scholarly journals Effects of Sodium Chloride on the Physical and Oxidative Stability of Filled Hydrogel Particles Fabricated with Phase Separation Behavior

Foods ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1027
Author(s):  
Chuanai Cao ◽  
Xin Li ◽  
Yongchao Yin ◽  
Baohua Kong ◽  
Fangda Sun ◽  
...  
Keyword(s):  
Sodium Chloride ◽  
Physical Stability ◽  
Viscoelastic Behavior ◽  
Whey Protein Concentrate ◽  
Future Application ◽  
Rheological Characterization ◽  
Zeta Potentials ◽  
Hydrogel Particles ◽  
Nacl Concentration ◽  
Phase Separation Behavior

The objective of this study was to investigate the influence of sodium chloride (NaCl) concentration (0–500 mM) on the physical and oxidative stabilities of filled hydrogel that were stabilized using heat-denatured whey protein concentrate and high methoxy pectin. Our results showed that with an increase in NaCl concentration, the particle sizes, zeta-potentials, and interfacial layer thickness of filled hydrogels significantly increased and the lightness and whiteness gradually decreased (p < 0.05). Moreover, rheological characterization revealed that the apparent viscosity and viscoelastic behavior gradually decreased at higher NaCl concentration, which was mainly ascribed to the influence of NaCl on the electrostatic repulsion between droplets, thereby adversely impacting the physical stability of filled hydrogels. Furthermore, the result of cryo-scanning electron microscopy also verified the abovementioned results. Notably, higher NaCl concentration significantly promoted the oxidation of lipids and proteins (p < 0.05), thereby decreasing the oxidative stabilities of filled hydrogels. Our results indicated that filled hydrogels prepared under different ionic strength conditions can provide the theoretical basis for their future application in emulsion-based foods.

scholarly journals Characterization of Virus Adsorption by Using DEAE-Sepharose and Octyl-Sepharose

2002 ◽  
Vol 68 (8) ◽  
pp. 3965-3968 ◽  
Author(s):  
Patricia A. Shields ◽  
Samuel R. Farrah
Keyword(s):  
Sodium Chloride ◽  
Electrostatic Interactions ◽  
Hydrophobic Interactions ◽  
Chloride Concentration ◽  
Sodium Chloride Concentration ◽  
Virus Adsorption ◽  
Nacl Concentration

ABSTRACT Viruses were characterized by their adsorption to DEAE-Sepharose or by their elution from octyl-Sepharose by using buffered solutions of sodium chloride with different ionic strengths. Viruses whose adsorption to DEAE-Sepharose was reduced most rapidly by an increase in the sodium chloride concentration were considered to have the weakest electrostatic interactions with the solids; these viruses included MS2, E1, and φX174. Viruses whose adsorption to DEAE-Sepharose was reduced least rapidly were considered to have the strongest electrostatic interactions with the column; these viruses included P1, T4, T2, and E5. All of the viruses studied adsorbed to octyl-Sepharose in the presence of 4 M NaCl. Viruses that were eluted most rapidly following a decrease in the concentration of NaCl were considered to have the weakest hydrophobic interactions with the column; these viruses included φX174, CB4, and E1. Viruses that were eluted least rapidly from the columns after the NaCl concentration was decreased were considered to have the strongest hydrophobic interactions with the column; these viruses included f2, MS2, and E5.

Subcutaneous Dihydrocodeine Tartrate: Compatibility in a Syringe Pump With Other Drugs Frequently Prescribed for the Management of Symptoms Associated With Brain Tumors

2021 ◽  
pp. 082585972110527
Author(s):  
Ruth Isherwood ◽  
Amy Forsyth ◽  
Anne Wilson
Keyword(s):  
Sodium Chloride ◽  
Brain Tumors ◽  
Physical Stability ◽  
Syringe Pump ◽  
Pump Design ◽  
Subcutaneous Infusion ◽  
Hyoscine Butylbromide ◽  
Stability Data ◽  
Future Work ◽  
Different Doses

Background Dihydrocodeine can be more effective in the management of headache due to brain tumor than other opioids. It can be used as a subcutaneous infusion, but at present, there is little available data to support its use in combination with other medicines in a syringe pump. Aim This project aimed to establish physical stability data for the use of dihydrocodeine with other drugs when combined in a syringe pump. Design: Dihydrocodeine was combined in a syringe pump with either cyclizine, midazolam, or hyoscine butylbromide at different doses chosen to represent routine clinical practice. Each drug combination was repeated twice—with 0.9% sodium chloride and with water for injections. Setting: The project was conducted in an independent hospice after seeking appropriate approvals to use the drugs for this purpose. Results Dihydrocodeine and midazolam appear compatible at when 0.9% sodium chloride is used as the diluent. Dihydrocodeine and cyclizine appeared compatible when either 0.9% saline or water for injections was used as the diluent. Dihydrocodeine and hyoscine butylbromide appeared compatible with either diluent at 24 hours. Conclusions Physical stability data has been described that will support the use of dihydrocodeine and other drugs that are commonly used to manage symptoms due to brain tumors at the end of life. This information will benefit patients and ensure that one syringe pump can be used where possible. Future work could expand on this data and explore the physical stability of three drug combinations in each syringe.

