scholarly journals The Immune and Inflammatory Basis of Acquired Pediatric Cardiac Disease

2021 ◽  
Vol 8 ◽  
Author(s):  
Elysa Jui ◽  
Kavya L. Singampalli ◽  
Kevin Shani ◽  
Yao Ning ◽  
Jennifer P. Connell ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Low Income ◽  
Inflammatory Responses ◽  
Cardiac Cells ◽  
Matrix Composition ◽  
Acquired Heart Disease ◽  
Blood Flow Patterns ◽  
The Relationship ◽  
Significant Health

Children with acquired heart disease face significant health challenges, including a lifetime of strict medical management, multiple cardiac surgeries, and a high mortality risk. Though the presentation of these conditions is diverse, a unifying factor is the role of immune and inflammatory responses in their development and/or progression. For example, infectious agents have been linked to pediatric cardiovascular disease, leading to a large health burden that disproportionately affects low-income areas. Other implicated mechanisms include antibody targeting of cardiac proteins, infection of cardiac cells, and inflammation-mediated damage to cardiac structures. These changes can alter blood flow patterns, change extracellular matrix composition, and induce cardiac remodeling. Therefore, understanding the relationship between the immune system and cardiovascular disease can inform targeted diagnostic and treatment approaches. In this review, we discuss the current understanding of pediatric immune-associated cardiac diseases, challenges in the field, and areas of research with potential for clinical benefit.

scholarly journals MR Assessment of Acute Pathologic Process after Myocardial Infarction in a Permanent Ligation Mouse Model: Role of Magnetic Nanoparticle-Contrasted MRI

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Cheongsoo Park ◽  
Eun-Hye Park ◽  
Jongeun Kang ◽  
Javeria Zaheer ◽  
Hee Gu Lee ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Mouse Model ◽  
Magnetic Nanoparticle ◽  
Inflammatory Responses ◽  
Myocardial Infarct ◽  
Correlation Coefficients ◽  
Myocardial Infarct Size ◽  
Manganese Enhanced Mri ◽  
The Relationship

We evaluated the relationship between myocardial infarct size and inflammatory response using cardiac magnetic resonance imaging (CMR) in an acute myocardial infarction (AMI) mouse model. Myocardial infarction (MI) was induced in 14 mice by permanent ligation of the left anterior descending artery. Late gadolinium enhancement (LGE), manganese-enhanced MRI (MEMRI), and magnetofluorescent nanoparticle MRI (MNP-MRI) were performed 1, 2, and 3 days after MI, respectively. The size of the enhanced lesion was quantitatively determined using Otsu’s thresholding method in area-based and sector-based approaches and was compared statistically. Linear correlation between the enhanced lesion sizes was evaluated by Pearson’s correlation coefficients. Differences were compared using Bland-Altman analysis. The size of the inflammatory area determined by MNP-MRI (57.1 ± 10.1%) was significantly larger than that of the infarct area measured by LGE (40.8 ± 11.7%, P<0.0001) and MEMRI (44.1 ± 14.9%, P<0.0001). There were significant correlations between the sizes of the infarct and inflammatory lesions (MNP-MRI versus LGE: r=0.3418, P=0.0099; MNP-MRI versus MEMRI: r=0.4764, P=0.0002). MNP-MRI provides information about inflammatory responses in a mouse model of AMI. Thus, MNP-MRI associated with LGE and MEMRI may play an important role in monitoring the disease progression in MI.

Psychological distress and circulating inflammatory markers in healthy young adults

2010 ◽  
Vol 40 (12) ◽  
pp. 2079-2087 ◽  
Author(s):  
S. Goldman-Mellor ◽  
L. Brydon ◽  
A. Steptoe
Keyword(s):  
Cardiovascular Disease ◽  
Young Adults ◽  
Psychological Distress ◽  
Longitudinal Research ◽  
Inflammatory Responses ◽  
General Health Questionnaire ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Cross Sectional ◽  
The Relationship

BackgroundAlthough a substantial body of research points to a link between psychological distress and inflammatory responses in middle-aged and older adults, particularly those with cardiovascular disease, the relationship between inflammation and distress in young, healthy individuals has not been established. This study was designed to investigate the cross-sectional association between psychological distress and inflammatory proteins in a young, healthy representative population of English adults.MethodParticipants were 1338 individuals aged 16–34 years from the 2006 Health Survey for England (HSE). Blood samples to measure plasma fibrinogen and high sensitivity C-reactive protein (hsCRP), as well as measures of psychological distress (using the General Health Questionnaire 12-item scale, GHQ-12) and covariates, were collected during home visits. Linear regression was used to assess the relationship between psychological distress and fibrinogen and hsCRP.ResultsHigher self-rated distress was positively associated with fibrinogen level in this young population, independently of age, sex, ethnicity, body mass index (BMI), high density lipoprotein (HDL) cholesterol, smoking, and alcohol and medication use (β=0.024, p<0.01). Psychological distress was not related to hsCRP.ConclusionsPsychological distress may negatively impact inflammatory processes in young adulthood before the onset of chronic health problems such as hypertension and cardiovascular disease. Longitudinal research is needed to elucidate the relationship between distress and inflammation in young adults and its significance for later disease states.

