scholarly journals A Language for Modeling and Optimizing Experimental Biological Protocols

Computation ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 107
Author(s):  
Luca Cardelli ◽  
Marta Kwiatkowska ◽  
Luca Laurenti

Automation is becoming ubiquitous in all laboratory activities, moving towards precisely defined and codified laboratory protocols. However, the integration between laboratory protocols and mathematical models is still lacking. Models describe physical processes, while protocols define the steps carried out during an experiment: neither cover the domain of the other, although they both attempt to characterize the same phenomena. We should ideally start from an integrated description of both the model and the steps carried out to test it, to concurrently analyze uncertainties in model parameters, equipment tolerances, and data collection. To this end, we present a language to model and optimize experimental biochemical protocols that facilitates such an integrated description, and that can be combined with experimental data. We provide probabilistic semantics for our language in terms of Gaussian processes (GPs) based on the linear noise approximation (LNA) that formally characterizes the uncertainties in the data collection, the underlying model, and the protocol operations. In a set of case studies, we illustrate how the resulting framework allows for automated analysis and optimization of experimental protocols, including Gibson assembly protocols.

Author(s):  
Bin Hu ◽  
Yong Huang ◽  
Jianzhong Xu

According to the Lefebvre's model and flame volume (FV) concept, an FV model about lean blow-out (LBO) was proposed by authors in early study. On the other hand, due to the model parameter (FV) contained in FV model is obtained based on the experimental data, FV model could only be used in LBO analysis instead of prediction. In view of this, a hybrid FV model is proposed that combines the FV model with numerical simulation in the present study. The model parameters contained in the FV model are all estimated from the simulated nonreacting flows. Comparing with the experimental data for 11 combustors, the maximum and average uncertainties of hybrid FV model are ±16% and ±10%.


Author(s):  
Resdianto Permata Raharjo ◽  
Ahmad Sudali

This journal explains the results of cohesion and coherence analysis in the current new news discourse in Indonesia published by Republika, Thursday 16 May 2019. The research uses descriptive methods by describing and explaining the results of the analysis found in the study. This research is a type of qualitative research because the results tend to be released and descriptive. the technique used in this study is to take data, data collection is done in two ways, namely listening and taking notes. This study found the results of the use of cohesion and and the use of coherence. Cohesion is the integration between the parts that are characterized by the use of language elements. Cohesion is divided into two parts, lexical cohesion and grammatical cohesion. Grammatical cohesion includes conjunction, reference, release, substitution. Lexical cohesion includes antonyms, synonyms, repetitions, metonymy, and hypomini. Whereas, cohorence is the relationship between elements one with the other elements so that it has an integrated meaning.  


Author(s):  
Zimmatul Liviana

The research grammatical interference in a collection ofshort stories Biarkan Aku Memula iwork Nurul F. Hudaisa collection ofshort storiesset in the back that Is start work Let Nurul F. Huda contains many grammatical interference.The problem of this   study were(1)how   the various morphologi calinterference containedin   a   collection of short stories Biarkan Aku Memulai work Nurul F. Huda. (2)how the various syntactic interference contained in a collection of short stories Biarkan Aku Memulai work Nurul F. Huda. The purposeof this studyis to describe the morphological and         Syntactic interference contained in a collection of short stories Biarkan Aku Memulai work Nurul F. Huda. Sociolinguistics is the study of language variation and use in society. Interference is the event of the use of language elements of one into the other language elements that occur in the speakers themselves. This research uses descriptive qualitative method because to describe the actual realityin order to obtainan accurateand objective. Qualitative descriptive methods were used to analyzethe elements ofa word orphrase that incorporated elements of other languages with the analysis and description of the formulation of the problem is the answer. Data collection techniques using observation techniques, the determination ofthe object of research, the selection of short stories.Based on the analysis of the data in this study can be found that there are six forms of interference morphology, namely (1) the prefix nasal N-sound, (2) the addition of the suffix, (3) the exchange prefix, (4) exchange suffixes, (5) exchange konfiks, (6) removal affixes. While the syntactic interference only on the words and phrases in a sentence. The results of the study it can be concluded that the interference morphology more common than syntactic interference.


