scholarly journals Multifunctional Therapeutic Potential of Phytocomplexes and Natural Extracts for Antimicrobial Properties

Antibiotics ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1076
Author(s):  
Md. Mominur Rahman ◽  
Md. Saidur Rahaman ◽  
Md. Rezaul Islam ◽  
Md. Emon Hossain ◽  
Faria Mannan Mithi ◽  
...  
Keyword(s):  
Antimicrobial Agents ◽  
Therapeutic Potential ◽  
Antimicrobial Properties ◽  
Antimicrobial Activities ◽  
New Drugs ◽  
Animal Origin ◽  
Multiple Drug ◽  
Common Source ◽  
Phagocytic Cells ◽  
Natural Extracts

Natural products have been known for their antimicrobial factors since time immemorial. Infectious diseases are a worldwide burden that have been deteriorating because of the improvement of species impervious to various anti-infection agents. Hence, the distinguishing proof of antimicrobial specialists with high-power dynamic against MDR microorganisms is central to conquer this issue. Successful treatment of infection involves the improvement of new drugs or some common source of novel medications. Numerous naturally occurring antimicrobial agents can be of plant origin, animal origin, microbial origin, etc. Many plant and animal products have antimicrobial activities due to various active principles, secondary metabolites, or phytochemicals like alkaloids, tannins, terpenoids, essential oils, flavonoids, lectins, phagocytic cells, and many other organic constituents. Phytocomplexes’ antimicrobial movement frequently results from a few particles acting in cooperative energy, and the clinical impacts might be because of the direct effects against microorganisms. The restorative plants that may furnish novel medication lead the antimicrobial movement. The purpose of this study is to investigate the antimicrobial properties of the phytocomplexes and natural extracts of the plants that are ordinarily being utilized as conventional medications and then recommended the chance of utilizing them in drugs for the treatment of multiple drug-resistant disease.

Medicinal Au(i) compounds targeting urease as prospective antimicrobial agents: unveiling the structural basis for enzyme inhibition

2021 ◽  
Author(s):  
Luca Mazzei ◽  
Lara Massai ◽  
Michele Cianci ◽  
Luigi Messori ◽  
Stefano Ciurli
Keyword(s):  
Antibiotic Resistance ◽  
Enzyme Inhibition ◽  
Antimicrobial Agents ◽  
Antimicrobial Properties ◽  
New Drugs ◽  
Structural Basis ◽  
Great Promise ◽  
Gold Compounds

A few gold compounds were recently found to show antimicrobial properties in vitro, holding great promise for the discovery of new drugs to overcome antibiotic resistance.

scholarly journals Facile Synthesis of Antimicrobial Aloe Vera-“Smart” Triiodide-PVP Biomaterials

Biomimetics ◽  
2020 ◽  
Vol 5 (3) ◽  
pp. 45 ◽  
Author(s):  
Zehra Edis ◽  
Samir Haj Bloukh
Keyword(s):  
Antimicrobial Agents ◽  
Microstructural Analysis ◽  
Aloe Vera ◽  
Antimicrobial Properties ◽  
Surgical Site Infections ◽  
Halogen Bonding ◽  
Polyglycolic Acid ◽  
Antimicrobial Activities ◽  
One Pot

