scholarly journals Linking Obesity with Colorectal Cancer: Epidemiology and Mechanistic Insights

Cancers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1408 ◽  
Author(s):  
Pengfei Ye ◽  
Yue Xi ◽  
Zhiying Huang ◽  
Pengfei Xu
Keyword(s):  
Colorectal Cancer ◽  
Molecular Mechanisms ◽  
The United States ◽  
Cancer Epidemiology ◽  
Medical Needs ◽  
The Third ◽  
Common Cancer ◽  
The World ◽  
Treatment Of Obesity ◽  
Unmet Medical Needs

The incidence of obesity and colorectal cancer (CRC) has risen rapidly in recent decades. More than 650 million obese and 2 billion overweight individuals are currently living in the world. CRC is the third most common cancer. Obesity is regarded as one of the key environmental risk factors for the pathogenesis of CRC. In the present review, we mainly focus on the epidemiology of obesity and CRC in the world, the United States, and China. We also summarize the molecular mechanisms linking obesity to CRC in different aspects, including nutriology, adipokines and hormones, inflammation, gut microbiota, and bile acids. The unmet medical needs for obesity-related CRC are still remarkable. Understanding the molecular basis of these associations will help develop novel therapeutic targets and approaches for the treatment of obesity-related CRC.

scholarly journals How Medically Favorable Is the Replacement of the Invasive Colonoscopy With Cologuard Non-Invasive Colorectal Cancer Screening?

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Markella Bibidakis ◽  
Patricia Talarczyk
Keyword(s):  
Colorectal Cancer ◽  
Cancer Diagnosis ◽  
Goodness Of Fit ◽  
True Positive ◽  
Chi Square ◽  
Non Invasive ◽  
The Third ◽  
Common Cancer ◽  
The World ◽  
Medical Health

In 2014, the FDA approved the non-invasive and economical Cologuard test for colorectal cancer diagnosis for people reaching the age of 50, a milestone previously met with the “gold standard” of colorectal cancer diagnosis: the colonoscopy. Though prevention and treatment for the third most common cancer in the world have been heavily researched, the diagnosis has been thought to be set with the colonoscopy, without much room for modifications. To assess the possibility of replacing the invasive and costly colonoscopy with Cologuard screening as the first step in colorectal cancer diagnosis, a retrospective cohort study was done with data collected from a medical health record database of a northeast Ohio hospital. Medical record numbers were matched with age, sex, any personal or family history, and the results of the colonoscopies of 111 patients with positive Cologuard tests. Of the 111 patients, 92 proceeded with the colonoscopy. The sensitivities, or true-positive rates of results, were calculated for groups organized with respect to age, sex, and previous family and personal oncologic history. Since the data is categorical, a goodness of fit chi-square was done for the statistical analysis, resulting in a failure to reject the null hypothesis with χ2=0.09318 and p=6.571. In conclusion, the replacement of the invasive colonoscopy with Cologuard non-invasive screening as the first step in colorectal cancer diagnosis could not be proven statistically significant and, therefore, medically favorable.

Educational Entrepreneurs in Tamil Nadu - A Profile

2015 ◽  
Vol 4 (1) ◽  
Author(s):  
Siluvai Raja
Keyword(s):  
Higher Education ◽  
United States ◽  
World Bank ◽  
Education System ◽  
Tamil Nadu ◽  
The United States ◽  
Educational Institutions ◽  
Higher Education System ◽  
The Third ◽  
The World

Education has been considered as an indispensable asset of every individual, community and nation today. Indias higher education system is the third largest in the world, after China and the United States (World Bank). Tamil Nadu occupies the first place in terms of possession of higher educational institutions in the private sector in the country with over 46 percent(27) universities, 94 percent(464) professional colleges and 65 percent(383) arts and science colleges(2011). Studies to understand the profile of the entrepreneurs providing higher education either in India or Tamil Nadu were hardly available. This paper attempts to map the demographic profile of the entrepreneurs providing higher education in Arts and Science colleges in Tamil Nadu through an empirical analysis, carried out among 25 entrepreneurs spread across the state. This paper presents a summary of major inferences of the analysis.

scholarly journals Single Nucleotide Polymorphism in SMAD7 and CHI3L1 and Colorectal Cancer Risk

