scholarly journals Nutritional Intervention Strategies Using Dietary Antioxidants and Organic Trace Minerals to Reduce the Incidence of Wooden Breast and Other Carcass Quality Defects in Broiler Birds

2021 ◽  
Vol 12 ◽  
Author(s):  
Vivek A. Kuttappan ◽  
Megharaja Manangi ◽  
Matthew Bekker ◽  
Juxing Chen ◽  
Mercedes Vazquez-Anon
Keyword(s):  
Oxidative Stress ◽  
Heat Stress ◽  
Dietary Intervention ◽  
Healing Process ◽  
Nutritional Intervention ◽  
Feed Additives ◽  
Mild Heat ◽  
Circulatory Insufficiency ◽  
Wooden Breast ◽  
Oxidized Fat

Wooden breast (WB) is a degenerative myopathy seen in modern broiler birds resulting in quality downgrade of breast fillets. Affected filets show increased toughness both before as well as after cooking and have decreased water holding capacity and marinade pick up compared to normal fillets. Although the exact etiology is unknown, the circulatory insufficiency and increased oxidative stress in the breast muscles of modern broiler birds could be resulting in damage and degeneration of muscle fibers leading to myopathies. Three independent experiments were conducted to evaluate the effect of various dietary interventions on the incidence of WB when birds are exposed to oxidative stress associated with feeding oxidized fat and mild heat stress. Feed additives such as dietary antioxidant [Ethoxyquin (ETX)], mineral methionine hydroxy analog chelate (MMHAC) of Zn, Cu, and Mn, and organic selenium (Org Se) were tested at recommended levels. In experiment 1, ETX reduced (P < 0.05) the incidence of severe WB induced by oxidized fat diet. The magnitude of improvement in percentage of normal (no WB) filets and reduction in muscle lipid peroxidation was greater (P < 0.05) when ETX and MMHAC were fed together as shown by experiment 2. In birds exposed to mild heat stress (Experiment 3), feeding MMHAC by itself reduced (P < 0.05) tissue damage by reducing incidence of tibial head lesions, skin scratches, breast blisters, in addition to increasing the incidence of normal (no WB) fillets. When MMHAC was combined with ETX and Org Se, further improvement (P < 0.05) in normal (no WB) filets was observed. In summary, under different oxidative stress conditions, dietary intervention programs that contain ETX, MMHA-Zn, -Cu, and -Mn and Org Se can improve performance and increase carcass integrity, reducing problems, such as WB, either independently or with additive effect. This effect is most likely attained by simultaneously improving the exogenous and endogenous antioxidant status, reducing oxidative stress, and improving tissue healing process of the bird.

scholarly journals A Role for Both V1a and V2 Receptors in Renal Heat Stress Injury Amplified by Rehydration with Fructose

2019 ◽  
Vol 20 (22) ◽  
pp. 5764
Author(s):  
Fernando E. García-Arroyo ◽  
Itzel Muñoz-Jiménez ◽  
Guillermo Gonzaga ◽  
Edilia Tapia ◽  
Horacio Osorio-Alonso ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heat Stress ◽  
Renal Damage ◽  
Tap Water ◽  
Renin Angiotensin System ◽  
Stress Injury ◽  
Mild Heat ◽  
Beneficial Effects ◽  
Vasopressin Receptors ◽  
Male Wistar Rats

Chronic vasopressin secretion induced by recurrent mild heat stress exposure is significantly enhanced by limited rehydration with a fructose-containing beverage both in rodents and in humans. Moreover, this effect has been associated with upregulation of the polyol–fructokinase pathway and increased renal oxidative stress. Previously, we have shown that pharmacological inhibition of both V1a and V2 vasopressin receptors with conivaptan improved such renal alterations. The aim of this study was to evaluate the independent contributions of V1a and V2 receptors to the renal damage caused by mild heat stress and limited rehydration with a fructose-containing beverage. Osmotic minipumps were used to deliver either relcovaptan (0.64 mg/day) or tolvaptan (0.25 mg/day) in male Wistar rats for two weeks. Corresponding dilution vehicles were used as controls. To induce dehydration, rats were exposed to mild heat stress (37 °C for 1 h, Monday to Friday). All groups received a 10% fructose solution as a rehydration fluid for 2 h after mild heat stress. For the remainder of the day and on weekends, rats received tap water. The independent blockade of either the V1a or the V2 receptor prevented renal damage, reduced oxidative stress, and decreased plasma cortisol and systemic inflammation. However, the beneficial effects were regulated by different mechanisms. Tolvaptan inhibited polyol–fructokinase pathway overactivation, while relcovaptan prevented upregulation of the renin–angiotensin system and SGK1 expression. These data suggest that both V1a and V2 receptors participate in renal damage caused by heat stress-induced dehydration when fructose-containing beverages are used as rehydration fluids.