Antibiotic resistance is an eminent threat for the survival of mankind. Nosocomial infections caused by multidrug resistant microorganisms are a reason for morbidity and mortality worldwide. Plant-based antimicrobial agents are based on synergistic mechanisms which prevent resistance and have been used for centuries against ailments. We suggest the use of cost-effective, eco-friendly Aloe Vera Barbadensis Miller (AV)-iodine biomaterials as a new generation of antimicrobial agents. In a facile, one-pot synthesis, we encapsulated fresh AV gel with polyvinylpyrrolidone (PVP) as a stabilizing agent and incorporated iodine moieties in the form of iodine (I2) and sodium iodide (NaI) into the polymer matrix. Ultraviolet-visible spectroscopy (UV-Vis), Fourier transform infrared spectroscopy (FT-IR), x-ray diffraction (XRD), microstructural analysis by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) verified the composition of AV-PVP-I2, AV-PVP-I2-NaI. AV, AV-PVP, AV-PVP-I2, AV-PVP-I2-NaI, and AV-PVP-NaI were tested in-vitro by disc diffusion assay and dip-coated on polyglycolic acid (PGA) sutures against ten microbial reference strains. All the tested pathogens were more susceptible towards AV-PVP-I2 due to the inclusion of “smart” triiodides with halogen bonding in vitro and on dip-coated sutures. The biocomplexes AV-PVP-I2, AV-PVP-I2-NaI showed remarkable antimicrobial properties. “Smart” biohybrids with triiodide inclusions have excellent antifungal and promising antimicrobial activities, with potential use against surgical site infections (SSI) and as disinfecting agents.

scholarly journals Green Alternatives to Synthetic Antioxidants, Antimicrobials, Nitrates, and Nitrites in Clean Label Spanish Chorizo

Antioxidants ◽  
2019 ◽  
Vol 8 (6) ◽  
pp. 184 ◽  
Author(s):  
Lorena Martínez ◽  
Pedro Bastida ◽  
Julian Castillo ◽  
Gaspar Ros ◽  
Gema Nieto
Keyword(s):  
Antioxidant Capacity ◽  
Meat Product ◽  
Meat Products ◽  
Antimicrobial Properties ◽  
Antimicrobial Activities ◽  
Total Phenolic ◽  
Nitrate Sources ◽  
Natural Extracts ◽  
Cured Meat

Natural extracts obtained from fruit and vegetable processing are important sources of phenolic compounds and nitrates, with excellent antioxidant and antimicrobial properties. The aim of this study was to characterize and determine the antioxidant and antimicrobial capacity of several natural extracts (citric (Ct), acerola (Ac), rosemary (R), paprika, garlic, oregano, beet (B), lettuce (L), arugula (A), spinach (S), chard (Ch), celery (Ce), and watercress (W)), both in vitro and applied to a cured meat product (chorizo). For that, the volatile compounds by GC-MS and microbial growth were determined. The total phenolic and nitrate contents were measured and related with their antioxidant capacity (measured by DPPH, ABTS, FRAP, and ORAC methods) and antimicrobial capacity against Clostridium perfringens growth in vitro. In order to study the antioxidant and antimicrobial activities of the extracts in food, their properties were also measured in Spanish chorizo enriched with these natural extracts. R and Ct showed the highest antioxidant capacity, however, natural nitrate sources (B, L, A, S, Ch, Ce, and W) also presented excellent antimicrobial activity against C. perfringens. The incorporation of these extracts as preservatives in Spanish chorizo also presented excellent antioxidant and antimicrobial capacities and could be an excellent strategy in order to produce clean label dry-cured meat products.

Phytochemical Screening, Antimicrobial Activities and Nutritional content of Jatropha Tanjorensis Leaves

2019 ◽  
Vol 1 ◽  
pp. 108-113
Author(s):  
B A Anhwange ◽  
I G Agbidye ◽  
B A Kyenge ◽  
P O Ngbede
Keyword(s):  
Proximate Composition ◽  
Antimicrobial Agents ◽  
Reducing Sugars ◽  
Antimicrobial Properties ◽  
Antimicrobial Activities ◽  
Phytochemical Screening ◽  
Bioactive Components ◽  
Standard Procedures ◽  
Hexane Extracts