scholarly journals Revealing the True Morphological Structure of Macroporous Soft Hydrogels for Tissue Engineering

2020 ◽  
Vol 10 (19) ◽  
pp. 6672
Author(s):  
Bohumila Podhorská ◽  
Miroslav Vetrík ◽  
Eva Chylíková-Krumbholcová ◽  
Lucie Kománková ◽  
Niloufar Rashedi Banafshehvaragh ◽  
...  
Keyword(s):  
Sodium Chloride ◽  
Pore Size ◽  
Laser Scanning ◽  
Morphological Changes ◽  
3D Structure ◽  
Morphological Structure ◽  
Laser Scanning Confocal Microscopy ◽  
Future Application ◽  
Sem Images ◽  
Hydrogel Scaffolds

(1) Background: Macroporous hydrogel scaffolds based on poly [N-(2-hydroxypropyl) methacrylamide] are one of the widely studied biocompatible materials for tissue reparation and regeneration. This study investigated the morphological changes during hydrogel characterization which can significantly influence their future application. (2) Methods: Three types of macroporous soft hydrogels differing in pore size were prepared. The macroporosity was achieved by the addition of sacrificial template particles of sodium chloride of various sizes (0–30, 30–50, and 50–90 µm) to the polymerizing mixture. The 3D structure of the hydrogels was then investigated by scanning electron microscopy (SEM) and laser scanning confocal microscopy (LSCM). The SEM was performed with specimens rapidly frozen to various temperatures, while non-frozen gels were visualized with LSCM. (3 and 4) Results and Conclusion: In comparison to LSCM, the SEM images revealed a significant alteration in the mean pore size and appearance of newly formed multiple connections between the pores, depending on the freezing conditions. Additionally, after freezing for SEM, the gel matrix between the pores and the fine pores collapsed. LSCM visualization aided the understanding of the dynamics of pore generation using sodium chloride, providing the direct observation of hydrogel scaffolds with the growing cells. Moreover, the reconstructed confocal z-stacks were a promising tool to quantify the swollen hydrogel volume reconstruction which is not possible with SEM.

Stability of Imipenem-Cilastatin Sodium in AutoDose Infusion System Bags

2003 ◽  
Vol 38 (2) ◽  
pp. 130-134
Author(s):  
Lawrence A. Trissel ◽  
Quanyun A. Xu
Keyword(s):  
Sodium Chloride ◽  
Chemical Stability ◽  
High Performance ◽  
Physical Stability ◽  
Analytical Techniques ◽  
Storage Condition ◽  
Evaluation Procedure ◽  
Drug Concentrations ◽  
Physical And Chemical ◽  
Infusion System

The objective of this study was to evaluate the physical and chemical stability of imipenem-cilastatin sodium 250 mg/100 mL and 500 mg/100 mL (of each drug component) admixed in 0.9% sodium chloride injection packaged in AutoDose Infusion System bags. Triplicate test samples were prepared by bringing the required amount of imipenem-cilastatin sodium injection to volume with 0.9% sodium chloride injection. A total of 100 mL of each of the test solutions was packaged in each of three ethylene vinyl acetate (EVA) AutoDose bags designed for use in the AutoDose Infusion System for each storage condition. Samples were protected from light and evaluated at appropriate intervals for up to three days at 23°C and 14 days at 4°C. Physical stability was assessed using a multistep evaluation procedure that included turbidimetric and particulate measurement in addition to visual inspection. Chemical stability was assessed with stability-indicating high performance liquid chromatography (HPLC) analytical techniques, based on initial drug concentrations and concentrations at appropriate intervals over the study periods. The admixtures were clear throughout the study when viewed in normal fluorescent room light and with a Tyndall beam. Measured turbidity and particulate content were low initially and exhibited little change throughout the study. HPLC analysis revealed extensive decomposition in the samples, with imipenem being the less stable component. The instability of the imipenem-cilastatin sodium admixtures is consistent with previous studies. Admixtures stored under refrigeration should be used immediately upon warming to room temperature due to the rapid rate of imipenem decomposition. The AutoDose Infusion System bags were not found to affect adversely or improve the physical and chemical stability of this drug.