scholarly journals How Is the Effect of Phytogenic Feed Supplementation Tested in Heat Stressed Pigs? Methodological and Sampling Considerations

Agriculture ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 257 ◽  
Author(s):  
Ildikó Jócsák ◽  
János Tossenberger ◽  
György Végvári ◽  
Gergő Sudár ◽  
Éva Varga-Visi ◽  
...  
Keyword(s):  
Climate Change ◽  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Heat Stress ◽  
Feed Additives ◽  
Meat Production ◽  
Oxygen Species ◽  
Feed Supplementation ◽  
Stress Metabolites ◽  
Methodological Aspects

Climate change will lead to increasingly hot summers where the temperature rises above the thermoneutral range of pigs; as a result, they get exposed to heat stress. One of the most damaging consequences of long-lasting heat stress is oxidative stress arising from the increasing level of reactive oxygen species. In order to eliminate oxidative stress, metabolites that are needed for maintaining life and growth may get depleted, which, in chronic cases in particular, negatively affects the economy of meat production. The effect of plant-originated phytogenic feed additives with high antioxidant content may be beneficial to pigs in reducing the effects of oxidative stress induced by heat stress. In this study, a range of methods that assess the effects of phytogenic feed additives on heat stress are reviewed. The main focus is presenting an overview of the investigational possibilities of the antioxidative system and feed uptake and utilization via traditional methods and molecular biological investigations. Furthermore, methodological aspects of sampling are taken into consideration in order to select the best methods for determining the effect of phytogenic feed supplementation on heat-stressed pigs.

scholarly journals Adverse Effects of Heat Stress on the Intestinal Integrity and Function of Pigs and the Mitigation Capacity of Dietary Antioxidants: A Review

Animals ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 1135
Author(s):  
Arth David Sol Valmoria Ortega ◽  
Csaba Szabó
Keyword(s):  
Oxidative Stress ◽  
Heat Stress ◽  
Adverse Effects ◽  
Environmental Temperature ◽  
Nutritional Intervention ◽  
Intestinal Histology ◽  
Dietary Antioxidants ◽  
Intestinal Integrity ◽  
And Function ◽  
And Oxidative Stress

Heat stress (HS) significantly affects the performance of pigs by its induced stressors such as inflammation, hypoxia and oxidative stress (OS), which mightily strain the intestinal integrity and function of pigs. As heat stress progresses, several mechanisms in the intestinal epithelium involved in the absorption of nutrients and its protective functions are altered. Changes in these mechanisms are mainly driven by cellular oxidative stress, which promotes disruption of intestinal homeostasis, leading to intestinal permeability, emphasizing intestinal histology and morphology with little possibility of recovering even after exposure to HS. Identification and understanding of these altered mechanisms are crucial for providing appropriate intervention strategies. Therefore, it is this papers’ objective to review the important components for intestinal integrity that are negatively affected by HS and its induced stressors. With due consideration to the amelioration of such effects through nutritional intervention, this work will also look into the capability of dietary antioxidants in mitigating such adverse effects and maintaining the intestine’s integrity and function upon the pigs’ exposure to high environmental temperature.

Access to shade reduces DNA damage of Holstein cows under mild heat stress

2020 ◽  
Vol 60 (12) ◽  
pp. 1539
Author(s):  
A. S. de Abreu ◽  
V. Fischer ◽  
A. Thaler ◽  
M. T. Stumpf ◽  
F. Petronilho ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Heat Stress ◽  
Thermal Stress ◽  
Dairy Cows ◽  
Cell Structure ◽  
Thiobarbituric Acid ◽  
Free Access ◽  
Negative Effects ◽  
Mild Heat

Context The effect of heat stress on the production and physiology of lactating dairy cows is well documented in literature. However, little is known about the effect of the provision of shade on DNA damage. Aims The present study aimed to evaluate the effects of shade provision on physiological, oxidative-stress, and DNA-strand damage in dairy cows exposed to mild heat stress. Methods The study was conducted at Lages, SC, Brazil, during 15 days in a southern hemisphere summer (January and February), with 14 lactating Holstein (n = 10) and Holstein × Jersey crossbreed (n = 4) dairy cows. Animals were randomly allocated to two groups of seven animals each (named as shaded and unshaded). These two groups were evaluated in the following three different periods: pre-stress period (5-day duration), stress period (4-day duration) and post-stress period (6-day duration). Shaded cows had free access to shade throughout the study; unshaded cows were prevented from accessing shade only in the stress period. Physiological (rectal temperature, heart and respiratory frequencies and panting score) and DNA-damage parameters (through Comet assay), as well as oxidative stress (in blood: carbonyl content, nitrite:nitrate ratio, thiobarbituric acid-reactive substances, TBARS) were evaluated. Key results In the stress period, shade deprivation resulted in higher values of respiratory rate, indicating that cows were under heat stress. In addition, DNA-damage levels were higher in this circumstance, probably due to inhibition of the DNA-repair systems by the thermal stress as well as thermal stress acting as a DNA-damage agent. Conclusions In a high-altitude subtropical region, during the hot season, shade provision decreases solar radiation heating effects and, thus, reduces DNA damage and the negative effects on cow metabolism and cell structure. Implications Shade effects on cow metabolism and cell structure must be taken into consideration in the planning of dairy farms and our results suggest that shade availability must not be disregarded, even in situations of mild heat stress.

