alkohol adalah suatu infiltrasi dari lemak, terutama trigliserida di dalam hepatosit atau sel-sel hati hingga lebih dari 5% berat organ hati. Terong ungu (Solanum melongena L.) merupakan tanaman sayur yang mengandung pigmen antosianin cukup tinggi yakni 8 – 85 mg per 100 gram nya serta serat pektin. Penelitian ini bertujuan untuk mengetahui efek jus terong ungu terhadap perlemakan hati tikus wistar yang diberi diet aterogenik. Penelitian eksperimental ini menggunakan metode Control Group Post Test Design bertempat di laboratorium farmakologi FKUB. Pemilihan sampel dilakukan menggunakan metode RAL (Rancangan Acak Lengkap) dengan jumlah sampel total sebanyak 30 tikus putih. Data diolah dan dianalisis menggunakan SPSS 16. Uji statistik menggunakan one way ANOVA dilanjutkan Post Hoc Tukey. Hasil penelitian menunjukkan terdapat hubungan yang signifikan antara dosis I (1,3 gr/3 ml), dosis II (2,6 gr/3 ml) dan dosis III (5,2 gr/3 ml) jus terong ungu terhadap perlemakan hati (p<0,001). Berdasarkan penelitian ini dapat disimpulkan bahwa jus terong ungu memiliki efek terhadap perlemakan hati tikus putih. Dari penelitian ini, disarankan konsumsi terong ungu sebagai sumber antosianin dan pektin untuk menurunkan perlemakan hati yang dipicu oleh faktor diet aterogenik. Kata kunci:perlemakan hati non alkohol, diet aterogenik, terong ungu, antosianin, pektin

Pengaruh Pemberian Ekstrak Rumput Laut Merah (Kappaphycus alvarezii) terhadap Kadar LDL Pada Tikus Putih (Rattus Norvegicus) Jantan Galur Wistar Yang Diberi Diet Tinggi Lemak

2018 ◽  
Vol 15 (2) ◽  
pp. 112
Author(s):  
MENTARI AMENDA SAPUTRI ◽  
HERIN SETIANINGSIH
Keyword(s):  
Rattus Norvegicus ◽  
Kappaphycus Alvarezii ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Post Test ◽  
One Way Anova ◽  
Test Control

<p class="Default">Penyakit kardiovaskular merupakan penyebab kematian nomor satu di dunia. Gaya hidup masyarakat terutama dalam mengkonsumsi diet yang tidak sehat dapat meningkatkan kadar LDL yang dapat menyebabkan  penyakit kardiovaskular. Rumput laut merah (<em>Kappaphycus alvarezii</em>)<em> </em>yang banyak dibudidayakan di Indonesia mengandung flavonoid dan triterpenoid yang diduga dapat menurunkan kadar LDL. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak rumput laut merah (<em>Kappaphycus alvarezii</em>) <em> </em>terhadap kadar LDL pada tikus putih (<em>Rattus norvegicus</em>) jantan galur Wistar yang diberi diet tinggi lemak. Penelitian ini adalah penelitian eksperimental murni laboratorik dengan rancangan penelitian <em>Post Test Control Group Design. </em>Sampel yang digunakan adalah 24 ekor tikus putih (<em>Rattus norvegicus</em>) jantan galur Wistar yang dibagi ke dalam tiga kelompok: kelompok yang diberi diet standar selama 28 hari (K1), kelompok yang diberi diet tinggi lemak selama 28 hari (K2), dan kelompok yang diberi diet tinggi lemak selama 28 hari dan pada hari ke-15 sampai hari ke-28 diberi ekstrak rumput laut merah (<em>Kappaphycus alvarezii</em>) dengan dosis 140mg/200grBB/hari (K3). Hasil analisis statistik <em>One Way Anova </em>menunjukkan bahwa terdapat perbedaan kadar LDL yang signifikan antara ketiga kelompok pada penelitian ini (p&lt;0,001). Kadar LDL pada K2 (=16,00±3,29) meningkat secara bermakna dibandingkan dengan K1 (=10,62±1,77). Sedangkan kadar LDL pada K3 (=6,88±2,42) menurun secara bermakna dibandingkan dengan K2. Dari hasil penelitian ini dapat disimpulkan bahwa ekstrak rumput laut merah (<em>Kappaphycus alvarezii</em>) berpengaruh terhadap kadar LDL darah pada tikus putih (<em>Rattus norvegicus</em>) jantan galur Wistar yang diberi diet tinggi lemak.</p><p><strong>Kata kunci</strong> : diet tinggi lemak, LDL, <em>Kappaphycus alvarezii</em></p>

scholarly journals Effect of fatty Amazon fish consumption on lipid metabolism

2014 ◽  
Vol 27 (1) ◽  
pp. 97-105 ◽  
Author(s):  
Francisca das Chagas do Amaral Souza ◽  
Nadja Pinto Garcia ◽  
Rejane Souza de Aquino Sales ◽  
Jaime Paiva Lopes Aguiar ◽  
Wallice Luiz Paxiúba Duncan ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Amazon Basin ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Fatty Fish ◽  
Serum Triglycerides