Hypothyroidism and cardiovascular system

2016 ◽  
Vol 94 (7) ◽  
pp. 497-503 ◽  
Author(s):  
A. F. Verbovoy ◽  
Lyudmila A. Sharonova ◽  
O. V. Kosareva ◽  
N. I. Verbovaya ◽  
Yu. A. Dolgikh
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Diseases ◽  
Vitamin D3 ◽  
Thyroid Dysfunction ◽  
Myocardial Remodeling ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
The Relationship

The article presents data on the relationship between thyroid dysfunction and cardiovascular diseases. The role of dyslipidemia, adipokines (adiponectin, leptin, resistin), C-reactive protein, deficiency of vitamin D3 in the development of cardiovascular disease in hypothyroidism is discussed. The article describes characteristics of myocardial remodeling, its dysfunction and their correlation with risk factors of cardiovascular diseases in patients with hypothyroidism.

scholarly journals Neighborhood and Parental Influences on Diet and Physical Activity Behaviors in Young Low-Income Pediatric Patients

2016 ◽  
Vol 56 (13) ◽  
pp. 1235-1243 ◽  
Author(s):  
Nakiya N. Showell ◽  
Katie Washington Cole ◽  
Katherine Johnson ◽  
Lisa Ross DeCamp ◽  
Megan Bair-Merritt ◽  
...  
Keyword(s):  
Physical Activity ◽  
Young Children ◽  
Low Income ◽  
Behavioral Interventions ◽  
Dynamic Relationship ◽  
Diet And Physical Activity ◽  
The Face ◽  
The Relationship ◽  
Racial Ethnic

This study explores the relationship between neighborhood characteristics and caregiver preferences for establishing diet and physical activity behaviors among low-income African American and Hispanic young children (2-5 years). Primary caregivers of young children were recruited from 2 urban pediatric clinics to participate in focus groups (n = 33). Thematic analysis of transcripts identified 3 themes: neighborhood constraints on desired behaviors, caregivers’ strategies in response to neighborhoods, and caregivers’ sense of agency in the face of neighborhood constraints. This study elucidates the dynamic relationship between neighborhoods and caregiver preferences, their interrelated impacts on establishment of diet and physical activity behaviors among young children, and the important role of caregiver agency in establishing behaviors among young children. To effectively address obesity disparities among young children, primary care behavioral interventions must leverage and support such resilient caregiver responses to neighborhood constraints in order to optimally address racial/ethnic and socioeconomic disparities in obesity among young children.

ADAPTATION TO CLIMATE CHANGE IN LOW-INCOME COUNTRIES: LESSONS FROM CURRENT RESEARCH AND NEEDS FROM FUTURE RESEARCH

2012 ◽  
Vol 03 (02) ◽  
pp. 1250005 ◽  
Author(s):  
ARUN S. MALIK ◽  
STEPHEN C. SMITH
Keyword(s):  
Climate Change ◽  
Low Income ◽  
Low Income Countries ◽  
Future Research ◽  
Adaptation To Climate Change ◽  
Autonomous Adaptation ◽  
Adaptation Decision ◽  
Planned Adaptation ◽  
The Relationship

We put in perspective the papers in this special issue by characterizing different forms of adaptation to climate change and discussing the role of adaptation in a developing country context. We highlight adaptation decision-making under uncertainty, empirics of autonomous adaptation, and data and methodological challenges. We identify unresolved questions, emphasizing interactions between autonomous and planned adaptation, adaptation externalities, and the relationship between adaptation and conflict.

scholarly journals The Role of Population in Economic Growth

SAGE Open ◽  
2017 ◽  
Vol 7 (4) ◽  
pp. 215824401773609 ◽  
Author(s):  
E. Wesley F. Peterson
Keyword(s):  
Economic Growth ◽  
Population Growth ◽  
Low Income ◽  
Low Income Countries ◽  
High Population Growth ◽  
Economic Analyses ◽  
The Relationship ◽  
Lower Population ◽  
Capita Output

The relationship between population growth and economic growth is controversial. This article draws on historical data to chart the links between population growth, growth in per capita output, and overall economic growth over the past 200 years. Low population growth in high-income countries is likely to create social and economic problems while high population growth in low-income countries may slow their development. International migration could help to adjust these imbalances but is opposed by many. Drawing on economic analyses of inequality, it appears that lower population growth and limited migration may contribute to increased national and global economic inequality.

scholarly journals Metabolic Syndrome: The Complex Relationship of Diet to Conditions of Disturbed Metabolism

2011 ◽  
Vol 1 (2) ◽  
pp. 1 ◽  
Author(s):  
Jeffrey S. Bland
Keyword(s):  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Clinical Studies ◽  
Inflammatory Responses ◽  
Lifestyle Modification ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Public Health Challenge ◽  
Relationship Of