The leaves of Jatropha tanjarensis were collected and assessed for their phytochemical compositions and antimicrobial activities using methanolic and hexane extracts as to determine the bioactive components and their effects on microorganisms. Also, the nutritional potential was investigated through the determination of proximate composition using standard procedures. The result of phytochemical screening indicated the presence of saponins, cardiac glycosides, reducing sugars, steroids, alkaloids and flavonoids in methanolic extract, the same observation was recorded in n-hexane extract except that reducing sugars were absent and phlobotannins were present. The antimicrobial activities of the leaves extract show that it have some antimicrobial properties. Results of the proximate composition and mineral analysis revealed that the plant is a good source of fiber and minerals. Therefore, leaves of Jatropha tanjarensisapart from being used as antimicrobial agents, can serve as good sources of fiber and minerals when used as vegetables.

scholarly journals Antimicrobial Ionic Liquids with Fumarate Anion

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Biyan He ◽  
Guangnan Ou ◽  
Changyi Zhou ◽  
Meihong Wang ◽  
Suyan Chen
Keyword(s):  
Ionic Liquids ◽  
Antimicrobial Agents ◽  
Antimicrobial Properties ◽  
Antimicrobial Activities ◽  
Biological Properties ◽  
Research Field ◽  
Potassium Sorbate ◽  
Gravimetric Analysis ◽  
Antimicrobial Drugs ◽  
Active Research

The shortage of new antimicrobial drugs and increasing resistance of microbe to antimicrobial agents have been of some concern. The formulation studies of new antibacterial and antifungal agents have been an active research field. Ionic liquids are known as designed liquids with controllable physical/chemical/biological properties and specific functions, which have been attracting considerable interest over recent years. However, no attention has been made towards the preparation of ionic liquids with antimicrobial activities. In this paper, a new class of ionic liquids (ILs) with fumarate anion was synthesized by neutralization of aqueous 1-butyl-3-methylimidazolium hydroxide with equimolar monoester fumarate and characterized using NMR and thermal gravimetric analysis. The ILs are soluble in water and polar organic solvents and also soluble in the common ILs. The antimicrobial activities of the ILs are more active than commercially available potassium sorbate and are greatly affected by the alkyl chain length. The significant antimicrobial properties observed in this research suggest that the ILs may have potential applications in the modern biotechnology.

Antimicrobial Evaluation, Molecular Docking and ADME Properties of Indole Amide Derivatives

2021 ◽  
Vol 18 ◽  
Author(s):  
Derya Doğanay ◽  
Sevval M. Özcan ◽  
Ahmet M. Şentürk ◽  
Süreyya Ölgen
Keyword(s):  
Molecular Docking ◽  
In Silico ◽  
Bacterial Infections ◽  
Antimicrobial Agents ◽  
Antimicrobial Properties ◽  
Antimicrobial Activities ◽  
In Vitro Tests ◽  
Lipinski’S Rule ◽  
Amide Derivatives

Background: Besides the viral infections, bacterial infections can cause serious and life-threatening complications and drug resistance is an important problem to fight bacterial infections. Therefore, it is important to discover novel antimicrobial agents to fight such infections. Objective: Several indole containing antimicrobial drug development studies have been reported in literature that provided strong evidences for good antimicrobial activities against a variety of microorganisms. Taken into consideration from these findings, antimicrobial properties of previously synthesized 16 indole amide derivatives were evaluated by in vitro tests against 14 different microorganisms, and also molecular docking and in silico prediction studies were used to identify structure-activity relationship of compounds. Methods: Antimicrobial activity of compounds was determined by disc diffusion and tube dilution methods. Molecular docking of compounds was studied to determine the relationship between the structure of compounds with DNA gyrase interactions of microorganisms by using the version of Autodock vina 4.2.6. Mol inspiration and Swiss ADME prediction online software programs were also used to identify drug-like properties of compounds. Results: The results showed that some compounds exhibited quite pronounced antibacterial and antifungal activities compared to reference drugs. These results were also supported by molecular docking studies and in silico ADME calculations presented that all tested compounds obey the Lipinski’s Rule of Five and are metabolized by CYP450 enzymes. Conclusion: It can be concluded that these results can be taken as reference in the development of new indole-based antimicrobial agents.