OBJECTIVE: The present study aimed to evaluate the effect of feeding diets enriched with fatty fish from the Amazon basin on lipid metabolism. METHODS: Male Wistar rats were divided into four groups: control group treated with commercial chow; Mapará group was fed diet enriched with Hypophthalmus edentatus; Matrinxã group was fed diet enriched with Brycon spp.; and, Tambaqui group was fed diet enriched with Colossoma macropomum. Rats with approximately 240g±0.60 of body weight were fed ad libitum for 30 days, and then were sacrificed for collection of whole blood and tissues. RESULTS: The groups treated with enriched diets showed a significant reduction in body mass and lipogenesis in the epididymal and retroperitoneal adipose tissues and carcass when compared with the control group. However, lipogenesis in the liver showed an increase in Matrinxã group compared with the others groups. The levels of serum triglycerides in the treated groups with Amazonian fish were significantly lower than those of the control group. Moreover, total cholesterol concentration only decreased in the group Matrinxã. High Density Lipoprotein cholesterol levels increased significantly in the Mapará and Tambaqui compared with control group and Matrinxã group. The insulin and leptin levels increased significantly in all treatment groups. CONCLUSION: This study demonstrated that diets enriched with fatty fish from the Amazon basin changed the lipid metabolism by reducing serum triglycerides and increasing high density lipoprotein-cholesterol in rats fed with diets enriched with Mapará, Matrinxã, and Tambaqui.

scholarly journals Pengaruh Jus Seledri (Apium graveolens L.) terhadap Gambaran Mikroskopis Hepar Tikus (Rattus norvegicus) yang Diinduksi Diet Hiperkolesterol

2019 ◽  
Vol 8 (1) ◽  
pp. 68
Author(s):  
Andina Dwinanda ◽  
Nita Afriani ◽  
Hardisman Hardisman
Keyword(s):  
Rattus Norvegicus ◽  
Apium Graveolens ◽  
Control Group ◽  
Post Test ◽  
One Way Anova ◽  
Test Control

Kadar kolesterol berlebihan dalam tubuh akan mengakibatkan penumpukan lemak di hepar. Salah satu alternatif obat tradisional yang dapat menurunkan kadar kolesterol adalah tanaman seledri. Penelitian sebelumnya menyatakan bahwa fraksi air herba seledri dapat menurunkan kadar kolesterol total pada keadaan hiperkolesterol. Tujuan penelitian ini adalah menentukan pengaruh pemberian jus seledri terhadap gambaran mikroskopis hepar yang diinduksi diet hiperkolesterol pada tikus percobaan. Jenis penelitian adalah eksperimental dengan desain post test control group. Sampel berjumlah 25 ekor tikus yang terdiri atas 5 kelompok yaitu kelompok kontrol negatif, kontrol positif, perlakuan 1, perlakuan 2 dan perlakuan 3. Masing-masing perlakuan diberikan diet hiperkolesterol yang dibuat dari minyak babi sebanyak 2 gram dan kuning telur puyuh rebus 1 gram selama 14 hari. Selanjutnya diberikan jus seledri dengan dosis masing-masing kelompok perlakuan yaitu 0,72ml/200gBB; 1,44ml/200gBB; dan 2,16ml/200gBB yang diberikan dua kali sehari selama 14 hari berikutnya. Histopatologi hepar tikus diamati dengan menghitung jumlah sel yang mengalami perlemakan. Analisis data menggunakan uji one way Anova terhadap semua kelompok. Hasil analisis memperlihatkan terjadi perubahan jumlah sel berlemak yang bermakna secara statistik antara kelompok kontrol dengan ketiga kelompok perlakuan dengan nilai p<0,05. Simpulan penelitian ini adalah jus seledri dapat mengurangi perlemakan sel hepar akibat penumpukan lemak dengan dosis efektif yaitu 0,72ml/200gBB.

scholarly journals Effect of Some Strains of Lactic Acid Bacteria and Their Mixture on the Level of Fats and Cholesterol in Albino Rats (Rattus norvegicus) Male with Hypothyroidism Induced Using Carbimazole

2021 ◽  
Vol 34 (1) ◽  
pp. 139-146
Author(s):  
Elham K. Nasser ◽  
Kithar R. Majeed ◽  
Hayder I. Ali
Keyword(s):  
High Density Lipoprotein ◽  
Low Density Lipoprotein ◽  
Control Sample ◽  
Density Lipoprotein ◽  
High Density ◽  
Control Group ◽  
Albino Rats ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Fortified Milk