Effects of N-acetyl-l-cysteine on heat stress-induced oxidative stress and inflammation in the hypothalamus of hens

2021 ◽  
pp. 102927
Author(s):  
Yulan Zhao ◽  
Yu Zhuang ◽  
Yan Shi ◽  
Zheng Xu ◽  
Changming Zhou ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heat Stress

Immunolocalization of antioxidant enzymes in testis of rams submitted to long-term heat stress

Zygote ◽  
2019 ◽  
Vol 27 (6) ◽  
pp. 432-435
Author(s):  
Thais Rose dos Santos Hamilton ◽  
Gabriela Esteves Duarte ◽  
José Antonio Visintin ◽  
Mayra Elena Ortiz D’Ávila Assumpção
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Antioxidant Enzymes ◽  
Heat Stress ◽  
Glutathione Peroxidase ◽  
Cell Types ◽  
Treated Group ◽  
Oxidative Balance ◽  
Testicular Cells

SummaryLong-term heat stress (HS) induced by testicular insulation generates oxidative stress (OS) on the testicular environment; consequently activating antioxidant enzymes such as superoxide dismutase (SOD), glutathione reductase (GR) and glutathione peroxidase (GPx). The aim of this work was to immunolocalize antioxidant enzymes present in different cells within the seminiferous tubule when rams were submitted to HS. Rams were divided into control (n = 6) and treated group (n = 6), comprising rams subjected to testicular insulation for 240 h. After the testicular insulation period, rams were subjected to orchiectomy. Testicular fragments were submitted to immunohistochemistry for staining against SOD, GR and GPx enzymes. We observed immunolocalization of GPx in more cell types of the testis after HS and when compared with other enzymes. In conclusion, GPx is the main antioxidant enzyme identified in testicular cells in an attempt to maintain oxidative balance when HS occurs.

scholarly journals Radical Response: Effects of Heat Stress-Induced Oxidative Stress on Lipid Metabolism in the Avian Liver

Antioxidants ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 35
Author(s):  
Nima K. Emami ◽  
Usuk Jung ◽  
Brynn Voy ◽  
Sami Dridi
Keyword(s):  
Oxidative Stress ◽  
Heat Stress ◽  
Lipid Metabolism ◽  
Egg Production ◽  
Well Being ◽  
Enzymatic Reactions ◽  
Poultry Production ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid ◽  
The Impact

Lipid metabolism in avian species places unique demands on the liver in comparison to most mammals. The avian liver synthesizes the vast majority of fatty acids that provide energy and support cell membrane synthesis throughout the bird. Egg production intensifies demands to the liver as hepatic lipids are needed to create the yolk. The enzymatic reactions that underlie de novo lipogenesis are energetically demanding and require a precise balance of vitamins and cofactors to proceed efficiently. External stressors such as overnutrition or nutrient deficiency can disrupt this balance and compromise the liver’s ability to support metabolic needs. Heat stress is an increasingly prevalent environmental factor that impairs lipid metabolism in the avian liver. The effects of heat stress-induced oxidative stress on hepatic lipid metabolism are of particular concern in modern commercial chickens due to the threat to global poultry production. Chickens are highly vulnerable to heat stress because of their limited capacity to dissipate heat, high metabolic activity, high internal body temperature, and narrow zone of thermal tolerance. Modern lines of both broiler (meat-type) and layer (egg-type) chickens are especially sensitive to heat stress because of the high rates of mitochondrial metabolism. While this oxidative metabolism supports growth and egg production, it also yields oxidative stress that can damage mitochondria, cellular membranes and proteins, making the birds more vulnerable to other stressors in the environment. Studies to date indicate that oxidative and heat stress interact to disrupt hepatic lipid metabolism and compromise performance and well-being in both broilers and layers. The purpose of this review is to summarize the impact of heat stress-induced oxidative stress on lipid metabolism in the avian liver. Recent advances that shed light on molecular mechanisms and potential nutritional/managerial strategies to counteract the negative effects of heat stress-induced oxidative stress to the avian liver are also integrated.

Heat stress aggravates oxidative stress, apoptosis, and endoplasmic reticulum stress in the cerebellum of male C57 mice

2021 ◽  
Author(s):  
Hajar Oghbaei ◽  
Leila Hosseini ◽  
Fereshteh Farajdokht ◽  
Sepideh Rahigh Aghsan ◽  
Alireza Majdi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endoplasmic Reticulum ◽  
Heat Stress ◽  
Endoplasmic Reticulum Stress
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