scholarly journals Halal antimicrobials in food: A review on prospects and challenges of antimicrobials from animal sources

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Muhamad Shirwan Abdullah Sani ◽  
Mohammad Aizat Jamaludin ◽  
Nurhidayu Al-Saari ◽  
Azman Azid ◽  
Nur Syatirah Noor Azri
Keyword(s):  
Microbial Contamination ◽  
Antimicrobial Agents ◽  
Antimicrobial Properties ◽  
Animal Origin ◽  
Future Research ◽  
Processed Food ◽  
Taste Changes ◽  
Allowable Range ◽  
Increasing Risk ◽  
Food Safety And Quality

Food antimicrobial agents (FAA) provide the first food defence system against pathogens for processed food products. In addition, they function as an antioxidant in preventing colour and taste changes for food safety and quality. Muslim consumers are concerned about the source of FAA which may contain non-permissible ingredients according to Islam including pig and unslaughtered permissible animal sources. They also raise concerns about the increasing risk of toxicity when the FAA is consumed and the possibility of the FAA rendering organoleptic effect on the food. The application of the FAA protects the food from microbial contamination and indirectly combats emerging devastating diseases. Hence, halal FAA (HFAA) can be introduced so that Muslim consumers can accept FAA usage. Generally, HFAA is categorised according to ingredient sources such as animal, plant, bacteria, or synthetic origins. There are doubts on the halal status of animal-origin FAA as the source might be originating from pig, unslaughtered animal, human, or origins which are filthy. The animal-origin FAA shows strong antimicrobial properties against Gram-positive and negative pathogens, as well as toxicity and organoleptic issues. Thus, the FAA should be used within the allowable range. HFAA has become one of the most studied FAAs due to these issues. Many HFAAs are produced from animals without the full verification of halal status. This review presents an overview of the origins and challenges of HFAA production. Furthermore, this study also highlights how FAA could be verified as halal which is the theme of future research in HFAA development.

scholarly journals Synergism of a Novel 1,2,4-oxadiazole-containing Derivative with Oxacillin against Methicillin-Resistant Staphylococcus aureus

Antibiotics ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 1258
Author(s):  
Elisabetta Buommino ◽  
Simona De Marino ◽  
Martina Sciarretta ◽  
Marialuisa Piccolo ◽  
Carmen Festa ◽  
...  
Keyword(s):  
Antimicrobial Agents ◽  
Therapeutic Potential ◽  
Opportunistic Pathogen ◽  
Multidrug Resistant ◽  
New Drugs ◽  
Vast Number ◽  
Methicillin Resistant ◽  
Inappropriate Use ◽  
Expression Of Genes ◽  
Index Value

Staphylococcusaureus is an important opportunistic pathogen that causes many infections in humans and animals. The inappropriate use of antibiotics has favored the diffusion of methicillin-resistant S. aureus (MRSA), nullifying the efforts undertaken in the discovery of antimicrobial agents. Oxadiazole heterocycles represent privileged scaffolds for the development of new drugs because of their unique bioisosteric properties, easy synthesis, and therapeutic potential. A vast number of oxadiazole-containing derivatives have been discovered as potent antibacterial agents against multidrug-resistant MRSA strains. Here, we investigate the ability of a new library of oxadiazoles to contrast the growth of Gram-positive and Gram-negative strains. The strongest antimicrobial activity was obtained with compounds 3 (4 µM) and 12 (2 µM). Compound 12, selected for further evaluation, was found to be noncytotoxic on the HaCaT cell line up to 25 µM, bactericidal, and was able to improve the activity of oxacillin against the MRSA. The highest synergistic interaction was obtained with the combination values of 0.78 μM for compound 12, and 0.06 μg/mL for oxacillin. The FIC index value of 0.396 confirms the synergistic effect of compound 12 and oxacillin. MRSA treatment with compound 12 reduced the expression of genes included in the mec operon. In conclusion, 12 inhibited the growth of the MRSA and restored the activity of oxacillin, thus resulting in a promising compound in the treatment of MRSA infection.