scholarly journals EFFECTS OF SEED PRIMING WITH SODIUM CHLORIDE ON SEEDLING PERFORMANCE OF COMMON BEAN (PHASEOLUS VULGARIS L.) UNDER GREEN HOUSE CONDITION

2016 ◽  
Vol 4 (6) ◽  
pp. 222-228
Author(s):  
Roba Tufa ◽  
Jima Nego
Keyword(s):  
Sodium Chloride ◽  
Phaseolus Vulgaris ◽  
Common Bean ◽  
Germination Rate ◽  
Shoot Length ◽  
Distilled Water ◽  
Seedling Height ◽  
Phaseolus Vulgaris L ◽  
Vigor Index ◽  
Nacl Concentration

This study was conducted at Jimma University College of Agriculture and Veterinary Medicine (JUCAVM) under controlled environmental conditions of greenhouse to determine the effects of different concentration of sodium chloride (NaCl) on germination and seedling growth of Phaseolus vulgaris L. Five concentrations of sodium chloride (o mol(distilled water), 0.1M, 0.2M,0.3M and 0.4M) with one control treatment of un-primed seeds were laid out  in completely randomized design (CRD) with three replication. Data were collected on standard germination, Rate of germination, Seedling height, Shoot length, Root length and Vigor index. The result revealed that different NaCl concentrations statistically (p≤0.05) affected standard germination, Rate of germination, Seedling height, Shoot length and Vigor index I of common bean crop. The highest value of all these parameters were obtained from seed primed with 0.1M NaCl as well as when the seed primed with distilled water. However, the lowest values of these parameters were recorded on the seed primed with the highest concentration (0.4M) of NaCl and un-primed seed. More of the examined parameters were decreased with increasing of NaCl concentration. In conclusion, priming seed with 0.1M of NaCl concentration enhanced germination and seedling performance of common bean.

scholarly journals Rheological characterization and physical-stability of gamma irradiated anthocyanin-loaded albumin nanoparticles

2021 ◽  
Author(s):  
Sofia Leila Candido ◽  
Macarena Siri ◽  
Estefania Achilli ◽  
Juan Cruz Moreno ◽  
Cristian Lillo ◽  
...  
Keyword(s):  
Physical Stability ◽  
Rheological Characterization ◽  
Albumin Nanoparticles ◽  
Gamma Irradiated

scholarly journals Pengaruh Lama Waktu Pengadukan Terhadap Pengikatan Impuritis untuk Meningkatkan Kadar NaCl Pada Garam Rakyat

2016 ◽  
Vol 1 (1) ◽  
pp. 9-14
Author(s):  
Rika Puji Astuti ◽  
Cicik Herlina Yulianti ◽  
Rahmad Aji Prasetya
Keyword(s):  
Sodium Chloride ◽  
Sodium Hydroxide ◽  
Barium Chloride ◽  
Chemical Compounds ◽  
Main Substance ◽  
Nacl Concentration ◽  
Before And After ◽  
Stirring Time ◽  
Standard Quality

ABSTRAKGaram dapat didefinisikan sebagai suatu kumpulan senyawa kimia yang bagian utamanya adalah Natrium Chlorida (NaCl) dengan zat-zat pengotor terdiri dari MgCl2, MgSO4, CaSO4, dan lain-lain. Dalam penelitian ini digunakan sampel garam rakyat dari Pasar Larangan Sidoarjo yang memiliki kualitas dibawah standar, dengan kadar NaCl 81,88% b/b. Oleh karena itu, diperlukan pemurnian garam dengan menggunakan metode rekristalisasi. Penelitian ini dilakukan untuk mengetahui pengaruh lama waktu pengadukan (15, 30, dan 45menit) terhadap penambahan beberapa senyawa kimia, seperti natrium hidroksida (NaOH), natrium karbonat (Na2CO3) dan barium klorida (BaCl2) untuk mengurangi ion polutan (Ca2+, Mg2+ dan SO42-). Sehingga kadar NaCl dalam garam rakyat akan meningkat. Kadar NaCl dihitung sebelum dan setelah diberi perlakuan dengan menggunakan metode titrasi argentometri. Hasil penelitian menunjukkan bahwa kadar NaCl tertinggi diperoleh pada rekristalisasi dengan lama waktu pengadukan 45 menit, dengan kadar 98,86% b/b. Kemurnian ini sesuai untuk memenuhi tuntutan kebutuhan masyarakat dan industri.Kata Kunci: Garam Rakyat, Kadar NaCl, Lama Waktu PengadukanABSTRACTSalt can be defined as chemical compounds which the main substance is Sodium Chloride (NaCl) with impurity substances consist of MgCl2, MgSO4, CaSO4, etc. This study used public salt from Larangan Market Sidoarjo which has sub-standard quality, and the concentration of NaCl is about 81,88%b/b. Hence, salt purification is needed using recrystallization method. This study was conducted to determine the influence of stirring time (15, 30, and 45 minutes) of the addition of several chemical compounds, such as sodium hydroxide (NaOH), sodiumcarbonate (Na2CO3) and barium chloride (BaCl2) in order to reduce the pollutant ions (Ca2+, Mg2+ and SO42-). Eventually the percentage of NaCl concentration in public salt will increase. NaCl concentration was calculated before and after treatment was using argentometry titration. The results shows that the highest NaCl concentration is obtained at recrystallization with stirring time 45 minutes, concentration 98,86% b/b. This purity suitable to meet the needs of society and industry demands.Keywords: Stirring Time, The Concentration Of NaCl, Public Salt.