The widespread prevalence and deleterious effects of metabolic syndrome have become a major public health challenge as it is associated with the development of type 2 diabetes and cardiovascular disease. Lifestyle modification focusing on diet has shown promise for managing cardiovascular disease risk, and clinical studies provide evidence that a Mediterranean diet supplemented with phytochemicals is a successful interventional approach. The role of phytochemicals in regulating gene expression and modulating intracellular kinase activity has only recently begun to be appreciated. Clinical studies investigating the effects of specific phytochemicals in metabolic syndrome patients have produced encouraging results, including normalization of metabolic function, reduction of cardiovascular risk, and resolution of metabolic syndrome. As research advances our understanding of the evolutionary relationships between plants and humans, details are emerging about the mechanisms by which phytochemicals regulate insulin signaling and inflammatory responses. This expanding field of research is likely to lead to novel, effective clinical approaches for combating chronic diseases such as metabolic syndrome.

scholarly journals Optimization of protocols of management of patients with generalized periodontitis at the background of cardiovascular disease

2021 ◽  
Vol 2 (2) ◽  
pp. 8-15
Author(s):  
O.V. Kopchak ◽  
H.F. Biloklytska ◽  
O.V. Asharenkova ◽  
K.A. Yanishevskyi
Keyword(s):  
Cardiovascular Disease ◽  
Periodontal Disease ◽  
Comorbid Conditions ◽  
Simultaneous Treatment ◽  
Pathogenetic Therapy ◽  
Autoimmune Processes ◽  
Shock Proteins ◽  
The Relationship

Many researchers have proven the relationship between periodontal disease and somatic pathology. Analysis of the data obtained from 348 patients showed that patients under the age of 49 were most often diagnosed with various forms of gingivitis — 36.3–51.65 % and generalized periodontitis (GP) I–II degree — 48.35–59.42 %. However, in patients aged 50–69 years, GP was the predominant disease and accounted for 93.2 %, with 56.03 % of patients having concomitant cardiovascular disease (CVD). Our studies showed that despite the significant prevalence of periodontal disease in patients with CVD, they did not systema-tically visit dentists for treatment. Our studies demonstrated a significant role of autoimmune processes in the formation and progression of chronic generalized periodontal disease in patients with concomitant comorbid conditions, in particular with cardiovascular disease. The data obtained by us demonstrated that one of the important autoantigens that determine the forms of syste-mic inflammatory response and progression of local and systemic endothelial dysfunction in GP with CVD is heat shock proteins. Taking this into consideration, a new differentiated approach to the treatment of GP in CVD was developed based on a new concept of pathogenesis. Pathogenetic therapy of GP in CVD is based on the simultaneous treatment of diseases (including the regenerative method of therapy) taking into account the severity of pathological processes that have an aggravating course. Interdisciplinary integration of dentists and cardiologists will optimize management protocols considering the presence and severity of somatic pathology and, therefore, will improve the quality of GP treatment in conditions of comorbidity.

scholarly journals THE ROLE OF INTRATUMORAL DENDRITIC CELLS IN THE PROGRESSION OF SQUAMOUS CELL CARCINOMAS

2019 ◽  
Vol 18 (4) ◽  
pp. 50-58
Author(s):  
L. N. Bondar ◽  
L. A. Tashireva ◽  
O. V. Savenkova ◽  
E. L. Choynzonov ◽  
V. M. Perelmuter
Keyword(s):  
Overall Survival ◽  
Squamous Cell ◽  
Inflammatory Responses ◽  
Survival Rates ◽  
Metastatic Tumor ◽  
Squamous Cell Carcinomas ◽  
The Relationship ◽  
Disease Free ◽  
Overall Survival Rates

The aim of the studywas to summarize data on the role of tumor-associated dendritic cells (DC) in the formation of squamous cell carcinoma microenvironment, their participation in the development of immune inflammatory responses in the tumor stroma and relation to tumor progression.Material and Methods. We analyzed 79 publications available from Pubmed, Google Scholar, Elibrary databases from January 2000 to December 2017.Results. The characteristics of different types of DC, including Langerhans cells (CR), were presented. The different methods of DC identification were described. The information on the presence of DC in squamous cell carcinomas was analyzed. The influence of the tumor on DCs, as well as the relationship between the number and functional characteristics of DCs and invasive/metastatic tumor potentialities was described. The prognostic value of DCs and their effect on disease-free, metastasis-free and overall survival rates were analyzed. The data on the association between DCs and the response to chemoradiotherapy were presented. The analysis of the relationship between the DC characteristics and the development of immuno-inflammatory responses in the tumor microenvironment was carried out.Conclusion. The methodological approaches to the detection of DCs are variable, but the sensitivity of each method, as well as the comparison of different methods for estimating the number and functional characteristics of DCs, have been little studied. There is no data on the relationship between the length of DC dendrites and the parameters of invasive/metastatic tumor potentialities, disease-free, metastasis-free and overall survival rates. Numerous studies indicate the association between the number of DCs and the tumor progression, however these data are contradictory. There is no data about the relationship between the number of DCs and hematogenous metastasis of squamous cell carcinomas. The association of tumor-associated DC with the types of immunoinflammatory responses in the tumor microenvironment has been insufficiently studied. 

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