scholarly journals Antimicrobial Activities and Time-Kill Kinetics of Extracts of Selected Ghanaian Mushrooms

2017 ◽  
Vol 2017 ◽  
pp. 1-15 ◽  
Author(s):  
Theresa Appiah ◽  
Yaw Duah Boakye ◽  
Christian Agyare
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Agents ◽  
Schizophyllum Commune ◽  
Antimicrobial Properties ◽  
Antimicrobial Activities ◽  
Methanol Extracts ◽  
Test Organisms ◽  
Antibacterial And Antifungal ◽  
Time Kill ◽  
Kinetics Of

The rapid rise of antimicrobial resistance is a worldwide problem. This has necessitated the need to search for new antimicrobial agents. Mushrooms are rich sources of potential antimicrobial agents. This study investigated the antimicrobial properties of methanol extracts of Trametes gibbosa, Trametes elegans, Schizophyllum commune, and Volvariella volvacea. Agar well diffusion, broth microdilution, and time-kill kinetic assays were used to determine the antimicrobial activity of the extracts against selected test organisms. Preliminary mycochemical screening revealed the presence of tannins, flavonoids, triterpenoids, anthraquinones, and alkaloids in the extracts. Methanol extracts of T. gibbosa, T. elegans, S. commune, and V. volvacea showed mean zone of growth inhibition of 10.00±0.0 to 21.50±0.84, 10.00±0.0 to 22.00±1.10, 9.00±0.63 to 21.83±1.17, and 12.00±0.0 to 21.17±1.00 mm, respectively. The minimum inhibitory concentration of methanol extracts of T. gibbosa, T. elegans, S. commune, and V. volvacea ranged from 4.0 to 20, 6.0 to 30.0, 8.0 to 10.0, and 6.0 to 20.0 mg/mL, respectively. Time-kill kinetics studies showed that the extracts possess bacteriostatic action. Methanol extracts of T. gibbosa, T. elegans, S. commune, and V. volvacea exhibited antimicrobial activity and may contain bioactive compounds which may serve as potential antibacterial and antifungal agents.

In vitro antimicrobial activity of the leaf extract of Harungana madagascariensis Lam. ex Poir. (Hypericaceae) against strains causing otitis externa in dogs and cats

2007 ◽  
Vol 55 (1) ◽  
pp. 97-105 ◽  
Author(s):  
B. Moulari ◽  
Y. Pellequer ◽  
J. Chaumont ◽  
Y. Guillaume ◽  
J. Millet
Keyword(s):  
Otitis Externa ◽  
Leaf Extract ◽  
Antimicrobial Agents ◽  
Antimicrobial Properties ◽  
Antimicrobial Activities ◽  
Phytochemical Analysis ◽  
Malassezia Pachydermatis ◽  
Staphylococcus Intermedius ◽  
Phytochemical Investigation

Otitis externa in dogs and cats is always caused by a combination of yeasts and bacteria, among which the most important are Malassezia pachydermatis, Staphylococcus intermedius and Pseudomonas species. These organisms often develop resistance to classical antimicrobial agents. Therefore, the aim of this study was to investigate the antimicrobial activities of an ethyl acetate leaf extract of Harungana madagascariensis against the organisms cited, to carry out the phytochemical investigation of this extract and to determine its bioactive chemical class using dilution techniques, the bioautography method and the standard phytochemical method described by Harborne (1973). Phytochemical analysis revealed the presence of saponins, tannins, flavonoids, alkaloids and anthracenic derivatives. The bioassay showed that the antimicrobial properties may be attributed to astilbin, a flavanone derivative identified on the basis of its spectroscopic data. The results suggest that the extract could be used in an antimicrobial preparation effective against the whole range of organisms incriminated in otitis externa in dogs and cats, with a minimal inhibitory concentration (MIC) of 250 μg/ml.

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