scholarly journals Effects of sodium chloride on germination and seedling growth of Sunflower (Helianthus annuus L.)

2018 ◽  
Vol 7 (1) ◽  
pp. 35-44
Author(s):  
FM Tonmoy Chowdhury ◽  
MA Halim ◽  
Feroza Hossain ◽  
Nahid Akhtar
Keyword(s):  
Sodium Chloride ◽  
Helianthus Annuus ◽  
Seedling Growth ◽  
Germination Percentage ◽  
Water Control ◽  
Helianthus Annuus L ◽  
Early Seedling Growth ◽  
Nacl Concentration ◽  
Early Seedling ◽  
Germination Indices

The response of BARI Sunflower-2 (Helianthus annuus L.) to sodium chloride (NaCl) at germination and early seedling growth was investigated. The seeds and seedlings of sunflower were treated with a series of eight different concentrations of NaCl viz 25, 50, 75, 100, 125, 150, 175 and 200 mM and distilled water (control) and were allowed to grow under plate culture condition. The results showed that the highest salinity concentration (200 mM NaCl) remarkably decreased the germination percentage, germination index and speed of germination of BARI Sunflower-2. Fresh and dry masses of both shoot and root were significantly reduced at a 25-200 mM NaCl solution. Significant reductions of shoot and root length were also noted with the increase of NaCl concentration. The results also illustrate that up to 50 mM NaCl concentration, all of the germination indices and fresh and dry biomass were withstand more than 70%. Thus the present study concluded that the BARI Sunflower-2 could be cultivated in moderately saline soil.Jahangirnagar University J. Biol. Sci. 7(1): 35-44, 2018 (June)

scholarly journals Processing and Formulation Optimization of Mandarin Essential Oil-Loaded Emulsions Developed by Microfluidization

Materials ◽  
2020 ◽  
Vol 13 (16) ◽  
pp. 3486
Author(s):  
Jenifer Santos ◽  
Nuria Calero ◽  
Luis Alfonso Trujillo-Cayado ◽  
María José Martín-Piñero ◽  
José Muñoz
Keyword(s):  
Essential Oil ◽  
Guar Gum ◽  
Loss Modulus ◽  
Flow Behavior ◽  
Physical Stability ◽  
Tween 80 ◽  
Rheological Characterization ◽  
Food Preservatives ◽  
Starting Point ◽  
Droplet Sizes

Emulsions can be used as delivery systems for bioactive ingredients for their incorporation in food products. Essential oils are natural compounds found in plants that present antioxidant and antimicrobial activity. Therefore, the main goal of this work was to develop emulsions, containing mandarin essential oil stabilized by two food-grade surfactants and guar gum, and to evaluate their physical stability. The initial droplet size of emulsions developed by microfluidization was optimized, obtaining diameters below one micron regardless of the processing conditions. However, the emulsion processed at 25,000 psi and one pass exhibited the lowest mean droplet sizes and polidispersity, and therefore, a higher stability. Different ratios of Tween 80 and Span 80 were assessed as stabilizers. Results obtained indicated that the ratio of surfactants had a significant effect on the mean droplet sizes, physical stability, and rheological properties. Thus, we found that the optimum ratio of surfactants was 75/25 (Tween80/Span80) on account of the lowest droplet mean diameters, lack of coalescence, and a low creaming rate. The rheological characterization of the stable emulsions showed a shear thinning flow behavior, and G″ (loss modulus) values higher than G′ (storage modulus) values, in all the frequency range. The rheological behavior may be governed by the guar gum, which was confirmed by field emission scanning electron microscopy (FESEM). This research can be considered as the starting point for future applications of mandarin essential oil in emulsions, which can be incorporated in products as food preservatives.

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