2019 ◽  
Author(s):  
Joseph John Pyne Simons ◽  
Ilya Farber

Not all transit users have the same preferences when making route decisions. Understanding the factors driving this heterogeneity enables better tailoring of policies, interventions, and messaging. However, existing methods for assessing these factors require extensive data collection. Here we present an alternative approach - an easily-administered single item measure of overall preference for speed versus comfort. Scores on the self-report item predict decisions in a choice task and account for a proportion of the differences in model parameters between people (n=298). This single item can easily be included on existing travel surveys, and provides an efficient method to both anticipate the choices of users and gain more general insight into their preferences.


2020 ◽  
Vol 17 (2) ◽  
pp. 291-320
Author(s):  
Asep Saefullah

Tulisan ini membahas fenomena penyebaran kitab-kitab cetak keaga­maan di Jawa Barat, khususnya di Sukabumi dan Cianjur. Jenis kitab ini biasanya menggunakan tulisan Arab dengan bahasa Sunda dan menggu­nakan aksara Pegon. Kitab-kitab cetak dari jenis-jenis itu diproduksi dan direproduksi, dan masih digunakan sampai hari ini. Oleh karena itu, fenomena ini dapat disebut sebagai “living tradition”. Pengumpulan data dilakukan dengan melacak dan merekam kitab-kitab yang diproduksi (disalin atau dikarang) dan direproduksi (dicetak atau digandakan) dengan metode seder­hana, yakni fotocopi dan pencetakan tradisional seperti stensil, sablon, dan "cetak toko". Tulisan ini bertujuan untuk memetakan dan merevisi kategorisasi kitab-kitab tersebut dari kajian terdahulu berdasarkan jenis karya, seperti karangan asli, tuqilan, terjemahan, syarḥ (penjelasan), khulasah (ringkasan) yang lain, dan juga berdasarkan bahasa dan aksara yang digunakan. Selain itu, tulisan ini juga mengamati lembaga-lembaga atau individu-individu yang masih mereproduksi buku-buku (kitab-kitab) keagamaan sederhana seperti perusahaan percetakan atau pesantren yang menerbitkan kitab-kitab tersebut. Pada akhir artikel ini, ada beberapa saran dalam upaya untuk melestarikan kitab-kitab cetak dan karya-karya tersebut.Kata kunci: kitab, jenis karya, pencetakan tradisional, Sunda, Pegon, Jawa Barat This paper discusses the phenomenon of the spreading of religious printed books (kitabs) in West Java, especially in Sukabumi and Cianjur, which are characterized by the use of Arabic writing in Sundanese (or known as Pegon script). The printed books (Kitabs) of those types are produced and reproduced, and are still used to this day. Therefore, this phenomenon can be called as a “living tradition”. Data collection was conducted by tracing and recording religious books (kitabs) that are pro-duced (rewritten or compossed) and reproduced (printed or duplicated) with a simple method, known as photocopying and traditional printing such as stencils, screen printing, and “shop printing”. This paper aims to map and revise the categorization of these Kitabs from previous studies based on the types of works including original essays, tuqilan (quotations), translation, sharh (explanation), khulaṣah (summary), or the other, and also based on the language and the script used. In addition, this paper also observes the institutions or individuals that are still reproducing these printed religious books such as the printing company or pesantren that publish such kitabs. At the end of this article, there are some suggestions in attempts to preserve those printed kitabs and the works.Keywords: Kitabs, type of work, traditional printing, Sunda, Pegon, West Java


2017 ◽  
Vol 2 (2) ◽  
pp. 155-168 ◽  
Author(s):  
David Wong

This research aims at analyzing (1) the effect of vendor’s ability, benevolence, and integrity variables toward e-commerce customers’ trust in UBM; (2) the effect of vendor’s ability, benevolence, and integrity variables toward the level of e-commerce customers’ participation in Indonesia; and (3) the effect of trust variable toward level of e-commerce customers participation in UBM. This research makes use of UBM e-commerce users as research samples while using Likert scale questionnaire for data collection. Furthermore, the questionnaires are sent to as many as 200 respondents. For data analysis method, Structural Equation Model was used. Out of three predictor variables (ability, benevolence, and integrity), it is only vendor’s integrity that has a positive and significant effect on customers’ trust. On the other hand, it is only vendor’s integrity and customer’s trust that have a positive and significant effect on e-commerce customers’ participation in UBM. Keywords: e-commerce customers’ participation, ability, benevolence, integrity