Fortified milk containing Lactobacillus plantarum, L. casei, and L. acidophilus isolates and their mixture were used in dosing the male albino rats at an age of 9-12 weeks at an average of 23 g with induced hypothyroidism at a concentration of 0.6 g.kg-1 of carbimazole. Total cholesterol, triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very-low-density lipoprotein (VLDL) were estimated. The results showed a significant increase in the level of triglycerides (TG), cholesterol and triglycerides. Low-density lipoprotein (LDL) and very-low-density lipoprotein (VLDL), with a significant decrease in the level of high-density lipoprotein (HDL) in infected male mice, compared to the control sample, and upon dosing with liquid milk fortified, it returned to its normal level without significant differences from the control group.

l-Carnitine-induced amelioration of HFD-induced hepatic dysfunction is accompanied by a reduction in hepatic TNF-α and TGF-β1

2018 ◽  
Vol 96 (6) ◽  
pp. 713-725 ◽  
Author(s):  
Mabrouk Attia Abd Eldaim ◽  
Fatma Mohamed Ibrahim ◽  
Saher Hassan Orabi ◽  
Azza Hassan ◽  
Hesham Saad El Sabagh
Keyword(s):  
Protein Expression ◽  
High Density Lipoprotein ◽  
Body Mass ◽  
Density Lipoprotein ◽  
Basal Diet ◽  
Serum Levels ◽  
High Density ◽  
Control Group ◽  
Tnf Α ◽  
Tgf Β1

In this study, we evaluated the possible mechanisms through which l-carnitine ameliorates the adverse effects from obesity in rats, induced with a high-fat diet (HFD). For this, 56 albino Wister rats were randomly assigned to 7 groups. The control group was fed a basal diet and injected with saline. The second group was fed the basal diet and injected with l-carnitine (200 mg/kg body mass, by intraperitoneal injection; i.p.). The third group were fed the HFD. The fourth group was fed the HFD and injected with l-carnitine (200 mg/kg body mass, i.p.) for 8 weeks. The fifth group was fed the HFD for 10 weeks. The sixth group were fed the HFD for 10 weeks and were also injected with l-carnitine (200 mg/kg body mass, i.p.) during the final 2 weeks. The seventh group was fed the HFD diet for 8 weeks then the basal diet for 2 weeks. The HFD induced significantly increased levels of hyperglycemia, lipid peroxidation, pathological changes, TNF-α and TGF-β1 protein expression in hepatic tissue, food intake, body weight gain, serum levels of total and non-high-density lipoprotein cholesterol, ketone bodies, triacylglycerol, urea, creatinine, AST, and ALT. However, the HFD diet significantly decreased serum levels of high-density lipoprotein (HDL) and hepatic levels of reduced glutathione. l-Carnitine ameliorated the effects of the HFD on the above-mentioned parameters. This study indicated that l-carnitine had protective and curative effects against HFD-induced hepatosteatosis by reducing hepatic oxidative stress and protein expression of TNF-α and TGF-β1.

Effectiveness of website application (Sumiferos) for preventing anemia with pregnant women compliance in consuming Fe tablets

2020 ◽  
Vol 11 (3) ◽  
pp. 197-200
Author(s):  
Rosmaria . ◽  
Sri Yun Utama ◽  
Titik Hindriati ◽  
Diniyati .
Keyword(s):  
Pregnant Women ◽  
Health Workers ◽  
Intervention Group ◽  
Control Group ◽  
Test Design ◽  
Communication Tool ◽  
Care Services ◽  
Post Test ◽  
Quasi Experimental ◽  
Group Post

Background: The consumption of Fe tablets needs to be the attention of midwives as one of the spearheads in providing antenatal care services. Due to the low level of compliance of pregnant women to consume Fe tablets, it is necessary to provide appropriate counseling as an effort to increase compliance with Fe tablets. Objective: This study aimed to determine the effectiveness of the application model (Sumiferos) for preventing anemia with pregnant women compliance in consuming Fe tablets at Putri Ayu Health Center in Jambi city. Materials and methods: This study used a quasi-experimental research design with a post-test design by involving an intervention group and a control group (post-test), two group designs. With the total of 70 subjects;the intervention group, 35 respondents were given a website application (sumiferos), and a control group 35 respondents were given a leflet. After a month, the number of Fe tablets that have been consumed was monitored. Compliance of pregnant women in consuming Fe tablets required a monitoring or supervisioncarried out by health workers. Therefore, an intervention was given by using a website-based application (sumiferos) for pregnant women as a communication tool that has been created and designed previously by researchers. Results: Posttest statistical analysis showed that pregnant women who were given a website application (sumiferos) in the intervention group showed better compliance than pregnant women in the control group given lefket. Conclusion: Based on the results,a website application (sumiferos) is more effective than leaflets in improving maternal compliance to consume Fe tablets given by health workers.

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