2018 ◽  
Vol 2018 ◽  
pp. 1-23 ◽  
Author(s):  
Amal Ahmed Abd El-Fattah ◽  
Nermin Abdel Hamid Sadik ◽  
Olfat Gamil Shaker ◽  
Amal Mohamed Kamal
Keyword(s):  
Colorectal Cancer ◽  
Genetic Variation ◽  
Sequence Variation ◽  
Regulatory Protein ◽  
Nucleotide Polymorphisms ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
The Third ◽  
Common Cancer ◽  
Cancer Initiation

Colorectal cancer (CRC) is one of the leading cancers throughout the world. It represents the third most common cancer and the fourth in mortality. Most of CRC are sporadic, arise with no known high-penetrant genetic variation and with no previous family history. The etiology of sporadic CRC is considered to be multifactorial and arises from the interaction of genetic variants of low-penetrant genes and environmental risk factors. The most common well-studied genetic variation is single nucleotide polymorphisms (SNPs). SNP arises as a point mutation. If the frequency of the sequence variation reaches 1% or more in the population, it is referred to as polymorphism, but if it is lower than 1%, the allele is typically considered as a mutation. Lots of SNPs have been associated with CRC development and progression, for example, genes of TGF-β1 and CHI3L1 pathways. TGF-β1 is a pleiotropic cytokine with a dual role in cancer development and progression. TGF-β1 mediates its actions through canonical and noncanonical pathways. The most important negative regulatory protein for TGF-β1 activity is termed SMAD7. The production of TGF-βcan be controlled by another protein called YKL-40. YKL-40 is a glycoprotein with an important role in cancer initiation and metastasis. YKL-40 is encoded by the CHI3L1 gene. The aim of the present review is to give a brief introduction of CRC, SNP, and examples of some SNPs that have been documented to be associated with CRC. We also discuss two important signaling pathways TGF-β1 and CHI3L1 that influence the incidence and progression of CRC.

scholarly journals Profile of Colorectal Tumor in Gastroentero-Hepatology Center, Department of Internal Medicine, Dr Soetomo Hospital, Surabaya

2020 ◽  
Vol 56 (1) ◽  
pp. 15
Author(s):  
Husin Thamrin ◽  
Khafidhotul Ilmiah ◽  
Ni Wajan Tirthaningsih
Keyword(s):  
Colorectal Cancer ◽  
Medical Records ◽  
Colorectal Tumor ◽  
Age And Gender ◽  
Male And Female ◽  
The Third ◽  
Common Cancer ◽  
Significant Difference ◽  
And Gender ◽  
Ethical Clearance

Colorectal cancer has became burden in the world.The latest study shows that colorectal cancer is the third most common cancer in men and second most common cancer in women globally. There are difference characteristic of epidemiology in every countries. Moreover, there is no study that represents epidemiology of colorectal cancer in Indonesia yet, especially in East Java. The aim of this study was to describe colorectal tumor profile by age and gender in Gastroentero-Hepatology Center, Dr Soetomo Hospital. This study has received a certificate of Ethical Clearance No.273/Panke.KKE/IV/2015, a descriptive retrospective study. We collected data using medical records, and patients who have been colonoscopy examination and suspected colorectal tumor were included. There were 201 patients, divided to 100 males and 101 females. The peak of incidence was on 51-60 years old group, but on the 31-40 years old incidence of colorectal tumor was increased. The youngest patient was 17 years old. And tumors are more likely develop in distal area, especially in rectum. This study shows a different characteristic profile of colorectal tumor, where tumor is developed at young people and there is no significant difference between male and female for the incidence.

scholarly journals A Complicated Colorectal Cancer Recurrence

2020 ◽  
Vol 18 (1) ◽  
pp. 25-27
Author(s):  
Anna Marija Lescinska ◽  
Valerija Grakova ◽  
Aleksandrs Malasonoks ◽  
Armands Sivins
Keyword(s):  
Colorectal Cancer ◽  
Case Report ◽  
Cancer Recurrence ◽  
Cancer Death ◽  
Treatment Results ◽  
Western Countries ◽  
The Third ◽  
Common Cancer ◽  
One Step ◽  
Colorectal Cancer Recurrence

SummaryThe case report demonstrates painstaking, one step at a time multitherapy for the third most common cancer and the third cause of cancer death in western countries – colorectal cancer. Multitherapeutic approach at specialized centers for the treatment of colorectal cancer is the cornerstone for reaching favorable treatment results and prognosis.