1992 ◽  
Vol 23 (2) ◽  
pp. 89-104 ◽  
Author(s):  
Ole H. Jacobsen ◽  
Feike J. Leij ◽  
Martinus Th. van Genuchten

Breakthrough curves of Cl and 3H2O were obtained during steady unsaturated flow in five lysimeters containing an undisturbed coarse sand (Orthic Haplohumod). The experimental data were analyzed in terms of the classical two-parameter convection-dispersion equation and a four-parameter two-region type physical nonequilibrium solute transport model. Model parameters were obtained by both curve fitting and time moment analysis. The four-parameter model provided a much better fit to the data for three soil columns, but performed only slightly better for the two remaining columns. The retardation factor for Cl was about 10 % less than for 3H2O, indicating some anion exclusion. For the four-parameter model the average immobile water fraction was 0.14 and the Peclet numbers of the mobile region varied between 50 and 200. Time moments analysis proved to be a useful tool for quantifying the break through curve (BTC) although the moments were found to be sensitive to experimental scattering in the measured data at larger times. Also, fitted parameters described the experimental data better than moment generated parameter values.


2012 ◽  
Vol 9 (1) ◽  
pp. 22-25
Author(s):  
S.V. Amel’kin ◽  
D.Ye. Igoshin

A self-assembly model for porous hydrate structures is proposed, which takes into account the sequence of basic physical processes: hydrate growth on the surface of the aqueous solution, formation of islet structure, capillary flow, separation and transfer of secondary crystallization nuclei to the meniscus. The model was studied within the cellular automata method. A good correspondence between the results of the simulation and the experimental data is obtained.


2006 ◽  
Vol 30 (1) ◽  
pp. 20-25 ◽  
Author(s):  
David A. Cole

Many outcome variables in developmental psychopathology research are highly stable over time. In conventional longitudinal data analytic approaches such as multiple regression, controlling for prior levels of the outcome variable often yields little (if any) reliable variance in the dependent variable for putative predictors to explain. Three strategies for coping with this problem are described. One involves focusing on developmental periods of transition, in which the outcome of interest may be less stable. A second is to give careful consideration to the amount of time allowed to elapse between waves of data collection. The third is to consider trait-state-occasion models that partition the outcome variable into two dimensions: one entirely stable and trait-like, the other less stable and subject to occasion-specific fluctuations.


Mathematics ◽  
2021 ◽  
Vol 9 (16) ◽  
pp. 1850
Author(s):  
Rashad A. R. Bantan ◽  
Farrukh Jamal ◽  
Christophe Chesneau ◽  
Mohammed Elgarhy

Unit distributions are commonly used in probability and statistics to describe useful quantities with values between 0 and 1, such as proportions, probabilities, and percentages. Some unit distributions are defined in a natural analytical manner, and the others are derived through the transformation of an existing distribution defined in a greater domain. In this article, we introduce the unit gamma/Gompertz distribution, founded on the inverse-exponential scheme and the gamma/Gompertz distribution. The gamma/Gompertz distribution is known to be a very flexible three-parameter lifetime distribution, and we aim to transpose this flexibility to the unit interval. First, we check this aspect with the analytical behavior of the primary functions. It is shown that the probability density function can be increasing, decreasing, “increasing-decreasing” and “decreasing-increasing”, with pliant asymmetric properties. On the other hand, the hazard rate function has monotonically increasing, decreasing, or constant shapes. We complete the theoretical part with some propositions on stochastic ordering, moments, quantiles, and the reliability coefficient. Practically, to estimate the model parameters from unit data, the maximum likelihood method is used. We present some simulation results to evaluate this method. Two applications using real data sets, one on trade shares and the other on flood levels, demonstrate the importance of the new model when compared to other unit models.


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