Transformations of the world order in the run-up to the third decade of the XXI century

2020 ◽  
pp. 13-24
Author(s):  
I. V. Bocharnikov ◽  
O. A. Ovsyannikova
Keyword(s):  
New World ◽  
World Order ◽  
The United States ◽  
Modern World ◽  
New World Order ◽  
World Community ◽  
The Third ◽  
The World ◽  
Main Factors ◽  
Run Up

Тhe article reveals the main directions of transformation of the modern world order caused by the decline of the American-centric system, as well as the crisis of European integration. The main factors that determine the development of these processes, problems and prospects for the formation of a new world order at the beginning of the third decade of the XXI century are determined. The most significant aspects of the transformation of the policy of the United States and its European allies in relation to Russia are considered, and historical analogies are drawn with the processes of transformation of the world community in the XIX and XX centuries.

The Treatment of Germany

2013 ◽  
Author(s):  
Franz Neumann
Keyword(s):  
United States ◽  
United Nations ◽  
The United States ◽  
German Society ◽  
Military Government ◽  
Short Term ◽  
The Third ◽  
The World ◽  
Probationary Period

This chapter considers a variety of methods of treating Germany. The main objective of the United Nations in the treatment of Germany is to prevent it from ever again becoming a threat to the security of the world. The problem of securing this objective could be approached through destruction of Germany's industrial potential, destruction of Germany as a political entity, and removal from German society of the causes of aggression. The chapter shows that the first two solutions should be deferred until it is clear that the third alternative proves unworkable. In order to eliminate the causes of aggressiveness in German society, temporary and long-term disabilities should be imposed upon Germany. The chapter also examines the causes of German aggression, the United States' policy toward Germany, short-term measures during the period of military government, conditional measures during the probationary period, and permanent impositions upon Germany.

Cancer epidemiology and public health

2021 ◽  
pp. 17-42
Author(s):  
Paolo Boffetta ◽  
Zuo-Feng Zhang ◽  
Carlo La Vecchia
Keyword(s):  
Public Health ◽  
Risk Factors ◽  
Molecular Mechanisms ◽  
Cancer Epidemiology ◽  
Attributable Risk ◽  
World Population ◽  
The World ◽  
Near Future ◽  
Epidemiology And Public Health

Neoplasms continue to dominate globally as one of the major sources of human disease and death. There are multiple modifiable causes of cancer and understanding their attributable risk factors for each cancer is of importance. This chapter covers the role of cellular and molecular mechanisms as well as the experimental and epidemiological approaches as determinants of the main cancers. Even if major discoveries in the clinical management of cancer patients will be accomplished in the near future, the changes will mainly affect the affluent part of the world population. Promising approaches focused on prevention of the known causes, reducing its consequences, notably in resource-constrained settings are highlighted.

scholarly journals MicroRNAs and Apoptosis in Colorectal Cancer

2020 ◽  
Vol 21 (15) ◽  
pp. 5353 ◽  
Author(s):  
Hsiuying Wang
Keyword(s):  
Colorectal Cancer ◽  
Treatment Resistance ◽  
Therapeutic Resistance ◽  
Cancer Therapies ◽  
Malignant Cells ◽  
Apoptosis Induction ◽  
The Third ◽  
Anti Cancer ◽  
The World

Colorectal cancer (CRC) is the third leading cause of cancer death in the world, and its incidence is rising in developing countries. Treatment with 5-Fluorouracil (5-FU) is known to improve survival in CRC patients. Most anti-cancer therapies trigger apoptosis induction to eliminate malignant cells. However, de-regulated apoptotic signaling allows cancer cells to escape this signaling, leading to therapeutic resistance. Treatment resistance is a major challenge in the development of effective therapies. The microRNAs (miRNAs) play important roles in CRC treatment resistance and CRC progression and apoptosis. This review discusses the role of miRNAs in contributing to the promotion or inhibition of apoptosis in CRC and the role of miRNAs in modulating treatment resistance in CRC cells.

scholarly journals Molecular and Translational Research on Colorectal Cancer

2020 ◽  
Vol 21 (11) ◽  
pp. 4105
Author(s):  
Alessandro Passardi ◽  
Emanuela Scarpi ◽  
Paola Ulivi
Keyword(s):  
Colorectal Cancer ◽  
Translational Research ◽  
The Third ◽  
The World

Colorectal cancer (CRC) is the third most frequently diagnosed cancer in the world [...]

Sign in / Sign up

Export Citation Format

Share Document